LOCUS       NM_001170472            3594 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cell cycle and apoptosis regulator 2 (Ccar2),
            mRNA.
ACCESSION   NM_001170472 XM_001069514 XM_224329
VERSION     NM_001170472.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3594)
  AUTHORS   Sakurabashi,A., Wada-Hiraike,O., Hirano,M., Fu,H., Isono,W.,
            Fukuda,T., Morita,Y., Tanikawa,M., Miyamoto,Y., Oda,K., Kawana,K.,
            Osuga,Y. and Fujii,T.
  TITLE     CCAR2 negatively regulates nuclear receptor LXRalpha by competing
            with SIRT1 deacetylase
  JOURNAL   J Steroid Biochem Mol Biol 149, 80-88 (2015)
   PUBMED   25661920
REFERENCE   2  (bases 1 to 3594)
  AUTHORS   Pangon,L., Mladenova,D., Watkins,L., Van Kralingen,C., Currey,N.,
            Al-Sohaily,S., Lecine,P., Borg,J.P. and Kohonen-Corish,M.R.
  TITLE     MCC inhibits beta-catenin transcriptional activity by sequestering
            DBC1 in the cytoplasm
  JOURNAL   Int J Cancer 136 (1), 55-64 (2015)
   PUBMED   24824780
REFERENCE   3  (bases 1 to 3594)
  AUTHORS   Kim,W. and Kim,J.E.
  TITLE     Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis
            of breast cancer cells through impaired responses to UV-induced DNA
            damage
  JOURNAL   Cancer Lett 333 (2), 180-186 (2013)
   PUBMED   23352644
REFERENCE   4  (bases 1 to 3594)
  AUTHORS   Chini,C.C., Escande,C., Nin,V. and Chini,E.N.
  TITLE     DBC1 (Deleted in Breast Cancer 1) modulates the stability and
            function of the nuclear receptor Rev-erbalpha
  JOURNAL   Biochem J 451 (3), 453-461 (2013)
   PUBMED   23398316
REFERENCE   5  (bases 1 to 3594)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   6  (bases 1 to 3594)
  AUTHORS   Koyama,S., Wada-Hiraike,O., Nakagawa,S., Tanikawa,M., Hiraike,H.,
            Miyamoto,Y., Sone,K., Oda,K., Fukuhara,H., Nakagawa,K., Kato,S.,
            Yano,T. and Taketani,Y.
  TITLE     Repression of estrogen receptor beta function by putative tumor
            suppressor DBC1
  JOURNAL   Biochem Biophys Res Commun 392 (3), 357-362 (2010)
   PUBMED   20074560
REFERENCE   7  (bases 1 to 3594)
  AUTHORS   Li,Z., Chen,L., Kabra,N., Wang,C., Fang,J. and Chen,J.
  TITLE     Inhibition of SUV39H1 methyltransferase activity by DBC1
  JOURNAL   J Biol Chem 284 (16), 10361-10366 (2009)
   PUBMED   19218236
REFERENCE   8  (bases 1 to 3594)
  AUTHORS   Zhao,W., Kruse,J.P., Tang,Y., Jung,S.Y., Qin,J. and Gu,W.
  TITLE     Negative regulation of the deacetylase SIRT1 by DBC1
  JOURNAL   Nature 451 (7178), 587-590 (2008)
   PUBMED   18235502
REFERENCE   9  (bases 1 to 3594)
  AUTHORS   Kim,J.E., Chen,J. and Lou,Z.
  TITLE     DBC1 is a negative regulator of SIRT1
  JOURNAL   Nature 451 (7178), 583-586 (2008)
   PUBMED   18235501
REFERENCE   10 (bases 1 to 3594)
  AUTHORS   Sundararajan,R., Chen,G., Mukherjee,C. and White,E.
