LOCUS       NM_019233                796 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 20 (Ccl20), mRNA.
ACCESSION   NM_019233
VERSION     NM_019233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 796)
  AUTHORS   Zhang,R., Xu,L., Zhang,D., Hu,B., Luo,Q., Han,D., Li,J. and Shen,C.
  TITLE     Cardioprotection of Ginkgolide B on Myocardial
            Ischemia/Reperfusion-Induced Inflammatory Injury via Regulation of
            A20-NF-kappaB Pathway
  JOURNAL   Front Immunol 9, 2844 (2018)
   PUBMED   30619251
  REMARK    GeneRIF: Ginkgolide B could alleviate MI/RI-induced inflammatory
            response through A20-NF-kappaB signal pathway, which may give us
            new insights into the preventive strategies for myocardial
            ischemia/reperfusion injury disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 796)
  AUTHORS   Zhang,Y., Liu,L., Wang,S., Zhao,Y., Liu,Y., Li,J., Nie,L. and
            Cheng,L.
  TITLE     Production of CCL20 on nucleus pulposus cells recruits
            IL-17-producing cells to degenerated IVD tissues in rat models
  JOURNAL   J Mol Histol 47 (1), 81-89 (2016)
   PUBMED   26704184
  REMARK    GeneRIF: The results suggest a potential mechanism for the
            recruitment of IL-17-producing cells to degenerated intervertebral
            discs via a CCL20/CCR6 axis in vivo.
REFERENCE   3  (bases 1 to 796)
  AUTHORS   Diao,R., Fok,K.L., Chen,H., Yu,M.K., Duan,Y., Chung,C.M., Li,Z.,
            Wu,H., Li,Z., Zhang,H., Ji,Z., Zhen,W., Ng,C.F., Gui,Y., Cai,Z. and
            Chan,H.C.
  TITLE     Deficient human beta-defensin 1 underlies male infertility
            associated with poor sperm motility and genital tract infection
  JOURNAL   Sci Transl Med 6 (249), 249ra108 (2014)
   PUBMED   25122636
REFERENCE   4  (bases 1 to 796)
  AUTHORS   Bunting,M.D., Comerford,I., Kara,E.E., Korner,H. and McColl,S.R.
  TITLE     CCR6 supports migration and differentiation of a subset of DN1
            early thymocyte progenitors but is not required for thymic nTreg
            development
  JOURNAL   Immunol Cell Biol 92 (6), 489-498 (2014)
   PUBMED   24638065
REFERENCE   5  (bases 1 to 796)
  AUTHORS   Caballero-Campo,P., Buffone,M.G., Benencia,F., Conejo-Garcia,J.R.,
            Rinaudo,P.F. and Gerton,G.L.
  TITLE     A role for the chemokine receptor CCR6 in mammalian sperm motility
            and chemotaxis
  JOURNAL   J Cell Physiol 229 (1), 68-78 (2014)
   PUBMED   23765988
REFERENCE   6  (bases 1 to 796)
  AUTHORS   Nakayama,T., Fujisawa,R., Yamada,H., Horikawa,T., Kawasaki,H.,
            Hieshima,K., Izawa,D., Fujiie,S., Tezuka,T. and Yoshie,O.
  TITLE     Inducible expression of a CC chemokine liver- and
            activation-regulated chemokine (LARC)/macrophage inflammatory
            protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role
            in atopic dermatitis
  JOURNAL   Int Immunol 13 (1), 95-103 (2001)
   PUBMED   11133838
REFERENCE   7  (bases 1 to 796)
  AUTHORS   Homey,B., Dieu-Nosjean,M.C., Wiesenborn,A., Massacrier,C.,
            Pin,J.J., Oldham,E., Catron,D., Buchanan,M.E., Muller,A., deWaal
            Malefyt,R., Deng,G., Orozco,R., Ruzicka,T., Lehmann,P.,
            Lebecque,S., Caux,C. and Zlotnik,A.
  TITLE     Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and
            CC chemokine receptor 6 in psoriasis
  JOURNAL   J Immunol 164 (12), 6621-6632 (2000)
   PUBMED   10843722
REFERENCE   8  (bases 1 to 796)
  AUTHORS   Kleeff,J., Kusama,T., Rossi,D.L., Ishiwata,T., Maruyama,H.,
            Friess,H., Buchler,M.W., Zlotnik,A. and Korc,M.
