LOCUS       NM_001014203            1863 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus coiled-coil domain containing 65 (Ccdc65), mRNA.
ACCESSION   NM_001014203 XM_343324
VERSION     NM_001014203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Austin-Tse,C., Halbritter,J., Zariwala,M.A., Gilberti,R.M.,
            Gee,H.Y., Hellman,N., Pathak,N., Liu,Y., Panizzi,J.R.,
            Patel-King,R.S., Tritschler,D., Bower,R., O'Toole,E., Porath,J.D.,
            Hurd,T.W., Chaki,M., Diaz,K.A., Kohl,S., Lovric,S., Hwang,D.Y.,
            Braun,D.A., Schueler,M., Airik,R., Otto,E.A., Leigh,M.W.,
            Noone,P.G., Carson,J.L., Davis,S.D., Pittman,J.E., Ferkol,T.W.,
            Atkinson,J.J., Olivier,K.N., Sagel,S.D., Dell,S.D., Rosenfeld,M.,
            Milla,C.E., Loges,N.T., Omran,H., Porter,M.E., King,S.M.,
            Knowles,M.R., Drummond,I.A. and Hildebrandt,F.
  TITLE     Zebrafish Ciliopathy Screen Plus Human Mutational Analysis
            Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary
            Dyskinesia
  JOURNAL   Am J Hum Genet 93 (4), 672-686 (2013)
   PUBMED   24094744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083683.1.
            
            On Apr 20, 2005 this sequence version replaced XM_343324.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083683.1, SRR8487227.134530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1863
                     /gene="Ccdc65"
                     /note="coiled-coil domain containing 65"
                     /db_xref="GeneID:362994"
                     /db_xref="RGD:1595842"
     exon            1..261
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1638
                     /gene="Ccdc65"
                     /note="coiled-coil domain-containing protein 65"
                     /codon_start=1
                     /product="dynein regulatory complex subunit 2"
                     /protein_id="NP_001014225.1"
                     /db_xref="GeneID:362994"
                     /db_xref="RGD:1595842"
                     /translation="MPKKGKKPKLPLTDEEQLILFQQKLLADEEAAKKKERLLTQFLK
                     DKLAKEEHNSSLNLNKINTQWRTVLREVKTRELHKDIEILSQIFERVVDCKDSVIKSL
                     ARDLTEAEEQYAHALRGHLHNVDQLLTLQRRRLSLLEENYNMELEVLTKEFETERKAI
                     LDHHDKEIHYLHDVFMAMEQNYVDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENV
                     VEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSKEIEVQMKKIQRLQEAISALK
                     GKIVAHSREGEWQNQCIRNDKELVHVQLRKLKIQRTQARTESQENLVKLTLESNATLK
                     ALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSALTPEEQEEVEIQSQEEITEDLA
                     KIMMDYLGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVL
                     SRLNPLFIVNHKSNLPQLPPSAAQPGGDRGPGGDRRLTYNVIEAAHIASHIL"
     exon            262..429
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            430..599
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            600..738
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            739..936
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1155
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1308
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1832
                     /gene="Ccdc65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtccaag gccccattac cttagctcca gaaggtccct gaaggggaac tttttccttc
       61 taatttctca caagcgggcc gtggcggcag gcagaggctc cttgcctgca cccagtccgc
      121 agcacagcca tgcctaaaaa aggaaaaaag cccaagttac ccctgacgga cgaagagcag
      181 ctgattttat ttcagcagaa gttgttggcc gacgaggagg cagccaagaa gaaagagagg
      241 ctcctcacgc agttcttgaa ggacaagttg gccaaagaag aacacaacag ctctctgaac
      301 cttaataaga ttaatacgca gtggagaacc gtcctcaggg aggtcaagac cagagagctt
      361 cacaaggaca ttgagatcct cagccaaatc tttgaacgag tggtggactg caaagacagt
      421 gtcattaagt ctctggcgag ggacctgact gaagctgagg agcaatacgc ccacgctctg
      481 cgcggccact tgcacaacgt tgaccagctc ttgaccctgc aacgacgcag gctcagcctc
      541 ctggaggaaa attacaacat ggagctggag gtcctaacca aagagtttga gaccgaaagg
      601 aaagcaatcc ttgaccatca cgataaggaa atccactacc tgcacgacgt cttcatggcc
      661 atggagcaga actatgtgga ctcggagtat gaaagcaagc tagaattcca gagcatgtgg
      721 gatgacctga aaaacaagaa tttagaagag aagcactttc ttcgcctaca actggagaac
      781 gtagtggaag acctgtggag gaggttccag gatgcactca agaattacac agatgccacg
      841 gaggaccgca agatcgcctt tgagaccctg aaggtgaagg atgagaaaag ctctaaagag
      901 attgaggtgc agatgaagaa gatccagagg ctgcaggagg ccatcagtgc cttgaaaggg
      961 aagatcgtag cccacagccg cgaaggtgaa tggcagaatc agtgtatccg aaacgacaag
     1021 gagctggtcc acgtgcagct tcgaaaactt aagatccaga ggacccaggc ccggaccgaa
     1081 tctcaggaga acttagtcaa actcaccctg gaaagtaacg ccaccctcaa ggccctgaaa
     1141 aaggttgtgg agaagggtga gaagatcctt aagcttgccg agatatgtag gaaatttgaa
     1201 accgaggaag aaaaagtact gcctttctat tcttcagcac tgacccccga ggagcaggag
     1261 gaggtcgaga tccagagcca ggaggagatc acagaggatc tcgccaagat tatgatggac
     1321 tacttgggaa tggagaactt ctggaagaga tacaacaagg tgaaactgga ggttctgagt
     1381 ctccagcaca ggcggctgca gctgctggat atcagcagca agctgcggga gatgctcaag
     1441 cagtacttgg acggcatctc ggtgagcgac gaggtgctga gccgcctcaa cccgctcttc
     1501 atagtaaacc acaaaagcaa cctgccccag ctgcccccat ccgcagcgca gcctggcggt
     1561 gacagaggac ctggtggcga cagaagactg acttacaacg tcatcgaggc ggcccacatt
     1621 gcctcccata tcctgtgacc cgaggaggag gaggaagcgt tctaaacccc agagactttt
     1681 tttcctttct tgaagcccga gtgctttgct ctcatgctta ggtggacact ccagcactgt
     1741 tccagttacc taccaccgcc ctatgtggca taaccaatta ttaatttttt aaaagaaaaa
     1801 tagagaaata aataaaataa aagagaaaat tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaa
//
