LOCUS       NM_001134688            5157 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus coiled-coil domain 40 molecular ruler complex
            subunit (Ccdc40), mRNA.
ACCESSION   NM_001134688 XM_001081764 XM_221189
VERSION     NM_001134688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5157)
  AUTHORS   Sugrue KF and Zohn IE.
  TITLE     Mechanism for generation of left isomerism in Ccdc40 mutant embryos
  JOURNAL   PLoS One 12 (2), e0171180 (2017)
   PUBMED   28182636
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5157)
  AUTHORS   Jeanson L, Thomas L, Copin B, Coste A, Sermet-Gaudelus I, Dastot-Le
            Moal F, Duquesnoy P, Montantin G, Collot N, Tissier S, Papon JF,
            Clement A, Louis B, Escudier E, Amselem S and Legendre M.
  TITLE     Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory
            Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal
            Disorganization
  JOURNAL   Hum Mutat 37 (8), 776-785 (2016)
   PUBMED   27120127
REFERENCE   3  (bases 1 to 5157)
  AUTHORS   Olbrich H, Cremers C, Loges NT, Werner C, Nielsen KG, Marthin JK,
            Philipsen M, Wallmeier J, Pennekamp P, Menchen T, Edelbusch C,
            Dougherty GW, Schwartz O, Thiele H, Altmuller J, Rommelmann F and
            Omran H.
  TITLE     Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia
            and Disrupt the Nexin-Dynein Regulatory Complex
  JOURNAL   Am J Hum Genet 97 (4), 546-554 (2015)
   PUBMED   26387594
REFERENCE   4  (bases 1 to 5157)
  AUTHORS   Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A,
            Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P,
            Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE,
            Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A,
            Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD,
            Chung EM, Shoemark A, Knowles MR, Omran H and Mitchison HM.
  CONSRTM   Uk10k
  TITLE     Mutations in CCDC39 and CCDC40 are the major cause of primary
            ciliary dyskinesia with axonemal disorganization and absent inner
            dynein arms
  JOURNAL   Hum Mutat 34 (3), 462-472 (2013)
   PUBMED   23255504
REFERENCE   5  (bases 1 to 5157)
  AUTHORS   Blanchon S, Legendre M, Copin B, Duquesnoy P, Montantin G, Kott E,
            Dastot F, Jeanson L, Cachanado M, Rousseau A, Papon JF, Beydon N,
            Brouard J, Crestani B, Deschildre A, Desir J, Dollfus H, Leheup B,
            Tamalet A, Thumerelle C, Vojtek AM, Escalier D, Coste A, de Blic J,
            Clement A, Escudier E and Amselem S.
  TITLE     Delineation of CCDC39/CCDC40 mutation spectrum and associated
            phenotypes in primary ciliary dyskinesia
  JOURNAL   J Med Genet 49 (6), 410-416 (2012)
   PUBMED   22693285
REFERENCE   6  (bases 1 to 5157)
  AUTHORS   Nakhleh N, Francis R, Giese RA, Tian X, Li Y, Zariwala MA, Yagi H,
            Khalifa O, Kureshi S, Chatterjee B, Sabol SL, Swisher M, Connelly
            PS, Daniels MP, Srinivasan A, Kuehl K, Kravitz N, Burns K, Sami I,
            Omran H, Barmada M, Olivier K, Chawla KK, Leigh M, Jonas R, Knowles
            M, Leatherbury L and Lo CW.
  TITLE     High prevalence of respiratory ciliary dysfunction in congenital
            heart disease patients with heterotaxy
  JOURNAL   Circulation 125 (18), 2232-2242 (2012)
   PUBMED   22499950
REFERENCE   7  (bases 1 to 5157)
  AUTHORS   Becker-Heck A, Zohn IE, Okabe N, Pollock A, Lenhart KB,
            Sullivan-Brown J, McSheene J, Loges NT, Olbrich H, Haeffner K,
            Fliegauf M, Horvath J, Reinhardt R, Nielsen KG, Marthin JK, Baktai
            G, Anderson KV, Geisler R, Niswander L, Omran H and Burdine RD.
