LOCUS       NM_031530                780 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 2 (Ccl2), mRNA.
ACCESSION   NM_031530
VERSION     NM_031530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Tarale,P., Chaudhary,S., Mukherjee,S. and Sarkar,D.K.
  TITLE     Ethanol-activated microglial exosomes induce MCP1 signaling
            mediated death of stress-regulatory proopiomelanocortin neurons in
            the developing hypothalamus
  JOURNAL   J Neuroinflammation 21 (1), 279 (2024)
   PUBMED   39478585
  REMARK    GeneRIF: Ethanol-activated microglial exosomes induce MCP1
            signaling mediated death of stress-regulatory proopiomelanocortin
            neurons in the developing hypothalamus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Li,L., Ding,Z., Ma,F., Zhang,K., Lu,D., Wang,H. and Yang,K.
  TITLE     Spinal nerve transection-induced upregulation of KDM4A in the
            dorsal root ganglia contributes to the development and maintenance
            of neuropathic pain via promoting CCL2 expression in rats
  JOURNAL   Eur J Neurosci 60 (6), 5169-5188 (2024)
   PUBMED   39136140
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of KDM4A in
            the dorsal root ganglia contributes to the development and
            maintenance of neuropathic pain via promoting CCL2 expression in
            rats.
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Deng,J., Liang,J., Cao,Y., Tong,X. and Li,H.
  TITLE     CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic
            Pelvic Pain Model
  JOURNAL   In Vivo 38 (1), 205-212 (2024)
   PUBMED   38148075
  REMARK    GeneRIF: CCL2- and Notch2-mediated Central Sensitization in a Rat
            Chronic Pelvic Pain Model.
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Li,Q., Yang,Z., Wang,K., Chen,Z. and Shen,H.
  TITLE     Suppression of microglial Ccl2 reduces neuropathic pain associated
            with chronic spinal compression
  JOURNAL   Front Immunol 14, 1191188 (2023)
   PUBMED   37497210
  REMARK    GeneRIF: Suppression of microglial Ccl2 reduces neuropathic pain
            associated with chronic spinal compression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 780)
  AUTHORS   He,Z., Chen,L. and Zhang,W.
  TITLE     LncRNA PCBP1-AS1 Induces Cerebral Ischemia/Reperfusion Injury via
            the miR-506-3p/CCL2 Axis
  JOURNAL   Ann Clin Lab Sci 53 (3), 438-447 (2023)
   PUBMED   37437927
  REMARK    GeneRIF: LncRNA PCBP1-AS1 Induces Cerebral Ischemia/Reperfusion
            Injury via the miR-506-3p/CCL2 Axis.
REFERENCE   6  (bases 1 to 780)
  AUTHORS   Manome,Y., Wen,P.Y., Hershowitz,A., Tanaka,T., Rollins,B.J.,
            Kufe,D.W. and Fine,H.A.
  TITLE     Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an
            effective tumor vaccine strategy for non-intracranial tumors
  JOURNAL   Cancer Immunol Immunother 41 (4), 227-235 (1995)
   PUBMED   7489565
REFERENCE   7  (bases 1 to 780)
  AUTHORS   Jones,M.L., Mulligan,M.S., Flory,C.M., Ward,P.A. and Warren,J.S.
  TITLE     Potential role of monocyte chemoattractant protein 1/JE in
            monocyte/macrophage-dependent IgA immune complex alveolitis in the
            rat
  JOURNAL   J Immunol 149 (6), 2147-2154 (1992)
   PUBMED   1387671
REFERENCE   8  (bases 1 to 780)
  AUTHORS   Yoshimura,T., Takeya,M. and Takahashi,K.
  TITLE     Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1)
            and its expression in rat spleen cells and tumor cell lines
  JOURNAL   Biochem Biophys Res Commun 174 (2), 504-509 (1991)
   PUBMED   1704226
REFERENCE   9  (bases 1 to 780)
  AUTHORS   Timmers,H.T., Pronk,G.J., Bos,J.L. and van der Eb,A.J.
