LOCUS       NM_013165               2145 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cholecystokinin B receptor (Cckbr), mRNA.
ACCESSION   NM_013165
VERSION     NM_013165.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Jiang,X., Liu,Y., Zhang,X.Y., Liu,X., Liu,X., Wu,X., Jose,P.A.,
            Duan,S., Xu,F.J. and Yang,Z.
  TITLE     Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates
            Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+
            Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated
            NHERF1 and NHERF2 Pathway
  JOURNAL   Hypertension 79 (8), 1668-1679 (2022)
   PUBMED   35674015
  REMARK    GeneRIF: Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor)
            Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal
            Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase
            C)-Mediated NHERF1 and NHERF2 Pathway.
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Cao,Y., Cao,X. and Liu,X.M.
  TITLE     Expression of cholecystokinin2-receptor in rat and human L cells
            and the stimulation of glucagon-like peptide-1 secretion by gastrin
            treatment
  JOURNAL   Acta Histochem 117 (2), 205-210 (2015)
   PUBMED   25601282
  REMARK    GeneRIF: treatment with gastrin, a CCK2R agonist, stimulated the
            secretion of GLP-1, and that this effect was likely due to
            increased expression of proglucagon and PCSK1 (also known as
            prohormone convertase 3 (PC3 gene)).
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Petkova-Kirova,P., Giovannini,M.G., Kalfin,R. and Rakovska,A.
  TITLE     Modulation of acetylcholine release by cholecystokinin in striatum:
            receptor specificity; role of dopaminergic neuronal activity
  JOURNAL   Brain Res Bull 89 (5-6), 177-184 (2012)
   PUBMED   22981453
  REMARK    GeneRIF: CCK-B receptors mediate acetylcholine release through cell
            bodies of cholinergic interneurons in the corpus striatum.
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Berna,M.J., Seiz,O., Nast,J.F., Benten,D., Blaker,M., Koch,J.,
            Lohse,A.W. and Pace,A.
  TITLE     CCK1 and CCK2 receptors are expressed on pancreatic stellate cells
            and induce collagen production
  JOURNAL   J Biol Chem 285 (50), 38905-38914 (2010)
   PUBMED   20843811
  REMARK    GeneRIF: CCK1 and CCK2 receptors are expressed on pancreatic
            stellate cells and induce collagen production
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   El-Kouhen,K. and Morisset,J.
  TITLE     Control of somatostatin (SS) secretion by CCK-1 and CCK-2
            receptors' occupation in RIN-14B cells, a rat pancreatic islet cell
            line
  JOURNAL   Pancreas 39 (2), 127-134 (2010)
   PUBMED   19959964
  REMARK    GeneRIF: Pancreatic islet CCK1/2 receptors initiate somatosatin
            secretion through constitutive secretion controlled at the level of
            protein synthesis.
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Jagerschmidt,A., Popovici,T., O'Donohue,M. and Roques,B.P.
  TITLE     Identification and characterization of various cholecystokinin B
            receptor mRNA forms in rat brain tissue and partial determination
            of the cholecystokinin B receptor gene structure
  JOURNAL   J Neurochem 63 (4), 1199-1206 (1994)
   PUBMED   7931273
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Lee,Y.M., Beinborn,M., McBride,E.W., Lu,M., Kolakowski,L.F. Jr. and
            Kopin,A.S.
  TITLE     The human brain cholecystokinin-B/gastrin receptor. Cloning and
            characterization
  JOURNAL   J Biol Chem 268 (11), 8164-8169 (1993)
   PUBMED   7681836
REFERENCE   8  (bases 1 to 2145)
  AUTHORS   Zhou,W., Povoski,S.P., Longnecker,D.S. and Bell,R.H. Jr.
  TITLE     Novel expression of gastrin (cholecystokinin-B) receptors in
            azaserine-induced rat pancreatic carcinoma: receptor determination
            and characterization
  JOURNAL   Cancer Res 52 (24), 6905-6911 (1992)
   PUBMED   1458479
REFERENCE   9  (bases 1 to 2145)
  AUTHORS   Pisegna,J.R., de Weerth,A., Huppi,K. and Wank,S.A.
  TITLE     Molecular cloning of the human brain and gastric cholecystokinin
            receptor: structure, functional expression and chromosomal
            localization
  JOURNAL   Biochem Biophys Res Commun 189 (1), 296-303 (1992)
   PUBMED   1280419
REFERENCE   10 (bases 1 to 2145)
  AUTHORS   Wank,S.A., Pisegna,J.R. and de Weerth,A.
  TITLE     Brain and gastrointestinal cholecystokinin receptor family:
            structure and functional expression
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8691-8695 (1992)
   PUBMED   1528881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013165.2.