  TITLE     Caspase-dependent processing activates the proapoptotic activity of
            deleted in breast cancer-1 during tumor necrosis
            factor-alpha-mediated death signaling
  JOURNAL   Oncogene 24 (31), 4908-4920 (2005)
   PUBMED   15824730
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001170472.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data from several strains because no single
            transcript was available for the full length of the gene. The
            extent of this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211644.1, SRR26643298.57805.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000015.1  51637591-51637663   c
            74-167              JAXUCZ010000015.1  51636629-51636722   c
            168-259             JAXUCZ010000015.1  51636340-51636431   c
            260-351             JAXUCZ010000015.1  51635808-51635899   c
            352-466             JAXUCZ010000015.1  51635489-51635603   c
            467-596             JAXUCZ010000015.1  51635191-51635320   c
            597-693             JAXUCZ010000015.1  51634913-51635009   c
            694-813             JAXUCZ010000015.1  51630137-51630256   c
            814-1036            JAXUCZ010000015.1  51627946-51628168   c
            1037-1150           JAXUCZ010000015.1  51627757-51627870   c
            1151-1314           JAXUCZ010000015.1  51627300-51627463   c
            1315-1486           JAXUCZ010000015.1  51626732-51626903   c
            1487-1714           JAXUCZ010000015.1  51626279-51626506   c
            1715-1951           JAXUCZ010000015.1  51625946-51626182   c
            1952-2096           JAXUCZ010000015.1  51625221-51625365   c
            2097-2179           JAXUCZ010000015.1  51624796-51624878   c
            2180-2326           JAXUCZ010000015.1  51624312-51624458   c
            2327-2438           JAXUCZ010000015.1  51624089-51624200   c
            2439-2627           JAXUCZ010000015.1  51623821-51624009   c
            2628-2833           JAXUCZ010000015.1  51623504-51623709   c
            2834-3594           JAXUCZ010000015.1  51622525-51623285   c
FEATURES             Location/Qualifiers
     source          1..3594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..3594
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /note="cell cycle and apoptosis regulator 2"
                     /db_xref="GeneID:306007"
                     /db_xref="RGD:1309922"
     exon            1..73
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            74..167
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2878
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /codon_start=1
                     /product="cell cycle and apoptosis regulator protein 2"
                     /protein_id="NP_001163943.1"
                     /db_xref="GeneID:306007"
                     /db_xref="RGD:1309922"
                     /translation="MSQFKRQRINPLPGGRNFSGAASTSLLGPPPGLLTPPVATDLSQ
                     NARHLQSGEKQRVFTGIVTSLHDYFGVVDEEVFFQLSVVKGRLPQLGEKVLVKAAYNP
                     GQAVPWNAVKVQTLSNQPLLKSPAPPLLHVAALGQKQGILGAQPQLIFQPHRIPPLFP
                     QKPLSLFQTSHTLHLSHLNRFPARGPHGRLDQGRSDDYDSKKRKQRAGGEPWGAKKPR
                     HDLPPYRVHLTPYAVDSPTCDFLELQRRYRSLLVPSDFLSVHLSWLSAFPLGQPFSLH
                     HPSRIQVSSEKEAAPDTGAEPSPEDSDPTYSSKVLLLSSPGLEEFYRCCMLFVDDMAE
