LOCUS       NM_053858                642 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 4 (Ccl4), mRNA.
ACCESSION   NM_053858
VERSION     NM_053858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 642)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   4  (bases 1 to 642)
  AUTHORS   Schutz,C., Barr,D., Andrade,B.B., Shey,M., Ward,A., Janssen,S.,
            Burton,R., Wilkinson,K.A., Sossen,B., Fukutani,K.F., Nicol,M.,
            Maartens,G., Wilkinson,R.J. and Meintjes,G.
  TITLE     Clinical, microbiologic, and immunologic determinants of mortality
            in hospitalized patients with HIV-associated tuberculosis: A
            prospective cohort study
  JOURNAL   PLoS Med 16 (7), e1002840 (2019)
   PUBMED   31276515
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 642)
  AUTHORS   Li,B., Abdalrahman,A., Lai,Y., Janicki,J.S., Ward,K.W., Meyer,C.J.,
            Wang,X.L., Tang,D. and Cui,T.
  TITLE     Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses
            in macrophages via activation of Nrf2
  JOURNAL   Biochem Biophys Res Commun 444 (4), 555-561 (2014)
   PUBMED   24486487
REFERENCE   6  (bases 1 to 642)
  AUTHORS   Bless,N.M., Huber-Lang,M., Guo,R.F., Warner,R.L., Schmal,H.,
            Czermak,B.J., Shanley,T.P., Crouch,L.D., Lentsch,A.B., Sarma,V.,
            Mulligan,M.S., Friedl,H.P. and Ward,P.A.
  TITLE     Role of CC chemokines (macrophage inflammatory protein-1 beta,
            monocyte chemoattractant protein-1, RANTES) in acute lung injury in
            rats
  JOURNAL   J Immunol 164 (5), 2650-2659 (2000)
   PUBMED   10679105
REFERENCE   7  (bases 1 to 642)
  AUTHORS   Franchin,G., Zybarth,G., Dai,W.W., Dubrovsky,L., Reiling,N.,
            Schmidtmayerova,H., Bukrinsky,M. and Sherry,B.
  TITLE     Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived
            macrophages through direct and sustained down-regulation of CC
            chemokine receptor 5
  JOURNAL   J Immunol 164 (5), 2592-2601 (2000)
   PUBMED   10679098
REFERENCE   8  (bases 1 to 642)
  AUTHORS   Blanpain,C., Lee,B., Vakili,J., Doranz,B.J., Govaerts,C.,
            Migeotte,I., Sharron,M., Dupriez,V., Vassart,G., Doms,R.W. and
            Parmentier,M.
  TITLE     Extracellular cysteines of CCR5 are required for chemokine binding,
            but dispensable for HIV-1 coreceptor activity
  JOURNAL   J Biol Chem 274 (27), 18902-18908 (1999)
   PUBMED   10383387
REFERENCE   9  (bases 1 to 642)
  AUTHORS   Combadiere,C., Ahuja,S.K., Tiffany,H.L. and Murphy,P.M.
  TITLE     Cloning and functional expression of CC CKR5, a human monocyte CC
            chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and
            RANTES
  JOURNAL   J Leukoc Biol 60 (1), 147-152 (1996)
   PUBMED   8699119
REFERENCE   10 (bases 1 to 642)
  AUTHORS   Ben-Baruch,A., Xu,L., Young,P.R., Bengali,K., Oppenheim,J.J. and
            Wang,J.M.
  TITLE     Monocyte chemotactic protein-3 (MCP3) interacts with multiple
            leukocyte receptors. C-C CKR1, a receptor for macrophage
            inflammatory protein-1 alpha/Rantes, is also a functional receptor
            for MCP3
  JOURNAL   J Biol Chem 270 (38), 22123-22128 (1995)
   PUBMED   7545673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 27, 2022 this sequence version replaced NM_053858.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI294833.1, FM141515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000010.1  68963893-68964043
            152-266             JAXUCZ010000010.1  68964560-68964674
            267-642             JAXUCZ010000010.1  68965353-68965728
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..642
                     /gene="Ccl4"
                     /gene_synonym="Mip1-b; Scya4"
                     /note="C-C motif chemokine ligand 4"
                     /db_xref="GeneID:116637"
                     /db_xref="RGD:620441"
     exon            1..151
                     /gene="Ccl4"
                     /gene_synonym="Mip1-b; Scya4"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..354
                     /gene="Ccl4"
                     /gene_synonym="Mip1-b; Scya4"
                     /note="C-C motif chemokine 4; MIP-1-beta; small-inducible
                     cytokine A4; macrophage inflammatory protein 1-beta;
                     chemokine (C-C motif) ligand 4"
                     /codon_start=1
                     /product="C-C motif chemokine 4 precursor"
                     /protein_id="NP_446310.2"
                     /db_xref="GeneID:116637"
                     /db_xref="RGD:620441"
                     /translation="MKLYVSAFSLLLLVAAFCDSVLSAPIGSDPPTSCCFSYTSRKIH
                     RNFVMDYYETSSLCSQPAVVFLTKKGRQICADPSEPWVNEYVNDLELN"
     exon            152..266
                     /gene="Ccl4"
                     /gene_synonym="Mip1-b; Scya4"
                     /inference="alignment:Splign:2.1.0"
     exon            267..642
                     /gene="Ccl4"
                     /gene_synonym="Mip1-b; Scya4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacactcag ccagcttctg aagcctctgg gccctgcagt tccagctctg tgcaaacctc
       61 tccccgagca acaccatgaa gctctacgtg tctgccttct ctctcctcct gcttgtggcc
      121 gccttctgcg attcagtgct gtcagcacca ataggctctg accctcccac ttcctgctgc
      181 ttctcttaca cctcccggaa gattcatcgg aactttgtga tggattacta tgagaccagc
      241 agcctttgct cccagccagc tgtggtattt ctgaccaaaa aaggcaggca aatctgtgcc
      301 gaccccagcg agccctgggt caatgagtat gtgaatgact tggagttgaa ctgagcagct
      361 ccagactcaa gacaggaaga gccacttctg gaaaggcctc ctcagccctg acacttctca
      421 ttgagaagta ccttgctcct tacattcaga tttcctgtcc ttcttaattt aaacctgtgt
      481 gtagactttg ttattttgtt tggtattatt tccattattt atgtttagtt atgggatatg
      541 tgtctcccat ggagatggtc caccattgtg cttctctgct attgtggata tggctgtgta
      601 attgatttca tgcaatttcg taataaatct ttctttaaga ta
//
