LOCUS       NM_031327               1986 bp    mRNA    linear   ROD 20-NOV-2023
DEFINITION  Rattus norvegicus cellular communication network factor 1 (Ccn1),
            mRNA.
ACCESSION   NM_031327
VERSION     NM_031327.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Xu H, Bao X, Yang J, Kong H, Li Y and Sun Z.
  TITLE     Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced
            proliferation inhibition in ovarian granulosa cells via suppressing
            NLRP3/caspase1-mediated pyroptosis
  JOURNAL   Hum Exp Toxicol 42, 9603271231152831 (2023)
   PUBMED   36650058
  REMARK    GeneRIF: Cysteine-rich 61(CYR61) alleviates
            cyclophosphamide-induced proliferation inhibition in ovarian
            granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis.
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Li Z, Wu Z, Xi X, Zhao F, Liu H and Liu D.
  TITLE     Cellular communication network factor 1 interlinks autophagy and
            ERK signaling to promote osteogenesis of periodontal ligament stem
            cells
  JOURNAL   J Periodontal Res 57 (6), 1169-1182 (2022)
   PUBMED   36199215
  REMARK    GeneRIF: Cellular communication network factor 1 interlinks
            autophagy and ERK signaling to promote osteogenesis of periodontal
            ligament stem cells.
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Wang Y, Wang Y, Wang X, Ma Y, Li Z and Di Y.
  TITLE     LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of
            Retinal Endothelial Cells in Retinopathy of Prematurity via
            MiR-145-5p
  JOURNAL   Front Med (Lausanne) 9, 803214 (2022)
   PUBMED   35445044
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Rauschner M, Reime S, Riemann A and Thews O.
  TITLE     Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in
            Experimental Tumours In Vivo
  JOURNAL   Adv Exp Med Biol 1395, 243-248 (2022)
   PUBMED   36527644
  REMARK    GeneRIF: Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and
            in Experimental Tumours In Vivo.
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Mahendiran T, Klingenberg R, Nanchen D, Gencer B, Meier D, Raber L,
            Carballo D, Matter CM, Luscher TF, Mach F, Rodondi N, Muller O and
            Fournier S.
  TITLE     CCN family member 1 (CCN1) is an early marker of infarct size and
            left ventricular dysfunction in STEMI patients
  JOURNAL   Atherosclerosis 335, 77-83 (2021)
   PUBMED   34597881
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Chaqour B, Whitbeck C, Han JS, Macarak E, Horan P, Chichester P and
            Levin R.
  TITLE     Cyr61 and CTGF are molecular markers of bladder wall remodeling
            after outlet obstruction
  JOURNAL   Am J Physiol Endocrinol Metab 283 (4), E765-E774 (2002)
   PUBMED   12217894
  REMARK    GeneRIF: Cyr61 is an early marker of extracellular matrix
            remodeling in rat bladder cells
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Grzeszkiewicz TM, Lindner V, Chen N, Lam SC and Lau LF.
  TITLE     The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports
            vascular smooth muscle cell adhesion and stimulates chemotaxis
            through integrin alpha(6)beta(1) and cell surface heparan sulfate
            proteoglycans
  JOURNAL   Endocrinology 143 (4), 1441-1450 (2002)
   PUBMED   11897702
  REMARK    GeneRIF: CYR61 is synthesized in arterial smooth muscle walls
            during proliferative restenosis
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   McLeod TL, Bechberger JF and Naus CC.
  TITLE     Determination of a potential role of the CCN family of growth
            regulators in connexin43 transfected C6 glioma cells
  JOURNAL   Cell Commun Adhes 8 (4-6), 441-445 (2001)
   PUBMED   12064632
  REMARK    GeneRIF: Data show that RNA levels of cyr61 and Nov are upregulated
            in C6 cells transfected with connexin 43.
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Albrecht C, von Der Kammer H, Mayhaus M, Klaudiny J, Schweizer M
            and Nitsch RM.
  TITLE     Muscarinic acetylcholine receptors induce the expression of the
            immediate early growth regulatory gene CYR61
  JOURNAL   J Biol Chem 275 (37), 28929-28936 (2000)
   PUBMED   10852911
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Wong M, Kireeva ML, Kolesnikova TV and Lau LF.
  TITLE     Cyr61, product of a growth factor-inducible immediate-early gene,
            regulates chondrogenesis in mouse limb bud mesenchymal cells
  JOURNAL   Dev Biol 192 (2), 492-508 (1997)
   PUBMED   9441684
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000079.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_031327.4.
