LOCUS       NM_031590               1757 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cellular communication network factor 5 (Ccn5),
            mRNA.
ACCESSION   NM_031590
VERSION     NM_031590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Ji,X., Liu,T., Zhao,S., Li,J., Li,L. and Wang,E.
  TITLE     WISP-2, an upregulated gene in hip cartilage from the DDH model
            rats, induces chondrocyte apoptosis through PPARgamma in vitro
  JOURNAL   FASEB J 34 (4), 4904-4917 (2020)
   PUBMED   32058630
  REMARK    GeneRIF: WISP-2, an upregulated gene in hip cartilage from the DDH
            model rats, induces chondrocyte apoptosis through PPARgamma in
            vitro.
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Zhang,Y., Yu,M., Dai,M., Chen,C., Tang,Q., Jing,W., Wang,H. and
            Tian,W.
  TITLE     miR-450a-5p within rat adipose tissue exosome-like vesicles
            promotes adipogenic differentiation by targeting WISP2
  JOURNAL   J Cell Sci 130 (6), 1158-1168 (2017)
   PUBMED   28167681
  REMARK    GeneRIF: miR-450a-5p promoted adipogenesis through repressing
            expression of WISP2 by targeting its 3' untranslated region.
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Myers,R.B., Wei,L. and Castellot,J.J. Jr.
  TITLE     The matricellular protein CCN5 regulates podosome function via
            interaction with integrin alphavbeta 3
  JOURNAL   J Cell Commun Signal 8 (2), 135-146 (2014)
   PUBMED   24488697
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Grunberg,J.R., Hammarstedt,A., Hedjazifar,S. and Smith,U.
  TITLE     The Novel Secreted Adipokine WNT1-inducible Signaling Pathway
            Protein 2 (WISP2) Is a Mesenchymal Cell Activator of Canonical WNT
  JOURNAL   J Biol Chem 289 (10), 6899-6907 (2014)
   PUBMED   24451367
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Wiesman,K.C., Wei,L., Baughman,C., Russo,J., Gray,M.R. and
            Castellot,J.J.
  TITLE     CCN5, a secreted protein, localizes to the nucleus
  JOURNAL   J Cell Commun Signal 4 (2), 91-98 (2010)
   PUBMED   20531984
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Yang,B., Shan,L., Song,W., Xiao,Z., Shi,L. and Yuan,H.
  TITLE     Copolymer-1 immunization reduces damage in retinal ganglion cells
            under high intraocular pressure through altering the expression of
            retinal neurotrophins
  JOURNAL   J Ocul Pharmacol Ther 26 (1), 11-19 (2010)
   PUBMED   20148653
  REMARK    GeneRIF: COP-1 immunization might increase NT-3 expression by some
            unknown mechanism in high IOP rats and the change may be related to
            COP-1 therapeutic intervention.
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Mason,H.R., Grove-Strawser,D., Rubin,B.S., Nowak,R.A. and
            Castellot,J.J. Jr.
  TITLE     Estrogen induces CCN5 expression in the rat uterus in vivo
  JOURNAL   Endocrinology 145 (2), 976-982 (2004)
   PUBMED   14605002
  REMARK    GeneRIF: data indicate that CCN5 protein is positively regulated by
            estrogen in the rat uterus and suggests that this gene may play an
            important role in maintaining normal uterine physiology
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Kumar,S., Hand,A.T., Connor,J.R., Dodds,R.A., Ryan,P.J.,
            Trill,J.J., Fisher,S.M., Nuttall,M.E., Lipshutz,D.B., Zou,C.,
            Hwang,S.M., Votta,B.J., James,I.E., Rieman,D.J., Gowen,M. and
            Lee,J.C.
  TITLE     Identification and cloning of a connective tissue growth
            factor-like cDNA from human osteoblasts encoding a novel regulator
            of osteoblast functions
  JOURNAL   J Biol Chem 274 (24), 17123-17131 (1999)
   PUBMED   10358067
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Zhang,R., Averboukh,L., Zhu,W., Zhang,H., Jo,H., Dempsey,P.J.,
            Coffey,R.J., Pardee,A.B. and Liang,P.
