LOCUS       NM_001108535            4438 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Rattus norvegicus cell division cycle and apoptosis regulator 1
            (Ccar1), transcript variant 1, mRNA.
ACCESSION   NM_001108535 XM_001058761 XM_001058883 XM_342143
VERSION     NM_001108535.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Mizuta,S., Minami,T., Fujita,H., Kaminaga,C., Matsui,K., Ishino,R.,
            Fujita,A., Oda,K., Kawai,A., Hasegawa,N., Urahama,N., Roeder,R.G.
            and Ito,M.
  TITLE     CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a
            novel pathway for GATA1 function
  JOURNAL   Genes Cells 19 (1), 28-51 (2014)
   PUBMED   24245781
  REMARK    Erratum:[Genes Cells. 2023 Jan;28(1):78. doi: 10.1111/gtc.12991.
            PMID: 36647803]
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Seo,W.Y., Jeong,B.C., Yu,E.J., Kim,H.J., Kim,S.H., Lim,J.E.,
            Kwon,G.Y., Lee,H.M. and Kim,J.H.
  TITLE     CCAR1 promotes chromatin loading of androgen receptor (AR)
            transcription complex by stabilizing the association between AR and
            GATA2
  JOURNAL   Nucleic Acids Res 41 (18), 8526-8536 (2013)
   PUBMED   23887938
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Kim,J.H., Yang,C.K., Heo,K., Roeder,R.G., An,W. and Stallcup,M.R.
  TITLE     CCAR1, a key regulator of mediator complex recruitment to nuclear
            receptor transcription complexes
  JOURNAL   Mol Cell 31 (4), 510-519 (2008)
   PUBMED   18722177
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Rishi,A.K., Zhang,L., Boyanapalli,M., Wali,A., Mohammad,R.M.,
            Yu,Y., Fontana,J.A., Hatfield,J.S., Dawson,M.I., Majumdar,A.P. and
            Reichert,U.
  TITLE     Identification and characterization of a cell cycle and apoptosis
            regulatory protein-1 as a novel mediator of apoptosis signaling by
            retinoid CD437
  JOURNAL   J Biol Chem 278 (35), 33422-33435 (2003)
   PUBMED   12816952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474016.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342143.3, XM_001058883.1, XM_001058761.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..4438
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /note="cell division cycle and apoptosis regulator 1"
                     /db_xref="GeneID:361849"
                     /db_xref="RGD:1560358"
     exon            1..140
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            141..261
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..3635
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle and apoptosis regulator protein 1; cell
                     division cycle and apoptosis regulator protein 1-like"
                     /codon_start=1
                     /product="cell division cycle and apoptosis regulator
                     protein 1 isoform 1"
                     /protein_id="NP_001102005.1"
                     /db_xref="GeneID:361849"
                     /db_xref="RGD:1560358"
                     /translation="MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQ
                     QTALAAAGLTTQTPANYQLTQTAALQQQAAAVLQQQYSQPQQALYSVQQQLQQPQQTI
                     LTQPAVALPTSLSLSTPQPAAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGF
                     VDEDVFFQLGAVKGKTPQVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLK
                     TPTAVIQPIVPQTTFGVQAQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLL
                     QPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERDRERRRSRERSPQRK
                     RSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFF
                     DAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNVAVLDPPDADHLYSAKVMLMA
                     SPSMEDLYHKSCALAEDPQDLRDGFQHPARLVKFLVGMKGKDEAMAIGGHWSPSLDGP
                     NPEKDPSVLIKTAIRCCKALTGIDLSVCTQWYRFAEIRYHRPEETHKGRTVPAHVETV