  TITLE     Analysis of the rat JE gene promoter identifies an AP-1 binding
            site essential for basal expression but not for TPA induction
  JOURNAL   Nucleic Acids Res 18 (1), 23-34 (1990)
   PUBMED   2106664
REFERENCE   10 (bases 1 to 780)
  AUTHORS   Santolini,B.M., Nai Fovino,P.L. and Rossoni,L.
  TITLE     [The behavior of intra-leukocyte peroxidase after irradiation with
            radar microwaves in intra-articular exudates]
  JOURNAL   Minerva Ortop 22 (12), 459-462 (1971)
   PUBMED   5135051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF058786.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF058786.1, M57441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMD00132287
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..780
                     /gene="Ccl2"
                     /gene_synonym="MCP-1; Scya2; Sigje"
                     /note="C-C motif chemokine ligand 2"
                     /db_xref="GeneID:24770"
                     /db_xref="RGD:3645"
     exon            1..151
                     /gene="Ccl2"
                     /gene_synonym="MCP-1; Scya2; Sigje"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..522
                     /gene="Ccl2"
                     /gene_synonym="MCP-1; Scya2; Sigje"
                     /note="small inducible gene JE; small inducible cytokine
                     A2; C-C motif chemokine 2; monocyte chemoattractant
                     protein 1; immediate-early serum-responsive JE protein;
                     immediate-early serum-responsive protein JE; monocyte
                     chemotactic protein 1; chemokine (C-C motif) ligand 2"
                     /codon_start=1
                     /product="C-C motif chemokine 2 precursor"
                     /protein_id="NP_113718.1"
                     /db_xref="GeneID:24770"
                     /db_xref="RGD:3645"
                     /translation="MQVSVTLLGLLFTVAACSIHVLSQPDAVNAPLTCCYSFTGKMIP
                     MSRLENYKRITSSRCPKEAVVFVTKLKREICADPNKEWVQKYIRKLDQNQVRSETTVF
                     YKIASTLRTSAPLNVNLTHKSEANASTLFSTTTSSTSVEVTSMTEN"
     exon            152..269
                     /gene="Ccl2"
                     /gene_synonym="MCP-1; Scya2; Sigje"
                     /inference="alignment:Splign:2.1.0"
     exon            270..780
                     /gene="Ccl2"
                     /gene_synonym="MCP-1; Scya2; Sigje"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagacac agacagaggc cagcccagaa accagccaac tctcactgaa gccagatctc
       61 tcttcctcca ccactatgca ggtctctgtc acgcttctgg gcctgttgtt cacagttgct
      121 gcctgtagca tccacgtgct gtctcagcca gatgcagtta atgccccact cacctgctgc
      181 tactcattca ctggcaagat gatcccaatg agtcggctgg agaactacaa gagaatcacc
      241 agcagcaggt gtcccaaaga agctgtagta tttgtcacca agctcaagag agagatctgt
      301 gctgacccca ataaggaatg ggtccagaag tacattagaa aactggacca gaaccaagtg
      361 agatcagaaa ctacagtctt ctataaaatt gcatcaaccc taaggacttc agcacctttg
      421 aatgtgaact tgacccataa atctgaagct aatgcatcca ctctcttttc cacaaccacc
      481 tcaagcactt ctgtagaagt gaccagtatg acagagaact agtgtgattt ggaatgtgat
      541 gccttaagta atgttaaact tatttaactt attgatatta cactattccc ttccatgaat
      601 actagaaatc cttaaatgca agatgtagat ccattttttt atttctctgt gaatcctggt
      661 tcaacacttt caatgtatga gagatgaatg ggtaaacttt gtgtttgaga gtccaaggta
      721 ttgtttaaaa tattattatg gatattccta attattaaaa gaaatatatt atttttgtac
//
