LOCUS       NM_030868               1475 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cellular communication network factor 3 (Ccn3),
            mRNA.
ACCESSION   NM_030868
VERSION     NM_030868.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Li,H., Ge,X., Pan,K., Sui,M., Cai,H., Cui,C., Li,C. and Lu,S.
  TITLE     The Predictive Role of Tenascin-C and Cellular Communication
            Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat
            Model and 50 Patients Following Partial Hepatectomy
  JOURNAL   Med Sci Monit 25, 6755-6766 (2019)
   PUBMED   31494663
  REMARK    GeneRIF: This study aimed to investigate the role of TNC and CCN3
            as prognostic factors for post hepatectomy liver failure (PHLF) in
            a rat model of partial hepatectomy and 50 patients following
            partial hepatectomy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Iwai,K., Nagasawa,K., Akaike,T., Oshima,T., Kato,T. and
            Minamisawa,S.
  TITLE     CCN3 secreted by prostaglandin E2 inhibits intimal cushion
            formation in the rat ductus arteriosus
  JOURNAL   Biochem Biophys Res Commun 503 (4), 3242-3247 (2018)
   PUBMED   30149912
  REMARK    GeneRIF: These results suggest that CCN3 is a secreted protein of
            the ductus arteriosus (DA) smooth muscle cells induced by PGE2 to
            suppress intimal cushion formation of the DA.
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Janune,D., Abd El Kader,T., Aoyama,E., Nishida,T., Tabata,Y.,
            Kubota,S. and Takigawa,M.
  TITLE     Novel role of CCN3 that maintains the differentiated phenotype of
            articular cartilage
  JOURNAL   J Bone Miner Metab 35 (6), 582-597 (2017)
   PUBMED   27853940
  REMARK    GeneRIF: CCN3 is expressed by articular chondrocytes in normal rat
            knees, whereas it is rapidly down-regulated in osteoarthritic
            knees.
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Hou,J.Y., Wang,Y.G., Ma,S.J., Yang,B.Y. and Li,Q.P.
  TITLE     Identification of a prognostic 5-Gene expression signature for
            gastric cancer
  JOURNAL   J Cancer Res Clin Oncol 143 (4), 619-629 (2017)
   PUBMED   28035468
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Liu,J., Ren,Y., Kang,L. and Zhang,L.
  TITLE     Overexpression of CCN3 inhibits inflammation and progression of
            atherosclerosis in apolipoprotein E-deficient mice
  JOURNAL   PLoS One 9 (4), e94912 (2014)
   PUBMED   24722330
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Gellhaus,A., Dong,X., Propson,S., Maass,K., Klein-Hitpass,L.,
            Kibschull,M., Traub,O., Willecke,K., Perbal,B., Lye,S.J. and
            Winterhager,E.
  TITLE     Connexin43 interacts with NOV: a possible mechanism for negative
            regulation of cell growth in choriocarcinoma cells
  JOURNAL   J Biol Chem 279 (35), 36931-36942 (2004)
   PUBMED   15181016
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Lin,C.G., Leu,S.J., Chen,N., Tebeau,C.M., Lin,S.X., Yeung,C.Y. and
            Lau,L.F.
  TITLE     CCN3 (NOV) is a novel angiogenic regulator of the CCN protein
            family
  JOURNAL   J Biol Chem 278 (26), 24200-24208 (2003)
   PUBMED   12695522
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Sakamoto,K., Yamaguchi,S., Ando,R., Miyawaki,A., Kabasawa,Y.,
            Takagi,M., Li,C.L., Perbal,B. and Katsube,K.
  TITLE     The nephroblastoma overexpressed gene (NOV/ccn3) protein associates
            with Notch1 extracellular domain and inhibits myoblast
            differentiation via Notch signaling pathway
  JOURNAL   J Biol Chem 277 (33), 29399-29405 (2002)
   PUBMED   12050162
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   McLeod,T.L., Bechberger,J.F. and Naus,C.C.
  TITLE     Determination of a potential role of the CCN family of growth
            regulators in connexin43 transfected C6 glioma cells
  JOURNAL   Cell Commun Adhes 8 (4-6), 441-445 (2001)
   PUBMED   12064632
  REMARK    GeneRIF: Data show that RNA levels of cyr61 and Nov are upregulated
            in C6 cells transfected with connexin 43.
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Liu,C., Liu,X.J., Crowe,P.D., Kelner,G.S., Fan,J., Barry,G.,
            Manu,F., Ling,N., De Souza,E.B. and Maki,R.A.
