LOCUS       NM_001037203            1363 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 25 (Ccl25), mRNA.
ACCESSION   NM_001037203 XM_341022
VERSION     NM_001037203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Watts,A.O., Verkaar,F., van der Lee,M.M., Timmerman,C.A.,
            Kuijer,M., van Offenbeek,J., van Lith,L.H., Smit,M.J., Leurs,R.,
            Zaman,G.J. and Vischer,H.F.
  TITLE     beta-Arrestin recruitment and G protein signaling by the atypical
            human chemokine decoy receptor CCX-CKR
  JOURNAL   J Biol Chem 288 (10), 7169-7181 (2013)
   PUBMED   23341447
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Cao,X., Ma,J., Wu,G., Zhang,C., Wang,L., Dai,S. and Xu,W.
  TITLE     Thymus-expressed chemokine promotes survival of PC12 cells via PI3K
            pathway
  JOURNAL   Neurochem Int 60 (2), 163-169 (2012)
   PUBMED   21672573
  REMARK    GeneRIF: Thymus-expressed TECK chemokine promotes survival of
            serum-deprived PC12 cells through its receptor CCR9 via the
            phosphatidylinositol 3-kinase (PI3K) pathway.
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Miles,A., Liaskou,E., Eksteen,B., Lalor,P.F. and Adams,D.H.
  TITLE     CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of
            lymphocytes to MAdCAM-1 under shear flow
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (5), G1257-G1267 (2008)
   PUBMED   18308860
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Penido,C., Costa,M.F., Souza,M.C., Costa,K.A., Candea,A.L.,
            Benjamim,C.F. and Henriques,Md.
  TITLE     Involvement of CC chemokines in gammadelta T lymphocyte trafficking
            during allergic inflammation: the role of CCL2/CCR2 pathway
  JOURNAL   Int Immunol 20 (1), 129-139 (2008)
   PUBMED   18056919
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Calabrese,G.C., Luczak,E.N. and Roux,M.E.
  TITLE     Importance of CCL25 in the attraction of T cells and the role of
            IL-7 on the signaling pathways in intestinal epithelial cells
  JOURNAL   Immunobiology 214 (6), 403-409 (2008)
   PUBMED   19249122
  REMARK    GeneRIF: presence of a mechanism by which gammadelta + T cells are
            increased in the intestinal villi, through different signaling path
            ways mediated by CCl25 and IL-7
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Matsumoto,T., Ajiki,T., Kajiwara,E., Mita,Y., Fujita,T.,
            Morimoto,H., Miyazawa,M. and Ku,Y.
  TITLE     Decreased expression of intestinal chemokine TECK/CCL25 in
            experimental obstructive jaundice and its reversal following
            internal biliary drainage
  JOURNAL   J Gastroenterol 43 (5), 390-396 (2008)
   PUBMED   18592157
  REMARK    GeneRIF: bile may contribute to high expression levels of
            TECK/CCL25 mRNA in the small intestine.
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Liu,C., Ueno,T., Kuse,S., Saito,F., Nitta,T., Piali,L., Nakano,H.,
            Kakiuchi,T., Lipp,M., Hollander,G.A. and Takahama,Y.
  TITLE     The role of CCL21 in recruitment of T-precursor cells to fetal
            thymi
  JOURNAL   Blood 105 (1), 31-39 (2005)
   PUBMED   15358618
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Gosling,J., Dairaghi,D.J., Wang,Y., Hanley,M., Talbot,D., Miao,Z.
            and Schall,T.J.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Norment,A.M., Bogatzki,L.Y., Gantner,B.N. and Bevan,M.J.
  TITLE     Murine CCR9, a chemokine receptor for thymus-expressed chemokine
            that is up-regulated following pre-TCR signaling
  JOURNAL   J Immunol 164 (2), 639-648 (2000)
   PUBMED   10623805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107945.1.
            
            On Nov 23, 2005 this sequence version replaced XM_341022.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107945.1, CV074292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132308,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..1363
                     /gene="Ccl25"
                     /note="C-C motif chemokine ligand 25"
                     /db_xref="GeneID:360750"
                     /db_xref="RGD:1305530"
     exon            1..44
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
     exon            45..167
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..538
                     /gene="Ccl25"
                     /note="C-C motif chemokine 25; chemokine (C-C motif)
                     ligand 25"
                     /codon_start=1
                     /product="C-C motif chemokine 25 precursor"
                     /protein_id="NP_001032280.1"
                     /db_xref="GeneID:360750"
                     /db_xref="RGD:1305530"
                     /translation="MKLQLFACLAACFVGAWVPVVRAQGAFEDCCLGYQPRIKWNVLR
                     HARHYHQQEVSGSCNLRAVIFYFRQKVVVCGNPEDKDVKRAVKILTARKQPVHSPQKS
                     TSDYPTERKKSNYMKFKVENPKGTRMRNATLGHPRMVMMSRKTNN"
     exon            168..285
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
     exon            286..407
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
     exon            408..504
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1348
                     /gene="Ccl25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccctacaa gcgggcacca cctttcagga ccagaaaggc actggtggcc ccattaaacc
       61 ttcaggtacc cagagaggag atccagcctt cagcatgaaa ctgcagctgt tcgcctgcct
      121 ggctgcctgc tttgttgggg cctgggtgcc agttgtccgt gcccaaggtg cctttgaaga
      181 ctgctgcctg ggttaccagc ctaggatcaa atggaatgtt ctccggcatg ctaggcatta
      241 tcaccagcag gaagtgagtg gaagctgcaa cctccgtgct gtgatattct acttccgcca
      301 gaaagtagta gtgtgtggga atccagagga caaggatgtg aagagggctg tgaagatctt
      361 aacagctagg aagcagccag tccacagtcc ccagaagagc acctcagact atccgaccga
      421 aaggaagaag tcaaactaca tgaagttcaa ggtggagaac cccaagggca caaggatgag
      481 gaatgccacc ctgggtcatc ccaggatggt gatgatgtcc agaaagacca acaattaagt
      541 taagttactc agagtaagca gcagctggag gatgggagga gtcccctgag gagctgtctt
      601 ctaggcacca cagtgccaac gaactcacgg aagctacagt tacctgtaca agactggacc
      661 caccaacgtc tcagcgcgta tgagtaagga cctacctatg ctaaaggccc taccactcac
      721 caatgagcta ttgactgttg atggttactg ggagaaggga gtctttttgt ttttgttttt
      781 ttctctccaa agcgtggctt gcccatagtc cagtatataa tcccctatct tcactcagac
      841 aagcaaccct aattaaatgc aatggccata tacaaaagga caaaggtttg aatggttttg
      901 gggcggggga gcttgttagg aagaagacat taacaggaga gagaggaact agagatcact
      961 gagtgtgtga aaatggtcaa aatgcataca tatgtgaaat ggtcaaagaa ttaaaaaata
     1021 aaaatttaaa aagctattaa aaagtgatta cttacagtga tgtgtggtgt atggcatgcc
     1081 ctcagggggt tagtgcctat acttctgact taacctgcta taaatcaagg ttcctttgac
     1141 tcctgtcaac actctggaaa gcactgtctt tatatttctt aattattcta tagcatgtta
     1201 caaaggctat ggatgatcta gaattggtgt tgctcaagga gtctacagta ggataatcac
     1261 atgcttgaga ccagcctggg ctacagtgca agtttgaggc tagcctggga tacaaagcaa
     1321 gaccctatct caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