  TITLE     Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage
            proinflammatory chemokine, and its CCR6 receptor in human
            pancreatic cancer
  JOURNAL   Int J Cancer 81 (4), 650-657 (1999)
   PUBMED   10225458
REFERENCE   9  (bases 1 to 796)
  AUTHORS   Utans-Schneitz,U., Lorez,H., Klinkert,W.E., da Silva,J. and
            Lesslauer,W.
  TITLE     A novel rat CC chemokine, identified by targeted differential
            display, is upregulated in brain inflammation
  JOURNAL   J Neuroimmunol 92 (1-2), 179-190 (1998)
   PUBMED   9916893
  REMARK    Erratum:[J Neuroimmunol 1999 Feb 1;94(1-2):222]
REFERENCE   10 (bases 1 to 796)
  AUTHORS   Varona,R., Zaballos,A., Gutierrez,J., Martin,P., Roncal,F.,
            Albar,J.P., Ardavin,C. and Marquez,G.
  TITLE     Molecular cloning, functional characterization and mRNA expression
            analysis of the murine chemokine receptor CCR6 and its specific
            ligand MIP-3alpha
  JOURNAL   FEBS Lett 440 (1-2), 188-194 (1998)
   PUBMED   9862452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019233.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90447.1, AF053312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000009.1  91837159-91837282
            125-242             JAXUCZ010000009.1  91838340-91838457
            243-320             JAXUCZ010000009.1  91838589-91838666
            321-796             JAXUCZ010000009.1  91839261-91839736
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..796
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /note="C-C motif chemokine ligand 20"
                     /db_xref="GeneID:29538"
                     /db_xref="RGD:3646"
     exon            1..124
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..342
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /note="C-C motif chemokine 20; MIP-3-alpha; CC chemokine
                     LARC; CC chemokine ST38; chemokine (C-C motif) ligand 20;
                     small-inducible cytokine A20; macrophage inflammatory
                     protein 3 alpha; liver and activation-regulated chemokine;
                     beta-chemokine exodus-1; small inducible cytokine
                     subfamily A20"
                     /codon_start=1
                     /product="C-C motif chemokine 20 precursor"
                     /protein_id="NP_062106.1"
                     /db_xref="GeneID:29538"
                     /db_xref="RGD:3646"
                     /translation="MACKHLPFLALAGVLLAYLCSQSEAASNFDCCLTYTKNVYHHAR
                     NFVGFTTQMADEACDINAIIFHLKSKRSVCADPKQIWVKRILHLLSLRTKKM"
     exon            125..242
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            243..320
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            321..796
                     /gene="Ccl20"
                     /gene_synonym="Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagggcac tgggtaccca gcactgagca gatcaattcc tggagctgag aatggcctgc
       61 aagcatctgc ccttcctggc tttggcgggg gtactgctgg cttacctctg cagccagtca
      121 gaagcagcaa gcaactttga ctgctgcctc acgtacacaa agaacgtgta tcatcatgcg
      181 agaaattttg tgggtttcac aacacagatg gccgacgaag cttgtgacat taatgctatc
      241 atctttcacc tgaagtcgaa aagatccgtg tgcgctgacc caaagcagat ctgggtgaaa
      301 aggattttgc acctcctcag cctaagaacc aagaagatgt aaaaacggat gcttttctgg
      361 gatggaattg gacacagccc aaggaggaaa tgatcacagc tggggttgga ggtttcacct
      421 gcacatcact gcacagacct gatttgtgtc ccagtggtct tgtccaatgg atgaagttga
      481 ttcatattgc atcatagtgt gtcatattta agctcatatt agagttaagt tgtattttgt
      541 gttatttata gatccgaatt ttctatgttt agctatttaa tgttaatttc ccacaatcta
      601 tgaggggcgc ttagtagaag gttcaatatt atgtttaagg cagtaagttt atatggccct
      661 tcttggaaac aataagctat tgtaaaaata tttaatgttc ttctgtgtgc ttaattgttt
      721 cttaaattga tacgatttac ttataaaaca gaaaggaatt ataagaatat attgaaaata
      781 aaagaactga aaggca
//
