LOCUS       NM_012688               1502 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus cholecystokinin A receptor (Cckar), mRNA.
ACCESSION   NM_012688 XM_341221
VERSION     NM_012688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Hamamah,S., Hajnal,A. and Covasa,M.
  TITLE     Reduced Striatal Dopamine Transporter Availability and Heightened
            Response to Natural and Pharmacological Stimulation in
            CCK-1R-Deficient Obese Rats
  JOURNAL   Int J Mol Sci 24 (11), 9773 (2023)
   PUBMED   37298724
  REMARK    GeneRIF: Reduced Striatal Dopamine Transporter Availability and
            Heightened Response to Natural and Pharmacological Stimulation in
            CCK-1R-Deficient Obese Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Xiang,T., Li,J.H., Su,H.Y., Bai,K.H., Wang,S., Traub,R.J. and
            Cao,D.Y.
  TITLE     Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity
            Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling
            Cascade
  JOURNAL   J Pain 23 (10), 1629-1645 (2022)
   PUBMED   35691467
  REMARK    GeneRIF: Spinal CCK1 Receptors Contribute to Somatic Pain
            Hypersensitivity Induced by Malocclusion via a Reciprocal
            Neuron-Glial Signaling Cascade.
            Erratum:[J Pain. 2024 Nov;25(11):104650. doi:
            10.1016/j.jpain.2024.104650.. PMID: 39283282]
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Cawthon,C.R. and de La Serre,C.B.
  TITLE     The critical role of CCK in the regulation of food intake and
            diet-induced obesity
  JOURNAL   Peptides 138, 170492 (2021)
   PUBMED   33422646
  REMARK    GeneRIF: The critical role of CCK in the regulation of food intake
            and diet-induced obesity.
            Review article
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Wu,X., Li,J.Y., Lee,A., Lu,Y.X., Zhou,S.Y. and Owyang,C.
  TITLE     Satiety induced by bile acids is mediated via vagal afferent
            pathways
  JOURNAL   JCI Insight 5 (14), 132400 (2020)
   PUBMED   32699194
  REMARK    GeneRIF: Satiety induced by bile acids is mediated via vagal
            afferent pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Parks,G.S., Wang,L., Wang,Z. and Civelli,O.
  TITLE     Identification of neuropeptide receptors expressed by
            melanin-concentrating hormone neurons
  JOURNAL   J Comp Neurol 522 (17), 3817-3833 (2014)
   PUBMED   24978951
  REMARK    GeneRIF: This study demonistrated that Cckar and
            Melanin-concentrating hormone colization in neuron in the lateral
            hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely
            expressed throughout the brain.
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Takata,Y., Takiguchi,S., Funakoshi,A. and Kono,A.
  TITLE     Gene structure of rat cholecystokinin type-A receptor
  JOURNAL   Biochem Biophys Res Commun 213 (3), 958-966 (1995)
   PUBMED   7654260
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Rosewicz,S., Riecken,E.O. and Kaiser,A.
  TITLE     Transient stabilization of cholecystokinin A receptor mRNA by
            glucocorticoids in pancreatic AR42J cells
  JOURNAL   Am J Physiol 267 (5 Pt 1), G772-G777 (1994)
   PUBMED   7977738
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Wank,S.A., Pisegna,J.R. and de Weerth,A.
  TITLE     Brain and gastrointestinal cholecystokinin receptor family:
            structure and functional expression
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8691-8695 (1992)
   PUBMED   1528881
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Wank,S.A., Harkins,R., Jensen,R.T., Shapira,H., de Weerth,A. and
            Slattery,T.
  TITLE     Purification, molecular cloning, and functional expression of the
            cholecystokinin receptor from rat pancreas
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3125-3129 (1992)
   PUBMED   1313582
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Hill,D.R., Shaw,T.M., Dourish,C.T. and Woodruff,G.N.
  TITLE     CCK-A receptors in the rat interpeduncular nucleus: evidence for a
            presynaptic location
  JOURNAL   Brain Res 454 (1-2), 101-105 (1988)
   PUBMED   3408996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M88096.1.
