LOCUS       NP_001012357             117 aa            linear   ROD 26-FEB-2024
DEFINITION  C-C motif chemokine 9 precursor [Rattus norvegicus].
ACCESSION   NP_001012357 XP_340861
VERSION     NP_001012357.1
DBSOURCE    REFSEQ: accession NM_001012357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 117)
  AUTHORS   Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat
            P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Moller M,
            Baler R, Sugden D, Rangel ZG, Munson PJ and Klein DC.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: There is a marked > 15-fold daily rhythm in expression of
            Ccl9 in the rat pineal gland, with day values elevated.  This
            probably reflects circadian neural stimulation by the
            suprachiasmatic nucleus.
REFERENCE   2  (residues 1 to 117)
  AUTHORS   Saad Y, Garrett MR, Manickavasagam E, Yerga-Woolwine S, Farms P,
            Radecki T and Joe B.
  TITLE     Fine-mapping and comprehensive transcript analysis reveals
            nonsynonymous variants within a novel 1.17 Mb blood pressure QTL
            region on rat chromosome 10
  JOURNAL   Genomics 89 (3), 343-353 (2007)
   PUBMED   17218081
REFERENCE   3  (residues 1 to 117)
  AUTHORS   Yang M, Mailhot G, MacKay CA, Mason-Savas A, Aubin J and Odgren PR.
  TITLE     Chemokine and chemokine receptor expression during colony
            stimulating factor-1-induced osteoclast differentiation in the
            toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in
            osteoclastogenesis in vivo and in vitro
  JOURNAL   Blood 107 (6), 2262-2270 (2006)
   PUBMED   16304045
  REMARK    GeneRIF: examination of all chemokine and receptor mRNAs from bone
            gene expression in vivo during rapid osteoclast differentiation
            induced by CSF-1 revealed CCL9 was strongly induced and peaked on
            day 2, as did its receptor, CCR1, and regulatory receptors
REFERENCE   4  (residues 1 to 117)
  AUTHORS   Yang M and Odgren PR.
  TITLE     Molecular cloning and characterization of rat CCL9 (MIP-1gamma),
            the ortholog of mouse CCL9
  JOURNAL   Cytokine 31 (2), 94-102 (2005)
   PUBMED   15919212
  REMARK    GeneRIF: like the mouse, the rat also uses CCL9 to promote the
            complex process of osteoclast formation
REFERENCE   5  (residues 1 to 117)
  AUTHORS   Ko J, Jang SW, Kim YS, Kim IS, Sung HJ, Kim HH, Park JY, Lee YH,
            Kim J and Na DS.
  TITLE     Human LZIP binds to CCR1 and differentially affects the chemotactic
            activities of CCR1-dependent chemokines
  JOURNAL   FASEB J 18 (7), 890-892 (2004)
   PUBMED   15001559
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089865.1.
            
            On Feb 18, 2005 this sequence version replaced XP_340861.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089865.1, CO557648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..117
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     Protein         1..117
                     /product="C-C motif chemokine 9 precursor"
                     /note="chemokine CCL9; C-C motif chemokine 9; chemokine
                     (C-C motif) ligand 9"
                     /calculated_mol_wt=10293
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2826
     Region          49..106
                     /region_name="SCY"
                     /note="Intercrine alpha family (small cytokine C-X-C)
                     (chemokine CXC); smart00199"
                     /db_xref="CDD:197570"
     Site            order(52..56,58,59..64,74..75,97..107)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:238170"
     Site            order(54,56,68,70,75,80..82,90..92,98..99,102..103,
                     106..107)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(54,56,72,74..75,81,89,91)
                     /site_type="other"
                     /note="dimer interface (P form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(54,81,90)
                     /site_type="active"
                     /note="putative receptor binding cleft [active]"
                     /db_xref="CDD:238170"
     Site            order(54..56,58,59..64)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238170"
     Site            order(56,68,70,80,82,90,92,98..99,102..103,106..107)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(58,59,62..64,86,88)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            order(70,77,95,97,100..101,104)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            74..75
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238170"
     Site            order(84,86)
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238170"
     CDS             1..117
                     /gene="Ccl9"
                     /coded_by="NM_001012357.1:109..462"
                     /db_xref="GeneID:360579"
                     /db_xref="RGD:1310563"
ORIGIN      
        1 mkpfhtalsf lifaatlgiq aqivhatetr evlkaeqghq lfslgfqdss dcclsytsrv
       61 hcsryknyfp tsggctkpai ifvskkgtlv canpsdlrvq kcikrleqns qpqiykq
//