                     VLFFPDVWHCLPTRSEWETLSRGYKQQLVEKLQGERKKADGEQDEEEKDDGEVKEIAT
                     PTHWSKLDPKAMKVNDLRKELESRALSSKGLKSQLIARLTKQLKIEEQKEEQKELEKS
                     EKEEEDEDDKKSEDDKEEEERKRQEEVERQRQERRYILPDEPAIIVHPNWAAKSGKFD
                     CSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQRDFGVRIYKSLLSLPEKEDKKD
                     KEKKSKKEERKDKKEEREDDIDEPKPKRRKSGDDKDKKEDRDERKKEEKRKDDSKDDD
                     ETEEDNNQDEYDPMEAEEAEEEEDDREEEEVNKRDDKRDVSRYCKDRPSKDKEKEKPQ
                     MVTVNRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQVKKLLNKVVLRESCF
                     YRKLTDTSKDGESHDEPESLQGDTTLGNRLLLPTPTVKQESKDGEENVGLIVYNGAMV
                     DVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDGKTILNLENSNKSLSGELREVKKDL
                     GQLQENLKVSENMNLQFENQLNKTLRNLSTVMDDIHTVLKKDNVKNEDRDQKSKENGS
                     SV"
     exon            262..425
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            426..470
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            471..503
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            504..697
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            698..812
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1005
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1135
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1297
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1523
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1637
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1804
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2015
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2099
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2285
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2477
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2717
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2829
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2912
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3059
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3369
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3575
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..4438
                     /gene="Ccar1"
                     /gene_synonym="RGD1560358"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgtccagc cgcacgcgcc cgttcctcct cgagaccgga ggaggtgcgg cgtggaggag
       61 gggagcagtg tgcgcatgcg cctgagcttg acgggttttg aaatggcttc tctgttaacc
      121 ccggcccgac tcaggtgaag atatctgctg tagaagagaa gcaagtgaag gtttcccccc
      181 cttgcatcat ggctcagttt ggaggacaga agaatcctcc atgggctact cagtttacag
      241 ccacggcggt gtcacaacca gctgcactag gtgttcagca gccatcactt ctgggagcat
      301 cccctaccat ctatacgcag cagactgcat tggcggccgc aggccttacc acgcagacgc
      361 cagcaaacta tcagttaaca caaactgcgg cactgcagca gcaagctgca gctgtcttac
      421 agcagcaata ttcacaacct cagcaggcct tgtatagtgt gcaacagcag ttacagcaac
      481 cccagcagac cattttaaca cagccagctg ttgcattgcc cacaagcctt agcctgtcta
      541 ctcctcagcc tgcagcacag attactgtgt cctatccaac accaaggtcc agtcaacagc
      601 agactcaacc tcagaagcag cgtgttttca caggagtggt tacaaaacta catgatacgt
      661 ttggatttgt ggatgaagat gtattctttc agcttggtgc tgttaaaggg aaaacccccc
      721 aagtgggtga tagagtcttg gttgaagcaa cctataatcc taatatgcct tttaaatgga
      781 atgcacaaag aattcaaaca ctaccaaatc agaatcagtc acaaacccaa cctttactga
      841 agactcctac tgctgttatc cagccgattg tgccacagac aacatttggt gttcaggcac
      901 agccccaacc ccagtcatta ttgcaagccc agatctcagc tgcttctatt acacccctat
      961 tgcagacgca gccacagccc ttactacagc agccacagca aaaagctggc ttattgcagc
     1021 ctcctgtccg aatagtatca cagccacaac ccgcacggag attagatccg ccatctagat
     1081 tttcaggaag aaatgacaga ggggatcaag tacctaatag aaaagatgac cgaagtcgtg
     1141 aaagggacag agaaagacgc agatccagag aaagatcacc tcagaggaaa cgttcccggg
     1201 agaggtcgcc ccggagagaa agagagcgat cccctcggag agtccgccgt gtcgttccac
     1261 ggtacacagt gcagttttca aagttttctt tagattgtcc cagttgtgac atgatggaat