  TITLE     The coiled-coil domain containing protein CCDC40 is essential for
            motile cilia function and left-right axis formation
  JOURNAL   Nat Genet 43 (1), 79-84 (2011)
   PUBMED   21131974
REFERENCE   8  (bases 1 to 5157)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Sep 5, 2008 this sequence version replaced
            XM_001081764.1, XM_221189.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..5157
                     /gene="Ccdc40"
                     /note="coiled-coil domain 40 molecular ruler complex
                     subunit"
                     /db_xref="GeneID:287867"
                     /db_xref="RGD:1592118"
     exon            1..657
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..4390
                     /gene="Ccdc40"
                     /note="coiled-coil domain containing 40"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 40"
                     /protein_id="NP_001128160.1"
                     /db_xref="GeneID:287867"
                     /db_xref="RGD:1592118"
                     /translation="MAEPEDQADGSNLEGEQTSAEEETEQQYTEGHEVSPQLENSGQK
                     TAEGREPTQDPERGITTDSEGRLEGEMVDAERVSTEGEAISEGEVGSIGEAFPETEVE
                     FIGEAPPDTVVEFIGEAPPGTEVEFIGETTPETQAEPTGEATPGVAVKTIRKAEQEVE
                     VIREVISETDVDSIVKAIQGVDLESIGATIPQKKVKYTAKARPQDEAEPTGEPAPEGD
                     FDVSEQEKAGHPSELDELSDIISSPAFSYSDVSPWDMGEEEAKALTTQDISQESVYEP
                     IELIQPTEPTEPPEDSVVRPIEPSRQRSFPMGARHRFRLSIMGSLTPSDIDDLPLETE
                     EALQQESVQPPPRAHEETRIQFLDQVQTLSLEDETQIERPMSEGSDEAEEEGAQLMVL
                     DPDHPLMVRFQEALKSYLNRQIDKLKLDIQELDVATKQTRIQRQELGVNLYGVQQHLA
                     RLQMQLEKSHDRHSLVACERRRKEEELQCNRALYNKTYATAKEERKKFAALQTEMESL
                     ALHLFYMQNIDQDVRDDIQVMKQVVKKTETEKMNAEIEKKKQDLFVDQLTERAHQLEE
                     NIALYEAQYLSQAEDTRVLRKAVTEAITEIDTIIMEKKRILQQWTTSLVGMKHRNEAY
                     RTVMDALRECEHQVKSIDSEIEAYKKSIMQEEEKNEKLARLLNRAETEAALVQKMTTQ
                     CLSKQETLQTEFNTYHLALQDTEEMLNKGYVEHSAVLSELQGTRQAVHQEQELRQKMD
                     ISIMDKLQEHGTSSKMTKYFHQLLRKLQKENTNLVTHLSKIDGDIAQATLDITNTNGK
                     VEMHKKTLLDLDKEVKRFNELITNSESEIVRRTILIERKQSLINFFNKQLEQMVSVLG
                     GEEAGPLELEIKRLSKLTEEYNTGVTQAQMTWLRLQQELVQISHEREERLESVDQLKK
                     EVHIMEQKKLRIENKIEHEKREQKMVSRHMRDLDNDLSKLNMLLDKNRCSSELLEQNN
                     AVAETEFVRTLKDAERETIQMQEKLSELCEEKATLLNSLVEAEHQIMLWEKKIQLAKE
                     MRSSVDSDTGQTEIRAMKAEIHRMRVKHGQLLKQQEKMIRDMELAVARRETIVIQAEG
                     QSKIDKKIVTKSDFHFQQSELRKKIREVHKATEECSKTVLELEEAQKLLSSSLQEKQQ
                     SLSDMQSDTDVLEEEISHLSALKRKNLLEIVALQTRAKHLQAAVDGKYVFLHRNSKAQ
                     LMERKRLGMKLSQLSSVLSRVQEDYPQYQEMLQKIQEKIATRLEAPEPS"
     exon            658..727
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1507
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1652
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1816
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1900
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2120
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2278
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2401
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2523
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2767
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2950
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3196
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3410
