LOCUS       NM_019205                978 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-C motif chemokine ligand 11 (Ccl11), mRNA.
ACCESSION   NM_019205
VERSION     NM_019205.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Dery,L., Charest,G., Guerin,B., Akbari,M. and Fortin,D.
  TITLE     Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and
            CCL11 as a Paradigm for a Promising Therapeutic Approach for
            Primary Brain Tumors
  JOURNAL   Int J Mol Sci 22 (22), 12150 (2021)
   PUBMED   34830041
  REMARK    GeneRIF: Chemoattraction of Neoplastic Glial Cells with CXCL10,
            CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach
            for Primary Brain Tumors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 978)
  AUTHORS   Park,J.Y., Kang,Y.W., Choi,B.Y., Yang,Y.C., Cho,B.P. and Cho,W.G.
  TITLE     CCL11 promotes angiogenic activity by activating the PI3K/Akt
            pathway in HUVECs
  JOURNAL   J Recept Signal Transduct Res 37 (4), 416-421 (2017)
   PUBMED   28279120
  REMARK    GeneRIF: our data suggest that the CCL11-CCR3 interaction mainly
            activates PI3K/Akt signal transduction pathway in HUVECs.
REFERENCE   3  (bases 1 to 978)
  AUTHORS   Lamoury,F.M., Hajarizadeh,B., Keoshkerian,E., Feld,J.J., Amin,J.,
            Teutsch,S., Matthews,G.V., Hellard,M., Dore,G.J., Lloyd,A.R.,
            Applegate,T.L. and Grebely,J.
  CONSRTM   ATAHC Study Group
  TITLE     HIV infection is associated with higher levels of monocyte
            chemoattractant protein-1 and eotaxin among people with recent
            hepatitis C virus infection
  JOURNAL   BMC Infect Dis 16, 241 (2016)
   PUBMED   27246604
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 978)
  AUTHORS   Chao,G.Y., Wallis,R.H., Marandi,L., Ning,T., Sarmiento,J.,
            Paterson,A.D. and Poussier,P.
  TITLE     Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the
            Th1/Th2 balance within the insulitic lesions
  JOURNAL   J Immunol 192 (8), 3645-3653 (2014)
   PUBMED   24646746
  REMARK    GeneRIF: Iddm30 controls pancreatic expression of Ccl11 (Eotaxin)
            and the Th1/Th2 balance within the insulitic lesions.
REFERENCE   5  (bases 1 to 978)
  AUTHORS   Cherney,D.Z., Reich,H.N., Scholey,J.W., Daneman,D., Mahmud,F.H.,
            Har,R.L. and Sochett,E.B.
  TITLE     The effect of aliskiren on urinary cytokine/chemokine responses to
            clamped hyperglycaemia in type 1 diabetes
  JOURNAL   Diabetologia 56 (10), 2308-2317 (2013)
   PUBMED   23893332
REFERENCE   6  (bases 1 to 978)
  AUTHORS   Sanz,M.J., Ponath,P.D., Mackay,C.R., Newman,W., Miyasaka,M.,
            Tamatani,T., Flanagan,B.F., Lobb,R.R., Williams,T.J., Nourshargh,S.
            and Jose,P.J.
  TITLE     Human eotaxin induces alpha 4 and beta 2 integrin-dependent
            eosinophil accumulation in rat skin in vivo: delayed generation of
            eotaxin in response to IL-4
  JOURNAL   J Immunol 160 (7), 3569-3576 (1998)
   PUBMED   9531320
REFERENCE   7  (bases 1 to 978)
  AUTHORS   Ishi,Y., Shirato,M., Nomura,A., Sakamoto,T., Uchida,Y., Ohtsuka,M.,
            Sagai,M. and Hasegawa,S.
  TITLE     Cloning of rat eotaxin: ozone inhalation increases mRNA and protein
            expression in lungs of brown Norway rats
  JOURNAL   Am J Physiol 274 (1), L171-L176 (1998)
   PUBMED   9458816
REFERENCE   8  (bases 1 to 978)
  AUTHORS   Williams,C.M., Newton,D.J., Wilson,S.A., Williams,T.J.,
            Coleman,J.W. and Flanagan,B.F.
