LOCUS       NM_171992               3809 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus cyclin D1 (Ccnd1), mRNA.
ACCESSION   NM_171992
VERSION     NM_171992.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Pedraza,N., Monserrat,M.V., Ferrezuelo,F., Torres-Rosell,J.,
            Colomina,N., Miguez-Cabello,F., Parraga,J.P., Soto,D.,
            Lopez-Merino,E., Garcia-Vilela,C., Esteban,J.A., Egea,J. and
            Gari,E.
  TITLE     Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation
            of GABAA receptors
  JOURNAL   Cell Mol Life Sci 80 (10), 280 (2023)
   PUBMED   37684532
  REMARK    GeneRIF: Cyclin D1-Cdk4 regulates neuronal activity through
            phosphorylation of GABAA receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Song,L., Tian,X. and Schekman,R.
  TITLE     Extracellular vesicles from neurons promote neural induction of
            stem cells through cyclin D1
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34309628
  REMARK    GeneRIF: Extracellular vesicles from neurons promote neural
            induction of stem cells through cyclin D1.
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Zhou,W., Ye,S.D. and Wang,W.
  TITLE     Elevated retinol binding protein 4 levels are associated with
            atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway
  JOURNAL   World J Diabetes 12 (4), 466-479 (2021)
   PUBMED   33889291
REFERENCE   4  (bases 1 to 3809)
  AUTHORS   Xie,M., Wu,Z., Ying,S., Liu,L., Zhao,C., Yao,C., Zhang,Z., Luo,C.,
            Wang,W., Zhao,D., Zhang,J., Qiu,W. and Wang,Y.
  TITLE     Sublytic C5b-9 induces glomerular mesangial cell proliferation via
            ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing
            Cyclin D1 in rat Thy-1 nephritis
  JOURNAL   Exp Mol Med 53 (4), 572-590 (2021)
   PUBMED   33811247
  REMARK    GeneRIF: Sublytic C5b-9 induces glomerular mesangial cell
            proliferation via ERK1/2-dependent SOX9 phosphorylation and
            acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis.
REFERENCE   5  (bases 1 to 3809)
  AUTHORS   Xu,Q., Liu,M., Zhang,F., Liu,X., Ling,S., Chen,X., Gu,J., Ou,W.,
            Liu,S. and Liu,N.
  TITLE     Ubiquitin-specific protease 2 regulates Ang -induced cardiac
            fibroblasts activation by up-regulating cyclin D1 and stabilizing
            beta-catenin in vitro
  JOURNAL   J Cell Mol Med 25 (2), 1001-1011 (2021)
   PUBMED   33314748
  REMARK    GeneRIF: Ubiquitin-specific protease 2 regulates Ang -induced
            cardiac fibroblasts activation by up-regulating cyclin D1 and
            stabilizing beta-catenin in vitro.
REFERENCE   6  (bases 1 to 3809)
  AUTHORS   Beauchamp,R.D., Sheng,H.M., Shao,J.Y., Thompson,E.A. and Ko,T.C.
  TITLE     Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4,
            and p21Cip1
  JOURNAL   Ann Surg 223 (5), 620-7 (1996)
   PUBMED   8651753
REFERENCE   7  (bases 1 to 3809)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   8  (bases 1 to 3809)
  AUTHORS   Bianchi,S., Fabiani,S., Muratori,M., Arnold,A., Sakaguchi,K.,
            Miki,T. and Brandi,M.L.
  TITLE     Calcium modulates the cyclin D1 expression in a rat parathyroid
            cell line
  JOURNAL   Biochem Biophys Res Commun 204 (2), 691-700 (1994)
   PUBMED   7980531
REFERENCE   9  (bases 1 to 3809)
  AUTHORS   Meyerson,M. and Harlow,E.
  TITLE     Identification of G1 kinase activity for cdk6, a novel cyclin D
            partner
  JOURNAL   Mol Cell Biol 14 (3), 2077-2086 (1994)
   PUBMED   8114739
REFERENCE   10 (bases 1 to 3809)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000044.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_171992.6.
