LOCUS       NM_171991               3273 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cyclin B1 (Ccnb1), mRNA.
ACCESSION   NM_171991 XM_579689
VERSION     NM_171991.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Li,B., Cheng,J., Wang,H., Zhao,S., Zhu,H., Li,C., Zhang,Y. and
            Zhao,P.
  TITLE     CCNB1 affects cavernous sinus invasion in pituitary adenomas
            through the epithelial-mesenchymal transition
  JOURNAL   J Transl Med 17 (1), 336 (2019)
   PUBMED   31585531
  REMARK    GeneRIF: CCNB1 affects cavernous sinus invasion in pituitary
            adenomas through the epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Veas-Perez de Tudela,M., Delgado-Esteban,M., Maestre,C.,
            Bobo-Jimenez,V., Jimenez-Blasco,D., Vecino,R., Bolanos,J.P. and
            Almeida,A.
  TITLE     Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial
            Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival
  JOURNAL   J Neurosci 35 (25), 9287-9301 (2015)
   PUBMED   26109654
  REMARK    GeneRIF: These results unveil a previously unrecognized role for
            mitochondrial cyclin B1 in the oxidative damage associated with
            neurological disorders.
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Su,H., Wan,Q., Tian,X.J., He,F.F., Gao,P., Tang,H., Ye,C., Fan,D.,
            Chen,S., Wang,Y.M., Meng,X.F. and Zhang,C.
  TITLE     MAD2B contributes to podocyte injury of diabetic nephropathy via
            inducing cyclin B1 and Skp2 accumulation
  JOURNAL   Am J Physiol Renal Physiol 308 (7), F728-F736 (2015)
   PUBMED   25651564
  REMARK    GeneRIF: that MAD2B may play an important role in high
            glucose-mediated podocyte injury of diabetic nephropathy via
            modulation of Cdh1, cyclin B1, and Skp2 expression
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Wang,Z., Fan,M., Candas,D., Zhang,T.Q., Qin,L., Eldridge,A.,
            Wachsmann-Hogiu,S., Ahmed,K.M., Chromy,B.A., Nantajit,D., Duru,N.,
            He,F., Chen,M., Finkel,T., Weinstein,L.S. and Li,J.J.
  TITLE     Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle
            G2/M progression
  JOURNAL   Dev Cell 29 (2), 217-232 (2014)
   PUBMED   24746669
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Bois,C., Delalande,C., Bouraima-Lelong,H., Durand,P. and Carreau,S.
  TITLE     17beta-Estradiol regulates cyclin A1 and cyclin B1 gene expression
            in adult rat seminiferous tubules
  JOURNAL   J Mol Endocrinol 48 (2), 89-97 (2012)
   PUBMED   22180637
  REMARK    GeneRIF: Data show that cyclin A1 and cyclin B1 gene expression is
            controlled by E(2) at a concentration of 10(-9)uM only in stages
            IX-I of spermatogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Kallakury,B.V., Sheehan,C.E., Rhee,S.J., Fisher,H.A., Kaufman,R.P.
            Jr., Rifkin,M.D. and Ross,J.S.
  TITLE     The prognostic significance of proliferation-associated nucleolar
            protein p120 expression in prostate adenocarcinoma: a comparison
            with cyclins A and B1, Ki-67, proliferating cell nuclear antigen,
            and p34cdc2
  JOURNAL   Cancer 85 (7), 1569-1576 (1999)
   PUBMED   10193948
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Brandeis,M., Rosewell,I., Carrington,M., Crompton,T., Jacobs,M.A.,
            Kirk,J., Gannon,J. and Hunt,T.
  TITLE     Cyclin B2-null mice develop normally and are fertile whereas cyclin
            B1-null mice die in utero
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4344-4349 (1998)
   PUBMED   9539739
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Markiewicz,D.A., McKenna,W.G., Flick,M.B., Maity,A. and
            Muschel,R.J.
  TITLE     The effects of radiation on the expression of a newly cloned and
            characterized rat cyclin B mRNA
  JOURNAL   Int J Radiat Oncol Biol Phys 28 (1), 135-144 (1994)
   PUBMED   8270434
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Trembley,J.H., Kren,B.T. and Steer,C.J.
