LOCUS       NM_022266               2349 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus cellular communication network factor 2 (Ccn2),
            mRNA.
ACCESSION   NM_022266
VERSION     NM_022266.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Yang,Y., Long,J., Yang,J., Zheng,H., Lai,Y., Chen,C., Tang,F.,
            Gao,Y., Chen,L. and He,Z.
  TITLE     METTL3-dependent m6A modification mediates bladder remodeling after
            partial bladder outlet obstruction through CCN2 activation
  JOURNAL   Neurourol Urodyn 42 (7), 1506-1521 (2023)
   PUBMED   37455557
  REMARK    GeneRIF: METTL3-dependent m6A modification mediates bladder
            remodeling after partial bladder outlet obstruction through CCN2
            activation.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Song,X., Cui,Y. and Zhu,T.
  TITLE     MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting
            connective tissue growth factor
  JOURNAL   Am J Med Sci 365 (4), 375-385 (2023)
   PUBMED   36539014
  REMARK    GeneRIF: MicroRNA-19 upregulation attenuates cardiac fibrosis via
            targeting connective tissue growth factor.
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Pi,L., Sun,C., Jn-Simon,N., Basha,S., Thomas,H., Figueroa,V.,
            Zarrinpar,A., Cao,Q. and Petersen,B.
  TITLE     CCN2/CTGF promotes liver fibrosis through crosstalk with the
            Slit2/Robo signaling
  JOURNAL   J Cell Commun Signal 17 (1), 137-150 (2023)
   PUBMED   36469291
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Yanagihara,T., Tsubouchi,K., Gholiof,M., Chong,S.G., Lipson,K.E.,
            Zhou,Q., Scallan,C., Upagupta,C., Tikkanen,J., Keshavjee,S., Ask,K.
            and Kolb,M.R.J.
  TITLE     Connective-Tissue Growth Factor Contributes to TGF-beta1-induced
            Lung Fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 66 (3), 260-270 (2022)
   PUBMED   34797990
  REMARK    GeneRIF: Connective-Tissue Growth Factor Contributes to
            TGF-beta1-induced Lung Fibrosis.
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Zhang,S., Wang,N., Ma,Q., Fan,F. and Ma,X.
  TITLE     LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF
            expression by sponging miR-133b in myocardial fibrosis after
            myocardial infarction
  JOURNAL   Cell Biol Int 45 (12), 2534-2543 (2021)
   PUBMED   34553456
  REMARK    GeneRIF: LncRNA TUG1 acts as a competing endogenous RNA to mediate
            CTGF expression by sponging miR-133b in myocardial fibrosis after
            myocardial infarction.
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Babic,A.M., Chen,C.C. and Lau,L.F.
  TITLE     Fisp12/mouse connective tissue growth factor mediates endothelial
            cell adhesion and migration through integrin alphavbeta3, promotes
            endothelial cell survival, and induces angiogenesis in vivo
  JOURNAL   Mol Cell Biol 19 (4), 2958-2966 (1999)
   PUBMED   10082563
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Murphy,M., Godson,C., Cannon,S., Kato,S., Mackenzie,H.S., Martin,F.
            and Brady,H.R.
  TITLE     Suppression subtractive hybridization identifies high glucose
            levels as a stimulus for expression of connective tissue growth
            factor and other genes in human mesangial cells
  JOURNAL   J Biol Chem 274 (9), 5830-5834 (1999)
   PUBMED   10026205
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Perbal,B., Martinerie,C., Sainson,R., Werner,M., He,B. and
            Roizman,B.
  TITLE     The C-terminal domain of the regulatory protein NOVH is sufficient
            to promote interaction with fibulin 1C: a clue for a role of NOVH
            in cell-adhesion signaling
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 869-874 (1999)
   PUBMED   9927660
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Kireeva,M.L., Latinkic,B.V., Kolesnikova,T.V., Chen,C.C.,
            Yang,G.P., Abler,A.S. and Lau,L.F.
  TITLE     Cyr61 and Fisp12 are both ECM-associated signaling molecules:
            activities, metabolism, and localization during development
  JOURNAL   Exp Cell Res 233 (1), 63-77 (1997)
   PUBMED   9184077
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Ryseck,R.P., Macdonald-Bravo,H., Mattei,M.G. and Bravo,R.
  TITLE     Structure, mapping, and expression of fisp-12, a growth
            factor-inducible gene encoding a secreted cysteine-rich protein
  JOURNAL   Cell Growth Differ 2 (5), 225-233 (1991)
   PUBMED   1888698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF120275.1 and AB023068.1.
