LOCUS       NM_031716               1874 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cellular communication network factor 4 (Ccn4),
            mRNA.
ACCESSION   NM_031716
VERSION     NM_031716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Chen,Y.Z., Sun,D.Q., Zheng,Y., Zheng,G.K., Chen,R.Q., Lin,M.,
            Huang,L.F., Huang,C., Song,D. and Wu,B.Q.
  TITLE     WISP1 silencing confers protection against epithelial-mesenchymal
            transition of renal tubular epithelial cells in rats via
            inactivation of the wnt/beta-catenin signaling pathway in uremia
  JOURNAL   J Cell Physiol 234 (6), 9673-9686 (2019)
   PUBMED   30556898
  REMARK    GeneRIF: WISP1 gene silencing suppresses the activation of the
            wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Ono,M., Masaki,A., Maeda,A., Kilts,T.M., Hara,E.S., Komori,T.,
            Pham,H., Kuboki,T. and Young,M.F.
  TITLE     CCN4/WISP1 controls cutaneous wound healing by modulating
            proliferation, migration and ECM expression in dermal fibroblasts
            via alpha5beta1 and TNFalpha
  JOURNAL   Matrix Biol 68-69, 533-546 (2018)
   PUBMED   29330021
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Jung,T.W., Kang,C., Goh,J., Chae,S.I., Kim,H.C., Lee,T.J., Abd
            El-Aty,A.M. and Jeong,J.H.
  TITLE     WISP1 promotes non-alcoholic fatty liver disease and skeletal
            muscle insulin resistance via TLR4/JNK signaling
  JOURNAL   J Cell Physiol 233 (8), 6077-6087 (2018)
   PUBMED   29319180
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Ferrand,N., Bereziat,V., Moldes,M., Zaoui,M., Larsen,A.K. and
            Sabbah,M.
  TITLE     WISP1/CCN4 inhibits adipocyte differentiation through repression of
            PPARgamma activity
  JOURNAL   Sci Rep 7 (1), 1749 (2017)
   PUBMED   28496206
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Li,L., Guleria,R.S., Thakur,S., Zhang,C.L., Pan,J., Baker,K.M. and
            Gupta,S.
  TITLE     Thymosin beta4 Prevents Angiotensin II-Induced Cardiomyocyte Growth
            by Regulating Wnt/WISP Signaling
  JOURNAL   J Cell Physiol 231 (8), 1737-1744 (2016)
   PUBMED   26627308
  REMARK    GeneRIF: Thymosin beta4 targets Wnt/WISP-1 signaling to protect
            against Ang II-induced cardiomyocyte growth.
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Ono,M., Inkson,C.A., Kilts,T.M. and Young,M.F.
  TITLE     WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity
  JOURNAL   J Bone Miner Res 26 (1), 193-208 (2011)
   PUBMED   20684029
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Colston,J.T., de la Rosa,S.D., Koehler,M., Gonzales,K., Mestril,R.,
            Freeman,G.L., Bailey,S.R. and Chandrasekar,B.
  TITLE     Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic
            growth factor
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (3), H1839-H1846 (2007)
   PUBMED   17616748
  REMARK    GeneRIF: WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast
            proliferation, and ECM expression in vitro. These results suggest
            that WISP-1 may play a critical role in post-myocardial infarction
            remodeling.
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   French,D.M., Kaul,R.J., D'Souza,A.L., Crowley,C.W., Bao,M.,
            Frantz,G.D., Filvaroff,E.H. and Desnoyers,L.
  TITLE     WISP-1 is an osteoblastic regulator expressed during skeletal
            development and fracture repair
  JOURNAL   Am J Pathol 165 (3), 855-867 (2004)
   PUBMED   15331410
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Tanaka,S., Sugimachi,K., Saeki,H., Kinoshita,J., Ohga,T.,
            Shimada,M., Maehara,Y. and Sugimachi,K.
  TITLE     A novel variant of WISP1 lacking a Von Willebrand type C module
            overexpressed in scirrhous gastric carcinoma
  JOURNAL   Oncogene 20 (39), 5525-5532 (2001)
   PUBMED   11571650
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Sleeman,M.A., Murison,J.G., Strachan,L., Kumble,K., Glenn,M.P.,
            McGrath,A., Grierson,A., Havukkala,I., Tan,P.L. and Watson,J.D.