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3580
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3672
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3793
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..3982
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            3983..4141
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..5157
                     /gene="Ccdc40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagcccg gaacgccgcg cccagcctct aacatcgggg tcccgcgcat ttgtcgatcc
       61 ctgctcgggc tctctgcaag tcctaccgcg cgccgggtac ccgagaccct gctctggatg
      121 ggagccctac gccctcagtc ctggaggcag ggcctccctg tgcccacaaa tgcgctcacc
      181 ccctgcgttc caatttttca aatttggggg tacgaaggaa tgatgcccac caaaaggtac
      241 tgggaccctc tcctctgaca acgacccctt agaaagaccc catggtgagg gtccttgtgg
      301 aacccaaagc tgaatatggg agaaccagag ctaggcgcct ttcccggacc cagcatcccc
      361 acccagcctg ccgctttccg agtccctgaa catctttagg tcgaaggagg tgtacattag
      421 cactattgtc cctctaccgg acccaagtct gggcgggaaa ggctgggaca catggcgaca
      481 gacagacaaa acacacattt gtgctttaat gtgtttgctc agtgtttccg tgagaactgg
      541 cggacgcagc caggccccgc ctcctgcggt ctctgagcgc gcggtccgga cttcgccgga
      601 tgttgatggc gtctcctagc aacgagagat ggcggagccg gaggaccagg ctgacgggtc
      661 aaacctggaa ggcgaacaga catctgcgga agaggagaca gagcagcagt acactgaagg
      721 ccatgaggta tcaccacagt tggaaaacag tggccaaaaa actgctgagg gtagagagcc
      781 cacccaagat cctgaaaggg gcattacaac tgatagcgaa ggcagattag aaggggaaat
      841 ggtggatgct gagagagtca gcactgaagg agaagccatc tctgaaggag aagtggggtc
      901 cattggagag gctttcccag aaacagaagt ggaattcatt ggagaggctc ccccagacac
      961 agtagtggaa ttcattggag aggctccccc aggaacagaa gtggaattca ttggagagac
     1021 cacaccagaa acacaggcgg aacccactgg agaggctacc ccaggagtgg ctgtgaaaac
     1081 catcagaaaa gcggaacaag aagttgaagt cattagagaa gtcatctcag aaactgatgt
     1141 ggactccatt gtaaaagcta tccaaggagt ggacttagaa tccattggag ccaccatacc
     1201 acaaaaaaaa gttaaataca ctgcaaaggc cagaccccaa gatgaagcgg aacccactgg
     1261 agaacctgcc ccagaaggag attttgacgt ttctgaacaa gagaaagcag gccatccctc
     1321 tgagttggac gagctctctg atataatcag ctctcctgcg ttctcctact ctgatgtcag
     1381 cccctgggac atgggggaag aggaggcaaa agccttaaca acacaggaca tatcccagga
     1441 aagcgtctac gagcccatag agctcataca gcccacagag cccacagagc ctccagagga
     1501 cagtgtggtg agacccatag agccctcccg tcaaagatcc tttcctatgg gggcacggca
     1561 ccgcttcaga ctgagcatta tgggaagttt gactccctcg gacattgacg atcttcccct
     1621 ggaaacagag gaagctcttc agcaagagtc agtgcagcca cctcccagag cccatgaaga
     1681 aacccgaata cagttcctag accaggtcca gaccctcagc ctcgaggacg agacccagat
     1741 cgaaagacca atgtctgaag ggagtgacga agcagaggag gaaggcgccc aactgatggt
     1801 gctagaccca gaccaccccc tgatggtcag attccaggag gctctgaaga gctacctcaa
     1861 ccggcagatc gacaagctga agttggacat ccaggaactg gatgtggcca ccaagcaaac
     1921 ccgaatccag aggcaggagc tgggcgtgaa cctctacggg gtccagcagc acctggcccg
     1981 cctgcagatg cagctggaga agagccatga ccgacactct ctggtcgcct gcgagcggag
     2041 gaggaaggag gaggagctgc agtgcaaccg cgccctctac aacaagacct atgcaaccgc
     2101 caaagaggaa cgaaagaagt ttgcggccct gcagaccgag atggagagcc tggccctgca
     2161 cctcttctac atgcagaaca tagaccagga cgtgcgtgat gacatccaag tcatgaagca
     2221 ggtggtgaaa aagaccgaga cagagaagat gaacgcagag atagagaaga aaaagcagga
     2281 cctgttcgtg gaccagctca cagaaagagc gcaccagctg gaagagaaca ttgccctgta
     2341 tgaggctcaa tacttgtccc aggctgagga cacccgggtt ctcaggaagg cagtgactga
