LOCUS       NM_012829                702 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus cholecystokinin (Cck), mRNA.
ACCESSION   NM_012829
VERSION     NM_012829.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 702)
  AUTHORS   Cawthon,C.R. and de La Serre,C.B.
  TITLE     The critical role of CCK in the regulation of food intake and
            diet-induced obesity
  JOURNAL   Peptides 138, 170492 (2021)
   PUBMED   33422646
  REMARK    GeneRIF: The critical role of CCK in the regulation of food intake
            and diet-induced obesity.
            Review article
REFERENCE   2  (bases 1 to 702)
  AUTHORS   Plaza,A., Merino,B., Del Olmo,N. and Ruiz-Gayo,M.
  TITLE     The cholecystokinin receptor agonist, CCK-8, induces adiponectin
            production in rat white adipose tissue
  JOURNAL   Br J Pharmacol 176 (15), 2678-2690 (2019)
   PUBMED   31012948
  REMARK    GeneRIF: The cholecystokinin receptor agonist, CCK-8, induces
            adiponectin production in rat white adipose tissue.
REFERENCE   3  (bases 1 to 702)
  AUTHORS   Plaza,A., Merino,B., Cano,V., Dominguez,G., Perez-Castells,J.,
            Fernandez-Alfonso,M.S., Sengenes,C., Chowen,J.A. and Ruiz-Gayo,M.
  TITLE     Cholecystokinin is involved in triglyceride fatty acid uptake by
            rat adipose tissue
  JOURNAL   J Endocrinol 236 (3), 137-150 (2018)
   PUBMED   29339381
  REMARK    GeneRIF: results show that cholecystokinin promotes lipid storage
            in white adipose tissue by acting on adipocyte cholecystokinin-2
            receptor
REFERENCE   4  (bases 1 to 702)
  AUTHORS   Booker,S.A., Althof,D., Degro,C.E., Watanabe,M., Kulik,A. and
            Vida,I.
  TITLE     Differential surface density and modulatory effects of presynaptic
            GABAB receptors in hippocampal cholecystokinin and parvalbumin
            basket cells
  JOURNAL   Brain Struct Funct 222 (8), 3677-3690 (2017)
   PUBMED   28466358
  REMARK    GeneRIF: Study provides the first direct comparative and
            quantitative data showing that presynaptic GABAB receptors exert
            differential inhibition at cholecystokinin (CCK) and parvalbumin
            (PV) basket cell (BC) synapses, resulting from a higher surface
            expression of the receptor at all CCK BC terminals and a lower
            protein density present in a subpopulation of boutons of PV BCs.
REFERENCE   5  (bases 1 to 702)
  AUTHORS   Roman,C.W., Sloat,S.R. and Palmiter,R.D.
  TITLE     A tale of two circuits: CCKNTS neuron stimulation controls appetite
            and induces opposing motivational states by projections to distinct
            brain regions
  JOURNAL   Neuroscience 358, 316-324 (2017)
   PUBMED   28684275
  REMARK    GeneRIF: The two projections from CCK(NTS) neurons reduce food
            intake through opposite motivational states; one pathway signals
            positive valence (CCK(NTS)-->paraventricular nucleus of the
            hypothalamus ) and the other signals negative valence
            (CCK(NTS)-->parabrachial nucleus).
REFERENCE   6  (bases 1 to 702)
  AUTHORS   Deschenes,R.J., Haun,R.S., Funckes,C.L. and Dixon,J.E.
  TITLE     A gene encoding rat cholecystokinin. Isolation, nucleotide
            sequence, and promoter activity
  JOURNAL   J Biol Chem 260 (2), 1280-1286 (1985)
   PUBMED   2981840
REFERENCE   7  (bases 1 to 702)
  AUTHORS   Deschenes,R.J., Haun,R.S., Sunkel,D., Roos,B.A. and Dixon,J.E.
  TITLE     Modulation of cholecystokinin gene expression
  JOURNAL   Ann N Y Acad Sci 448, 53-60 (1985)
   PUBMED   3861130
REFERENCE   8  (bases 1 to 702)
  AUTHORS   Conrath-Verrier,M., Dietl,M. and Tramu,G.
  TITLE     Cholecystokinin-like immunoreactivity in the dorsal horn of the
            spinal cord of the rat: a light and electron microscopic study
  JOURNAL   Neuroscience 13 (3), 871-885 (1984)
   PUBMED   6084830
REFERENCE   9  (bases 1 to 702)
  AUTHORS   Deschenes,R.J., Lorenz,L.J., Haun,R.S., Roos,B.A., Collier,K.J. and
            Dixon,J.E.
  TITLE     Cloning and sequence analysis of a cDNA encoding rat
            preprocholecystokinin
  JOURNAL   Proc Natl Acad Sci U S A 81 (3), 726-730 (1984)
   PUBMED   6199787
REFERENCE   10 (bases 1 to 702)
  AUTHORS   McLaughlin,C.L., Baile,C.A. and Peikin,S.R.
  TITLE     Hyperphagia during lactation: satiety response to CCK and growth of
            the pancreas
  JOURNAL   Am J Physiol 244 (1), E61-E65 (1983)
   PUBMED   6185005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 26, 2010 this sequence version replaced NM_012829.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X01032.1, FQ144519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000008.1  130037490-130037597 c
            109-324             JAXUCZ010000008.1  130036226-130036441 c
            325-702             JAXUCZ010000008.1  130031013-130031390 c
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..702
                     /gene="Cck"
                     /note="cholecystokinin"
                     /db_xref="GeneID:25298"
                     /db_xref="RGD:2288"
     exon            1..108
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     exon            109..324
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..458
                     /gene="Cck"
                     /codon_start=1
                     /product="cholecystokinin preproprotein"
                     /protein_id="NP_036961.1"
                     /db_xref="GeneID:25298"
                     /db_xref="RGD:2288"
                     /translation="MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQL
                     RAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMD
                     FGRRSAEDYEYPS"
     exon            325..702
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagtaccgg gcggggctat ttaagaggag tcgccctgcc gcctgccctc aacttagctg
       61 gacagcagcc gttggaaacc gccaagccag ctgactccgc atccgaagat atgaagtgcg
      121 gcgtgtgtct gtgcgtggtg atggcagtcc tggcagcagg cgccctggcg cagccggtag
      181 tccctgtaga agctgtggac cctatggagc agcgggcgga ggaggcgccc cgaaggcagc
      241 tgagggctgt gctccgaccg gacagcgagc cccgagcgcg cctgggcgca ctgctagccc
      301 gatacatcca gcaggtccgc aaagctccct ctggccgcat gtccgttctt aagaacctgc
      361 agggcctgga ccctagccat aggataagtg accgggacta catgggctgg atggatttcg
      421 gccggcgcag tgctgaggac tacgaatacc catcgtagtg ggccagcctc tcggcgctgc
      481 ttggaggagg cggaatgaga aaacaaccac gcacacgacc cctcgcctcg aatgtttgac
      541 attttgcgtt tatttattaa gtccccaatg tgaaatctgt ccagagtgtg caatgcagcc
      601 acacacctca gcccagctga gcggtgggaa ggcaatgttt ccctccggtg gctcccagac
      661 ctaatgttgc tatgctatta aagagatttc cttctgtccc tc
//
