LOCUS       NM_001401395            7405 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus coiled-coil domain containing 50 (Ccdc50),
            transcript variant 1, mRNA.
ACCESSION   NM_001401395 XM_017597920
VERSION     NM_001401395.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7405)
  AUTHORS   Smith,C.J., Berry,D.M. and McGlade,C.J.
  TITLE     The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal
            sorting of the epidermal growth factor receptor
  JOURNAL   J Cell Sci 126 (Pt 6), 1366-1380 (2013)
   PUBMED   23418353
REFERENCE   2  (bases 1 to 7405)
  AUTHORS   Farfsing,A., Engel,F., Seiffert,M., Hartmann,E., Ott,G.,
            Rosenwald,A., Stilgenbauer,S., Dohner,H., Boutros,M., Lichter,P.
            and Pscherer,A.
  TITLE     Gene knockdown studies revealed CCDC50 as a candidate gene in
            mantle cell lymphoma and chronic lymphocytic leukemia
  JOURNAL   Leukemia 23 (11), 2018-2026 (2009)
   PUBMED   19641524
REFERENCE   3  (bases 1 to 7405)
  AUTHORS   Modamio-Hoybjor,S., Mencia,A., Goodyear,R., del Castillo,I.,
            Richardson,G., Moreno,F. and Moreno-Pelayo,M.A.
  TITLE     A mutation in CCDC50, a gene encoding an effector of epidermal
            growth factor-mediated cell signaling, causes progressive hearing
            loss
  JOURNAL   Am J Hum Genet 80 (6), 1076-1089 (2007)
   PUBMED   17503326
REFERENCE   4  (bases 1 to 7405)
  AUTHORS   Vazza,G., Picelli,S., Bozzato,A. and Mostacciuolo,M.L.
  TITLE     Identification and characterization of C3orf6, a new conserved
            human gene mapping to chromosome 3q28
  JOURNAL   Gene 314, 113-120 (2003)
   PUBMED   14527723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Feb 10, 2022 this sequence version replaced XM_017597920.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3068088.1,
                                           SRR26643299.48638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000011.1  86899856-86899980   c
            126-188             JAXUCZ010000011.1  86882830-86882892   c
            189-315             JAXUCZ010000011.1  86881755-86881881   c
            316-406             JAXUCZ010000011.1  86879024-86879114   c
            407-524             JAXUCZ010000011.1  86866740-86866857   c
            525-1046            JAXUCZ010000011.1  86861707-86862228   c
            1047-1162           JAXUCZ010000011.1  86856454-86856569   c
            1163-1207           JAXUCZ010000011.1  86855736-86855780   c
            1208-1312           JAXUCZ010000011.1  86855545-86855649   c
            1313-1389           JAXUCZ010000011.1  86854679-86854755   c
            1390-1496           JAXUCZ010000011.1  86845019-86845125   c
            1497-7405           JAXUCZ010000011.1  86837624-86843532   c
FEATURES             Location/Qualifiers
     source          1..7405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..7405
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /note="coiled-coil domain containing 50"
                     /db_xref="GeneID:288022"
                     /db_xref="RGD:727841"
     exon            1..125
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1516
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 50; protein Ymer;
                     putative C3orf6 protein homolog"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 50 isoform
                     1"
                     /protein_id="NP_001388324.1"
                     /db_xref="GeneID:288022"
                     /db_xref="RGD:727841"
                     /translation="MADVSVDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLAS
