LOCUS       NM_057203               1770 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 22 (Ccl22), mRNA.
ACCESSION   NM_057203 XM_344722
VERSION     NM_057203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Gao HX, Su Y, Zhang AL, Xu JW, Fu Q and Yan L.
  TITLE     MiR-34c-5p plays a protective role in chronic obstructive pulmonary
            disease via targeting CCL22
  JOURNAL   Exp Lung Res 45 (1-2), 1-12 (2019)
   PUBMED   31032652
  REMARK    GeneRIF: MiR-34c-5p could target CCL22 to down-regulate its
            expression.
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Zhao M, Li Y, Wei X, Zhang Q, Jia H, Quan S, Cao D, Wang L, Yang T,
            Zhao J, Pei M, Tian S, Yu Y, Guo Y and Yang X.
  TITLE     Negative immune factors might predominate local tumor immune status
            and promote carcinogenesis in cervical carcinoma
  JOURNAL   Virol J 14 (1), 5 (2017)
   PUBMED   28086903
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Poddar D, Basu A, Baldwin WM 3rd, Kondratov RV, Barik S and
            Mazumder B.
  TITLE     An extraribosomal function of ribosomal protein L13a in macrophages
            resolves inflammation
  JOURNAL   J Immunol 190 (7), 3600-3612 (2013)
   PUBMED   23460747
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Bhorade SM, Chen H, Molinero L, Liao C, Garrity ER, Vigneswaran WT,
            Shilling R, Sperling A, Chong A and Alegre ML.
  TITLE     Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage
            from lung transplant recipients correlates with development of
            bronchiolitis obliterans syndrome
  JOURNAL   Transplantation 90 (5), 540-546 (2010)
   PUBMED   20628341
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Wu C, Zhou Q, Qin XJ, Qin SM and Shi HZ.
  TITLE     CCL22 is involved in the recruitment of CD4+CD25 high T cells into
            tuberculous pleural effusions
  JOURNAL   Respirology 15 (3), 522-529 (2010)
   PUBMED   20337996
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Chiu BC, Freeman CM, Stolberg VR, Komuniecki E, Lincoln PM, Kunkel
            SL and Chensue SW.
  TITLE     Cytokine-chemokine networks in experimental mycobacterial and
            schistosomal pulmonary granuloma formation
  JOURNAL   Am J Respir Cell Mol Biol 29 (1), 106-116 (2003)
   PUBMED   12600821
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Garcia GE, Xia Y, Harrison J, Wilson CB, Johnson RJ, Bacon KB and
            Feng L.
  TITLE     Mononuclear cell-infiltrate inhibition by blocking
            macrophage-derived chemokine results in attenuation of developing
            crescentic glomerulonephritis
  JOURNAL   Am J Pathol 162 (4), 1061-1073 (2003)
   PUBMED   12651599
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL and Miller RJ.
  TITLE     Chemokines and glycoprotein120 produce pain hypersensitivity by
            directly exciting primary nociceptive neurons
  JOURNAL   J Neurosci 21 (14), 5027-5035 (2001)
   PUBMED   11438578
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Chantry D, Romagnani P, Raport CJ, Wood CL, Epp A, Romagnani S and
            Gray PW.
  TITLE     Macrophage-derived chemokine is localized to thymic medullary
            epithelial cells and is a chemoattractant for CD3(+), CD4(+),
            CD8(low) thymocytes
  JOURNAL   Blood 94 (6), 1890-1898 (1999)
   PUBMED   10477717
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Gonzalo JA, Pan Y, Lloyd CM, Jia GQ, Yu G, Dussault B, Powers CA,
            Proudfoot AE, Coyle AJ, Gearing D and Gutierrez-Ramos JC.
  TITLE     Mouse monocyte-derived chemokine is involved in airway
            hyperreactivity and lung inflammation
  JOURNAL   J Immunol 163 (1), 403-411 (1999)
   PUBMED   10384142
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088218.1.
