LOCUS       NP_071988                949 aa            linear   ROD 04-JUN-2024
DEFINITION  coiled-coil domain-containing protein 80 precursor [Rattus
            norvegicus].
ACCESSION   NP_071988 XP_001059868 XP_001059935 XP_573284
VERSION     NP_071988.2
DBSOURCE    REFSEQ: accession NM_022543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 949)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (residues 1 to 949)
  AUTHORS   O'Leary,E.E., Mazurkiewicz-Munoz,A.M., Argetsinger,L.S.,
            Maures,T.J., Huynh,H.T. and Carter-Su,C.
  TITLE     Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding
            protein
  JOURNAL   Mol Endocrinol 27 (4), 619-634 (2013)
   PUBMED   23449887
  REMARK    GeneRIF: Ccdc80 preferentially binds activated,
            tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2.
REFERENCE   3  (residues 1 to 949)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (residues 1 to 949)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   5  (residues 1 to 949)
  AUTHORS   Bommer,G.T., Jager,C., Durr,E.M., Baehs,S., Eichhorst,S.T.,
            Brabletz,T., Hu,G., Frohlich,T., Arnold,G., Kress,D.C., Goke,B.,
            Fearon,E.R. and Kolligs,F.T.
  TITLE     DRO1, a gene down-regulated by oncogenes, mediates growth
            inhibition in colon and pancreatic cancer cells
  JOURNAL   J Biol Chem 280 (9), 7962-7975 (2005)
   PUBMED   15563452
  REMARK    GeneRIF: DRO1 may have a role in the development of colorectal and
            pancreatic cancers
REFERENCE   6  (residues 1 to 949)
  AUTHORS   Visconti,R., Schepis,F., Iuliano,R., Pierantoni,G.M., Zhang,L.,
            Carlomagno,F., Battaglia,C., Martelli,M.L., Trapasso,F., Santoro,M.
            and Fusco,A.
  TITLE     Cloning and molecular characterization of a novel gene strongly
            induced by the adenovirus E1A gene in rat thyroid cells
  JOURNAL   Oncogene 22 (7), 1087-1097 (2003)
   PUBMED   12592395
REFERENCE   7  (residues 1 to 949)
  AUTHORS   Marcantonio,D., Chalifour,L.E., Alaoui-Jamali,M.A., Alpert,L. and
            Huynh,H.T.
  TITLE     Cloning and characterization of a novel gene that is regulated by
            estrogen and is associated with mammary gland carcinogenesis
  JOURNAL   Endocrinology 142 (6), 2409-2418 (2001)
   PUBMED   11356689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF223677.1, AY548105.1 and CB322543.1.
            
            On or before Sep 16, 2006 this sequence version replaced
            XP_573284.1, XP_001059868.1, XP_001059935.1, NP_071988.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY548105.1, AF223677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     Protein         1..949
                     /product="coiled-coil domain-containing protein 80
                     precursor"
                     /note="coiled-coil domain-containing protein 80; SSG-1;
                     steroid-sensitive gene 1 protein; down-regulated by
                     oncogenes 1 protein; steroid sensitive gene 1"
                     /calculated_mol_wt=104737
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2973
     Region          24..79
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QD51.1)"
     mat_peptide     28..949
                     /product="Coiled-coil domain-containing protein 80.
                     /id=PRO_0000282420"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QD51.1)"
                     /calculated_mol_wt=104737
     Region          142..270
                     /region_name="DUF4174"
                     /note="Domain of unknown function (DUF4174); pfam13778"
                     /db_xref="CDD:463980"
     Region          289..360
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QD51.1)"
     Region          408..609
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6QD51.1)"
     Site            467
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6QD51.1)"
     Region          614..747
                     /region_name="DUF4174"
                     /note="Domain of unknown function (DUF4174); pfam13778"
                     /db_xref="CDD:463980"
     Region          770..901
                     /region_name="DUF4174"
                     /note="Domain of unknown function (DUF4174); pfam13778"
                     /db_xref="CDD:463980"
     CDS             1..949
                     /gene="Ccdc80"
                     /gene_synonym="CL2; Dro1; Ssg1"
                     /coded_by="NM_022543.2:389..3238"
                     /db_xref="GeneID:64387"
                     /db_xref="RGD:69421"
ORIGIN      
        1 mtwkmgphft mllamwlvcg sasqssalds dgrpgrkvpl aspissrsar ylrhtgrsgg
       61 vekstqeepn pqsfqrrksv pvlrlahptv rpppsginga pvrpelkpia rgsasemvrd
      121 egssartrml rfpsgssspn ilasfagknr vwvisaphas egyyrlmmsl lkddvycela
      181 erhiqqivlf hqageeggkv rritsegqil eqpldpnlip klmsflklek gkfsmvllkk
      241 tlqveerypy pvrleamyev idqgpirrie kirqkgfvqk ckasgieghv vqegnngggg
      301 ggstglgsdk rkedprrtqi hptrepprkq tttkaatpqp pptprattlp papvttatra
      361 tsrvvtvaar pttttaypat qrpwtsrlhp fsvshrppat aemttvrgps vseqlyplpr
      421 keqqrekpqa trrpnkatny gsftatpptt lwegstravg tsrfrdnrtd krehghqdpn
      481 vvpgphkpik gklpkkkeki lsneyeakyd lsrpttsqge eelqvdnips qnakeskkhe
      541 kpekpekekk kkgksakpdk llrsekqmkk aekkskqeke ktkkkkagkt eqddyqkpta
      601 khlapsprks vadllgsfeg krrlllittp kaennmyvqq rdeylesfck matrrisvvt
      661 ifgpvnnssm kidhfqldne kpmrvvdded lvdqhlisel rkeygmtynd ffmvltdvdl
      721 rvkqyyevpi amksvfdlid tfqsrikdme kqkkegitck edkrqslenf lsrfrwrrrl
      781 lvisapnded waysqqlsal ngqacnfglr hitilkllgv geevggilel fpingsstve
      841 redvpahlvk dirnyfqvsp eyfsmllvgk dgnvkswyps pmwsmvivyd lidsmqlrrq
      901 emaiqqslgm rcpedeyagy gyhsyhqgyq dgyqddyrhh esyhhgypy
//
