LOCUS       NM_001011949            1761 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin A1 (Ccna1), mRNA.
ACCESSION   NM_001011949 XM_215565
VERSION     NM_001011949.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Bois,C., Delalande,C., Bouraima-Lelong,H., Durand,P. and Carreau,S.
  TITLE     17beta-Estradiol regulates cyclin A1 and cyclin B1 gene expression
            in adult rat seminiferous tubules
  JOURNAL   J Mol Endocrinol 48 (2), 89-97 (2012)
   PUBMED   22180637
  REMARK    GeneRIF: Data show that cyclin A1 and cyclin B1 gene expression is
            controlled by E(2) at a concentration of 10(-9)uM only in stages
            IX-I of spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Maziere,C., Trecherel,E., Ausseil,J., Louandre,C. and Maziere,J.C.
  TITLE     Oxidized low density lipoprotein induces cyclin A synthesis.
            Involvement of ERK, JNK and NFkappaB
  JOURNAL   Atherosclerosis 218 (2), 308-313 (2011)
   PUBMED   21764057
  REMARK    GeneRIF: Oxidized low density lipoprotein induces cyclin A
            synthesis in a process involving ERK, JNK and NFkappaB
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Wegiel,B., Bjartell,A., Tuomela,J., Dizeyi,N., Tinzl,M.,
            Helczynski,L., Nilsson,E., Otterbein,L.E., Harkonen,P. and
            Persson,J.L.
  TITLE     Multiple cellular mechanisms related to cyclin A1 in prostate
            cancer invasion and metastasis
  JOURNAL   J Natl Cancer Inst 100 (14), 1022-1036 (2008)
   PUBMED   18612129
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Chen,B. and Wang,W.
  TITLE     The expression of cyclins in neurons of rats after focal cerebral
            ischemia
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 28 (1), 60-64 (2008)
   PUBMED   18278459
  REMARK    GeneRIF: analysis of expression of Cyclin D1, E, A and B1 in
            neurons of cerebral cortex and hippocampus
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Malumbres,M. and Barbacid,M.
  TITLE     Mammalian cyclin-dependent kinases
  JOURNAL   Trends Biochem Sci 30 (11), 630-641 (2005)
   PUBMED   16236519
  REMARK    Review article
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Diederichs,S., Baumer,N., Schultz,N., Hamra,F.K., Schrader,M.G.,
            Sandstede,M.L., Berdel,W.E., Serve,H. and Muller-Tidow,C.
  TITLE     Expression patterns of mitotic and meiotic cell cycle regulators in
            testicular cancer and development
  JOURNAL   Int J Cancer 116 (2), 207-217 (2005)
   PUBMED   15800920
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Katabami,M., Donninger,H., Hommura,F., Leaner,V.D., Kinoshita,I.,
            Chick,J.F. and Birrer,M.J.
  TITLE     Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced
            anchorage-independent growth in RAT1a cells
  JOURNAL   J Biol Chem 280 (17), 16728-16738 (2005)
   PUBMED   15737994
REFERENCE   8  (bases 1 to 1761)
  AUTHORS   Sherr,C.J.
  TITLE     The Pezcoller lecture: cancer cell cycles revisited
  JOURNAL   Cancer Res 60 (14), 3689-3695 (2000)
   PUBMED   10919634
  REMARK    Review article
REFERENCE   9  (bases 1 to 1761)
  AUTHORS   Yang,R., Nakamaki,T., Lubbert,M., Said,J., Sakashita,A.,
            Freyaldenhoven,B.S., Spira,S., Huynh,V., Muller,C. and
            Koeffler,H.P.
  TITLE     Cyclin A1 expression in leukemia and normal hematopoietic cells
  JOURNAL   Blood 93 (6), 2067-2074 (1999)
   PUBMED   10068680
REFERENCE   10 (bases 1 to 1761)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079234.1.
