LOCUS       NM_022543               4114 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus coiled-coil domain containing 80 (Ccdc80), mRNA.
ACCESSION   NM_022543 XM_001059868 XM_001059935 XM_573284
VERSION     NM_022543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4114)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 4114)
  AUTHORS   O'Leary,E.E., Mazurkiewicz-Munoz,A.M., Argetsinger,L.S.,
            Maures,T.J., Huynh,H.T. and Carter-Su,C.
  TITLE     Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding
            protein
  JOURNAL   Mol Endocrinol 27 (4), 619-634 (2013)
   PUBMED   23449887
  REMARK    GeneRIF: Ccdc80 preferentially binds activated,
            tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2.
REFERENCE   3  (bases 1 to 4114)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 4114)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (bases 1 to 4114)
  AUTHORS   Bommer,G.T., Jager,C., Durr,E.M., Baehs,S., Eichhorst,S.T.,
            Brabletz,T., Hu,G., Frohlich,T., Arnold,G., Kress,D.C., Goke,B.,
            Fearon,E.R. and Kolligs,F.T.
  TITLE     DRO1, a gene down-regulated by oncogenes, mediates growth
            inhibition in colon and pancreatic cancer cells
  JOURNAL   J Biol Chem 280 (9), 7962-7975 (2005)
   PUBMED   15563452
  REMARK    GeneRIF: DRO1 may have a role in the development of colorectal and
            pancreatic cancers
REFERENCE   6  (bases 1 to 4114)
  AUTHORS   Visconti,R., Schepis,F., Iuliano,R., Pierantoni,G.M., Zhang,L.,
            Carlomagno,F., Battaglia,C., Martelli,M.L., Trapasso,F., Santoro,M.
            and Fusco,A.
  TITLE     Cloning and molecular characterization of a novel gene strongly
            induced by the adenovirus E1A gene in rat thyroid cells
  JOURNAL   Oncogene 22 (7), 1087-1097 (2003)
   PUBMED   12592395
REFERENCE   7  (bases 1 to 4114)
  AUTHORS   Marcantonio,D., Chalifour,L.E., Alaoui-Jamali,M.A., Alpert,L. and
            Huynh,H.T.
  TITLE     Cloning and characterization of a novel gene that is regulated by
            estrogen and is associated with mammary gland carcinogenesis
  JOURNAL   Endocrinology 142 (6), 2409-2418 (2001)
   PUBMED   11356689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF223677.1, AY548105.1 and CB322543.1.
            
            On or before Sep 16, 2006 this sequence version replaced
            XM_573284.2, XM_001059868.1, XM_001059935.1, NM_022543.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY548105.1, AF223677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AF223677.1         109-126
            19-3604             AY548105.1         19-3604
            3605-4114           CB322543.1         1-510               c
FEATURES             Location/Qualifiers
     source          1..4114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4114
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /note="coiled-coil domain containing 80"
                     /db_xref="GeneID:64387"
                     /db_xref="RGD:69421"
     exon            1..377
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..2263
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..3238
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /note="coiled-coil domain-containing protein 80; SSG-1;
                     steroid-sensitive gene 1 protein; down-regulated by
                     oncogenes 1 protein; steroid sensitive gene 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 80
                     precursor"
                     /protein_id="NP_071988.2"