                     NIQRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYKALEQHDCEIAQEIQEKLTIEAERR
                     RIQEKKDEDIARLLQEKELQEEKKRKKHTPEFSGGSASGDNYYYEDGDQSRSRRDREL
                     GSGHSKSGRLQNDGKTVKQKENLRHRQENLEELDEQHPSERPLPSVSWGRGRDDVHTA
                     CEQQERKQRGRERPWKSPLPKISGEVFLTGSEDWEANCSPGTPSWEKQSRHHGRLSPK
                     SSQKTGLPCKEIVYGRDLGQGNHRERRHRPRTSPFSEDKELRHHHVAGMKSRGINEAV
                     SAPARVSHRDQEWYDAEIARKLQEEELLATHMDIRAAQVAQDEEIARLLMAEEKKAYK
                     KAKDREKSSLDKRKHDYDCKSKAKSAHSKSKEGDETQRAKIDRPSRPPPPAAMAPEDV
                     DPTHFTNQHSNTRHFSKSESSHKGFHNKQ"
     exon            126..188
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            189..315
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            316..406
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            407..524
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            525..1046
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1162
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1207
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1312
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1389
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1496
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..7405
                     /gene="Ccdc50"
                     /gene_synonym="c3orf6; C3orf6h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcggcgtc gacccggcca gcccgcgagg tgggcgtgcg ccgaggtctc cgtgcgcccg
       61 aggcccagcg gccgccatgg ccgacgtgag cgtggatcag tccaagttgc ccggcgtgaa
      121 ggaagtgtgt cgagattttg ctgtcctgga ggaccacacc ctggctcaca gcctgcagga
      181 gcaagagatt gagcatcatt tagcatccaa cattcagcgg aaccgtctgg tccagcatga
      241 tctgcaggtt gccaagcagc tccaagagga agacctcaaa gcccaagctc agctccagaa
      301 gcgctacaaa gcccttgaac aacatgattg tgaaattgct caggaaatcc aggagaagct
      361 gacaatcgag gctgagagac gacgtattca ggagaagaag gatgaggaca tagcacgtct
      421 tttgcaagag aaggaactac aggaagagaa aaagaggaag aaacacactc cagagttttc
      481 tggaggcagt gcttctggag ataactacta ttatgaggat ggagaccagt caaggtcaag
      541 gagggacagg gaactgggtt ctggacactc aaaatctggt agactccaaa acgatgggaa
      601 gactgtaaag cagaaggaaa acttgaggca tcggcaggag aacttggaag agctggacga
      661 acagcatccg tcagagagac ccctgccttc tgtgagctgg ggcagaggga gggatgatgt
      721 ccacactgcc tgtgagcagc aggaaaggaa gcagcgcggt cgggagaggc cctggaagtc
      781 cccgctgccg aagatcagtg gggaggtgtt tctgactggc tctgaagact gggaagctaa
      841 ctgtagccct ggaactccga gttgggaaaa gcagtctcga caccatggca gactttcacc
      901 caagtcttca cagaaaacag gacttccctg taaggaaatt gtgtatggga gggaccttgg
      961 gcaaggtaac cacagagaaa ggagacatag gcccagaact tctcccttct cagaggataa
     1021 agaacttcgc caccaccatg ttgcaggaat gaaatcaaga ggaataaatg aagctgtctc
     1081 tgctccagct cgagtgagtc acagggacca ggagtggtat gatgcagaaa ttgcccggaa
     1141 attgcaagaa gaagaacttt tggctactca tatggacata agagcagctc aggttgccca
     1201 ggatgaggaa attgctcgac ttctgatggc tgaagaaaaa aaagcttaca agaaagccaa
     1261 agatcgagaa aagtcatctt tggacaaaag gaaacatgac tatgactgca agtcaaaagc
     1321 aaagtcagca cactcaaagt caaaagaagg tgatgaaaca cagcgtgcca agattgacag
     1381 gccgtcacga ccaccgccac ccgcagcgat ggcccctgag gatgtggatc ccacccactt
     1441 cacaaaccag catagtaata cacgtcattt ttcaaagtca gagtcctcac acaaaggctt
     1501 ccataataag cagtaaaaca aaacagaaca aaacaacaaa aagggatctg cctcgaaaat
     1561 ggacttcttg tagcacatat tactggaaga tacaacatgc attccacatt ggctgttgtc
     1621 cttctatgtg ccattgctgg gagtttctct caagtgtttt ctaactaaaa acgtatttca