            
            Summary: Cholecystokinin was one of the first gastrointestinal
            peptides discovered in the mammalian brain. Cholecystokinin
            receptors are members of the G protein-coupled receptor
            superfamily, stimulating phosphatidylinositol turnover and
            intracellular calcium mobilization. This gene encodes a
            cholecystokinin receptor of the B subtype. These receptors occur
            throughout the central nervous system where they modulate anxiety,
            analgesia, arousal, and neuroleptic activity. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99418.1, SRR26643298.4381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000001.1  169183578-169183763
            187-438             JAXUCZ010000001.1  169191008-169191259
            439-688             JAXUCZ010000001.1  169191417-169191666
            689-861             JAXUCZ010000001.1  169191933-169192105
            862-2145            JAXUCZ010000001.1  169192300-169193583
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2145
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /note="cholecystokinin B receptor"
                     /db_xref="GeneID:25706"
                     /db_xref="RGD:2290"
     exon            1..186
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1394
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /note="CCK-B receptor; cholecystokinin-2 receptor; CCK-BR;
                     CCK2-R; CCK2 receptor"
                     /codon_start=1
                     /product="gastrin/cholecystokinin type B receptor"
                     /protein_id="NP_037297.2"
                     /db_xref="GeneID:25706"
                     /db_xref="RGD:2290"
                     /translation="MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCEPPRI
                     RGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLL
                     LAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPL
                     QARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTW
                     SVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPG
                     PVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKK
                     RVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNP
                     LVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLG
                     PG"
     exon            187..438
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /inference="alignment:Splign:2.1.0"
     exon            439..688
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /inference="alignment:Splign:2.1.0"
     exon            689..861
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /inference="alignment:Splign:2.1.0"
     exon            862..2145
                     /gene="Cckbr"
                     /gene_synonym="Cck2r; Cholrec"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcttagcag agctaagtgg gacttcactg gagccatgga gctgctcaag ctgaaccgca
       61 gcgtgcaggg accaggaccc gggtcggggt cttctttgtg ccgcccgggt gtctcccttc
      121 tcaacagcag tagtgccggg aacctcagct gtgaaccccc tcgtatccgc ggaaccggga
      181 ccagagaatt ggagatggcg attagaatca ccctttatgc agtgatcttt ctgatgagtg
      241 ttggcggaaa cgtgctcatc atcgtggtcc tgggactgag ccgacgccta agaacggtca
      301 ccaacgcctt cctgctctcc ctggcagtca gcgacctcct gctggccgtg gcttgcatgc
      361 ccttcacact cctgcccaac ctcatgggca cattcatctt cggcacagtc atctgcaagg
      421 ccatttccta cctcatgggg gtatcagtga gtgtatccac tctaaatctc gtggccatag
      481 ccctggagcg atacagcgcc atctgccgac cactgcaagc acgagtatgg caaacacgct
      541 cccacgcagc tcgggtgatc ttagccacgt ggctgctgtc tggactgctt atggtaccct
      601 accctgtgta caccatggta cagccagtgg gacctcgagt gctgcagtgc atgcatcgct
      661 ggcccagtgc acgtgtccaa caaacctggt ccgtgctact gctactgctt ttgttcttca
      721 tcccgggtgt ggttattgcg gtggcctatg gactcatctc ccgcgaactc tacctaggac
      781 tccactttga tggtgaaaat gacagcgaga cccaaagccg ggcccgaaac caagggggcc
      841 tgccgggtgg ggcagcacca gggcctgtcc accagaacgg gggctgccgg cctgtaacca
      901 gcgtagctgg ggaagacagt gatggctgct gtgtgcaact tccgcgttcc cgactggaga
      961 tgacaacgct aaccacaccc actcctgggc cagtccctgg ccctcggccc aaccaggcca
     1021 agctgctggc taagaagcgg gtggtgcgaa tgctgctagt gattgttttg cttttcttcc
     1081 tgtgttggct gccagtgtac agcgtcaaca cgtggcgcgc cttcgatggc ccaggcgcac
     1141 aacgagcact ctcaggcgcc cctatctctt tcatccactt gctgagctac gtctctgctt
     1201 gtgtcaaccc cctggtctac tgtttcatgc accgccgctt ccgccaggcc tgcctggaca
     1261 catgtgcccg ctgttgccca cgccctccac gagctcgccc acagcctctt ccagatgagg
     1321 atcctcctac cccctccatc gcttcgctgt ccaggctaag ctataccacc atcagcacac
     1381 tggggcctgg ctgaggggtt gggagattgg agaaagagac aagatacata attactatca
     1441 aatgacccat ccaaacacat aagaaacaaa attcagaatt aatccaggtg aacacccaac
     1501 accatggaca gacagacccc tacacacaga aaataatatc tttgctgccc tacctgaaac
     1561 agataggagt ctcataggaa aggaggctca cttctgataa ggggctgagt cccttcctag
     1621 acatcttgca ctgaccccat tacatggaca gacacaaggt ccgtagcagt aaactttacc
     1681 tataaagggg aactctgaca agggctgatt ggctcctcat atgaacatat tactgacact
     1741 attctgtagt gcccatagcc tagtgcagaa gtgacttagg acattgtggc tgttcccgtt
     1801 tgacttcatt attgccttcc tcatccagca ctgaaattat caaccacacg cctttcgcct
     1861 ttcggagctg ccgatcgttc agcactgaaa agtccccccc cactcctttc cattggagac
     1921 tgtggaaagt cctcttccct cctgcctctc ctccctcacc agaccacatc ataaaaggat
     1981 aagtgactta gtgtcctcct ggacttcttg aggtaggtga acaggtgtgg tttatgggaa
     2041 gcttcttcat ttattggctc ccatgactaa tctaccccat atccaacctt gtgcaaaaag
     2101 gccagggtat gaagataggg atgagcgtac cctctcttgg ttgtc
//