                     /db_xref="GeneID:64387"
                     /db_xref="RGD:69421"
                     /translation="MTWKMGPHFTMLLAMWLVCGSASQSSALDSDGRPGRKVPLASPI
                     SSRSARYLRHTGRSGGVEKSTQEEPNPQSFQRRKSVPVLRLAHPTVRPPPSGINGAPV
                     RPELKPIARGSASEMVRDEGSSARTRMLRFPSGSSSPNILASFAGKNRVWVISAPHAS
                     EGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITSEGQILEQPLDPNL
                     IPKLMSFLKLEKGKFSMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKG
                     FVQKCKASGIEGHVVQEGNNGGGGGGSTGLGSDKRKEDPRRTQIHPTREPPRKQTTTK
                     AATPQPPPTPRATTLPPAPVTTATRATSRVVTVAARPTTTTAYPATQRPWTSRLHPFS
                     VSHRPPATAEMTTVRGPSVSEQLYPLPRKEQQREKPQATRRPNKATNYGSFTATPPTT
                     LWEGSTRAVGTSRFRDNRTDKREHGHQDPNVVPGPHKPIKGKLPKKKEKILSNEYEAK
                     YDLSRPTTSQGEEELQVDNIPSQNAKESKKHEKPEKPEKEKKKKGKSAKPDKLLRSEK
                     QMKKAEKKSKQEKEKTKKKKAGKTEQDDYQKPTAKHLAPSPRKSVADLLGSFEGKRRL
                     LLITTPKAENNMYVQQRDEYLESFCKMATRRISVVTIFGPVNNSSMKIDHFQLDNEKP
                     MRVVDDEDLVDQHLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEVPIAMKSVFDLID
                     TFQSRIKDMEKQKKEGITCKEDKRQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLS
                     ALNGQACNFGLRHITILKLLGVGEEVGGILELFPINGSSTVEREDVPAHLVKDIRNYF
                     QVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPE
                     DEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY"
     exon            2264..2420
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2557
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2706
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2810
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2891
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..4097
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagggaa gagcgagctt cagaactcac caggacttca cttttaggaa aaaccttgtg
       61 gcagccaagg accggcacac acagatccag gaggaactgc agacaaatgg agatacaaac
      121 agtcccaggg acagcaacag tcaccccatc ccactggacc agaaggtaaa agacagccag
      181 aaagaggaat cagcccagac tggcctccct ggggccgctt tgcagacagg aacccagcat
      241 acccttttgt attgctcacc ctccacaagg agactgaggg caggaaggag aaacgatctc
      301 acctaggaaa ctgtcctcgg gaccaacctt caagtttctt ttaaaagcct ctgcacgcca
      361 tctccatgaa ccactgttgg ataacacaat gacgtggaaa atgggacccc acttcaccat
      421 gctcttggcc atgtggctgg tgtgtggatc agcatctcag tcttctgcct tggatagcga
      481 tggccgccca ggaaggaaag tacctttggc ttctccaatc agcagtaggt cagctcgata
      541 tctgaggcac actgggaggt ctggtggagt tgagaaatcc actcaggaag aaccaaatcc
      601 tcagtctttc caaaggagga agagtgtacc agtgttgaga ttagctcacc cgactgtgag
      661 accgcccccc tcaggtatca atggagcccc agtcagacct gagttgaaac ccatagctag
      721 gggctccgcg agtgagatgg tccgagatga ggggtcctct gctcggacaa gaatgttgcg
      781 attcccctct ggatccagtt ctcccaatat cctggccagc tttgcaggaa agaacagggt
      841 gtgggtcatc tcagcccctc atgcctcaga gggttactac cgcctcatga tgagcctcct
      901 gaaggatgat gtgtactgtg agctggcaga aaggcacatt caacagattg tgctgttcca
      961 ccaggcaggg gaggaagggg ggaaggtacg gaggatcacc agtgaggggc agatcctgga
     1021 gcagcctctg gacccaaatc tcatccccaa gctgatgagc ttcctgaaac tggagaaggg
     1081 caagtttagc atggtgctgt tgaaaaagac cctccaggtg gaggagcgct acccctaccc
     1141 agtcagactg gaagccatgt atgaggttat tgatcaaggc cccatccgca ggattgagaa
     1201 aatcaggcag aagggttttg tccaaaagtg taaggcctcg ggcatagagg gccatgtggt
     1261 ccaggaaggg aacaatggcg gtggtggagg aggaagcaca ggcctgggca gtgacaagag