  TITLE     Identification of rCop-1, a new member of the CCN protein family,
            as a negative regulator for cell transformation
  JOURNAL   Mol Cell Biol 18 (10), 6131-6141 (1998)
   PUBMED   9742130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_031590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF259981.1, SRR26643295.16322.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000003.1  172910691-172910945
            256-348             JAXUCZ010000003.1  172911155-172911247
            349-565             JAXUCZ010000003.1  172914637-172914853
            566-820             JAXUCZ010000003.1  172918162-172918416
            821-1757            JAXUCZ010000003.1  172921125-172922061
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1757
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /note="cellular communication network factor 5"
                     /db_xref="GeneID:29576"
                     /db_xref="RGD:621867"
     exon            1..255
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..348
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1041
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /note="secreted protein; CTGF-L; WISP-2; CCN family
                     protein COP-1; connective tissue growth factor-like
                     protein; CCN family member 5; WNT1 inducible signaling
                     pathway protein 2"
                     /codon_start=1
                     /product="CCN family member 5 precursor"
                     /protein_id="NP_113778.2"
                     /db_xref="GeneID:29576"
                     /db_xref="RGD:621867"
                     /translation="MRGSPLIHLLATSFLCLLSMVCAQLCRTPCTCPWTPPQCPQGVP
                     LVLDGCGCCKVCARRLGESCDHLHVCDPSQGLVCQPGAGPGGHGAVCLLDEDDGSCEV
                     NGRRYLDGETFKPNCRVLCRCDDGGFTCLPLCSEDVRLPSWDCPRPKRIQVPGRCCPE
                     WVCDQGVTPAIQRSTAQGHQLSALVTPASADAPCPNWSTAWGPCSTTCGLGIATRVSN
                     QNRFCQLEIQRRLCLPRPCLAARSHSSWNSAF"
     exon            349..565
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..820
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1757
                     /gene="Ccn5"
                     /gene_synonym="Wisp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcaggaca cagtgggtca gatctgcaaa gcatctgaca gacgcttctg atctccagag
       61 gaccctgggg tgggacaggg gccttggcaa ggctgcagcc gctgggcagt ggcttggaat
      121 ggaggtcttt attactggga actgaggagc taagaggctc ctgtcagctt gtcctaaact
      181 cttagcactt gtggtggctt gggcttcaca cactgtcaga caccttcgtg gtggcctcca
      241 cggcctcacc ttcaggtttg aagctggctc cacaagggac acggtgacat gaggggcagc
      301 ccactgatcc atcttctggc cacttccttc ctctgccttc tctcaatggt gtgtgcccag
      361 ctgtgccgga caccctgtac ctgtccttgg acaccacccc agtgcccaca gggggtaccc
      421 ctggtgctgg atggctgtgg ctgctgtaaa gtgtgtgcac ggaggctggg ggagtcctgc
      481 gaccacctgc atgtctgcga ccccagccag ggcctggttt gtcagcctgg ggcaggccct
      541 ggcggccatg gggctgtgtg tctcttggat gaggatgacg gtagctgtga ggtgaatggc
      601 cgcaggtacc tggatggaga gacctttaaa cccaattgca gggtcctgtg ccgctgtgat
      661 gacggtggct tcacctgcct gccgctgtgc agtgaggatg tgcggctgcc cagctgggat
      721 tgcccacgcc ccaagagaat acaggtgcca ggaaggtgct gccccgagtg ggtatgtgac
      781 cagggagtga caccggcgat ccagcgctcc acggcgcaag gacaccaact ttctgccctt
      841 gtcactcctg cctctgctga tgctccttgt ccaaattgga gcacagcctg gggcccctgc
      901 tcaaccacct gtgggctggg catagccacc cgagtgtcca accagaaccg attctgccaa
      961 ctggagatcc aacgccgcct gtgtctgccc agaccctgcc tggcagccag gagccacagc
     1021 tcatggaaca gtgctttcta aggccaactg gggatgcgga tacagggcct gccatcctca
     1081 gcaaatgacc ctaggaccag gccctggact gctggtagat gctcttctcc atgctcttgg
     1141 ctgcagttaa ctgtcctgct tggattcact gtgtagagcc actgagcaat ccctgctctg
     1201 tctgaggtag gcggagcagg tgaccagctc cagttctctg gttcagcctg ggattctggg
     1261 ttctcctggc tcattcctca aaacatccct gtacaaaaag gacaaccaaa aagaccttta
     1321 aacctaggct atactgggca aacctggcca ccgtgctggg gataaggtca atgttaggac
     1381 cagacagcag attgcctgaa acttccaatt cccttcttgg acttctgtat gcttgtcccc
     1441 aaagatgatg aatgaactcg taagtgtacc ttccctgacc tgagaacacc ctgcctgctc
     1501 gggaagtatt caggggcaga attctctgtg aacatgaaga gatgaatcac actgtcctta
     1561 agaaattcct caaagtccag gaacttgagc tttgtatttt caggaatgca catctcttaa
     1621 gcactcgcaa aacaggaagg ctccacacct ctggtaggcc agggcctttc tcttcagcat
     1681 gagaaagaca agggacagca gagtactctc ctctggagga ctagtccagc ctagaataaa
     1741 cacccaaatc aagcgtg
//
