LOCUS       NM_001004202            1390 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 6 (Ccl6), mRNA.
ACCESSION   NM_001004202 XM_213553
VERSION     NM_001004202.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Li,X., Aishan,B., Yang,Y., Xie,Y., Lati,D. and Tuerxun,P.
  TITLE     Chemokine (C-C motif) Ligand 6 Aggravates Hypoxia
            Reoxygenation-induced Apoptosis in H9c2 Cells Through Enhancing the
            Expression of Insulin-like Growth Factor 2-Antisense
  JOURNAL   J Cardiovasc Pharmacol 76 (5), 549-555 (2020)
   PUBMED   32833905
  REMARK    GeneRIF: Chemokine (C-C motif) Ligand 6 Aggravates Hypoxia
            Reoxygenation-induced Apoptosis in H9c2 Cells Through Enhancing the
            Expression of Insulin-like Growth Factor 2-Antisense.
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Nakagawa,S., Izumi,Y., Takada-Takatori,Y., Akaike,A. and Kume,T.
  TITLE     Increased CCL6 expression in astrocytes and neuronal protection
            from neuron-astrocyte interactions
  JOURNAL   Biochem Biophys Res Commun 519 (4), 777-782 (2019)
   PUBMED   31551151
  REMARK    GeneRIF: data suggest that astrocytes protect neurons by activating
            CCR1 in neurons. Moreover, this neuroprotective action of astrocyte
            CCL6 is mediated by CCR1, and downstream by PI3K
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Jiang,N., Zheng,Y.H., Chen,X.J., Qiu,C., Zhang,X.F., Wen,S.H. and
            Bian,G.X.
  TITLE     Molecular cloning and functional characterization of a mouse ccl6
            analog gene in the rat
  JOURNAL   Genet Mol Res 11 (4), 3889-3898 (2012)
   PUBMED   23212328
  REMARK    GeneRIF: The mouse C10 analog gene in the rat, and named it as
            ccl6, was identified and cloned.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Saad,Y., Garrett,M.R., Manickavasagam,E., Yerga-Woolwine,S.,
            Farms,P., Radecki,T. and Joe,B.
  TITLE     Fine-mapping and comprehensive transcript analysis reveals
            nonsynonymous variants within a novel 1.17 Mb blood pressure QTL
            region on rat chromosome 10
  JOURNAL   Genomics 89 (3), 343-353 (2007)
   PUBMED   17218081
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Yang,M., Mailhot,G., MacKay,C.A., Mason-Savas,A., Aubin,J. and
            Odgren,P.R.
  TITLE     Chemokine and chemokine receptor expression during colony
            stimulating factor-1-induced osteoclast differentiation in the
            toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in
            osteoclastogenesis in vivo and in vitro
  JOURNAL   Blood 107 (6), 2262-2270 (2006)
   PUBMED   16304045
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Kanno,M., Suzuki,S., Fujiwara,T., Yokoyama,A., Sakamoto,A.,
            Takahashi,H., Imai,Y. and Tanaka,J.
  TITLE     Functional expression of CCL6 by rat microglia: a possible role of
            CCL6 in cell-cell communication
  JOURNAL   J Neuroimmunol 167 (1-2), 72-80 (2005)
   PUBMED   16087246
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   Yi,F., Jaffe,R. and Prochownik,E.V.
  TITLE     The CCL6 chemokine is differentially regulated by c-Myc and L-Myc,
            and promotes tumorigenesis and metastasis
  JOURNAL   Cancer Res 63 (11), 2923-2932 (2003)
   PUBMED   12782599
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Berkhout,T.A., Gohil,J., Gonzalez,P., Nicols,C.L., Moores,K.E.,
            Macphee,C.H., White,J.R. and Groot,P.H.