     1321 gaaagaggac ccaaggagaa cacaaatcca ccccactaga gagcctccaa gaaagcagac
     1381 caccaccaag gcagccactc ctcaacctcc cccgactcca agggccacca cgcttcctcc
     1441 tgctccagtc acaacagcca ctcgggccac atcccgggtg gtgacagtag ctgcaagacc
     1501 tacaactacc actgcctatc cagctactca gaggccctgg acatctcggc tacatccctt
     1561 ctcagtctcc cataggcctc cggcaacagc tgagatgacc accgtcaggg gcccctcagt
     1621 ctcagagcag ctctaccctc tacctcggaa ggagcaacag agagaaaagc cacaggccac
     1681 caggaggcct aacaaagcca ccaactatgg aagcttcaca gccaccccgc ctaccaccct
     1741 ctgggagggc agcacaagag ctgtgggcac aagccgtttc cgggacaacc ggacagacaa
     1801 acgagaacat ggccatcagg acccaaatgt ggtgccaggt cctcacaagc ccataaaggg
     1861 gaagctgccc aaaaagaagg agaaaattct cagcaatgag tatgaagcta agtatgacct
     1921 cagccggccc accacctctc agggggagga ggagctgcag gtggataaca ttccctccca
     1981 gaatgccaag gagtcaaaaa agcatgaaaa gcccgagaaa cccgagaagg agaagaaaaa
     2041 aaaggggaag agtgcaaaac cagacaagtt actcaggagc gaaaagcaaa tgaagaaagc
     2101 tgagaaaaag agcaagcagg agaaagagaa gactaagaag aaaaaggcag gtaagacaga
     2161 gcaggacgac tatcagaagc ccacagcaaa acatctcgct ccgagtccca ggaagtcagt
     2221 ggccgacctg ttggggtctt tcgaaggcaa acgaagactc ctcctgatca ccactcccaa
     2281 ggccgagaac aatatgtacg tgcagcagcg ggatgagtat ctggagagct tctgcaagat
     2341 ggccaccagg aggatctctg tggttactat ctttggtcct gtcaacaaca gctccatgaa
     2401 aattgaccac ttccagctag ataatgagaa acccatgcgt gtggtggatg acgaggactt
     2461 ggtagaccag catctcatca gtgagctgag gaaggagtat ggaatgacct acaatgactt
     2521 cttcatggtg ctgacagatg tggatctcag agtcaagcaa tactacgaag tgccaatagc
     2581 aatgaagtcc gtgtttgatc tgatcgatac tttccaatcc cgaatcaaag atatggaaaa
     2641 gcagaagaag gagggcatta cctgcaagga ggacaagagg cagtccctgg agaatttcct
     2701 atccaggttc cgatggagga ggcggttgct ggtgatctct gctcccaatg acgaagactg
     2761 ggcctattca cagcagctct ccgccctcaa cggtcaggca tgcaattttg gcctgcgaca
     2821 tataaccatt ttgaagcttt tgggcgttgg agaggaagtt ggaggcattt tagaactgtt
     2881 cccaattaat gggagctcca ctgttgagcg ggaagatgtg ccagcccacc tggtcaaaga
     2941 catccgcaac tattttcaag tgagcccaga gtacttctcc atgcttctag ttggaaaaga
     3001 tggcaatgtt aaatcttggt atccttctcc tatgtggtcg atggtcatcg tgtatgactt
     3061 aattgattcc atgcaacttc ggagacagga aatggccatt cagcagtcac tggggatgcg
     3121 ctgtccagaa gatgagtatg cgggatatgg ttaccatagt tatcaccaag gataccagga
     3181 tggctaccag gatgactacc gtcatcatga aagttaccac catggatacc cttactgaac
     3241 agaaatgtgt aaccttattc ccatccagtt tccccttcat ctgctaaagc tgtgtgcaga
     3301 cagcttcata agggaatttc tccatattct acataccctg cctttttctc tcagtgttct
     3361 tacaagatta aaggaatagt aaactttccc ctactcatga gttattatta agacatttaa
     3421 aagaactctc tatcttgaga gaggaaaatg tgctgctaaa taatttttac tgaaaaacaa
     3481 aaggtagtat ctcttttctc atataatagc tattattaga tatgcaaatg tatataaact
     3541 atttgtacat cttcatttct tctatcaatt tgtaagtaaa aaattgtgtt aaggaatatt
     3601 aaaactcaca gtacaaatgt tttcgtagaa catctggata gacacagaag gaaacagatg
     3661 gcttagtttt ccttttgaga aaggatctct ctgtgttgct ctgactgacc tagaactcac
     3721 tatgtagatc aggtttgtct gaaactcaca agttccacct gcctctgcct cccaaatgct
     3781 gggattaaag gcatgaatca ccatatctgg cttcagatgg cttaacactt gaaatgtcag
     3841 tctaaaaata tttacaacag ttctatgcca tatgatgttc ttttgcagct cttagcaaag
     3901 aattgagttt tgggtgacct gggcagggca gatagccaag gtcccaggtc ttttgtcagc
     3961 taccacagca gcaacagtgg tagcagtggt ggtgtgagcc tggccagcca cgcagtccca
     4021 aggcctagca atgaatgctt cagatcgaac ttttccccta gtgttacagc tcagtaaaag
     4081 cagtcactcc cacatgaaaa aaaaaaaaaa aaaa
//
