LOCUS       NP_476492                103 aa            linear   ROD 01-MAY-2025
DEFINITION  C-C motif chemokine 17 precursor [Rattus norvegicus].
ACCESSION   NP_476492
VERSION     NP_476492.2
DBSOURCE    REFSEQ: accession NM_057151.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 103)
  AUTHORS   Ge,Y., Waldemer,R.J., Nalluri,R., Nuzzi,P.D. and Chen,J.
  TITLE     RNAi screen reveals potentially novel roles of cytokines in
            myoblast differentiation
  JOURNAL   PLoS One 8 (7), e68068 (2013)
   PUBMED   23844157
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 103)
  AUTHORS   Vijayanand,P., Durkin,K., Hartmann,G., Morjaria,J., Seumois,G.,
            Staples,K.J., Hall,D., Bessant,C., Bartholomew,M., Howarth,P.H.,
            Friedmann,P.S. and Djukanovic,R.
  TITLE     Chemokine receptor 4 plays a key role in T cell recruitment into
            the airways of asthmatic patients
  JOURNAL   J Immunol 184 (8), 4568-4574 (2010)
   PUBMED   20237293
REFERENCE   3  (residues 1 to 103)
  AUTHORS   Aki,K., Shimizu,A., Masuda,Y., Kuwahara,N., Arai,T., Ishikawa,A.,
            Fujita,E., Mii,A., Natori,Y., Fukunaga,Y. and Fukuda,Y.
  TITLE     ANG II receptor blockade enhances anti-inflammatory macrophages in
            anti-glomerular basement membrane glomerulonephritis
  JOURNAL   Am J Physiol Renal Physiol 298 (4), F870-F882 (2010)
   PUBMED   20071465
REFERENCE   4  (residues 1 to 103)
  AUTHORS   Chiba,Y., Sato,S. and Misawa,M.
  TITLE     GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits
            infiltration of inflammatory cells into airways in mouse
            experimental asthma
  JOURNAL   Int J Immunopathol Pharmacol 22 (4), 929-935 (2009)
   PUBMED   20074456
REFERENCE   5  (residues 1 to 103)
  AUTHORS   Yogo,Y., Fujishima,S., Inoue,T., Saito,F., Shiomi,T., Yamaguchi,K.
            and Ishizaka,A.
  TITLE     Macrophage derived chemokine (CCL22), thymus and
            activation-regulated chemokine (CCL17), and CCR4 in idiopathic
            pulmonary fibrosis
  JOURNAL   Respir Res 10 (1), 80 (2009)
   PUBMED   19715610
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 103)
  AUTHORS   Jakubzick,C., Wen,H., Matsukawa,A., Keller,M., Kunkel,S.L. and
            Hogaboam,C.M.
  TITLE     Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni
            egg-induced pulmonary granuloma formation in mice
  JOURNAL   Am J Pathol 165 (4), 1211-1221 (2004)
   PUBMED   15466387
REFERENCE   7  (residues 1 to 103)
  AUTHORS   Inoue,T., Fujishima,S., Ikeda,E., Yoshie,O., Tsukamoto,N., Aiso,S.,
            Aikawa,N., Kubo,A., Matsushima,K. and Yamaguchi,K.
  TITLE     CCL22 and CCL17 in rat radiation pneumonitis and in human
            idiopathic pulmonary fibrosis
  JOURNAL   Eur Respir J 24 (1), 49-56 (2004)
   PUBMED   15293604
REFERENCE   8  (residues 1 to 103)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
REFERENCE   9  (residues 1 to 103)
  AUTHORS   Miyazaki,E., Nureki,S., Fukami,T., Shigenaga,T., Ando,M., Ito,K.,
            Ando,H., Sugisaki,K., Kumamoto,T. and Tsuda,T.
  TITLE     Elevated levels of thymus- and activation-regulated chemokine in
            bronchoalveolar lavage fluid from patients with eosinophilic
            pneumonia
  JOURNAL   Am J Respir Crit Care Med 165 (8), 1125-1131 (2002)
   PUBMED   11956056
REFERENCE   10 (residues 1 to 103)
  AUTHORS   Kawasaki,S., Takizawa,H., Yoneyama,H., Nakayama,T., Fujisawa,R.,
            Izumizaki,M., Imai,T., Yoshie,O., Homma,I., Yamamoto,K. and
            Matsushima,K.
  TITLE     Intervention of thymus and activation-regulated chemokine
            attenuates the development of allergic airway inflammation and
            hyperresponsiveness in mice
  JOURNAL   J Immunol 166 (3), 2055-2062 (2001)
   PUBMED   11160256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 13, 2022 this sequence version replaced NP_476492.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312687.1, SRR23984936.1100008.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..103
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     Protein         1..103
                     /product="C-C motif chemokine 17 precursor"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 17; C-C motif chemokine 17; chemokine (C-C motif)
                     ligand 17; CC chemokine TARC; small-inducible cytokine
                     A17; thymus and activation-regulated chemokine"
                     /calculated_mol_wt=8112
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3525
     Region          43..99
                     /region_name="Chemokine_CC"
                     /note="1 of 4 subgroup designations based on the
                     arrangement of the two N-terminal cysteine residues;
                     includes a number of secreted growth factors and
                     interferons involved in mitogenic, chemotactic, and
                     inflammatory activity; some members (e.g. 2HCC) contain
                     an...; cd00272"
                     /db_xref="CDD:238170"
     Site            order(43..47,49..56,66..67,89..99)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:238170"
     Site            order(45,47,60,62,67,72..74,82..84,90..91,94..95,98..99)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(45,47,64,66..67,73,81,83)
                     /site_type="other"
                     /note="dimer interface (P form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(45,73,82)
                     /site_type="active"
                     /note="putative receptor binding cleft [active]"
                     /db_xref="CDD:238170"
     Site            order(45..47,49..56)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238170"
     Site            order(47,60,62,72,74,82,84,90..91,94..95,98..99)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(49..51,54..56,78,80)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            order(62,69,87,89,92..93,96)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            66..67
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238170"
     Site            order(76,78)
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238170"
     CDS             1..103
                     /gene="Ccl17"
                     /gene_synonym="Scya17; Tarc"
                     /coded_by="NM_057151.2:106..417"
                     /db_xref="GeneID:117518"
                     /db_xref="RGD:619924"
ORIGIN      
        1 mktfawtsgt mmslqmllla alllgtslqh asaaratnvg reccldyfkg aipirklvtw
       61 frtsvecprd aivfetvqgr lictdpkdkh vkkairhlkn qrl
//