  TITLE     Gene expression in rat dermal papilla cells: analysis of 2529 ESTs
  JOURNAL   Genomics 69 (2), 214-224 (2000)
   PUBMED   11031104
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031716.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF228049.1, SRR26643285.28368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               JAXUCZ010000007.1  100534578-100534802
            226-505             JAXUCZ010000007.1  100549774-100550053
            506-766             JAXUCZ010000007.1  100555823-100556083
            767-960             JAXUCZ010000007.1  100560122-100560315
            961-1874            JAXUCZ010000007.1  100562194-100563107
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1874
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /note="cellular communication network factor 4"
                     /db_xref="GeneID:65154"
                     /db_xref="RGD:69431"
     exon            1..225
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1260
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /note="ELM-1; WISP-1; CCN family member 4; WNT1 inducible
                     signaling pathway protein 1"
                     /codon_start=1
                     /product="CCN family member 4 precursor"
                     /protein_id="NP_113904.2"
                     /db_xref="GeneID:65154"
                     /db_xref="RGD:69431"
                     /translation="MRWLLPWTLAAVAVLMVGNILATALSPTPTTMTFTPAPLEETIT
                     RPEFCKWPCECPQAPPRCPLGVSLITDGCECCKICAQQLGDNCTEAAVCDPHRGLYCD
                     YSGDRPRYAIGVCAQVVGVGCVLDGVRYTNGESFQPNCRYNCTCIDGTVGCTPLCLSP
                     RPPRLWCRQPRHVRVPGQCCEQWVCDDDARRPRQTALLDTRAFAASGAVEQRYENCIA
                     YTSPWSPCSTTCGLGISTRISNVNARCWPEQESRLCNLRPCDVDIRPHIKAGKKCLAV
                     YQPEEATNFTLASCVSTRTYQPKYCGVCTDNRCCIPYKSKTISVDFQCPEGPGFSRQV
                     LWINACFCNLSCRNPNDIFADLESYPDFAEIAN"
     exon            226..505
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..766
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..960
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1874
                     /gene="Ccn4"
                     /gene_synonym="Wisp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctgacgt cagatgtcgc tttcacaaac ccccccgggg gctgaagaag gctctccgct
       61 gctctgatgg gccagcccag tcctggccca gctccctgga gaggcacccg catcctctgg
      121 gctgagctgt agctcctgtg acgctgactt ccaggcatga ggtggctcct gccctggacg
      181 ctggcagccg tggcagtcct gatggtgggc aacatcctgg ccacggccct ctctccaacc
      241 cccacaacca tgaccttcac cccagcacca ctggaggaaa cgattacacg gccggaattc
      301 tgcaagtggc cgtgtgagtg cccacaagcc ccacctcgct gcccactggg tgtcagccta
      361 atcacagatg gctgtgaatg ctgtaagata tgtgcccagc agcttgggga caactgcaca
      421 gaggctgccg tctgtgaccc acaccggggc ctctactgcg attacagtgg ggaccgcccg
      481 aggtacgcaa taggagtgtg tgcacaggtg gtcggtgtgg gctgtgtcct ggatggcgtg
      541 cgctacacca atggagagtc cttccaaccc aactgcaggt acaactgcac ctgtattgat
      601 ggcaccgtgg gctgcacacc actgtgcctg agccccaggc ccccacgcct ctggtgccgc
      661 cagccccgtc acgtgagagt ccctggccag tgctgtgaac aatgggtatg tgatgatgat
      721 gccaggaggc cacgccagac tgcactgctg gacaccagag cctttgcagc ttcgggtgca
      781 gtggagcaac ggtatgagaa ctgcatagcc tacactagcc cctggagtcc ctgctcaaca
      841 acctgtggcc taggtatctc gactcgcatc tctaatgtca atgcgcggtg ctggccagag
      901 caggaaagtc gcctctgcaa cctgcggcca tgtgatgtgg acatccgacc acacatcaag
      961 gcagggaaga aatgcctggc tgtgtaccag ccagaggagg ccacgaactt cactctcgca
     1021 agctgtgtca gcacacgcac ctaccaaccc aagtactgtg gagtctgtac tgacaatagg
     1081 tgttgcatcc cctacaagtc taagaccatc agtgttgatt tccagtgtcc agaggggccg
     1141 ggtttctctc ggcaggtcct atggattaat gcttgcttct gcaacctgag ctgcaggaat
     1201 cctaatgata tctttgctga cttggaatct taccctgact ttgcagagat tgccaactag
     1261 gtaggtgtgt ggcttggaga acagctccat gttgcaaagc agtcagccct ctgtggccca
     1321 ggacttcaca attgagcctt atttcatcta cttcctcctc aattctgcat tccctgaccc
     1381 tgaccctcag tttctgttcc tattttgacc gttccaatgg cccaggaaag tgctgctcag
     1441 gctcagacaa tgggtccctc ctttgggaca ttctatatca ctccaaagaa aacacctctc
     1501 tgaactgttc acaatgaaag ccaagcctga ccccagccag tctggctcca acctgtgcaa
     1561 gttgtcagaa atcctaatgg gacagtccaa ggaaaaaaca gcaactgaag aaccagaatc
     1621 acagactccc tcttcagatg cccagcctga ggatgttgag atcctttcag acacatggat
     1681 gggattgggg gaacgggaat aagctatcat cccttaccaa atgatactat cctgggaatt
     1741 tctgcccaca acataccaaa agtgctctta ttccaaagat ctatgtatca caagtcacca
     1801 aacatgttct aggtgaggaa aatacttgca ccattttgat ttgaaattga aaatcatatt
     1861 taaaagaaga aaaa
//