  TITLE     Posttranscriptional regulation of cyclin B messenger RNA expression
            in the regenerating rat liver
  JOURNAL   Cell Growth Differ 5 (1), 99-108 (1994)
   PUBMED   8123599
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Tamura,K., Kanaoka,Y., Jinno,S., Nagata,A., Ogiso,Y., Shimizu,K.,
            Hayakawa,T., Nojima,H. and Okayama,H.
  TITLE     Cyclin G: a new mammalian cyclin with homology to fission yeast
            Cig1
  JOURNAL   Oncogene 8 (8), 2113-2118 (1993)
   PUBMED   8336937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FN800625.1, FN800627.1 and FN800629.1.
            
            On Oct 7, 2014 this sequence version replaced NM_171991.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60768.1, BC059113.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 JAXUCZ010000002.1  33655224-33655225   c
            3-698               FN800625.1         1-696
            699-1092            FN800627.1         352-745
            1093-1540           FN800629.1         202-649
            1541-3273           JAXUCZ010000002.1  33646252-33647984   c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3273
                     /gene="Ccnb1"
                     /note="cyclin B1"
                     /db_xref="GeneID:25203"
                     /db_xref="RGD:2291"
     exon            1..122
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1373
                     /gene="Ccnb1"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B1"
                     /protein_id="NP_741988.1"
                     /db_xref="GeneID:25203"
                     /db_xref="RGD:2291"
                     /translation="MALRVTRNTKINTENKAKVSMAGAKRVPVAVAASKPLLRSRTAL
                     GDIGNKVSEQSRIPLKKETKKLGSGTVTVKALPKPVDKVPVCEPEVELDEPEPEPVME
                     VKHSPEPILVDTPSPSPMETSGCAPAEEYLCQAFSDVILAVSDVDADDGGDPNLCSEY
                     VKDIYAYLRQLEEEQSVRPKYLLGREVTGNMRAILIDWLIQVQMKFRLLQETMYMTVS
                     IIDRFMQDSCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTKHQIRQME
                     MKILRVLNFSLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELSMLDYDMVHFAPSQI
                     AAGAFCLALKILDNGEWTPTLQHYLSHTEESLLPVMQHLAKNIVMVNRGLTKHMTIKN
                     KYATSKHAKISTLAQLNCTLVQNLSKAVTKA"
     exon            123..284
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..434
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..617
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..776
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1013
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1154
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1265
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..3273
                     /gene="Ccnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccggcgtg ctgtggggga acggctgtta gtgtttaggt gtgggcagcc agaggttagg
       61 gtgtcttctc agatcggcga acctctgctt caggaggagc catggcgctc agggtcacta
      121 ggaacacgaa aattaacaca gaaaataagg ccaaggtcag catggcaggc gccaagcgtg
      181 tgcctgtggc agttgctgcc tccaaacccc tgctgagatc gagaactgct cttggagaca
      241 ttggtaataa agtcagcgaa cagtcaagaa tacccctcaa aaaggaaaca aaaaagttag
      301 gttctggaac agttactgtt aaagccctac caaaacctgt ggacaaggtg ccagtgtgcg
      361 aaccagaggt ggaactggat gagcctgagc ctgaacctgt tatggaagtg aaacactctc
      421 ctgagcctat tttggttgat actccctctc caagcccaat ggaaacatct ggatgtgcac
      481 ctgccgaaga atatctgtgt caggctttct ccgatgtgat tcttgcagtg agtgatgtag