            
            On Feb 10, 2021 this sequence version replaced NM_171992.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM258963.2, FQ231654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JACYVU010000044.1  27027459-27027781   c
            324-539             JACYVU010000044.1  27025852-27026067   c
            540-699             JACYVU010000044.1  27025153-27025312   c
            700-848             JACYVU010000044.1  27022651-27022799   c
            849-3809            JACYVU010000044.1  27018259-27021219   c
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3809
                     /gene="Ccnd1"
                     /note="cyclin D1"
                     /db_xref="GeneID:58919"
                     /db_xref="RGD:68384"
     exon            1..323
                     /gene="Ccnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1013
                     /gene="Ccnd1"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D1"
                     /protein_id="NP_741989.3"
                     /db_xref="GeneID:58919"
                     /db_xref="RGD:68384"
                     /translation="MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSY
                     FKCVQREIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLL
                     GATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDF
                     IEHFLSKMPEADENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLG
                     SPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNIDPKATEEEGE
                     VEEEAGLACTPTDVRDVDI"
     exon            324..539
                     /gene="Ccnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..699
                     /gene="Ccnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..848
                     /gene="Ccnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..3809
                     /gene="Ccnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagtagca gagagctgca gactccgcgc gctccggaga ccggtcgtag agcgcgaggc
       61 agcgcgcgtc agcagcagac accggagccc aacccggacc acagccctcc ccaggcggcc
      121 gcgccatgga acaccagctc ctgtgctgcg aagtggagac catccgccgc gcgtaccctg
      181 acaccaatct cctcaacgac cgggtgctgc gagccatgct taagactgag gagacctgcg
      241 cgccctccgt ttcttacttc aagtgcgtgc agagggagat tgtgccatcc atgcggaaaa
      301 tcgtggccac ctggatgcta gaggtctgcg aggagcagaa gtgcgaagag gaggtcttcc
      361 cgctggccat gaactacctg gaccgtttct tgtctctgga gcccctgaag aagagccgcc
      421 tgcagcttct gggggccacc tgcatgttcg tggcctctaa gatgaaggag accattcccc
      481 tgactgccga gaagttgtgc atctacactg acaactctat ccgccccgag gagttgctgc
      541 aaatggaact gcttctggtg aacaagctca aatggaacct ggccgccatg actccccacg
      601 atttcatcga acacttcctc tccaaaatgc cagaggcgga tgagaacaag cagatcatcc
      661 gcaaacatgc acagaccttt gtggccctct gtgccacaga tgtgaagttc atttccaacc
      721 caccctccat ggtggctgct gggagtgtgg tggccgcgat gcagggcctg aacctgggca
      781 gccccaacaa cttcctctcc tgctaccgca caacgcactt tctttccaga gtcatcaagt
      841 gtgacccgga ctgcctccgt gcctgccagg aacagattga agcccttctg gagtcaagcc
      901 tgcgccaggc ccagcagaac atcgatccca aggccaccga ggaggaaggg gaagtggagg
      961 aagaagctgg tctggcttgc acacccaccg acgtccgaga tgtggacatc tgagggccac
     1021 cgggcaggcg ggagtcacca agtagtggca tccgcgaaga gaaaggagcc agcccgggtg
     1081 ctcctgacga ggtccccctt ggggatgtgt tgttaccaga aggggaagtt ttgttctctt