  TITLE     Nephroblastoma overexpressed gene (NOV) codes for a growth factor
            that induces protein tyrosine phosphorylation
  JOURNAL   Gene 238 (2), 471-478 (1999)
   PUBMED   10570975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072548.1.
            
            On Jun 20, 2004 this sequence version replaced NM_030868.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072548.1, AF171936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q32"
     gene            1..1475
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /note="cellular communication network factor 3"
                     /db_xref="GeneID:81526"
                     /db_xref="RGD:621553"
     exon            1..105
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1095
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /note="protein NOV homolog; novH; CCN family member 3;
                     nephroblastoma-overexpressed gene protein homolog;
                     nephroblastoma overexpressed"
                     /codon_start=1
                     /product="CCN family member 3 precursor"
                     /protein_id="NP_110495.1"
                     /db_xref="GeneID:81526"
                     /db_xref="RGD:621553"
                     /translation="MSVFLRKQCLCLGFLLLHLLNQVSATLRCPSRCPSQCPSISPTC
                     APGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNETGICMVPEGD
                     NCVFDGVIYRNGEKFEPNCQYHCTCRDGQIGCVPRCQLDVLLPGPDCPAPKKVAVPGE
                     CCEKWTCGSEEKGTLGGLALPAYRPEATVGVELSDSSINCIEQTTEWSACSKSCGMGL
                     STRVTNRNLQCEMVKQTRLCMVRPCEQEPGEATDMKGKKCLRTKKSLKSIHLQFKNCT
                     SLYTYKPRFCGICSDGRCCTPFNTKTIQVEFQCLPGQIIKKPVMVIGTCTCHSNCPQN
                     NEAFLQELELKTSRGEM"
     exon            106..331
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            332..583
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            584..798
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1451
                     /gene="Ccn3"
                     /gene_synonym="Nov"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccgtctc caactggtaa cagccccagc aggcagaaca tgagcgtctt cctgcgaaag
       61 caatgcctct gcctaggctt cctgctcctc catctcttaa atcaagtctc tgcaactctg
      121 cgctgcccgt ctcggtgccc gagccagtgc cccagtatat caccgacctg cgcccccggg
      181 gtgcgctcgg tgctagacgg ctgctcctgc tgtccggtgt gcgcccgcca gcgcggggag
      241 agttgctctg agatgagacc ctgcgaccag agcagcggtc tctactgcga ccgcagcgcg
      301 gaccccaaca acgagactgg catttgcatg gttccagagg gagacaactg tgtgttcgat
      361 ggggtcattt accgcaatgg agagaagttt gagccgaact gtcaatacca ctgcacctgc
      421 agagatgggc aaattggctg tgtgccccgc tgccagctgg atgtgcttct gccaggtcct
      481 gactgcccag ctccaaaaaa agtcgcagtg cccggggagt gttgcgaaaa gtggacctgt
      541 ggctcagagg agaaggggac actgggaggc ctggcccttc cagcctacag accggaagct
      601 accgtaggag tcgaactctc tgactccagc atcaactgca ttgagcagac tacagagtgg
      661 agcgcgtgtt ccaagagctg tggaatgggc ttgtccaccc gggtcaccaa caggaatctc
      721 caatgtgaga tggtaaaaca gactcgtctc tgcatggttc ggccttgtga gcaagagcct
      781 ggggaagcaa cagacatgaa aggtaaaaag tgtctccgga ccaagaagtc cctgaaatcc
      841 atccacctac agttcaagaa ttgcactagc ctgtacacct ataagcccag gttctgtggg
      901 atctgcagtg acgggcgctg ctgtacgccc ttcaatacca aaaccatcca ggtggagttt
      961 cagtgtttgc cagggcaaat catcaaaaaa ccagtcatgg tcattggaac ctgtacctgc
     1021 cactccaact gccctcagaa caatgaggcc ttcctccaag agctggagct gaagacgagc
     1081 agaggagaaa tgtaacaggt gcccagggaa gtgcattcgt tgaggcaaac tgttgctgtc
     1141 acaaggcccg ccatcacctg tatataagaa acatagtgaa ggagttgtcc cgtgtatgtt
     1201 tctgtgatca tatgaggtca tttatatttg tctctgtttt taatgaaaac tgttccaaat
     1261 gtaaacttag aatcaagata agctcaggat atggcttagg ggtgacttgc tttcctgtgc
     1321 tgttcattac aagtgcaaat ttgtgtaaat ttaagtcaca tagatgatct agttggtaga
     1381 atgtgtcaca tcacactcat tttctgtaca ttagttaaat cccaataaat gttacagaaa
     1441 tgattggcac aaaaaaaaaa aaaaaaaaaa aaaaa
//