  TITLE     Selective binding of the truncated form of the chemokine CKbeta8
            (25-99) to CC chemokine receptor 1(CCR1)
  JOURNAL   Biochem Pharmacol 59 (5), 591-596 (2000)
   PUBMED   10660125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001004202.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079460.1, SRR26643290.36361.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000010.1  68883243-68883366   c
            125-172             JAXUCZ010000010.1  68879550-68879597   c
            173-281             JAXUCZ010000010.1  68879143-68879251   c
            282-1390            JAXUCZ010000010.1  68877692-68878800   c
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1390
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /note="C-C motif chemokine ligand 6"
                     /db_xref="GeneID:287910"
                     /db_xref="RGD:1303200"
     exon            1..124
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..396
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /note="C-C motif chemokine 6; chemokine ligand 6;
                     small-inducible cytokine A6; chemokine (C-C motif) ligand
                     6"
                     /codon_start=1
                     /product="C-C motif chemokine 6 precursor"
                     /protein_id="NP_001004202.1"
                     /db_xref="GeneID:287910"
                     /db_xref="RGD:1303200"
                     /translation="MRHSKTAISFFILVAVLGSQAGLIQDTVKEDRPFNPTIIHQGFQ
                     DSSDCCFSYASQIPCSRFIYYFPTSGGCTKPGIIFVTRKRKRVCANPSDQRVQTCIST
                     LKLGPRSGNSAIA"
     exon            125..172
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /inference="alignment:Splign:2.1.0"
     exon            173..281
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1390
                     /gene="Ccl6"
                     /gene_synonym="Mrp-1; Scay6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagtgagc agagatcccc agaccagctg ggcctgtcct tcaggatgat gagacattcc
       61 aagactgcca tttcattctt tatccttgtg gccgtccttg ggtcccaggc tgggctcata
      121 caagatacgg taaaagaaga tcgtcccttt aatcctacaa taattcacca aggctttcaa
      181 gactcttcag actgctgctt ctcctatgcc tcacagatcc catgttcaag atttatatat
      241 tattttccaa ccagtggtgg gtgcaccaag ccaggcatca tctttgtcac caggaagagg
      301 aagcgggtct gtgccaaccc gagtgatcag agagttcaga cgtgcataag caccctgaag
      361 ctaggcccaa gatctgggaa cagtgccatt gcttgagaag gagggcgtac tgccacctgc
      421 attcttctgt ctccccagtg accacctagg aagcgctaag catttgtttt tatagatatt
      481 taaagcacgt attcttctgt acaggtttaa agcagcacat gtagtccaca gtattcacat
      541 ggattcagcc tgacatgatt agagccatct cgaggtgtaa ccatcatgag tgtctttggg
      601 taactgttgg gttttcttgc atagttcctc agcagattat aaatggataa actactagtc
      661 tttgggactt tggaatgtgt ctggttttga tgcaagctta agccaggtgt atccagctga
      721 gatgaaatca atttttgccc taagccatac atatgtccaa ctttgtgggg acccagctgt
      781 tcttcctgcc accatagagc agtaagtgac cccaataaag tgcactccat gtagctatgg
      841 gtctgtctct cttcagattc atagggctgt ggggccagtc tgaaatcggg ctattagaat
      901 gaaagtatcc cactcactcg ctcgctcacc ttgaatacag cagggagaaa gggatcatat
      961 aactgaatat tctaaatgat ataaatttct aatatataat atttctaaat ataatttcta
     1021 aatattctaa tgatagaaat tttaaaaaaa aattaaaaca cagttttttc cgatatattc
     1081 ctctgagttt ggtgcaaaat ggaagaatgc ctgttccagc agggcatctt cttctctacc
     1141 tgaccttctc tggggaacct gacccccaaa ccctctacca aaggaagttc agatagctgt
     1201 cgacaaattg ttcaacttcc tttttccagc aattacctgg gattcccgga atggctctcc
     1261 atgcaaatga ggcattccca atactttaaa cttcatccaa taatttacat tttaccccga
     1321 aaactcctac ccacactcca aggttcatgt ataggcctgg ttcaccccaa ataaagtgtg
     1381 catgcgcaaa
//