      541 atgcagacga tggtggtgat ccaaacctct gtagtgaata tgtgaaagat atctatgctt
      601 acctcagaca actggaggaa gagcagtcag ttagaccaaa atacctactg ggtcgtgaag
      661 tcactggaaa catgagagcc atcctaatcg actggctaat acaggttcag atgaaatttc
      721 ggctgctgca ggagaccatg tacatgactg tgtccattat cgatcggttc atgcaggaca
      781 gttgtgtgcc caagaagatg ctgcagctgg ttggtgtaac tgccatgttt attgcaagca
      841 aatacgagga gatgtaccct ccagagatcg gtgacttcgc ttttgtgact aacaacactt
      901 acaccaagca ccagatcaga cagatggaga tgaagattct gagagttctg aacttcagtc
      961 tgggtcgccc tctgcctctg cacttcctcc gtagagcatc taaaattgga gaggtcgatg
     1021 tggagcagca tactttggcc aaatacctca tggagctctc catgctggac tacgacatgg
     1081 tgcattttgc cccttctcaa attgcagctg gggctttttg cttagccctg aaaatccttg
     1141 acaacggtga atggacacca actctgcagc actacctgtc ccacacggag gaatctctgc
     1201 ttcctgtgat gcagcacctg gctaagaaca tagtcatggt gaaccgtggc ctcacaaagc
     1261 acatgacgat caagaacaag tatgcaacat ctaagcatgc taagatcagc actctggcac
     1321 agctgaattg tacactagtt cagaatttgt ctaaggccgt gacaaaggcg taactcgaat
     1381 ggactacctc gtctgcagat gcagttggca ccatgtgccg cctgtacata ggataccatg
     1441 tttatttgct cttcaataaa ggttgtgact tttttacttt gcatagctca actcatttga
     1501 atgtggttgc ttctgacttt aggataacag aagttgtcaa agaatttagg agtatatcaa
     1561 aaactgcttc tagtttaaca gtggattcag ttaatgtata tatgtgtagc ctatatttta
     1621 tatacttgct tcactttgtg tgtccttatc atgtagtcat ctgcctagct ctgggttaaa
     1681 ctccaagtct accagctagt cctgctgcct gaaaccactg tctcttgagc tgtcaacttt
     1741 cagatcttga aacgaagtgt ttttgttatg taattattta tttgttctta attggaaggt
     1801 aggatgttca aaattaaagg tgtcttaaaa taatttgccc ctaagtctca gtaccaacag
     1861 ataagggtgt attcttgtat atcctgtata gatataatca tgcatttatt gtcgaggaga
     1921 tgtttttatg tgggttcatt tatcaacagt aatcctttta gcatccttca aggcctatat
     1981 tgcatttcct agtgtgaata aacgatgtaa tatagtagtc aatcgttccc ttagtgatat
     2041 tcaagtgcat tctctcactg cctctccaca atgctgctta acactgttta ataccttgcc
     2101 tggctccatg catagtagct ctcccagggg gtgtgctttc aattctgaca gccagatgag
     2161 tgcggctggc accatgccaa ggtgccactt ctttctcctg ttttgtaaca ccaactggaa
     2221 aaaaatcctg tctcatttgc tgttttaatt tatacatctg attccgagtt gaataaaatt
     2281 gtatttctgg aaagctttct ttcccattca catttgccct cttgactgtg tgttgtcttt
     2341 tgctatatgg aaccttctgt tgctaacaaa catcttccta tagttctaga tttatttttt
     2401 tttttattct tttttttctc ggagcagggg accgaaccca gggccttgtg cttgctaggc
     2461 aagtgctcta ccactgagct aaatccccaa ccccctagat tttcaatcat aaggtgggcc
     2521 acaccttgtc ccagcacaat ggaggcagag acaggtagac tttttatggg ttcaaggcca
     2581 gaccctgtct cagaaaaaat ttttttccaa aatgctttct cttaggtgta cattccttcc
     2641 ttcgatgagt aaagtctaag tgtatgacga tgtacgatgt atgtcggtga ttaagtgtac
     2701 atttctggtc taaatgttgg tttgcccctg taataatagt ttttaaaacc gagttccaga
     2761 gtttttgtgg ccacctacta tggcttgact gttctcaagt acttggcatt gtcaaacatt
     2821 tgccatatga acttgaacag tgttcagttg ccagtgcaag gttttaactg ttgtctatta
     2881 catcagcttg gtgtagagct gcgtgtatct tgttatttag aaacttcttg ttgagccttc
     2941 actgtacagt cctgaggttc cttacttatg ctggggtgaa aacttgtgaa aaatcaactt
     3001 ctttgaaatt aaattaaaat ctaattgtgt aatttcccct ttacttttct tcagcctctc
     3061 ccatggaacc caccctcccc ttgcattctc aagctcatga cctctggctt ttgttgatgt
     3121 gaatatgttc ataagtatat aatcggcaca atatgttgta tgtatttcag cactgacccc
     3181 tgttacctgt agttgtcttg gattgcctcc cacccccatg agtttcccct tctgggttga
     3241 tatcatcttt attaaagtcc tgattaaact tta
//
