LOCUS       NM_001109488             666 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 26 (Ccl26), mRNA.
ACCESSION   NM_001109488 XM_001065934 XM_006249188
VERSION     NM_001109488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 666)
  AUTHORS   Shou,J., Peng,J., Zhao,Z., Huang,X., Li,H., Li,L., Gao,X., Xing,Y.
            and Liu,H.
  TITLE     CCL26 and CCR3 are associated with the acute inflammatory response
            in the CNS in experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 333, 576967 (2019)
   PUBMED   31151084
  REMARK    GeneRIF: CCL26 levels in EAE rats were significantly increased.
            CCL26 levels in the serum and in brain tissues were positively
            correlated with the inflammatory scores. CCL26, which binds to the
            receptor CCR3, showed pro-inflammatory effects and aggravated
            tissue damage involving BBB impairment, especially in the acute
            stage of EAE.
REFERENCE   2  (bases 1 to 666)
  AUTHORS   Larose,M.C., Chakir,J., Archambault,A.S., Joubert,P., Provost,V.,
            Laviolette,M. and Flamand,N.
  TITLE     Correlation between CCL26 production by human bronchial epithelial
            cells and airway eosinophils: Involvement in patients with severe
            eosinophilic asthma
  JOURNAL   J Allergy Clin Immunol 136 (4), 904-913 (2015)
   PUBMED   25936567
REFERENCE   3  (bases 1 to 666)
  AUTHORS   Wang,J., Zhang,T., Ma,C. and Wang,S.
  TITLE     Puerarin attenuates airway inflammation by regulation of eotaxin-3
  JOURNAL   Immunol Lett 163 (2), 173-178 (2015)
   PUBMED   25530546
REFERENCE   4  (bases 1 to 666)
  AUTHORS   Ji,P., Hu,H., Yang,X., Wei,X., Zhu,C., Liu,J., Feng,Y., Yang,F.,
            Okanurak,K., Li,N., Zeng,X., Zheng,H., Wu,Z. and Lv,Z.
  TITLE     AcCystatin, an immunoregulatory molecule from Angiostrongylus
            cantonensis, ameliorates the asthmatic response in an aluminium
            hydroxide/ovalbumin-induced rat model of asthma
  JOURNAL   Parasitol Res 114 (2), 613-624 (2015)
   PUBMED   25399816
REFERENCE   5  (bases 1 to 666)
  AUTHORS   Caldwell,J.M., Collins,M.H., Stucke,E.M., Putnam,P.E.,
            Franciosi,J.P., Kushner,J.P., Abonia,J.P. and Rothenberg,M.E.
  TITLE     Histologic eosinophilic gastritis is a systemic disorder associated
            with blood and extragastric eosinophilia, TH2 immunity, and a
            unique gastric transcriptome
  JOURNAL   J Allergy Clin Immunol 134 (5), 1114-1124 (2014)
   PUBMED   25234644
REFERENCE   6  (bases 1 to 666)
  AUTHORS   Chae,S.C., Park,Y.R., Oh,G.J., Lee,J.H. and Chung,H.T.
  TITLE     The suggestive association of eotaxin-2 and eotaxin-3 gene
            polymorphisms in Korean population with allergic rhinitis
  JOURNAL   Immunogenetics 56 (10), 760-764 (2005)
   PUBMED   15580493
REFERENCE   7  (bases 1 to 666)
  AUTHORS   Chae,S.C., Lee,Y.C., Park,Y.R., Shin,J.S., Song,J.H., Oh,G.J.,
            Hong,S.T., Pae,H.O., Choi,B.M. and Chung,H.T.
  TITLE     Analysis of the polymorphisms in eotaxin gene family and their
            association with asthma, IgE, and eosinophil
  JOURNAL   Biochem Biophys Res Commun 320 (1), 131-137 (2004)
   PUBMED   15207712
REFERENCE   8  (bases 1 to 666)
  AUTHORS   Kagami,S., Kakinuma,T., Saeki,H., Tsunemi,Y., Fujita,H.,
            Nakamura,K., Takekoshi,T., Kishimoto,M., Mitsui,H., Torii,H.,
            Komine,M., Asahina,A. and Tamaki,K.