     1681 cttcatttta aaatgttggt tatgtttgtc acttgggcag tgtaagaaaa tgtacttctg
     1741 aatattggcc atctcttctg tggaaatatg ctgggatgta ataagtctag gaaatgacag
     1801 ttgctagtta gaggatattg gcatctagag aattgagttt gtttagcaat tagaagtgta
     1861 cagagattca ttatccaggc ataacatttg gattcaggag gcggaggaaa gtgtgaaatg
     1921 gctacattgc tgttcattct tatgagacta taaagacaca gcctttgctt ttatcctttt
     1981 cagaaaaagt aaaatcacaa caataaagta tagggaagcc cagagcagtg gaaacctgtg
     2041 ttcctgaatc agtggattgg tggcggctct gggtggccgt gtaaccctga cccattagcc
     2101 tactgctgtt tcctcaggat caagtcttct cccatgccct taggcaatga tcatgtgcta
     2161 atttttattt gtatagacct taattttcat attttctcag gtccatgaat taaagaacac
     2221 gtagcctcca ttgccttttc taatttaatt atagagtgaa aggaatagaa cagtttccac
     2281 aagacttgat actgtccgtc agttcaccta gcgtgcagat ccagcctcct gatcctagga
     2341 tacaacagtt ttggttcacc tcacagtgat gttttaggca cctgcaatat tagattaatt
     2401 caatggaagt tgaatttgat gaagtgagtc attatccagg tatatacatc tatgcagatg
     2461 gtcatcatat tcttctctta agacctttaa actgctctag aaagcctcag tctgtgtatt
     2521 tatccgtacc ccttactaat ctaaatggca gctgtgcctg ctgaacctac agatgagtgc
     2581 cattttccca gcttgacctg ctcttctctt caatgtatgg atctgacgtt ttctgtcatt
     2641 tcagtatgct gtttacttag acagaaataa ggttgccgag aaataattta aggactacct
     2701 gccttccatt gccttgtctt ttcaaactgt cttaaacttg gggaggattc tgggaggctg
     2761 ctcccaacag attttgatct ctgattttga aaacaatctt ctgtcataaa gtgacagctg
     2821 atagaaagtt gagtgaaaag tggcaggagt ggagccgtgg gagccacagt aatctggaaa
     2881 gacacacagg gctgtggcag tgccgtcacg gggagtgaat acatgctgag tgtcagccat
     2941 caagcacgtg caggcagagc ctccagggaa ggaggcaaac ggagagccca gccttaagtc
     3001 agtctacaga atggttttaa tgtcacagcc tagtcttacc aacagtgtaa tgctgtgtct
     3061 ttctttatct gccctttgct aaattttact tcagttttaa aggtattatg aaatggtaac
     3121 taaagaaaaa atataattgc atttttattt gataattagg caaaatagac aacatcttct
     3181 gccatatttt agttttataa atatttattt ttctatctca tgaaataatc acttttaact
     3241 ataaaagctg cattttttgt tttgcacgaa cttcatttaa tcatatttat tactgtaaaa
     3301 tggacatgtt ttagttttaa aaaatgccaa gtcacttaac cagaatgctg gagtcgccat
     3361 ggatggccaa aggcagtgct acctgtatga tggccagctc aacatcagta ttggaaaatt
     3421 tgttaccttt tagggttttt ttaaggacta caattttaaa atattttatt ttattttatt
     3481 tttgtaaagt gaacagtttt ttaagagtac cagtaattat tatgagtaag aagatagaaa
     3541 aatgttctta attattctta attaaaattt ttgctatcag tcaaataata tatctttgag
     3601 atgatcgaaa caaccatcag ctcctaatga actgccagtc ttcactgtgg tctctgctct
     3661 tttagttttt aacttctata tcaaaaggaa agcatttatt ttgttcctgt tattgagaac
     3721 atgcaattta attattaggt ccacactgta ttgtgttttg ttatcaacac atggactaat
     3781 tcttctagcc ttgagaactc tttggtttat aaacctgttt tctttgcagg ccgagtgctg
     3841 ttaaccccag tattactgca tgagcaccgt gtgttaagga gcccattgca ggctgcctgg
     3901 cacgacgcta aaagatgcca gtaaaagtca gcttaaatat gccgacctga aagatgatta
     3961 gtcccagcat tcaagctact attcatcata attgccttgt taggagaata gaaaaaatgc
     4021 ttctttgttc tcagagaata ttgagaattt ttgcaagtga cttattgaaa tgctgggggt
     4081 cacgtgactt cctgacaaat ggaagtgttg taaggagctc aaaactcaaa cagccacaac
     4141 caaactatgt gctctgattt ggagaaacat ttaaattagg acgagagata tgcataaatg
     4201 tatacccaaa gaaaactctt ttcactgcac ctaggcagcc agtgtaaggt atgtgacctg
     4261 tggtccactg gacgctttaa tactgtcaga gctcccctaa gtctatttgt gccaaattca
     4321 aagcaaagac aaaaacatac agtaatgcgg tgcatcctgt ttaccatata aatggttagc
     4381 attttacagc cttgattttt aatgagtaat gcctttgtat aaaactcact ttgggaaata
     4441 ggaaaatctg ttaccctcct ctcaaaagta actcatgatt ggctgaggtc atcagcctag
     4501 tgaagggctg aggcccatgt agacatggat ccaaggcctg aggtagaata gacttcaagt
