LOCUS       NM_001008513             860 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 21 (Ccl21), mRNA.
ACCESSION   NM_001008513 XM_216379
VERSION     NM_001008513.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Subburaman M and Edderkaoui B.
  TITLE     Evaluation of CCL21 role in post-knee injury inflammation and early
            cartilage degeneration
  JOURNAL   PLoS One 16 (3), e0247913 (2021)
   PUBMED   33651836
  REMARK    GeneRIF: Evaluation of CCL21 role in post-knee injury inflammation
            and early cartilage degeneration.
            Erratum:[PLoS One. 2021 Oct 28;16(10):e0259553. PMID: 34710183]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Wang T, Fu J, Liu XQ and Zhang Q.
  TITLE     [Expression and significance of chemokines CCL21, E-selectins and
            Hsp90 in periodontal tissues of rats with experimental
            periodontitis]
  JOURNAL   Shanghai Kou Qiang Yi Xue 29 (4), 350-354 (2020)
   PUBMED   33089280
  REMARK    GeneRIF: [Expression and significance of chemokines CCL21,
            E-selectins and Hsp90 in periodontal tissues of rats with
            experimental periodontitis].
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF and
            Yen JJ.
  TITLE     CBAP functions as a novel component in chemokine-induced
            ZAP70-mediated T-cell adhesion and migration
  JOURNAL   PLoS One 8 (4), e61761 (2013)
   PUBMED   23620790
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Rollag H, Ueland T, Asberg A, Hartmann A, Jardine AG, Humar A,
            Pescovitz MD, Bignamini AA and Aukrust P.
  TITLE     Characterization of cytomegalovirus disease in solid organ
            transplant recipients by markers of inflammation in plasma
  JOURNAL   PLoS One 8 (4), e60767 (2013)
   PUBMED   23593305
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van
            Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ and Vischer
            HF.
  TITLE     beta-Arrestin recruitment and G protein signaling by the atypical
            human chemokine decoy receptor CCX-CKR
  JOURNAL   J Biol Chem 288 (10), 7169-7181 (2013)
   PUBMED   23341447
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Yanagawa Y and Onoe K.
  TITLE     CCR7 ligands induce rapid endocytosis in mature dendritic cells
            with concomitant up-regulation of Cdc42 and Rac activities
  JOURNAL   Blood 101 (12), 4923-4929 (2003)
   PUBMED   12609829
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Yanagawa Y and Onoe K.
  TITLE     CCL19 induces rapid dendritic extension of murine dendritic cells
  JOURNAL   Blood 100 (6), 1948-1956 (2002)
   PUBMED   12200351
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan
            T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E
            and Zlotnik A.
  TITLE     Involvement of chemokine receptors in breast cancer metastasis
  JOURNAL   Nature 410 (6824), 50-56 (2001)
   PUBMED   11242036
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T and Yoshie O.
  TITLE     Secondary lymphoid-tissue chemokine is a functional ligand for the
            CC chemokine receptor CCR7
  JOURNAL   J Biol Chem 273 (12), 7118-7122 (1998)
   PUBMED   9507024
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Tanabe S, Lu Z, Luo Y, Quackenbush EJ, Berman MA, Collins-Racie LA,
            Mi S, Reilly C, Lo D, Jacobs KA and Dorf ME.
  TITLE     Identification of a new mouse beta-chemokine, thymus-derived
            chemotactic agent 4, with activity on T lymphocytes and mesangial
            cells
  JOURNAL   J Immunol 159 (11), 5671-5679 (1997)
   PUBMED   9548511
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086571.1.
            
            On Dec 16, 2004 this sequence version replaced XM_216379.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086571.1, CF110012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..860
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /note="C-C motif chemokine ligand 21"
                     /db_xref="GeneID:298006"
                     /db_xref="RGD:1311996"
     exon            1..115
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..450
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /note="chemokine (C-C motif) ligand 21b (serine); small
                     inducible cytokine A21; C-C motif chemokine 21"
                     /codon_start=1
                     /product="C-C motif chemokine 21 precursor"
                     /protein_id="NP_001008513.1"
                     /db_xref="GeneID:298006"
                     /db_xref="RGD:1311996"
                     /translation="MAQMLALSLLSLVLVLCVPWTQGSDGGGQDCCLRYSQKKIPYNI
                     VRGYRKQEPSLGCPIPAILFAPRKQSQPELCANPEEAWVQKLMRRLDQPPAPGKQNCR
                     KNRGTSKSGKKGRGSKGCKGTEQTDSKRVSQ"
     exon            116..236
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /inference="alignment:Splign:2.1.0"
     exon            237..413
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /inference="alignment:Splign:2.1.0"
     exon            414..838
                     /gene="Ccl21"
                     /gene_synonym="Ccl21b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccatctca cctacagctc tggtctcatc ctcaactcaa ccacagccat ggctcagatg
       61 ctggctctga gcctccttag cttggtcctg gttctctgcg tcccgtggac ccaaggcagt
      121 gacggagggg gtcaggactg ctgtcttagg tacagccaga agaagattcc ctacaacatt
      181 gtccgaggct acaggaagca agaaccgagc ctaggttgcc ccatcccagc aatcctgttc
      241 gcaccccgga agcaatctca gcctgagcta tgcgcaaacc ctgaggaagc ctgggtgcag
      301 aagctgatgc gacgtctgga ccagcctcca gccccaggga aacaaaactg caggaagaat
      361 cgaggaacct ctaagtctgg gaagaaagga aggggctcca aaggctgcaa ggggactgaa
      421 cagacagact ccaagagggt atcccagtga catgcctgga gtccaggaag tcctccgtga
      481 acttcaacct gagtgcttca cagtccaact cacaggcaaa gagggagcta gagagcagaa
      541 agactcaggg gccccagagc agtcacctca tgctggcctt gtcacaccct tgtctgcttc
      601 aaccatcaca tctgcatggc cgtccctttc ttctatggcg gagcggcctt ccctgggata
      661 gacctaggga gtcagaagaa agagtgtctc ccagggaagg aagaaggaga cagcaggact
      721 gtcccctcta ggaggtcact caggtcccaa gacctgcact tgctctccat ggcacccttc
      781 ctttttcctt gcacctatga tatataccta actgaataaa aagctggtcc agcctcaaaa
      841 aaaaaaaaaa aaaaaaaaaa
//