  TITLE     Significant elevation of serum levels of eotaxin-3/CCL26, but not
            of eotaxin-2/CCL24, in patients with atopic dermatitis: serum
            eotaxin-3/CCL26 levels reflect the disease activity of atopic
            dermatitis
  JOURNAL   Clin Exp Immunol 134 (2), 309-313 (2003)
   PUBMED   14616792
REFERENCE   9  (bases 1 to 666)
  AUTHORS   Ye,J., Mayer,K.L., Mayer,M.R. and Stone,M.J.
  TITLE     NMR solution structure and backbone dynamics of the CC chemokine
            eotaxin-3
  JOURNAL   Biochemistry 40 (26), 7820-7831 (2001)
   PUBMED   11425309
REFERENCE   10 (bases 1 to 666)
  AUTHORS   Guo,R.F., Ward,P.A., Hu,S.M., McDuffie,J.E., Huber-Lang,M. and
            Shi,M.M.
  TITLE     Molecular cloning and characterization of a novel human CC
            chemokine, SCYA26
  JOURNAL   Genomics 58 (3), 313-317 (1999)
   PUBMED   10373330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Feb 2, 2022 this sequence version replaced
            XM_006249188.4, NM_001109488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.92383.1,
                                           SRR26360181.1190863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000012.1  26745972-26746116
            146-293             JAXUCZ010000012.1  26747551-26747698
            294-408             JAXUCZ010000012.1  26747784-26747898
            409-666             JAXUCZ010000012.1  26750667-26750924
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..666
                     /gene="Ccl26"
                     /note="C-C motif chemokine ligand 26"
                     /db_xref="GeneID:685958"
                     /db_xref="RGD:1587817"
     exon            1..145
                     /gene="Ccl26"
                     /inference="alignment:Splign:2.1.0"
     exon            146..293
                     /gene="Ccl26"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..505
                     /gene="Ccl26"
                     /note="C-C motif chemokine 26; chemokine (C-C motif)
                     ligand 26"
                     /codon_start=1
                     /product="C-C motif chemokine 26 precursor"
                     /protein_id="NP_001102958.1"
                     /db_xref="GeneID:685958"
                     /db_xref="RGD:1587817"
                     /translation="MKTFSLGPIVLLAVFLSVQLGVATCESEMPMPCCSYFSHYVIPW
                     HWLYSYQITDSSCPNEGVIFTTKTGKQYCVQPGDKWVQRYISLLNAKKHW"
     exon            294..408
                     /gene="Ccl26"
                     /inference="alignment:Splign:2.1.0"
     exon            409..666
                     /gene="Ccl26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccataaca acagaagaat ttcagacagg tatccatggt agcagaagtt caatggctag
       61 ccagactttg aggagcacct cagatggagg agggttcttg agcgtccaca caaaagtagt
      121 cagatcacaa ccagcaacgt ggatggtatc acacagactc agagaagaca aaccaggagg
      181 agctgaggag ccatctataa agggcccggg tgaatggacc atgaagacct tctctttagg
      241 tcccattgtt ctcctggccg tcttcctcag tgtccagctt ggtgttgcca cgtgtgagag
      301 tgaaatgccc atgccctgct gttcctattt cagccactac gtgatcccgt ggcactggct
      361 gtacagctac cagatcaccg acagctcctg ccccaatgag ggcgtcatat tcaccacaaa
      421 aactggtaag caatactgtg tccagccagg ggacaagtgg gtgcagagat acatttcctt
      481 gttgaacgcc aagaagcatt ggtgaccccg ctgaattttc ggcccgagga ccattcaatg
      541 cagctctcgg ctcctttgcg ctcatggaat ctggtgcatt gctttaaaga cttcgcagcc
      601 ctgctggaag gagagcgtgg ttttcattgc agatttttaa ataaagattt gatttcaata
      661 ggtcta
//
