LOCUS       NM_001108661             715 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 19 (Ccl19), mRNA.
ACCESSION   NM_001108661 XM_001061447 XM_342824
VERSION     NM_001108661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 715)
  AUTHORS   Liu Y, Luo S, Kou L, Tang C, Huang R, Pei Z and Li Z.
  TITLE     Ischemic stroke damages the intestinal mucosa and induces
            alteration of the intestinal lymphocytes and CCL19 mRNA in rats
  JOURNAL   Neurosci Lett 658, 165-170 (2017)
   PUBMED   28859865
  REMARK    GeneRIF: an upregulation of CCL19 mRNA expression was detected at
            6h after stroke
REFERENCE   2  (bases 1 to 715)
  AUTHORS   Hsu YL, Wang MY, Ho LJ, Huang CY and Lai JH.
  TITLE     Up-regulation of galectin-9 induces cell migration in human
            dendritic cells infected with dengue virus
  JOURNAL   J Cell Mol Med 19 (5), 1065-1076 (2015)
   PUBMED   25754930
REFERENCE   3  (bases 1 to 715)
  AUTHORS   Zhang W, Tu G, Lv C, Long J, Cong L and Han Y.
  TITLE     Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7
            interaction via PI3K/Akt pathway and is involved in CCL19-driven
            BMSCs migration
  JOURNAL   Biochem Biophys Res Commun 451 (2), 222-228 (2014)
   PUBMED   25086360
  REMARK    GeneRIF: CCL19/CCR7 contributes to the migration of bone marrow
            mesenchymal stem cells by upregulating MMP9 potentially via the
            PI3K/Akt pathway.
REFERENCE   4  (bases 1 to 715)
  AUTHORS   Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van
            Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ and Vischer
            HF.
  TITLE     beta-Arrestin recruitment and G protein signaling by the atypical
            human chemokine decoy receptor CCX-CKR
  JOURNAL   J Biol Chem 288 (10), 7169-7181 (2013)
   PUBMED   23341447
REFERENCE   5  (bases 1 to 715)
  AUTHORS   Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry ML,
            Magistrelli G, Masternak K, Chevailler A, Delneste Y and Jeannin P.
  TITLE     CCR7 is involved in the migration of neutrophils to lymph nodes
  JOURNAL   Blood 117 (4), 1196-1204 (2011)
   PUBMED   21051556
REFERENCE   6  (bases 1 to 715)
  AUTHORS   Gibejova A, Mrazek F, Subrtova D, Sekerova V, Szotkowska J, Kolek
            V, du Bois RM and Petrek M.
  TITLE     Expression of macrophage inflammatory protein-3 beta/CCL19 in
            pulmonary sarcoidosis
  JOURNAL   Am J Respir Crit Care Med 167 (12), 1695-1703 (2003)
   PUBMED   12626344
REFERENCE   7  (bases 1 to 715)
  AUTHORS   Yanagawa Y and Onoe K.
  TITLE     CCR7 ligands induce rapid endocytosis in mature dendritic cells
            with concomitant up-regulation of Cdc42 and Rac activities
  JOURNAL   Blood 101 (12), 4923-4929 (2003)
   PUBMED   12609829
REFERENCE   8  (bases 1 to 715)
  AUTHORS   Yanagawa Y and Onoe K.
  TITLE     CCL19 induces rapid dendritic extension of murine dendritic cells
  JOURNAL   Blood 100 (6), 1948-1956 (2002)
   PUBMED   12200351
REFERENCE   9  (bases 1 to 715)
  AUTHORS   Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z and
            Schall TJ.
  TITLE     Cutting edge: identification of a novel chemokine receptor that
            binds dendritic cell- and T cell-active chemokines including ELC,
            SLC, and TECK
  JOURNAL   J Immunol 164 (6), 2851-2856 (2000)
   PUBMED   10706668
REFERENCE   10 (bases 1 to 715)
  AUTHORS   Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T and Yoshie O.
  TITLE     Secondary lymphoid-tissue chemokine is a functional ligand for the
            CC chemokine receptor CCR7
  JOURNAL   J Biol Chem 273 (12), 7118-7122 (1998)
   PUBMED   9507024
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342824.3, XM_001061447.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV717387.1, CB608116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..715
                     /gene="Ccl19"
                     /note="C-C motif chemokine ligand 19"
                     /db_xref="GeneID:362506"
                     /db_xref="RGD:1310336"
     exon            1..243
                     /gene="Ccl19"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..509
                     /gene="Ccl19"
                     /note="C-C motif chemokine 19; chemokine (C-C motif)
                     ligand 19"
                     /codon_start=1
                     /product="C-C motif chemokine 19 precursor"
                     /protein_id="NP_001102131.1"
                     /db_xref="GeneID:362506"
                     /db_xref="RGD:1310336"
                     /translation="MASRVTPLLAFSLLVLWTFSAPALGGANDAEDCCLSVTQRPIPG
                     NIVKAFRYLLIQDGCRVPAVVFTTLRGYQLCAPLDQPWVERIIRRLKKSSSKSKGGST
                     KRGPVS"
     exon            244..376
                     /gene="Ccl19"
                     /inference="alignment:Splign:2.1.0"
     exon            377..470
                     /gene="Ccl19"
                     /inference="alignment:Splign:2.1.0"
     exon            471..715
                     /gene="Ccl19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcacggg ttcactcggg ctcacttgct ctggctcctg aaccccttcg ctccacacta
       61 ggacgccgag tactttccat cactccccct gtgaacccgc cggagccttg gcctctcaga
      121 ttggtgcacg cgcagtctct caggctcatt cattctctgt ggcctgcctc agagcacctg
      181 ccatggcatc ccgtgtgacc ccactactgg ccttcagcct gctggttctc tggaccttct
      241 cagccccagc tctggggggt gctaacgatg cggaagactg ctgcctgtct gtgacccagc
      301 gccccatccc tggtaacatc gtgaaagcct tccgctacct tcttatccaa gatggctgca
      361 gggtgcctgc tgttgtgttc accacactaa ggggctacca gctctgtgca cctctagacc
      421 agccctgggt agaacgcatc atccgaagac tgaagaagtc ttcctccaag agcaaaggcg
      481 gcagcaccaa aaggggccct gtgtcttgag tgaagagatg tgactcactc tggcccagga
      541 aaccaaggac cagaagagag gaccaagcct cccgatctgc ccgagacctg acctagccca
      601 gtctgtgcct agagagtcgg tgtgaacgtg agtgtgagca tgacagtttg tgtggctaga
      661 acatcgcctc tccacggcca gactgcagtg cttccaataa agcttggtac tgtgg
//