                     PRETPEHPLKQLKFLLGRKEEEAVLVGGEWSPSLDGLDPQADPQVLVRTAIRCAQAQT
                     GIDLSTCTKWWRFAEFQYLQPGPPRQLHTVVVYLPDVWTIMPTLEEWEALCQQKATEA
                     APQPQEASGEAEATEQAPDVSEQADTSKQDTETAEATTQQDVDTELPEAPPPPLEPAV
                     MARPGCVNLSLYGIVEDRRPKERISFEVVVLAELFVEMLQRDFGYRIYKVLLSLPEKV
                     VSPPEPEKEEAAKEDVVKEEEAVKEEAVKVSKDEVQNEGTAAEADSPLKEDGLLPKQP
                     SAGGEEEEKARGEAAEDLCEMALDPDLLLLRDDGEEEFAGAKLEETEVRSVASNQSEM
                     EYSSLQDMPKELDPSAVLPLDCLLAFVFFDANWCGYLHRRDLERILLTLGIRLSAEQA
                     KQLVSRVVAQNICQYRSLQYSRAEALDDGLPEDVLFGNLDLLPPSGKSTKPGAAPTEH
                     KGLVPHNGSLINVGSLLQRAEQQDSGRLYLENKIHTLELKLEESHNRFSATEVTNKTL
                     AAEMQELRARLAEAEETARTVERQKNQLQRQMQDFRRRLTPLHLEMQRIVEKADSWVE
                     KEEPTPSN"
     exon            168..259
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            260..351
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            352..466
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            467..596
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            597..693
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            694..813
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1036
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1150
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1314
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1486
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1714
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1951
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2096
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2179
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2326
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2438
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2627
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2833
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3594
                     /gene="Ccar2"
                     /gene_synonym="RGD1309922"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtggtgg cagcagcagc tgcggtggtt ccgggtgtct ttgtccccct ggtgtcgtgg
       61 ccctggcccg caggtttcca cccaagacct tgaaaggaca gcattccaaa tgtcccagtt
      121 taagcgccag aggatcaacc cacttccagg gggacggaac ttctcaggcg cagcttcaac
      181 atctcttttg ggtcctcctc ctggtctgct tactcctcct gtggccacag acttgtccca
      241 aaatgccagg caccttcaga gtggggagaa gcagcgagtc ttcactggca ttgttaccag
      301 cttgcatgac tactttgggg tggtagatga agaagtcttt tttcagctaa gtgtggtgaa
      361 gggccgacta ccccagctgg gtgagaaggt gctggtgaag gctgcgtata acccaggcca
      421 ggcagtgccc tggaatgctg tcaaggtgca gacgctctcc aaccagccct tactgaagtc
      481 tccagcacct ccccttctac atgtggcagc tctgggccag aagcaaggga tcctcggagc
      541 tcagccccag ttgatctttc agcctcaccg aattccccca cttttccctc agaagcctct
      601 gagtctcttc cagacatccc atacacttca cctgagccac ctgaacagat ttcctgctcg
      661 gggtcctcat ggaaggctgg accagggccg aagtgacgac tatgactcga agaaacgcaa
      721 acagcgggct ggtggagagc cttggggtgc taagaaacct aggcatgacc tgcctcctta
      781 ccgggtgcat ctcactccct atgctgtgga cagtcccacc tgtgacttcc tagaactgca
      841 gcgacgttac cgcagcctgt tggtcccctc agattttctt tccgttcact tgagctggct
      901 gtcagccttc ccactgggcc agcccttttc cctccaccac ccgagtcgga tccaggtctc
