LOCUS       NM_001126275            1807 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus CCM2 scaffold protein (Ccm2), mRNA.
ACCESSION   NM_001126275
VERSION     NM_001126275.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Lu CC, Appler JM, Houseman EA and Goodrich LV.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Cuadrado A and Nebreda AR.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Sweeney SM,
            Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH
            and Kahn ML.
  TITLE     Regulation of cardiovascular development and integrity by the heart
            of glass-cerebral cavernous malformation protein pathway
  JOURNAL   Nat Med 15 (2), 169-176 (2009)
   PUBMED   19151727
  REMARK    Erratum:[Nat Med. 2009 May;15(5):584. Sweeney, Shawn M [added]]
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Cuenda A and Rousseau S.
  TITLE     p38 MAP-kinases pathway regulation, function and role in human
            diseases
  JOURNAL   Biochim Biophys Acta 1773 (8), 1358-1375 (2007)
   PUBMED   17481747
  REMARK    Review article
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Liquori CL, Berg MJ, Squitieri F, Leedom TP, Ptacek L, Johnson EW
            and Marchuk DA.
  TITLE     Deletions in CCM2 are a common cause of cerebral cavernous
            malformations
  JOURNAL   Am J Hum Genet 80 (1), 69-75 (2007)
   PUBMED   17160895
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Zawistowski JS, Stalheim L, Uhlik MT, Abell AN, Ancrile BB, Johnson
            GL and Marchuk DA.
  TITLE     CCM1 and CCM2 protein interactions in cell signaling: implications
            for cerebral cavernous malformations pathogenesis
  JOURNAL   Hum Mol Genet 14 (17), 2521-2531 (2005)
   PUBMED   16037064
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Denier C, Goutagny S, Labauge P, Krivosic V, Arnoult M, Cousin A,
            Benabid AL, Comoy J, Frerebeau P, Gilbert B, Houtteville JP, Jan M,
            Lapierre F, Loiseau H, Menei P, Mercier P, Moreau JJ,
            Nivelon-Chevallier A, Parker F, Redondo AM, Scarabin JM, Tremoulet
            M, Zerah M, Maciazek J and Tournier-Lasserve E.
  CONSRTM   Societe Francaise de Neurochirurgie
  TITLE     Mutations within the MGC4607 gene cause cerebral cavernous
            malformations
  JOURNAL   Am J Hum Genet 74 (2), 326-337 (2004)
   PUBMED   14740320
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC160889.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160889.1, SRR8487227.110860.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1807
                     /gene="Ccm2"
                     /note="CCM2 scaffold protein"
                     /db_xref="GeneID:305505"
                     /db_xref="RGD:1308067"
     exon            1..64
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1396
                     /gene="Ccm2"
                     /note="malcavernin; cerebral cavernous malformation 2;
                     CCM2 scaffolding protein"
                     /codon_start=1
                     /product="cerebral cavernous malformations 2 protein"
                     /protein_id="NP_001119747.1"
                     /db_xref="GeneID:305505"
                     /db_xref="RGD:1308067"
                     /translation="MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHT
                     VVLALPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDKAKRSHQLP
                     GHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQD
                     PGISPSQSLCAEGSRGLSAGSLSESAVGPVEACCLVIMATESKVAAEELCSLLSQVFQ
                     IVYTESTIDFLDRAIFDGASTPTHHLSVHSDDSSTKVDMKDSYDADASTFCFPDSGDV
                     GGLPPLPFCMQASPHSKTVSESELSTSATELLQDYMLTLRTKLSSQEIQQFAALLHEY
                     RNGASIHEFCISLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITD
                     SFGRHRRALSTTSTSTTNGNRTTGSPDDRSAPSEGDEWDRMISDISSDIEALGCSMDQ
                     DSA"
     exon            65..238
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..322
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..506
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..643
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..779
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..837
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..976
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1115
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1782
                     /gene="Ccm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggggcgg gccgcggggg ccgcacgcgg cgacatggag gaggagggca agaagggcaa
       61 gaagcctgga attgtgtcgc cgtttaaacg agtattccta aaaggtgaaa agagtagaga
      121 taagaaagcc catgagaagg tgacagagag gcgccctcta cacactgtgg tgctggcctt
      181 gcctgagcga gtcgagccag acagactgct gagcgactat attgagaagg aggtgaagta
      241 tttagggcag ttaacatcca ttcctggcta cctgaaccct tccagtagga cggaaatcct
      301 gcatttcata gacaaggcaa agcggtccca ccaactccct gggcacctga ctcaggagca
      361 tgatgctgtg ctcagtctgt ccgcctacaa tgtcaagctg gcctggaggg atggggagga
      421 cattatcctc agggtgccca tccacgacat cgctgctgtc tcctatgtcc gagatgatgc
      481 tgcacacctg gtggtcctga agacagccca ggacccaggc atctctccca gccaaagtct
      541 gtgtgcggaa ggttctagag gcctcagcgc aggctccttg tcagaaagtg cagtggggcc
      601 agtagaggcc tgttgcctgg tcatcatggc cacagagagc aaggtcgccg ctgaagaact
      661 gtgctccctg ctcagccagg tcttccagat cgtctacaca gagtccacca tcgactttct
      721 ggaccgagca atattcgacg gggcctccac ccctacccac cacctgtcag tgcacagcga
      781 tgactcttcc acgaaagtgg acatgaagga cagttatgac gccgacgcca gcaccttctg
      841 cttcccggac tctggggatg tggggggctt gccgcccttg cccttctgca tgcaggcatc
      901 cccccacagc aagacggtca gcgagagtga gctgagtacc agcgccacgg agctgctgca
      961 ggactacatg ctcacgttac gtaccaagct gtcatcacag gagatccagc agtttgcagc
     1021 cctgctgcat gaataccgca acggggcctc catccatgag ttctgcatca gcctgcggca
     1081 gctctatgga gacagccgca agttcctgct gcttggtctg aggcccttta tacctgagaa
     1141 ggacagtcag cactttgaaa acttcctgga gaccattggc gtgaaagacg gccgtggcat
     1201 catcactgac agctttggca ggcatcgccg tgctctgagc accacctcca catccaccac
     1261 caatgggaac aggaccacag gcagccctga tgaccgctca gcgccctcag agggggatga
     1321 gtgggaccgc atgatctcag acatcagcag tgatattgaa gcactaggct gcagcatgga
     1381 ccaggactca gcgtgaagga gcgtgacagc ctgtctcaca gccatcccag gccttccttc
     1441 ctgggaggag tgcccagacc caagtgctag cccctccctc ccagcttgga gctagggagg
     1501 ggctgcagac aaaggtggct ctggtggcca ggtcctctac tgtgaaggag tggagagctg
     1561 ccacaggaca tgtgccccaa cacagggcgg aaagctctgt gcctattcct caggggccca
     1621 gcaatgcctg tagcacatcc ccactcgggg agggccaggt gcagctgcag ggagagccag
     1681 tcctgccggc ctggccctgc acagctgata tttgcacatg actctcctct cctaattctc
     1741 agagacctta aaaagaagtt tactgcaatg tgaataattt aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaaa
//