     1141 tgttggttgt ttttccttaa tctttctcct ttctatctga tttaagcaaa agagaaaaaa
     1201 aatacctgaa agctgtctta aagagagaga gagagataga attcgcatca ccctgagtat
     1261 agggagacgg gggggtgcta caaaaataga attctgtacc ccagtaatca actagttttc
     1321 tattaatgtg cttgtctgtt ctaagaatag gattaacaca caggaagtct tgagaaggat
     1381 ttttgattct tttatgtgtt taagaaaaaa aagcttaaga aacattgctt taaaaaaaga
     1441 aggaaaaaaa atacagcaaa ccattgttaa agtagaaggg ttttaggtag agaaatgtac
     1501 tctgctttgc tgaaaaggca cagctttggc aaggtcctca acctcactcc cctgcttgtt
     1561 cagtgcctac agccctgtta cctgatgata cctgtgcttt atcccaggag tgggcagacc
     1621 tcttaacctt actgatggtc gattcgacct ctagcggcct cgtggcgtgt ggcaccctcc
     1681 agggctcatg ttatgggccc tctgcccccc acaacctgca ggttcacaga gcgccagcca
     1741 gccacgcagc ggtagggatg aaatagtgac ataatatatt ctatttttgt aaccttcctg
     1801 ttttgtagtt cctgtttaga gagatgctgg tttttgcctg gtggccctgc agcccactca
     1861 catcaggttg aacccacagc ttttcttttg tgtgtggttt gttttgttat gttttccttc
     1921 tccatgttcc aaaaccattc catttcaaag cacttttggt cagctagctg gaggcagtgt
     1981 tgctgggtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcggtgggg
     2041 gagggggtct agtggaatgg ttgggggatg tccacacact caattctgat ggctgcacag
     2101 caggtgtgta gggctggtag catgaggtgc ttgggaagtt ttgttgggtc gagaagagaa
     2161 agctctgttc tcgtaccacc gggatcttcc tgcaaagtcg gagggatctt ttggtgccag
     2221 ctggcgtttg gaagtaggga ccgtgatggc attacctgga caaggggatt caggacgact
     2281 cttaagtctt tcacacagga ggcttttaaa cactaaaatc tctaatttat acgtaaggct
     2341 acagaagagt atttattggg aaggttgccc atgacccgtg tgactcaaag caatgtgatc
     2401 ttcccttgat tcaaacgcac accttctgcc ctgctggcga aggtttaggg ccatgtctga
     2461 gagactggtc ttttattggg caagtggggg tgtcctcaaa aaaaaacaaa ccacaaagac
     2521 ggagatgtgg tctccttgac tttcccaacc caattggccc cattggagag ccatccaaac
     2581 tgaggaaaat taggggactc caaaagagtc ttgagtctgg cacattcttg ccgccgctcc
     2641 caagttagca acagtaggta atttgcacac ctctggctct gcctttctgt tcaggatgtg
     2701 ttggtgggag gtggagagcg ggtggctgga gaggggatgt gagagaagaa gtatggaggg
     2761 tagggaccac acgggacagg ccgcggctcc tttcacagcg ctgctaccaa tgactcccag
     2821 gatccccggc gttcggaacc agattcacgt tgctttgtat ctttcatgtt gttttcgctg
     2881 ctattggagg gtcagtttta ttttgttgtt gttggtttgt ttgttttttt tttacaatgt
     2941 cataaactgc catgttcaag ttttaatttc ctcgtagaag agtgtattta cagatgccct
     3001 tttttgtact ttttttttta ttgtgattca attttggatt aatgtgatta ccgctgtatt
     3061 ccaaaaaaaa aaaaaaaaac cacacacaca cacacacaca cacacacaca cacacacaca
     3121 cacacacaca cacacaaaca ggttcctgta cacaatacct catgtatcac ctagccatgc
     3181 ataggcctgg caggcgggtg gggtggtctg cctccaggga ccctgggacc ctgctgggga
     3241 tcatcctgtc atgctgggcc ttcatttgat ctgggacata gcatcacagc agtcagggca
     3301 actgtgttct gttagttatc aatattgtta cttgtagcgg cctgttgtgc atgccaccat
     3361 gctgctggac ccggagagat ttgttctgag tctctggtgc atcatttaat ctgttaggtt
     3421 ctagtgttct gtcttgtttt gtgttactca cagcattgtg ctaatgtaaa gccagccgca
     3481 atgctgtagg ccccaggttc cctagcaagc tgccaaacca aaagggtcac caccagctta
     3541 gctgaggcgt cccaaccagg caggaccctt gagggctgct gtgtccatgg tgatggggtg
     3601 aagttttggc caaagggcca aaggctggtg gatccacaca gtctgccctg tgacatgaat
     3661 ggctttgagg ggctctggct ggtggtcagg ttggctttgt gtattctggt tgacacacca
     3721 tggcgcttcc cagcacagac atgtgaccag catggtccag gaaaaaaaaa aagacaaaaa
     3781 aatctagaaa taaaattggt aaaatccca
//