            
            On Jan 14, 2005 this sequence version replaced XM_344722.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088218.1, AF163477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..1770
                     /gene="Ccl22"
                     /gene_synonym="Mdc; Scya22"
                     /note="C-C motif chemokine ligand 22"
                     /db_xref="GeneID:117551"
                     /db_xref="RGD:619933"
     exon            1..96
                     /gene="Ccl22"
                     /gene_synonym="Mdc; Scya22"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..302
                     /gene="Ccl22"
                     /gene_synonym="Mdc; Scya22"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 22; small inducible cytokine A22; C-C motif
                     chemokine 22; small inducible cytokine subfamily A
                     (Cys-Cys) member 22; chemokine (C-C motif) ligand 22"
                     /codon_start=1
                     /product="C-C motif chemokine 22 precursor"
                     /protein_id="NP_476551.1"
                     /db_xref="GeneID:117551"
                     /db_xref="RGD:619933"
                     /translation="MASLRVPLLVALVLLAVALQTSDAGPYGANVEDSICCQDYIRHP
                     LPPRFVKEFYWTSKSCRKPGVVLITIKNRDICADPRMLWVKKILHKLA"
     exon            97..220
                     /gene="Ccl22"
                     /gene_synonym="Mdc; Scya22"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1745
                     /gene="Ccl22"
                     /gene_synonym="Mdc; Scya22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgactggg atacacacac atcatggcca gcctgcgagt cccactcctg gtggctctcg
       61 tccttcttgc tgtggcactt cagacctccg atgcaggtcc ctatggtgcc aatgtggaag
      121 acagtatctg ctgccaggac tacatccgtc accctctgcc accacgtttc gtgaaggagt
      181 tctactggac ctcaaagtcc tgccgcaagc ctggcgtcgt tttgataacc atcaagaacc
      241 gagatatctg tgctgacccc aggatgctct gggtgaagaa gatactccac aagttggcct
      301 agggagaagg gcctgatgac cacgggtctg gtgtctccac aaggctcagc aaaccctatc
      361 cttctgccat ccagcaagag ccttgccaac aactccacct ttgctcacct ccatcccctg
      421 ggttgtcact ctgtgaagcc tcaggtccct gtacttcctg tccgtcccct ccagctcatt
      481 ctcttccaac gtggcagccg ggaagcactt ctggctagcc ttacccaata cctactcccc
      541 actgctttag atgagaccag ggtccttgtt ttggtgcctt tggatcctat gatgccttgg
      601 cccccttctc ttcttacatg tagggaacac caatatcttt caagtatgtg ctacccagtt
      661 cctcttcctc ggaggctgct gggacccgga atattatccc tgctgcaggc cctctccagc
      721 accactcacc tcccaggctt ccatccgtcc cagtcccaag ccccatgctt cagacttcct
      781 tggcccccac ctacactcag aattctggga gtctcagact ggtccactag gccccaaggg
      841 aggaggtccc cacaagagct cctcctgttt ctcggtctcc agcacaggag tgggctcaga
      901 atcagatttc tgaaaggagc tgcaaattct accagtaaaa ttaatcttcc cccatccctg
      961 atgtaggcaa aaggcagtct cctctcaaca cggagactca ggttgttaga aaggggctat
     1021 gtaggtcaac tgtgacctaa attcaccaag aatcaacttc catccatccc tcttcaaccg
     1081 aatgttaggt cttttacttt ttctacttct gactccatgc ctgtgtagtt gataatcaaa
     1141 gtcatgctat ggtgacagtg atcgccatag cttggtatta taagctatag ttatatttat
     1201 ataggaaaga ggataaatat atgtgaggcc aaatagacga actggagagt cttgggacct
     1261 gggggcagga aggaccatac aaagcccttc agaaagcagc tggttgtggg agctacaggc
     1321 acagtggcat agttaaatta aagaacttag ttgaaattat tcttgagtgg ctggggccaa
     1381 gtcaggaatt taaaactcac tcttgcttcc ctggagacaa cagtgcccca gggtggggaa
     1441 ataaatctgc ttgctcctct ggagggaaca gtggcctggc ttagctgagt gactggattg
     1501 cgtgagcctg aggacattgc ttttcccctc ggagcctcag ctgacagaat atgggaccac
     1561 aaagggtttt ccccaaccca cagggactga cagtgccagc cacagctgtg tccagggctt
     1621 atgtccttcc agaaggagca cccgatgacc agggccacca ttagtgctac tctgcccact
     1681 gccatgcatg tcctgagggt cacctcctct cctacttctg ggaaaataaa tgctcgtcaa
     1741 tagtgaaaaa aaaaaaaaaa aaaaaaaaaa
//