            
            On Oct 28, 2005 this sequence version replaced NM_022266.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF120275.1, AB023068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2327              AF120275.1         1-2327
            2328-2349           AB023068.1         2317-2338
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2349
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="cellular communication network factor 2"
                     /db_xref="GeneID:64032"
                     /db_xref="RGD:621392"
     exon            1..284
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1268
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /note="connective tissue growth-related protein; CCN
                     family member 2; connective tissue growth factor"
                     /codon_start=1
                     /product="CCN family member 2 precursor"
                     /protein_id="NP_071602.1"
                     /db_xref="GeneID:64032"
                     /db_xref="RGD:621392"
                     /translation="MLASVAGPVSLALVLLLCTRPATGQDCSAQCQCAAEAAPRCPAG
                     VSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCV
                     FGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCE
                     EWVCDEPKDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTR
                     VTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVKT
                     YRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDIF
                     ESLYYRKMYGDMA"
     exon            285..507
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            508..759
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..971
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2336
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; CTGRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagctctt ctctccaaga agactcagcc agacccactc cagctccgac cctaggagac
       61 cgacctcctc cagacggcag cagccccagc ccagtggaca accccaggag ccaccacctg
      121 gagcgtccgg acaccaacct ccgccccgag accgagtcca ggctccggcc gcgcccctcg
      181 tcgcctctgc accccgctgt gcgtcctcct gccgcgcccc gaccatgctc gcctccgtcg
      241 cgggtcccgt tagcctcgcc ttggtgctcc tcctctgcac ccggcctgcc accggccagg
      301 actgcagcgc gcagtgtcag tgcgcagctg aagcggcgcc gcgctgcccc gccggcgtga
      361 gcctggtgct ggacggctgc ggctgctgcc gcgtctgcgc caagcagctg ggagaactgt
      421 gcacggagcg tgatccctgc gacccacaca agggtctctt ctgcgacttc ggctcccccg
      481 ccaaccgcaa gattggcgtg tgcactgcca aagatggtgc accctgtgtc ttcggtgggt
      541 ccgtgtaccg cagcggcgag tccttccaaa gcagttgcaa ataccagtgc acttgcctgg
      601 atggggccgt gggctgtgtg cccctgtgca gcatggacgt gcgcctgccc agccctgact
      661 gccccttccc gagaagggtc aagctgcccg ggaaatgctg tgaggagtgg gtgtgtgatg
      721 agcccaagga ccgcacagtg gttggccctg ccctagctgc ctaccgactg gaagacacat
      781 ttggccctga cccaactatg atgcgagcca actgcctggt ccagaccaca gagtggagcg
      841 cctgttctaa gacctgtggg atgggcatct ccacccgggt taccaatgac aataccttct
      901 gcaggctgga gaagcagagt cgtctctgca tggtcaggcc ctgtgaagct gacctagagg
      961 aaaacattaa gaagggcaaa aagtgcatcc ggacgcctaa aattgccaag cctgtcaagt
     1021 ttgagctttc tggctgcacc agtgtgaaga cctaccgggc taagttctgt ggggtgtgca
     1081 cggacggccg ctgctgcaca ccgcacagaa ccaccacact gccggtggag ttcaagtgcc
     1141 ccgatggcga gatcatgaaa aagaacatga tgttcatcaa gacctgtgcc tgccattaca
     1201 actgtcccgg ggacaatgac atctttgagt ccttgtacta caggaagatg tatggagaca
     1261 tggcgtaaag ccagggagta agggacacga actcatttag actataactt gaactgagtt
     1321 acatctcatt ttcttctgta aaaaaacaaa aaggattaca gtagcacatt aatttaaatc
     1381 tgggttccta actgctgtgg gagaaaacac cccaccgaag tgagaaccgt gtgtcattgt
     1441 catgcaaata gcctgtcaat ctcagacact ggtttcgaga cagtttagac ttgacagttg
     1501 ttcactagcg cacagtgaca gaacgcacac taaggtgagc ctcctggaag agtggagatg
     1561 ccaggagaaa gacaggtact agctgaggtc attttaaaag cagcgatatg cctacttttt
     1621 ggagtgtgac aggggaggga cattatagct tgcttgcaga cagacctgct ctagcaagag
     1681 ctgggtgtgt gtcctccact cggtgaggct gaagccagct attctttcag taagaacagc
     1741 agtttcagcg ctgacattct gattccagtg acactggtcg ggagtcagaa ccttgtctat
     1801 tagactggac agcttgtggc aagtgaattt gccggtaaca agccagattt ttatggatct
     1861 tgtaaatatt gtggataaat atatatattt gtacagttat ctaagttaat ttaaagacgt
     1921 ttgtgcctat tgttcttgtt ttaagtgctt ttggaatttt taaactgata gcctcaaact
     1981 ccaaacacca tcgataggac ataaagcttg tctgtgattc aaaacaaagg agatactgca
     2041 gtggaaactg taacctgagt gactgtctgt cagaacatat ggtacgtaga cggtaaagca
     2101 atggatcaga agtcagattt ctagtaggaa atgtaaaatc actgttggcg aacaaatggc
     2161 ctttattaag aaatggcttg ctcagggtaa ctggtcagat ttccacgagg aagtgtttgc
     2221 tgcttctttg actatgactg gtttgggagg cagtttattt gttgagagtg tgaccaaaag
     2281 ttacatgttt gcacctttct agttgaaaat aaagtatata tattttttat atgaaaaaaa
     2341 aaaaaaaaa
//
