LOCUS       NM_022267               1414 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cyclin D2 (Ccnd2), mRNA.
ACCESSION   NM_022267 XM_216276
VERSION     NM_022267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1414)
  AUTHORS   Qian,Y., Wang,J.W., Fang,Y., Yuan,X.D., Fan,Y.C., Gao,S. and
            Wang,K.
  TITLE     Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in
            Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein
            Levels in Patients with Hepatitis B Virus-Associated Hepatocellular
            Carcinoma
  JOURNAL   Med Sci Monit 26, e927444 (2020)
   PUBMED   33320844
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1414)
  AUTHORS   Jin,M., Ren,J., Luo,M., You,Z., Fang,Y., Han,Y., Li,G. and Liu,H.
  TITLE     Long non-coding RNA JPX correlates with poor prognosis and tumor
            progression in non-small-cell lung cancer by interacting with
            miR-145-5p and CCND2
  JOURNAL   Carcinogenesis 41 (5), 634-645 (2020)
   PUBMED   31253987
REFERENCE   3  (bases 1 to 1414)
  AUTHORS   Park,S.Y., Lee,C.J., Choi,J.H., Kim,J.H., Kim,J.W., Kim,J.Y. and
            Nam,J.S.
  TITLE     The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell
            persistence and radioresistance
  JOURNAL   J Exp Clin Cancer Res 38 (1), 399 (2019)
   PUBMED   31511084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1414)
  AUTHORS   Anwar,S.L., Hasemeier,B., Schipper,E., Vogel,A., Kreipe,H. and
            Lehmann,U.
  TITLE     LINE-1 hypomethylation in human hepatocellular carcinomas
            correlates with shorter overall survival and CIMP phenotype
  JOURNAL   PLoS One 14 (5), e0216374 (2019)
   PUBMED   31059558
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1414)
  AUTHORS   Hung,C.S., Wang,S.C., Yen,Y.T., Lee,T.H., Wen,W.C. and Lin,R.K.
  TITLE     Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential
            Biomarker and Drug Target
  JOURNAL   Int J Mol Sci 19 (10), 3096 (2018)
   PUBMED   30308939
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1414)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   7  (bases 1 to 1414)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 1414)
  AUTHORS   Wu,F., Buckley,S., Bui,K.C. and Warburton,D.
  TITLE     Differential expression of cyclin D2 and cdc2 genes in
            proliferating and nonproliferating alveolar epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 12 (1), 95-103 (1995)
   PUBMED   7811475
REFERENCE   9  (bases 1 to 1414)
  AUTHORS   Hosokawa,Y., Onga,T. and Nakashima,K.
  TITLE     Induction of D2 and D3 cyclin-encoding genes during promotion of
            the G1/S transition by prolactin in rat Nb2 cells
  JOURNAL   Gene 147 (2), 249-252 (1994)
   PUBMED   7926809
REFERENCE   10 (bases 1 to 1414)
  AUTHORS   Tamaru,T., Okada,M. and Nakagawa,H.
  TITLE     Differential expression of D type cyclins during neuronal
            maturation
  JOURNAL   Neurosci Lett 168 (1-2), 229-232 (1994)
   PUBMED   8028782
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022267.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09752.1, FQ234359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840127 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000004.1  161675231-161675422 c
            193-408             JAXUCZ010000004.1  161673349-161673564 c
            409-568             JAXUCZ010000004.1  161670771-161670930 c
            569-717             JAXUCZ010000004.1  161663857-161664005 c
            718-1414            JAXUCZ010000004.1  161653048-161653744 c
FEATURES             Location/Qualifiers
     source          1..1414
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1414
                     /gene="Ccnd2"
                     /note="cyclin D2"
                     /db_xref="GeneID:64033"
                     /db_xref="RGD:621083"
     CDS             1..867
                     /gene="Ccnd2"
                     /note="vin-1 proto-oncogene"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D2"
                     /protein_id="NP_071603.2"
                     /db_xref="GeneID:64033"
                     /db_xref="RGD:621083"
                     /translation="MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFK
                     CVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGA
                     VCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIE
                     HILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEE
                     VNALTCDALTELLAKITHTDVDCLKACQEQIEAVLLNSLQQFRQEQHNGSKSVEDPDQ
                     ATTPTDVRDVDL"
     exon            1..192
                     /gene="Ccnd2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..408
                     /gene="Ccnd2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..568
                     /gene="Ccnd2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..717
                     /gene="Ccnd2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1414
                     /gene="Ccnd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagctgc tgtgctgtga ggtggacccg gtccgcaggg ccgtgccgga ccgcaacctg
       61 ctggaagacc gcgtcctgca gaacctgttg actatcgagg agcgctacct cccgcagtgt
      121 tcctatttca agtgcgtgca gaaggacatc cagccgtaca tgcgcaggat ggtggctacc
      181 tggatgctag aggtctgtga ggaacagaag tgtgaagaag aggtctttcc tctggccatg
      241 aattacctgg accgtttctt ggctggagtc ccgactccta agacccatct ccagctcctg
      301 ggcgctgtgt gcatgttcct agcttccaag ctgaaagaga ccatcccgct gactgccgaa
      361 aagctgtgta tttacaccga caattctgtg aaaccccagg agctgctgga gtgggaactg
      421 gtggtgctgg gtaagctgaa gtggaacctg gctgcagtaa cccctcacga cttcattgag
      481 cacatcctac gcaagctgcc ccagcagaag gagaagctgt ccctgatccg caagcatgcg
      541 cagaccttca tcgctctgtg tgctaccgac ttcaagtttg ccatgtaccc gccatcgatg
      601 atcgcaactg gaagcgtggg agcagccatc tgcgggcttc agcaggacga ggaagtgaat
      661 gcactcacgt gcgatgccct gacggagctg ctggccaaga tcacccacac cgatgtggat
      721 tgtctcaaag cctgccagga gcaaatcgag gctgtgctgc ttaacagcct tcagcagttc
      781 cgtcaagagc agcacaacgg ctccaagtct gtggaagatc cggaccaagc caccacccct
      841 acagacgtgc gggatgttga cctgtgagga agccattcgg gcggcaagag agaggcgtgt
      901 tcgtcatctg ctagcccctt ctctctctct ctctagttat gtcttgttct tttgtgtttt
      961 aggatgaaag ttcaaaacaa aaaacaaaaa caaaaacaaa aacaaaatct acccccacct
     1021 agatcatatt taaaggtctt ttagaagtga gagggaaagg ccatatagtt gaggcacatg
     1081 tggtacctgt tcaaagtcca gcagaaaggg atcccttgta tatgcgaacc attatcatgt
     1141 gatgatgtaa gagttctagt gagatgctta caggagagcc ctcagactag ctagagaaca
     1201 tgtatacctg cagtatggga acgaattaga ggagactgtc tcttgtgctt gggaactagt
     1261 gcatatgccc cctttagtag aattgcaaga aaccatggat gccggtgcgg catgagtagt
     1321 ttgcaaagca ttgaacccaa gaaggaatca gaaatgagaa gggacacgct ggggaggtta
     1381 tgcagaacca cccaaccaca cgactgaacc attt
//