     4561 aatggcttct tcctgaggcc tgaggtagaa tagacttcaa gtaatggctt cttcctgagg
     4621 cctgaggtag aatagacttc aagtaatggc ttcttccgtt tggggagggt ggtgtttgtg
     4681 gaaggagcgc tgacattgaa gtcacactga tgaggagatg ttcccctgta tttcactgtg
     4741 aacgctgtgc catgttctca gcacactatt acaaaacagc tccttaaaca ttcagagtct
     4801 gatcttttat tgaaaccagt ctgcagtgtg tctgtcatac gctgttcata gcaaagaagt
     4861 gacccagtca cccattctct cttcccctct cacaaccaga gaagcagccc tagagtctcc
     4921 ccacttccct ccctgtctgt gtgctttaga gccatagctg tgtctgacag gtaccaggat
     4981 gcttgcttct tcctactctg taataaggaa tacaggcagg gagagcccag agcagagtat
     5041 cctgctaatg ctgcatggag cagtattatg ggaatatgtg gtgggagttt tcgtttgttt
     5101 gatgagtttt tatgatgatg atgatatgta agataattga agggaagaat tgaaggcttt
     5161 gctgcttccg ctataactca tcagaaatgc tcacatttaa ttgtagcatc tccaagaagg
     5221 caaggataag ctaatgacat tagtaatagc cacctttctg atgagccctg cactttatgc
     5281 cagcaatgtc tgaagatgag ttttgcctta aattagtttg aatccacccg aggccattgt
     5341 gttaggtata tctgaggtct cgtcagctct ccactggcat gcaattcata aaagagcctc
     5401 aagcgtcacc atctcctggg atgagctttg agcttctccc actctactct ggttgacttg
     5461 taacattaac attagaagta tcttctcagt tcctcgagta gcagaggcgt ggccagagca
     5521 ctgccagggg acaattccct ggcgggcgat agtatccacg tgatgataac ttcctgtaca
     5581 ggtgggagct tcctgttctt ttttatggtg actgcaagag atgttctaaa ggttctttgg
     5641 ttcagtgaca atattcagat tatttctaag aattttaaca attaccgtta cgtattcaaa
     5701 agcttaccta gcattaacag acacaggaga aacccctcct ccgagatgga ggtattactt
     5761 gcaatggtgt tatcaagagt gctctaattt atttttttaa cagaattaag cagtaaaatg
     5821 tgggtatggt tgagaagata gaaaaacagc ttttctaggc cgtgcttaga caagtagtca
     5881 tgcaggtaac tacactgatt cacctacatg tttgtcacta aaagccattt tctgccctta
     5941 taacctcccc cagcattgct attaatatgt aaatcatata tttcatatgc ctttgggtat
     6001 tataagtaaa agtgatcttt tctcctttta aaaagttgct gtaatagtat gctgacttca
     6061 gtattttagg tcagggcagg attaattatg taactgtatt gcccaggtct ttattggtga
     6121 gattcaaatg tgaagatgag aaaaaaattt aaaaaggttt gagtaacaaa tcagcaagga
     6181 ttgccaacag taaagagtag gcattgcaag gatatctggt aatgggggat attctttgga
     6241 tgttttgcta cactgagttc acactataat tgttgaaatt gagtctagct aaaagtttgg
     6301 taagagtttt gggtgttaga agttttatac ttatgtatga atagtttcta aattccttta
     6361 ggctgtagac cttgatgtaa ttgaaagaca gatgtccttt cccaaggata gctgtatttt
     6421 tcatggtttt aaatgaggaa ccaaatattc atttcatgaa ataatataaa tattagaaaa
     6481 caatacggaa aatgacatat aaaagtgaca tttaaaaatg aaagtctctg taatgcctgg
     6541 tgtctgctga gaacaatcta tccctgtgaa acgtttgaaa gatgttgaat ttgaaagtcc
     6601 aagagtttgt tatataaatc aagtttctca ggacatttga ggtgacattg tcatgtattt
     6661 ctgttgtcgt ttggaaaagg catttcttta gttaggctat gaggaaacca cacacttcat
     6721 tttgtaagag tccttaagtg cagtgacgta gagaagagta gaacatgtga gctgggatcc
     6781 ccagtgctcg tcagttcatg gtcaacccac tcccccagtg gggctgtgaa gtgcatattt
     6841 catggagctg aacaaagcct caatagaata tcgtctctta tctgaggaaa gaccacctta
     6901 aaccacatgc ctatttagag attgaataaa actgtgagga cacactgtgt ggatgcctta
     6961 aggtgactgg tgttggtgct ggtgctggtg ctggtggaca tgtatgcacc catgaattag
     7021 gctgcaggga acagtctatt tccattcatc ttcatataac ccaagtcgtt cctgtgcata
     7081 accttgctga ggaaatgaga aacacggtgc tggttacttt gatgtgtttg gggaggctga
     7141 tgtcattggt taatattaag gcactaacca gtgcccaagc cttccttcag taccactcat
     7201 acatctacat ccattcattc atctatgcaa gcttgcgttt ttgtgatttg tattttacac
     7261 ctgaacgtca ggtttaacat cgtgttttaa ataattttaa accaaagtat tgtataagtc
     7321 tgtgtgcttt gtttttgtga atagtttgtg ataaatacct atcttgtttt ctcttaataa
     7381 agttatctgt ttattgagtc actga
//
