LOCUS       NM_001100472            3307 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus cyclin C (Ccnc), mRNA.
ACCESSION   NM_001100472 XM_001058860 XM_342812
VERSION     NM_001100472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Poss,Z.C., Ebmeier,C.C. and Taatjes,D.J.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Zhao,X., Feng,D., Wang,Q., Abdulla,A., Xie,X.J., Zhou,J., Sun,Y.,
            Yang,E.S., Liu,L.P., Vaitheesvaran,B., Bridges,L., Kurland,I.J.,
            Strich,R., Ni,J.Q., Wang,C., Ericsson,J., Pessin,J.E., Ji,J.Y. and
            Yang,F.
  TITLE     Regulation of lipogenesis by cyclin-dependent kinase 8-mediated
            control of SREBP-1
  JOURNAL   J Clin Invest 122 (7), 2417-2427 (2012)
   PUBMED   22684109
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Rao,H.V., Thirumangalakudi,L. and Grammas,P.
  TITLE     Cyclin C and cyclin dependent kinases 1, 2 and 3 in
            thrombin-induced neuronal cell cycle progression and apoptosis
  JOURNAL   Neurosci Lett 450 (3), 347-350 (2009)
   PUBMED   19103257
  REMARK    GeneRIF: These results suggest that decreases in G1-S regulators
            cyclin C and cdks 3, cdk2 and cdk1 in response to thrombin could
            make conditions unfavorable for S phase entry and favor neuronal
            apoptosis.
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Zhang,T., Li,T.Z., Xu,Y.B., Qi,S.H., Liang,H.Z., Xie,J.L.,
            Chen,X.D. and Zheng,S.S.
  TITLE     [Influence of aerosols on the expression of cyclin B1, cyclin C and
            proliferating cell nuclear antigen in wound tissue healing of
            burned rat models]
  JOURNAL   Zhonghua Wai Ke Za Zhi 43 (19), 1280-1283 (2005)
   PUBMED   16271231
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Brower,C.S., Sato,S., Tomomori-Sato,C., Kamura,T., Pause,A.,
            Stearman,R., Klausner,R.D., Malik,S., Lane,W.S., Sorokina,I.,
            Roeder,R.G., Conaway,J.W. and Conaway,R.C.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
REFERENCE   7  (bases 1 to 3307)
  AUTHORS   Li,H., Lahti,J.M., Valentine,M., Saito,M., Reed,S.I., Look,A.T. and
            Kidd,V.J.
  TITLE     Molecular cloning and chromosomal localization of the human cyclin
            C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in
            human tumors
  JOURNAL   Genomics 32 (2), 253-259 (1996)
   PUBMED   8833152
REFERENCE   8  (bases 1 to 3307)
  AUTHORS   Demetrick,D.J., Matsumoto,S., Hannon,G.J., Okamoto,K., Xiong,Y.,
            Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of the genes for the human cell cycle proteins
            cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 190-192 (1995)
   PUBMED   7698009
REFERENCE   9  (bases 1 to 3307)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Oct 14, 2007 this sequence version replaced
            XM_001058860.1, XM_342812.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.18409.1,
                                           SRR26643296.14805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000005.1  40063683-40063825
            144-250             JAXUCZ010000005.1  40066307-40066413
            251-335             JAXUCZ010000005.1  40067368-40067452
            336-405             JAXUCZ010000005.1  40067634-40067703
            406-457             JAXUCZ010000005.1  40070682-40070733
            458-513             JAXUCZ010000005.1  40072241-40072296
            514-549             JAXUCZ010000005.1  40073407-40073442
            550-641             JAXUCZ010000005.1  40074063-40074154
            642-709             JAXUCZ010000005.1  40074495-40074562
            710-789             JAXUCZ010000005.1  40077495-40077574
            790-908             JAXUCZ010000005.1  40077802-40077920
            909-3307            JAXUCZ010000005.1  40079333-40081731
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..3307
                     /gene="Ccnc"
                     /note="cyclin C"
                     /db_xref="GeneID:114839"
                     /db_xref="RGD:70905"
     exon            1..143
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..963
                     /gene="Ccnc"
                     /codon_start=1
                     /product="cyclin-C"
                     /protein_id="NP_001093942.1"
                     /db_xref="GeneID:114839"
                     /db_xref="RGD:70905"
                     /translation="MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFF
                     TNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGV
                     VSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLL
                     QYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFA
                     ELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQ
                     NSSYSQS"
     exon            144..250
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            251..335
