LOCUS       NM_031116                584 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 5 (Ccl5), mRNA.
ACCESSION   NM_031116
VERSION     NM_031116.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 584)
  AUTHORS   Li,X., Ma,S., Wang,Q., Li,Y., Ji,X., Liu,J., Ma,J., Wang,Y.,
            Zhang,Z., Zhang,H., Chen,H., Xi,L., Zhang,Y., Xie,W., Sun,L.,
            Fu,Z., Yang,P., Wang,C. and Zhai,Z.
  TITLE     A new integrative analysis of histopathology and single cell
            RNA-seq reveals the CCL5 mediated T and NK cell interaction with
            vascular cells in idiopathic pulmonary arterial hypertension
  JOURNAL   J Transl Med 22 (1), 502 (2024)
   PUBMED   38797830
  REMARK    GeneRIF: A new integrative analysis of histopathology and single
            cell RNA-seq reveals the CCL5 mediated T and NK cell interaction
            with vascular cells in idiopathic pulmonary arterial hypertension.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 584)
  AUTHORS   Shi,D.D., Zhang,Y.D., Zhang,S., Liao,B.B., Chu,M.Y., Su,S.,
            Zhuo,K., Hu,H., Zhang,C. and Wang,Z.
  TITLE     Stress-induced red nucleus attenuation induces anxiety-like
            behavior and lymph node CCL5 secretion
  JOURNAL   Nat Commun 14 (1), 6923 (2023)
   PUBMED   37903803
  REMARK    GeneRIF: Stress-induced red nucleus attenuation induces
            anxiety-like behavior and lymph node CCL5 secretion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 584)
  AUTHORS   Han,X., Yang,Y., Zhang,M., Li,L., Xue,Y., Jia,Q., Wang,X. and
            Guan,S.
  TITLE     Liquiritin Protects Against Cardiac Fibrosis After Myocardial
            Infarction by Inhibiting CCL5 Expression and the NF-kappaB
            Signaling Pathway
  JOURNAL   Drug Des Devel Ther 16, 4111-4125 (2022)
   PUBMED   36483459
  REMARK    GeneRIF: Liquiritin Protects Against Cardiac Fibrosis After
            Myocardial Infarction by Inhibiting CCL5 Expression and the
            NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 584)
  AUTHORS   Hassan,A.O., Case,J.B., Winkler,E.S., Thackray,L.B., Kafai,N.M.,
            Bailey,A.L., McCune,B.T., Fox,J.M., Chen,R.E., Alsoussi,W.B.,
            Turner,J.S., Schmitz,A.J., Lei,T., Shrihari,S., Keeler,S.P.,
            Fremont,D.H., Greco,S., McCray,P.B. Jr., Perlman,S., Holtzman,M.J.,
            Ellebedy,A.H. and Diamond,M.S.
  TITLE     A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by
            Neutralizing Antibodies
  JOURNAL   Cell 182 (3), 744-753 (2020)
   PUBMED   32553273
REFERENCE   5  (bases 1 to 584)
  AUTHORS   Li,S., Jiang,L., Li,X., Lin,F., Wang,Y., Li,B., Jiang,T., An,W.,
            Liu,S., Liu,H., Xu,P., Zhao,L., Zhang,L., Mu,J., Wang,H., Kang,J.,
            Li,Y., Huang,L., Zhu,C., Zhao,S., Lu,J., Ji,J. and Zhao,J.
  TITLE     Clinical and pathological investigation of patients with severe
            COVID-19
  JOURNAL   JCI Insight 5 (12), 138070 (2020)
   PUBMED   32427582
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 584)
  AUTHORS   Ben-Baruch,A., Xu,L., Young,P.R., Bengali,K., Oppenheim,J.J. and
            Wang,J.M.
  TITLE     Monocyte chemotactic protein-3 (MCP3) interacts with multiple
            leukocyte receptors. C-C CKR1, a receptor for macrophage
            inflammatory protein-1 alpha/Rantes, is also a functional receptor
            for MCP3
  JOURNAL   J Biol Chem 270 (38), 22123-22128 (1995)
   PUBMED   7545673
REFERENCE   7  (bases 1 to 584)
  AUTHORS   Turner,L., Ward,S.G. and Westwick,J.
