LOCUS       NM_053702               1730 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cyclin A2 (Ccna2), mRNA.
ACCESSION   NM_053702 XM_342229
VERSION     NM_053702.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y and
            Piao D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Chang CF, Yang J, Li XF, Zhao WM, Chen SS, Wang GP and Xu CS.
  TITLE     [SPINK3: A novel growth factor that promotes rat liver
            regeneration]
  JOURNAL   Mol Biol (Mosk) 50 (3), 457-465 (2016)
   PUBMED   27414783
  REMARK    GeneRIF: SPINK3 along with Ccna2 and EGFR accelerated cell
            proliferation during rat liver regeneration via P38 MAPK, PKC,
            JAK-STAT and AKT pathways.
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Deng H, Cheng Y, Guo Z, Zhang F, Lu X, Feng L, Wang X and Xu Z.
  TITLE     Overexpression of CyclinA2 ameliorates hypoxia-impaired
            proliferation of cardiomyocytes
  JOURNAL   Exp Ther Med 8 (5), 1513-1517 (2014)
   PUBMED   25289051
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB and
            Scheiffele P.
  TITLE     mSYD1A, a mammalian synapse-defective-1 protein, regulates
            synaptogenic signaling and vesicle docking
  JOURNAL   Neuron 78 (6), 1012-1023 (2013)
   PUBMED   23791195
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Li Y, Hu S, Ma G, Yao Y, Yan G, Chen J, Li Y and Zhang Z.
  TITLE     Acute myocardial infarction induced functional cardiomyocytes to
            re-enter the cell cycle
  JOURNAL   Am J Transl Res 5 (3), 327-335 (2013)
   PUBMED   23634243
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW.
  TITLE     Oncogenic ras provokes premature cell senescence associated with
            accumulation of p53 and p16INK4a
  JOURNAL   Cell 88 (5), 593-602 (1997)
   PUBMED   9054499
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Russo AA, Jeffrey PD, Patten AK, Massague J and Pavletich NP.
  TITLE     Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor
            bound to the cyclin A-Cdk2 complex
  JOURNAL   Nature 382 (6589), 325-331 (1996)
   PUBMED   8684460
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Hirai H, Roussel MF, Kato JY, Ashmun RA and Sherr CJ.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Pahel G, Aulabaugh A, Short SA, Barnes JA, Painter GR, Ray P and
            Phelps WC.
  TITLE     Structural and functional characterization of the HPV16 E7 protein
            expressed in bacteria
  JOURNAL   J Biol Chem 268 (34), 26018-26025 (1993)
   PUBMED   8245034
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Pagano M, Pepperkok R, Verde F, Ansorge W and Draetta G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY317814.1, AF367448.1, DY551463.1, CV114678.1 and CK845133.1.
            
            On Nov 19, 2006 this sequence version replaced NM_053702.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               DY317814.1         6-521
            517-617             AF367448.1         416-516
            618-961             DY551463.1         329-672
            962-1422            CV114678.1         229-689
            1423-1730           CK845133.1         1-308               c
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1730
                     /gene="Ccna2"
                     /note="cyclin A2"
                     /db_xref="GeneID:114494"
                     /db_xref="RGD:621059"
     exon            1..272
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1358
                     /gene="Ccna2"
                     /codon_start=1
                     /product="cyclin-A2"
                     /protein_id="NP_446154.3"
                     /db_xref="GeneID:114494"
                     /db_xref="RGD:621059"
                     /translation="MPGNSRQAGSALLSQQEDQENVNPEKVAPAQQPRAQAVLKAGKV
                     RGPAPQQRLKTRRVAPLKDLPINDEHVPTVPSWKAVSKQPAFTIHVDEAEETQKRPAE
                     QKETQCEDALAFSAAVSLPGARKPLVPLDYPMDGSFESPHAMDISIVLEDEKPVNVNE
                     VPDYHEDIHTYLREMEVKCKPKVSYMKRQPDITNSMRAILVDWLVEVGEEYKLQNETL
                     HLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYSKKQ
                     VLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCKVESLAMFLGELSLIDADPYL
                     KYLPSLIAGAAFHLALYTVTGQSWPESLVQKTGYTLESLKPCLMDLHQTYLKAPQHAQ
                     QSIREKYKHSKYHSVSLLNPPETLNV"
     exon            273..516
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..629
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..853
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1061
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1175
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1309
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1712
                     /gene="Ccna2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgcctg ctccgtgcgt cggccgccag ggtcccgcgc agcccgggag cggcgggcgc
       61 cttgcacgct ctgccgccga cggatccgga ccggagccgc aatgccgggc aactcgagac
      121 aggcgggctc ggccctgctc tcccagcagg aagaccagga gaatgtcaac cccgaaaaag
      181 tggcgccagc ccagcagccg cgggcgcagg cggtgctgaa ggccgggaag gtgcggggac
      241 cggcgccgca gcagaggctc aagactcggc gggttgcgcc tcttaaggac cttcctataa
      301 acgatgagca cgtccctact gttccttcat ggaaagcagt cagtaaacag cctgccttca
      361 ccattcatgt ggatgaagct gaagagactc agaagaggcc agctgagcaa aaagaaactc
      421 agtgtgaaga tgccctggct tttagtgccg ctgtctcttt acccggagcc agaaaaccac
      481 tggtacctct tgattatcca atggatggta gttttgaatc accccatgct atggatatat
      541 ctattgtctt agaagacgaa aagccagtga atgttaatga agtacctgac tatcatgaag
      601 atattcacac gtaccttagg gaaatggagg ttaaatgtaa acctaaagtg agttatatga
      661 agaggcagcc agacatcact aacagtatgc gggccatcct tgtggactgg ctagttgaag
      721 tgggagaaga atataaacta cagaatgaga ccctgcattt ggctgtgaac tacattgata
      781 gattcctctc ctccatgtct gtgttaagag gaaagcttca gcttgtgggc acagctgcta
      841 tgctgctagc ttcaaagttt gaagaaatat accccccaga agtagcagag tttgtgtata
      901 ttacggacga tacctattcc aagaagcagg ttctgagaat ggagcacctt gtattgaaag
      961 tccttgcttt tgacttggct gcaccaacag taaatcagtt ccttacccag tacttcctgc
     1021 acctgcagcc tgccaactgc aaggtagaaa gcttagcgat gtttttggga gagttaagtt
     1081 tgatagatgc tgacccatac ctcaagtatt tgccatcgct tattgctgga gctgccttcc
     1141 acttagctct ctacacagtc acaggacaaa gctggcctga gtcattggta caaaagactg
     1201 gatataccct agaaagtctt aagccttgtc tcatggacct tcaccagacc tacctcaaag
     1261 caccacagca tgcccaacag tcaataaggg aaaagtacaa gcattcaaaa tatcacagtg
     1321 tttctcttct caacccacca gagacactaa atgtgtgaga gtgaaagact gaaatggaaa
     1381 tcgctcagag ttcatgctgt acagttttta tctttggttt taatttcaca atcatttctg
     1441 aatgtagatg gtatagccac agacaaatta tgttatccat tacttttaaa atggttttaa
     1501 tttgtatatc ttttgtacat gtgtctatct tagattttgg ctaattttta attggtttgt
     1561 taacattggt gctgccaact gtcaagataa taagaataaa ttgatttgga aatctttgaa
     1621 agtgatagat aatttggcta attttaattg gtttgttaac attggtgctg ccaactgtca
     1681 ggataataag aataaattga ttcagaaatc ttaaaaaaaa aaaaaaaaaa
//