            
            On Feb 11, 2005 this sequence version replaced XM_215565.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..1761
                     /gene="Ccna1"
                     /note="cyclin A1"
                     /db_xref="GeneID:295052"
                     /db_xref="RGD:1310639"
     exon            1..249
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..438
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1539
                     /gene="Ccna1"
                     /codon_start=1
                     /product="cyclin-A1"
                     /protein_id="NP_001011949.1"
                     /db_xref="GeneID:295052"
                     /db_xref="RGD:1310639"
                     /translation="MRRHSSKSGVALPPVGQGPDACQMLTRAQLGQDPPQRTVLGVLT
                     ENEQYRRACGQEIATIRCFSGSENVFPAAGKKVLPDNGVSEPAKHGFDIYMDDPEQGD
                     RDSCPGREGIVFEDVYEVDTSMLKSDLHFLLDFNTVSPMLVDSTAHAQSEEATDFGSD
                     VINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRT
                     ETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYT
                     KRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADP
                     FLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLSELHKACLSIPHR
                     PQQAIREKYKASKYLHVSLMEPPVVLPLQ"
     exon            439..685
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..810
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1034
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1239
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1353
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1487
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1729
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaggggt tcgtgtctgt tgggggaacc ggttcctggg gaacagtccc tttcagggcg
       61 gccacagtgg tcaggccgcc atccgccctc cctggtgacg ccgaccaagg ggcgcgagtg
      121 gcgacgtgct gtgcgttgcg gttcggtgtg cctggcaccc ctggctttgc ggctcaggag
      181 ccccgggctg cgcggttggc cgcgccccgc agcgccccgg gggccgagca tcagcggaca
      241 gcgctgcagc agcaggctgt ggcttgctag gcaatgcgtc gccacagctc gaagagtgga
      301 gtcgcactgc ctccagtggg ccaaggtcct gatgcttgtc agatgctcac ccgagctcag
      361 cttggccagg atcccccaca gagaaccgtg ctaggagtgt tgactgaaaa tgagcagtac
      421 aggagggcct gtggccagga gatcgcaacg atcagatgtt tttctggatc agaaaatgtc
      481 ttccctgcag ctggaaagaa agtactccct gacaacgggg tcagtgagcc agccaagcat
      541 ggatttgata tctacatgga tgatcctgaa cagggggaca gagacagctg cccagggaga
      601 gagggcatag tgtttgagga tgtgtatgaa gtagacacca gcatgctcaa gtcagatctc
      661 cacttcctgc tggatttcaa cacagtttcc ccaatgctgg ttgactccac cgcccatgcc
      721 cagtcggagg aagcaacgga ttttggttca gatgtgatca acgtaacgga atatgcagag
      781 gagattcatc gataccttcg agaagctgaa gtaagacaca gacccaaggc tcactacatg
      841 aggaagcagc cggacatcac ggagggcatg cgcgccatcc tggtggactg gctggtggag
      901 gttggggaag aatataaact ccgcacagag accctgtact tggctgtcaa cttcctggac
      961 aggtttcttt cctgcatgtc tgttctgaga gggaaattgc agcttgtcgg gacagcagct
     1021 attctcctgg cttcgaaata cgaagagata tacccgcccg atgtcgatga gtttgtctac
     1081 atcactgacg acacgtacac aaagcgacag ctactgagga tggagcatct gctgctgaaa
     1141 gtcctggcat tcgatctgac cgttccaacc accaaccagt tcctccttca gtacttaagg
     1201 cggcaagggg tgtgcatcag gactgagaat ttggccaagt atgttgcaga actgagcctt
     1261 ctggaagctg acccattctt gaagtatctt ccttccttgg tagcagcagc agcttactgt
     1321 ctggcaaact atattgtgaa cagacacttc tggccagaaa cacttgctgc atttacgggc
     1381 tattcattaa atgagattgt gccttgcctg agtgagctgc ataaagcatg cctcagtata
     1441 ccccatcgac cgcagcaagc aatcagggag aagtacaagg cttcgaagta cctgcacgtg
     1501 tccctcatgg agccacccgt agttcttccc ctgcagtgaa cgggtcagct caacagccac
     1561 accagcaggc ttactctgac ctgttacagt tttctgcggg tcgggccaac taatgtcagt
     1621 tgtagatgtc accttcaaca tatgagtgtt aggttctttt agacgtcggt agtttataat
     1681 ttatatagat atagacaggt attttaaaag aataaacaac ttgctgtgta aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaaaa a
//