  TITLE     RANTES-activated human T lymphocytes. A role for phosphoinositide
            3-kinase
  JOURNAL   J Immunol 155 (5), 2437-2444 (1995)
   PUBMED   7544376
REFERENCE   8  (bases 1 to 584)
  AUTHORS   Neote,K., Mak,J.Y., Kolakowski,L.F. Jr. and Schall,T.J.
  TITLE     Functional and biochemical analysis of the cloned Duffy antigen:
            identity with the red blood cell chemokine receptor
  JOURNAL   Blood 84 (1), 44-52 (1994)
   PUBMED   7517217
REFERENCE   9  (bases 1 to 584)
  AUTHORS   Heeger,P., Wolf,G., Meyers,C., Sun,M.J., O'Farrell,S.C.,
            Krensky,A.M. and Neilson,E.G.
  TITLE     Isolation and characterization of cDNA from renal tubular
            epithelium encoding murine Rantes
  JOURNAL   Kidney Int 41 (1), 220-225 (1992)
   PUBMED   1375672
REFERENCE   10 (bases 1 to 584)
  AUTHORS   Schall,T.J., Bacon,K., Toy,K.J. and Goeddel,D.V.
  TITLE     Selective attraction of monocytes and T lymphocytes of the memory
            phenotype by cytokine RANTES
  JOURNAL   Nature 347 (6294), 669-671 (1990)
   PUBMED   1699135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 14, 2023 this sequence version replaced NM_031116.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM392383.1, BM986527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000010.1  68824749-68824884   c
            137-248             JAXUCZ010000010.1  68823536-68823647   c
            249-584             JAXUCZ010000010.1  68820330-68820665   c
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..584
                     /gene="Ccl5"
                     /gene_synonym="Rantes; Scya5"
                     /note="C-C motif chemokine ligand 5"
                     /db_xref="GeneID:81780"
                     /db_xref="RGD:69069"
     exon            1..136
                     /gene="Ccl5"
                     /gene_synonym="Rantes; Scya5"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..336
                     /gene="Ccl5"
                     /gene_synonym="Rantes; Scya5"
                     /note="C-C motif chemokine 5; chemokine (C-C motif) ligand
                     5; SIS-delta; small-inducible cytokine A5; T-cell-specific
                     protein RANTES; regulated upon activation normal T-cell
                     expressed and secreted"
                     /codon_start=1
                     /product="C-C motif chemokine 5 precursor"
                     /protein_id="NP_112378.2"
                     /db_xref="GeneID:81780"
                     /db_xref="RGD:69069"
                     /translation="MKISTAASLTVILVAAALCTPAPASPYGSDTTPCCFAYLSLALP
                     RAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS"
     exon            137..248
                     /gene="Ccl5"
                     /gene_synonym="Rantes; Scya5"
                     /inference="alignment:Splign:2.1.0"
     exon            249..584
                     /gene="Ccl5"
                     /gene_synonym="Rantes; Scya5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcagatg attctgagac aacgcatgca tcttccacag tctctgcttc aggtaccatg
       61 aagatctcca cagctgcatc cctcaccgtc atcctcgttg cagccgccct ctgcaccccc
      121 gcacctgcct ccccatatgg ctcggacacc actccctgct gctttgccta cctctccctc
      181 gcactgcccc gtgcccacgt gaaggagtat ttttacacca gcagcaagtg ctccaacctt
      241 gcagtcgtct ttgtcactcg aaggaaccgc caagtgtgtg ccaacccaga gaagaagtgg
      301 gttcaagaat acatcaacta tttggagatg agctagaata gagggtctct ccattctgat
      361 cctgtatagc tttcctgtca ttgcttgctc tagtcctaac cagctgggga tgccactgag
      421 caacccccta ctcccactca ttcctgggag ggcatagatg ctatcatacc atagagatta
      481 taactgtgtc ctctcctatg gcctgggagg tgtgctcttc acaggctctg tacagcaaat
      541 gtaagaaatc agcatttcat taaaatgtct gatgcaaaga caaa
//