  TITLE     Conserved structure and tissue expression of rat eotaxin
  JOURNAL   Immunogenetics 47 (2), 178-180 (1998)
   PUBMED   9396866
REFERENCE   9  (bases 1 to 978)
  AUTHORS   Rothenberg,M.E., MacLean,J.A., Pearlman,E., Luster,A.D. and
            Leder,P.
  TITLE     Targeted disruption of the chemokine eotaxin partially reduces
            antigen-induced tissue eosinophilia
  JOURNAL   J Exp Med 185 (4), 785-790 (1997)
   PUBMED   9034156
REFERENCE   10 (bases 1 to 978)
  AUTHORS   Rothenberg,M.E., Luster,A.D. and Leder,P.
  TITLE     Murine eotaxin: an eosinophil chemoattractant inducible in
            endothelial cells and in interleukin 4-induced tumor suppression
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8960-8964 (1995)
   PUBMED   7568052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019205.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08358.1, CF110709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000010.1  67525975-67526084
            111-222             JAXUCZ010000010.1  67529317-67529428
            223-978             JAXUCZ010000010.1  67529821-67530576
FEATURES             Location/Qualifiers
     source          1..978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..978
                     /gene="Ccl11"
                     /gene_synonym="Scya11"
                     /note="C-C motif chemokine ligand 11"
                     /db_xref="GeneID:29397"
                     /db_xref="RGD:3644"
     exon            1..110
                     /gene="Ccl11"
                     /gene_synonym="Scya11"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..328
                     /gene="Ccl11"
                     /gene_synonym="Scya11"
                     /note="eotaxin; C-C motif chemokine 11; small-inducible
                     cytokine A11; eosinophil chemotactic protein; small
                     inducible cytokine subfamily A11; chemokine (C-C motif)
                     ligand 11"
                     /codon_start=1
                     /product="eotaxin precursor"
                     /protein_id="NP_062078.1"
                     /db_xref="GeneID:29397"
                     /db_xref="RGD:3644"
                     /translation="MQLSTALLFLLLTATSFTSQVLAHPGSIPTSCCFTMTSKKIPNT
                     LLKSYKRITNNRCTLKAIVFKTKLGKEICADPKKKWVQDATKHLDQKLQTPKP"
     exon            111..222
                     /gene="Ccl11"
                     /gene_synonym="Scya11"
                     /inference="alignment:Splign:2.1.0"
     exon            223..978
                     /gene="Ccl11"
                     /gene_synonym="Scya11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcaacgtagt aacttccatc tgtccccccc caccatgcag ctctccacag cacttctatt
       61 cctgctgctc acggccactt ccttcacctc ccaggtgctg gctcacccag gttccatccc
      121 aacttcctgc tgctttacca tgaccagtaa gaagatcccc aacacactac tgaagagcta
      181 caaaagaatc accaacaaca gatgcacgct gaaagccata gtcttcaaga ccaagcttgg
      241 caaagagatc tgtgctgacc ccaagaaaaa gtgggtccag gatgccacaa agcacctgga
      301 ccaaaaactc caaactccaa aaccataaac aacctcctct tttgacacta acccagagcc
      361 taagaaatgc ttgattcctt ctcttttcta agatatgcta tgggagaata tcggcaccca
      421 tcccccaagg acttggcttc atgtagttac agatgggact ggaagtcatg atgtttgatg
      481 agataagcca gactcaaaag gttgtgtgat ttcttgcata tgcaacatct taaaaggaga
      541 gagcatggaa ggagatgtag gattattgag gaatagaaag gaatgagtta ggggtaactg
      601 aggatgatag gaggactaaa tactatcaaa gcaccttata cacatatgaa aatgtcataa
      661 catgacccat tgtttttcaa aattaatata cactgattaa aatgctaata tttaaggaca
      721 tgttacattt aagaaattgg aattttaaag catattttaa tggatcttgg ttctttttgt
      781 tgttttgctg tttgcttgtt tgaaataggg tctcactgta tcaccctgat tgacctgcaa
      841 cttactatgt agaccaggct gacctcaaac tcacagagat ttacctattt ctgcctttaa
      901 cgtgccatca tgccaagcca gaatggtttt agtattagta tgtactaatt atgtataata
      961 aaaaatttta ctaccaca
//