            
            On Nov 27, 2020 this sequence version replaced NM_031327.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218568.1, BC081689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JACYVU010000079.1  21664653-21664900   c
            249-462             JACYVU010000079.1  21664119-21664332   c
            463-807             JACYVU010000079.1  21663433-21663777   c
            808-1022            JACYVU010000079.1  21663097-21663311   c
            1023-1986           JACYVU010000079.1  21661940-21662903   c
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1986
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /note="cellular communication network factor 1"
                     /db_xref="GeneID:83476"
                     /db_xref="RGD:620763"
     exon            1..248
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1325
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /note="protein CYR61; insulin-like growth factor-binding
                     protein 10; IBP-10; IGFBP-10; CCN family member 1;
                     IGF-binding protein 10; cysteine rich protein 61;
                     cysteine-rich, angiogenic inducer, 61"
                     /codon_start=1
                     /product="CCN family member 1 precursor"
                     /protein_id="NP_112617.3"
                     /db_xref="GeneID:83476"
                     /db_xref="RGD:620763"
                     /translation="MSSSTIKTLAVAVTLLHLTRLALSTCPAACHCPLEAPKCAPGVG
                     LVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEY
                     NSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEE
                     WVCDEDSIKDSLDDQDDLLGFDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLYN
                     PLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYS
                     SLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFR
                     CEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD"
     exon            249..462
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /inference="alignment:Splign:2.1.0"
     exon            463..807
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1022
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1986
                     /gene="Ccn1"
                     /gene_synonym="Cyr61"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagcgaga gcgccctaga gaagcgcctg caatctctgc gcctcctccg ccagcacctc
       61 gagagaagga cacccgccgc ctcggccctc atctcaccgc actccgggcg cattcgatcc
      121 ggctgctcgc ccgctccttg gcttccgtgt cgccacgctc gccccggctc ctcctgcgcg
      181 ccacaatgag ctccagcacc atcaagacgc tcgctgtcgc cgtcaccctt ctccacttga
      241 ccaggctggc actctccacc tgccctgccg cctgccactg ccctctggag gcgcccaagt
      301 gcgccccggg agtcggcttg gtccgggacg gctgcggctg ctgtaaggtc tgcgcgaagc
      361 aactcaacga ggactgcagc aaaacgcagc cctgcgacca caccaagggg ctggaatgca
      421 atttcggcgc cagttccacc gctctgaaag ggatctgcag agctcagtca gaaggcagac
      481 cctgtgaata taactccagg atctaccaga acggggagag cttccaaccc aactgtaaac
      541 atcagtgcac atgtattgac ggtgctgtgg gctgcattcc tctgtgtccc caagaactgt
      601 ctctccccaa tctgggctgt cccaaccccc ggctggtgaa agtcagcggg cagtgctgtg
      661 aggaatgggt ctgtgatgaa gacagcatta aggactccct ggacgaccag gacgacctcc
      721 ttggattcga tgcctcggag gtggagttaa caagaaacaa tgagttaatc gcaattggca
      781 aaggcagctc actgaagagg cttcctgtct ttggcacgga acctcgagtc ctttacaacc
      841 ccctgcatgc ccatggccag aaatgcatcg ttcagactac gtcctggtcc cagtgctcca
      901 agagctgcgg aactggcatc tccacacgag ttaccaatga caacccggag tgccgcctgg
      961 tgaaagagac ccggatctgt gaagtgcgtc cttgtggaca accagtgtac agcagcctaa
     1021 aaaagggcaa gaaatgcagc aagaccaaga aatccccaga accagtccga tttacttatg
     1081 caggatgctc cagtgtgaag aaataccggc ccaaatactg cggctcctgc gtggacggcc
     1141 ggtgctgcac acctctgcag accaggaccg tgaagatgcg gttccggtgc gaagatggcg
     1201 agatgttctc caagaacgtc atgatgattc agtcctgcaa gtgtaactac aactgcccgc
     1261 atcccaacga ggcgtcgttt cgcctctaca gtctgttcaa cgatatccac aagttcaggg
     1321 actaaaggtc tcctgggttt ctagtgtggg tcggacagag gtgttgagca tcgtggagac
     1381 gtgggcagac ggtgggcgaa cagtgccttg ctcatcatca agtaggatta aggtgtttca
     1441 aaactgccgt aggggctgct gctatggatg gacagtaacg cagtcgcagt tggagaatac
     1501 ttcgcttcat agtactggag cccgggttac gtacgcttca tattggagca tgtttataga
     1561 tgatgttctg ttttctgttt gtaaattatt ttgctaagtg tttttttttc tttttttttt
     1621 ttttttttgc tccatttctc cccctccccc cttggttcta caattgtaat agagataaaa
     1681 taagactagt tgggtcaagt gaaagccccg cttgtccttt gacagaagta aaatgaaagg
     1741 cctctcctgc cttccccagt ggaggcgggg gacactctgt gagtgccctt gaggctacta
     1801 cctgcactct aaactgcaaa cagaaaccag gtgttctaag attgaatgtt tttatttatc
     1861 aaaatgtagc tttcggggag ggatggggaa atgtaatact ggaataattt gtaaatgatt
     1921 ttaattttat atcagtgaag agaatttatt tataaaatta atcatttaat aaagaaatat
     1981 ttacct
//