     1321 taaggcgccg ttatcagaac ttatatattc ctagtgactt ttttgatgct cagtttacat
     1381 gggtggatgc tttccctttg tcaagaccat ttcaactggg aaattactgc aatttttatg
     1441 tgatgcaccg agaagtggag tccttagaaa aaaatgtggc tgttcttgac ccacctgatg
     1501 ctgaccacct gtacagtgca aaggtaatgc tgatggctag ccctagtatg gaagatttgt
     1561 atcataagtc atgtgctctt gctgaagacc cacaagacct tcgtgatggt tttcagcatc
     1621 ctgctagact tgttaagttt ctagtgggaa tgaaaggcaa ggatgaagcc atggccattg
     1681 gaggccactg gtctccttcg ctggatggac caaacccaga aaaagacccc tctgtgttga
     1741 ttaagactgc cattcgttgt tgtaaggccc tgacaggcat tgatctaagt gtgtgcacac
     1801 aatggtaccg ttttgcagag attcgctacc atcgccctga ggagacccac aaggggcgta
     1861 cagttccagc tcatgtggag acagtggttt tatttttccc ggatgtttgg cattgccttc
     1921 ccacccgctc agagtgggaa accctctccc gaggatacaa gcagcagctg gtcgagaagc
     1981 ttcagggtga acgcaagaag gctgatggag aacaggatga agaagagaag gatgatggtg
     2041 aagttaaaga aattgctact cctacccatt ggtctaaact tgatccaaag gcaatgaagg
     2101 taaacgatct ccgaaaagaa ttagaaagtc gagctcttag ttccaaagga ctaaaatcgc
     2161 agttaatagc tcgcctgaca aagcagctta aaatagaaga acagaaagaa gagcagaagg
     2221 aattagagaa gtctgaaaag gaagaggaag atgaggatga taagaagtct gaggatgata
     2281 aagaggaaga agaaagaaaa cgtcaagaag aagtggaacg ccaacgccaa gaaagaagat
     2341 acattttgcc tgatgagcct gccataattg tccatccaaa ctgggctgca aaaagtggga
     2401 agtttgattg cagcatcatg tctttgagtg tccttttaga ctacagattg gaagataata
     2461 aagaacattc gtttgaggtt tcattgtttg cagaactttt caatgaaatg cttcaaagag
     2521 attttggggt cagaatatac aaatcattac tctctcttcc tgagaaagag gacaaaaaag
     2581 ataaggaaaa gaaaagcaaa aaagaagaga gaaaagataa aaaagaagag agagaagatg
     2641 atattgatga accaaaacca aaacggagaa aatcgggcga tgataaagac aaaaaagaag
     2701 acagagatga gaggaagaaa gaagagaaaa gaaaagatga ttctaaggat gatgatgaaa
     2761 ctgaagaaga taacaatcag gatgagtatg accccatgga ggcagaggag gcggaggagg
     2821 aggaggacga cagggaggag gaggaagtga acaaacgaga cgacaaaagg gacgtcagcc
     2881 gatactgcaa ggacagaccc tcaaaggaca aggaaaaaga gaagcctcaa atggtcacag
     2941 ttaacaggga tctgctaatg gcctttgttt attttgatca aagtcattgt ggttaccttc
     3001 ttgaaaagga tttggaagaa atactttata ctcttggact gcatctttct cgggctcagg
     3061 taaagaaact gctcaataaa gtagtgctcc gagaatcgtg cttctatcgg aaattaacag
     3121 acacctcaaa agacggcgag agccatgacg agccagagtc gctgcagggg gacacgacgc
     3181 tgggaaacag gttactactt cccacaccaa cagtgaagca ggaatcgaag gatggagaag
     3241 aaaacgtagg gcttattgtg tacaacggtg caatggtgga tgttgggagt ctcttacaaa
     3301 agctggaaaa gagtgaaaaa gtaagagctg aggtagaaca gaagctccag ttactagagg
     3361 agaaaacaga tgaagacgga aaaactatat taaacttgga gaattctaac aaaagcctct
     3421 ctggtgaact tagagaggtc aaaaaagacc ttggtcaatt acaagaaaac ttgaaggttt
     3481 cagaaaacat gaatttgcaa tttgaaaacc aattgaataa aacactcaga aacttatcca
     3541 cagtcatgga tgatatccac actgtcctaa aaaaggataa cgtaaagaat gaagacagag
     3601 atcagaaatc caaggagaat ggttcaagtg tatgataaaa tacatttggt gatgaggagt
     3661 ggtgttaaat aatgtactat ataaaaatca tgacacagga atgtttgagg gcaatgcatg
     3721 tttgatttta gtagtataaa catatgttag ttcaaatgat gtataaagtt ttatgaatgt
     3781 gagtttgctt ttgaaaattg cctgtaattt ctagcattca aattaaatac tcactgagtg
     3841 aagaattttg cattgcaaaa tcttttagga tgaactttgt tatagtttta accccaataa
     3901 agttcatcag tttaattgac aataacttgt aattactaaa tgtcttttat tgaaatatct
     3961 agacattttg cttttattta tagaactatt gttttatagt tttatagttc acttttttta
     4021 gtgtcagtat gtatcataaa atagcatgct ccttaatatt tgcaaccttt ttggactagt
     4081 attttcagtg tttaaatgta gttgttaagc cgtctgctca tggtggcaca tcccattaac
     4141 cccagtgaga cactgtctca ggaacaatgc aattaatcca aaagacgctg tgtaaaagcc
     4201 tacaactgag aaagcgatcg agctagcatt gtgcttagag tttacacaaa gtaaccgtct
     4261 tgacagtagt tactgtactc agttaattgt tttacttgcc ctggatactt ctattttaat
     4321 tttcagaagt taaaaaggag gcagtggaca tcaaatgcac agcttagtga caagccagta
     4381 catcgtcagt ttgattgatg ccttaagtta agtcattaaa aaatattttt ttaattaa
//