            
            On Aug 30, 2012 this sequence version replaced NM_012688.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1502              M88096.1           5-1506
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..1502
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /note="cholecystokinin A receptor"
                     /db_xref="GeneID:24889"
                     /db_xref="RGD:2289"
     exon            1..306
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1484
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /function="'stimulates pancreatic secretion, pancreatic
                     growth andgastrointestinal smooth muscle contracton'"
                     /note="CCK1-R; CCK-A receptor; cholecystokinin-1 receptor"
                     /codon_start=1
                     /product="cholecystokinin receptor type A"
                     /protein_id="NP_036820.1"
                     /db_xref="GeneID:24889"
                     /db_xref="RGD:2289"
                     /translation="MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFC
                     LDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSD
                     LMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICR
                     PLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSD
                     AMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSST
                     RYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVI
                     VVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKR
                     FRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP"
     exon            307..558
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /inference="alignment:Splign:2.1.0"
     exon            559..820
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /inference="alignment:Splign:2.1.0"
     exon            821..948
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1502
                     /gene="Cckar"
                     /gene_synonym="Cck-ar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgcttgcc cagatgctct gagaatggcg aactcaagtt gcctttagga atggctgcaa
       61 agcccacacc tggaaatctc cccctccctg ctcctccacg gcaggttgca tttgggagac
      121 cctgtgatca ttagaggaga gagacaggaa tgagccattc accagctcgc cagcacttgg
      181 tagaaagcag caggatggac gtggtcgaca gccttcttat gaatgggagc aacatcactc
      241 ccccctgtga actcggactg gaaaatgaga cgcttttctg cttggatcaa cctcaacctt
      301 caaaagagtg gcagtctgca ctgcagattc tcctgtactc catcatattc cttctcagtg
      361 tgctggggaa cacgctggtt ataacggtgc tgattcgaaa caagaggatg cggacggtca
      421 ccaacatctt cctgctgtcc ctggctgtca gtgacctcat gctctgcctc ttctgcatgc
      481 cgttcaacct catccccaac ctgctcaagg atttcatctt cggaagtgcc gtgtgcaaga
      541 ctaccaccta cttcatgggc acttccgtga gcgtttccac cttcaacctg gtagccatct
      601 ctctggagag atatggcgcc atctgcagac ccctacagtc ccgcgtctgg caaacaaagt
      661 cccatgcttt gaaggtcatc gctgccacct ggtgcctctc ctttaccatc atgactccgt
      721 accccattta cagcaacttg gtgcctttta ctaaaaataa taaccagacg gcgaacatgt
      781 gccgcttcct gttgccaagt gacgctatgc agcagtcctg gcaaacattc ctgctactca
      841 tcctctttct tctccctggg attgtgatgg tggtggccta cgggttgatc tctctggaac
      901 tctaccaagg aatcaaattt gatgccagcc agaagaaatc tgccaaagag aagaagccga
      961 gcactggcag cagcacccga tatgaggata gtgatggctg ttacttgcag aagtcccggc
     1021 ccccgaggaa gctggagctt cagcagctgt ctagcggcag cggtggcagc agactcaacc
     1081 ggatcaggag cagcagttca gctgccaacc tgatagccaa gaagcgcgtg atccgcatgc
     1141 tcattgtcat cgtggtcctc ttcttcctgt gctggatgcc catcttcagc gccaacgcct
     1201 ggcgggcata tgacacggtt tctgccgaga agcacctctc agggactccc atctccttca
     1261 tcctcctcct ctcctacacc tcctcctgtg ttaaccccat catctattgc ttcatgaaca
     1321 aacgctttcg cctgggcttc atggccacct tcccttgttg cccgaatccc ggtcccccag
     1381 gggtgagagg agaggtggga gaggaggagg atgggaggac cataagggca ttgctgtcca
     1441 ggtattccta cagccacatg agcacctctg ctccaccccc ctgaactcca cctggtccac
     1501 tg
//