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            336..405
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            406..457
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            458..513
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            514..549
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            550..641
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            642..709
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            710..789
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            790..908
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
     exon            909..3307
                     /gene="Ccnc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcaatcc agccggtctg gttgagtaac acagtccagg gactgtgtct atggttgctc
       61 cgcgggccgc tttgccggct ggtgcttttg tatcagggca agcagtattc catggcaggg
      121 aacttctggc agagctccca ctatttgcag tggattttgg ataaacaaga tctgttgaaa
      181 gagcgccaga aggacctaaa gtttctctca gaagaggagt attggaaatt acaaatattt
      241 tttacaaatg ttatccaagc attaggggaa catcttaaat taagacaaca agttattgct
      301 actgctacag tctatttcaa gagattctat gccaggtatt ctctgaaaag tatagatcct
      361 gtattaatgg ctcctacatg tgtgtttctg gcatccaaag tagaggaatt tggtgtcgtc
      421 tcaaatacaa gattgattgc tgctactact tctgtattaa aaactagatt ttcatatgcc
      481 tttccaaagg aatttcctta caggatgaat catatactag aatgtgaatt ttacctctta
      541 gaattaatgg actgttgctt gatagtgtat catccttata gacctttgct ccagtatgtg
      601 caggacatgg gccaagaaga cgtgttgctt ccccttgcat ggaggatagt gaatgacacc
      661 tacaggacgg atctttgtct tctgtatcct cctttcatga tagctttagc ttgcctacat
      721 gtagcctgtg ttgtacaaca gaaagacgct agacaatggt ttgcagaact ttctgtggat
      781 atggagaaga ttttggaaat aatcagggtt attttaaaac tgtatgagca gtggaagaat
      841 tttgatgaga gaaaagagat ggcgactatt cttagtaaga tgccgaaacc aaaaccacct
      901 ccgaacagtg aaggagagca gggtccaaat ggaagtcaga actctagcta cagccaatct
      961 taaaacaccc tgaagaatcc cgtagtggac cacttggaag gaaagcattg gagagtttga
     1021 gtaatgtctt cattggaaag cagatgcaaa tgaatagctt gtttctgtcg agcatattgg
     1081 gaattgactt aatttccaca aaataagttt catttcctaa cttgattcta gtgtataatt
     1141 tattaaatct taattacaaa atttagtgag actcttaagg aacctatagc catatacaaa
     1201 catttcaggg ttaacttctc ttttacatac tcatgcacat agacacatac tagtactggt
     1261 tttttattag gaaattgaag ggtttattat cttttttgta ttaagtcagg aagcatgaaa
     1321 tgtcatttgt tcacattttt ctttgggcat tgagggacca aaaaggacat aaaaagtcaa
     1381 taaaactccc cccgacccaa ttaaatttta aaactagatt taagaagtta aatcttagaa
     1441 aatcctaggt tttagaaatg ataattacaa tttgaaggag attaatcaag agcttactga
     1501 ttttaaaata tattgtattc aatacttttt gtatcatcac agaagatact ggcccagcct
     1561 atcaaaaaag tgcaatatat atatatatat atatagcata ccttgacaat gtaaaggttg
     1621 tattgactta ctagctgtat tgaaatgctg ggaaacctga aagaaaaggc tatttacaac
     1681 taatttatag ttattaagca ttttaaaagt ttaatttgat taaatgctta agttaaaatt
     1741 tggtgaaatt ttaatgttta atttgtcctg aaatttttta tgagacatat atacccgatt
     1801 taattttagt gttttagtgt aagctaacag atgtacagaa ggcattctga gttgggaagg
     1861 aacctggtca ggttttaggc cagtaagatt cttaattctc atgggtatag acttcaggat
     1921 aaatgttaca tttgtgagac ttcataaatt aactcatttt cttcagactc aaaggaagaa
     1981 gtataaataa aacttggagt aatgagatat tattgtgtag ttttgcactt tttaaaaaat
     2041 catgaaaaaa ttactcagtg ttgacttcct ggttaaaatt ggaagaataa aagttaagtt
     2101 tttcagctat attcactaat gtcttgaatt cctgttgcta agtttgactt agggtttctg
     2161 agactctttg tgcatgttaa attagaaccc taaactttgt aaaggggtga ttttgcctgg
     2221 tttatgaata gaggaatatg aggaaagttc tgcttctgtg tggagagtat cagatgcaga
     2281 tgcactggaa agggaacaaa tatgggctct gctaaggtcg tacagggata agaaaccaac
     2341 caacaggctc tcccaggcct gaagggttaa tccaagctta gcttggatgt tagtgattgc
     2401 ttctcacagc cattaactgc agttttatat ttaggctttt ttaaatccag tttctttttt
     2461 cagatttatc tttgtgcttc atagtttttt tgcaaatgct attgtggaaa attaagattt
     2521 tgcaagagca gacaaagcag tgaagtaaac ctccatgtgt gtatgatgta gcctcagcta
     2581 ttactgattc gtagccagtt tcaccttatt taaacttcca caccagtctc cagtttgtat
     2641 attattttga agaaaattct agatatatca ttttatccat aaatatttca tactcataat
     2701 aggtaaaata attatttaat attatattaa aattctcaat tccctgagcg ttgcagagca
     2761 ttctttgaat tcatttataa atccttttag ttttagattc atggattctt cctccattct
     2821 ataacatgcc ctgctttcat ttgttcatat attaagctcc cgtagcctat gtgttactgt
     2881 gagcattttt agcatgccat ttagtgaggg tttttctcct ttgtatttcc gtaaactgat
     2941 aattgccttt gaaggctgac cacattgaga ttctttttgg tttggctaga ctactgtagg
     3001 gtggtgtctc ttgcattagt caacacatag tggctgttgc tgaattgtcc tcacttatga
     3061 caagtactgt ttcagattca gtcataggca cactgtccag tctcagccac cagccactta
     3121 cagatgaaca gttactatgt ggcttgtctg aatgcagata tgcgtaaatg tgcaaacatg
     3181 ttggaattca ggtacttact aatacaacac aaaataatgt taaaaatctc aatttgttta
     3241 taaccattat gtgttttaaa tgataatatt ttggatacat agaattaaat aaaacattgt
     3301 taaaata
//