      961 ttcagagaag gaggcagctc cagacactgg tgctgagccc agccctgagg acagtgaccc
     1021 cacttacagt tccaaggtgc tgctgctctc ctccccaggc ctagaggagt tctatcgttg
     1081 ctgcatgctg tttgtggatg acatggctga gccaagggag acaccagagc atcctctgaa
     1141 gcagctaaag tttttgctgg gccgaaaaga agaagaggca gtgctggttg ggggtgagtg
     1201 gtctccttcc ctggatggcc tcgaccccca ggcagacccg caggtgctgg tgcgcacagc
     1261 catccgctgt gcacaagccc agactggcat tgacttgagc acctgtacca aatggtggcg
     1321 ttttgctgag tttcagtatt tgcagccggg gccgccccgg cagttacaca cagtagtggt
     1381 gtacctgcca gatgtgtgga ccatcatgcc cactttggag gagtgggagg cactgtgcca
     1441 acagaaagcc acagaagcag ctccccaacc gcaggaggca tcaggggagg cagaggctac
     1501 tgaacaggct cctgacgtgt cagagcaagc agacacttct aaacaggaca cagagacagc
     1561 agaggccacc acacagcaag atgtggacac tgagctccca gaggcccctc cgcctcctct
     1621 agaacctgcg gtgatggcac gtcctggctg tgtcaacctg tctctctacg gaattgtgga
     1681 ggatcggagg ccaaaagaaa ggatctcttt tgaggtggtg gtgctggccg agctgtttgt
     1741 ggagatgctg cagagggact ttggctatag aatttataag gtgctgctga gccttccaga
     1801 aaaagttgtg tctcctcctg aacctgagaa ggaggaggca gccaaggagg atgtggtcaa
     1861 agaggaggag gctgtcaaag aggaggcagt gaaggtgtcc aaggatgagg tacagaatga
     1921 gggcacagct gccgaggcag acagcccact gaaggaggat gggcttctgc ccaaacagcc
     1981 ctctgcaggg ggagaagagg aggagaaggc ccggggtgag gcagctgagg acctctgtga
     2041 aatggccttg gacccagacc tgctgcttct gagggatgat ggagaggaag agtttgcagg
     2101 agcaaagcta gaggaaacgg aggttcgctc tgttgcctcc aaccagtccg agatggaata
     2161 ttcttctctt caggacatgc ctaaggagct ggatccctca gctgtgctcc ccttggactg
     2221 ccttctggct tttgtgtttt ttgatgccaa ctggtgtggc tacttgcaca ggcgagactt
     2281 ggagaggatc ctcctcacct tggggatccg gctcagtgca gagcaggcca aacagctggt
     2341 tagtagagtg gtggcacaga acatctgcca gtatcggagc cttcagtata gccgtgctga
     2401 ggcgctggat gacgggcttc cagaagacgt gctctttgga aacctggatc tactgcctcc
     2461 ttcaggaaag agcacaaagc caggtgctgc ccccacagag cacaaaggcc tggtgcccca
     2521 caatggtagc ctcatcaatg tgggaagcct gttacagcgt gcagagcagc aagacagtgg
     2581 ccgcctgtac ctggagaaca agattcacac actggaattg aagcttgagg agagccataa
     2641 ccgattttca gccactgaag tgacaaataa gacactggca gcagagatgc aggagctgcg
     2701 ggctcggctg gccgaggcgg aggagacagc ccggacagtg gaacgacaga agaaccagct
     2761 ccagcgtcag atgcaggact tccgcagacg cctgacccca ctgcaccttg agatgcagcg
     2821 gatcgttgaa aaggctgaca gctgggtaga gaaagaggag ccaacgccta gcaactgagt
     2881 ggctgcctag tgaggtctgc gatggagcct gatgacatta gagacctttg ggtaccagaa
     2941 agcagctgga gcagggcctg ggagccatag caggggtggc ttgagttctg tgctcagcct
     3001 ctgtagggaa catcaaactc tcagtatggg gttcgtgctg tgtggatgga tgtgtaagga
     3061 accccagttc cagctacaac taaatacaac atcttttgca cccctagaat gtcattttgc
     3121 cctcaatctt ggaatttctc ccagggccct tgtagtcttg tgctgtctcc tgtccttgtc
     3181 cattttagag caagatggga ggaaaaggct tttccagccc agaacaaggt ctaatgccaa
     3241 taaatgggag gaatgggtgt agagtcggtg cagccaagaa tgttggtcct ctgggcggca
     3301 tgagtcccgc aggctctgtt aggtgataga gcccattctg ggaagcactt ggtgttgggt
     3361 caaggtcgcc aatagaacac tgtgtcccag ctgccccaac ttgccagaag aaccagcact
     3421 tctctctcca gctcttatgt tcagatgtgg tattggccct ggcctagccc tttcccattt
     3481 cccacaattc ttgcctcttt ccacaattca tggtttcagt ttgactttgt atataaagtt
     3541 gttgtttttt tttttttttt ggctttttgt tttttaaata aaccaaagtg aaaa
//