     2401 ggccatcaca gagattgaca ctattatcat ggagaaaaag cgtatcctgc agcagtggac
     2461 caccagccta gtgggcatga agcaccgtaa tgaggcatac aggaccgtga tggatgcact
     2521 gagggagtgt gagcatcagg tgaagtccat agacagtgag atcgaggcct ataagaagtc
     2581 catcatgcag gaggaagaga agaacgagaa gctggcccgc ctcctgaacc gcgcagagac
     2641 agaagccgcc ctggtgcaga agatgaccac ccagtgctta agcaagcaag agaccctgca
     2701 gactgagttt aacacgtacc acctcgccct gcaggacacc gaggagatgc tgaacaaggg
     2761 ctatgtggaa cactcggccg tcttgagcga actccagggc acccgccagg ctgtccatca
     2821 ggagcaggag ctacgacaaa agatggacat atccatcatg gacaagctgc aggagcacgg
     2881 gacctccagc aagatgacca agtactttca tcagctcctt cgcaagctgc aaaaggaaaa
     2941 cacgaacctg gtgacacacc tttcaaaaat tgatggtgac atcgcccagg ccaccctaga
     3001 catcaccaac accaacggca aggtagagat gcataagaag acactgttag atctggacaa
     3061 ggaggtaaag aggttcaacg agctcatcac caacagcgag agcgagatcg tccggcgcac
     3121 catcctcatc gagaggaagc agagcctcat caacttcttc aacaagcagc tagagcagat
     3181 ggtgtccgtg ctgggggggg aagaagctgg acccctggaa ctggagatca aaaggctgtc
     3241 gaagctgaca gaagagtaca acaccggagt gacccaggcc cagatgacct ggttgcgatt
     3301 gcagcaggaa ctggtccaga tcagccacga gcgtgaggag cggctggagt ctgtggacca
     3361 actgaagaag gaggtgcaca tcatggagca aaagaagctt cgcatagaga acaagattga
     3421 gcatgagaag agggagcaaa agatggtgag ccgccacatg agggacttag ataacgacct
     3481 gagcaagctc aatatgctgt tggacaagaa ccggtgcagt tcggaactgc tggagcagaa
     3541 caacgctgtg gctgagacag agttcgtgcg cactctgaag gatgcggaaa gagagaccat
     3601 ccaaatgcag gaaaagctgt ccgaactctg tgaggaaaag gccactctcc tcaacagcct
     3661 agtggaggcc gaacaccaga tcatgctctg ggagaaaaaa atccaactgg ccaaggagat
     3721 gcgcagctcg gtggactccg atactgggca gacggagatc cgtgccatga aggcggagat
     3781 ccacaggatg agggttaagc acggacagct actgaagcag caggagaaga tgatccgaga
     3841 catggagctg gctgtggccc gcagggagac catcgtcatc caggctgaag ggcagagcaa
     3901 gatagacaag aagatagtca ccaagtccga cttccacttc cagcagagcg agctgcggaa
     3961 gaaaatcagg gaggttcaca aggccacaga ggagtgctcc aaaaccgtct tggaactgga
     4021 ggaagctcag aagctcctga gcagctccct ccaggaaaag cagcagtcgc tgtcggatat
     4081 gcagagtgac acagatgttc ttgaagagga gatcagccat ctctcggccc tcaaacggaa
     4141 gaaccttttg gagatcgtgg ccctgcagac ccgcgccaag cacctgcagg ccgccgttga
     4201 tgggaaatac gtgttcttgc accgcaacag caaggcccag cttatggagc gtaagcgcct
     4261 gggcatgaag ctgtcccagc tcagcagcgt cctctcccgc gtgcaggaag actaccccca
     4321 gtaccaggag atgctgcaga aaattcaaga gaagattgct accaggctgg aggccccaga
     4381 gccctcctag acagcacctg gccccaccct actaacctgg ccccacactt actaggactg
     4441 ccttggaagc agacccagga agtcaccccg ggttctgaaa agccacgtgc ccactagaac
     4501 agcaccctgt ctaagaaaca tgggcgggcc agacactcga atcgtagcct ctctgcccgc
     4561 cattcacacc aggtgtaact cagccaccct gaccccgacg ctttggcgag catgcccaca
     4621 gaggcatcgc ctgggtgtaa aaatcccacc cttccattgg acttacccat tcaggtaaga
     4681 ccatcctgtt ggcagttcta tggtctgcat cgggtgcctt tcactgtact gggacaggcc
     4741 cttgtggagc aaggtgccca aggaagccag gcacaaggga gccaggtgca agatagactg
     4801 tttcagccct gggaagcctg ctccggccag tctgaagccc agaagatacc ctcattctct
     4861 accccacaga aagcacagcc atctcctgcc cccgcctccc aggaagcatt aaatttagac
     4921 tgaaagccaa agaccaaagc caagggcccc aggagtccaa ggacagcaaa tgtctatgga
     4981 gcagaaactg cttcagtaaa ggggcacctg tttctcatcc accaacctcg gacctctctc
     5041 tccttcaact ctgcctcccc tcccctgggt attcctaggt accagttgcc tttttgctgg
     5101 tatagatgtg aaatggaaaa cgtcccgtgg gatagtttca gttttaaact tcacaga
//
