LOCUS       NM_001270984            3353 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus coiled-coil and C2 domain containing 1B (Cc2d1b),
            mRNA.
ACCESSION   NM_001270984 XM_233342
VERSION     NM_001270984.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Kondaurova,E.M., Ilchibaeva,T.V., Tsybko,A.S., Kozhemyakina,R.V.,
            Popova,N.K. and Naumenko,V.S.
  TITLE     5-HT1A receptor gene silencers Freud-1 and Freud-2 are differently
            expressed in the brain of rats with genetically determined high
            level of fear-induced aggression or its absence
  JOURNAL   Behav Brain Res 310, 20-25 (2016)
   PUBMED   27150226
  REMARK    GeneRIF: Freud-1 and Freud-2 levels were different in rats
            selectively bred for 85 generations for either high level of
            fear-induced aggression or its absence. Freud-1 protein level was
            decreased in the hippocampus, whereas Freud-2 protein level was
            increased in the frontal cortex of highly aggressive rats. There no
            differences in 5-HT1A receptor gene expression were found in the
            brains of highly aggressive and nonaggressive rats.
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Hadjighassem,M.R., Galaraga,K. and Albert,P.R.
  TITLE     Freud-2/CC2D1B mediates dual repression of the serotonin-1A
            receptor gene
  JOURNAL   Eur J Neurosci 33 (2), 214-223 (2011)
   PUBMED   21155902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 18, 2012 this sequence version replaced XM_233342.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2441064.1,
                                           SRR26643293.28914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000005.1  128581994-128582126
            134-216             JAXUCZ010000005.1  128583430-128583512
            217-361             JAXUCZ010000005.1  128585834-128585978
            362-468             JAXUCZ010000005.1  128586829-128586935
            469-630             JAXUCZ010000005.1  128587249-128587410
            631-756             JAXUCZ010000005.1  128587795-128587920
            757-916             JAXUCZ010000005.1  128588031-128588190
            917-1089            JAXUCZ010000005.1  128588335-128588507
            1090-1165           JAXUCZ010000005.1  128588655-128588730
            1166-1276           JAXUCZ010000005.1  128588832-128588942
            1277-1407           JAXUCZ010000005.1  128589026-128589156
            1408-1480           JAXUCZ010000005.1  128589398-128589470
            1481-1605           JAXUCZ010000005.1  128589650-128589774
            1606-1723           JAXUCZ010000005.1  128590183-128590300
            1724-1896           JAXUCZ010000005.1  128590382-128590554
            1897-2022           JAXUCZ010000005.1  128590884-128591009
            2023-2081           JAXUCZ010000005.1  128591877-128591935
            2082-2198           JAXUCZ010000005.1  128592021-128592137
            2199-2272           JAXUCZ010000005.1  128592370-128592443
            2273-2331           JAXUCZ010000005.1  128592554-128592612
            2332-2383           JAXUCZ010000005.1  128592815-128592866
            2384-2483           JAXUCZ010000005.1  128593778-128593877
            2484-2574           JAXUCZ010000005.1  128594024-128594114
            2575-2707           JAXUCZ010000005.1  128595073-128595205
            2708-3353           JAXUCZ010000005.1  128595400-128596045
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3353
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /note="coiled-coil and C2 domain containing 1B"
                     /db_xref="GeneID:313478"
                     /db_xref="RGD:1306630"
     exon            1..133
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            134..216
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2703
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /note="freud-2; FRE under dual repression-binding protein
                     2; five prime repressor element under dual
                     repression-binding protein 2"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1B"
                     /protein_id="NP_001257913.1"
                     /db_xref="GeneID:313478"
                     /db_xref="RGD:1306630"
                     /translation="MPGPRPRKGPKTSGQGAETAKQLGLFVEFNPEDMLLGMDETEDD
                     GDLEAELLALTGETGSTSRKPAPKGRAPLPMAHIEKLAADCMRDVEEEGEEEEGLEDD
                     ADLLTELQEVLGVDEETGLVDDSEETSPDLSEEKTRDNTEQPVAPAAFQQALPAAVAQ
                     AGGPRGLQALLEERIQNYREAAASAKEAGEAAKARRCERGLKTLESQLATVRKGGKIC
                     EDEIPPPVALGKRPPAHQERPSKDSEIDSAGSCAMDPGDLSQPESSLPAVAALPDSDP
                     DPQALLLARQREYKAAALSAKRAGDLDRARELMRIGKRFGTVLEALEKGQPVDLSGMP
                     PAPEDLKALPQASEASAATQVLSPAVEQMQPVMSSDLPATPAAPAEPKTVLDALQQRL
                     NRYREAGIQARASGDERKARMHDRIAKQYQDAIRAHQAGRKVDFAELPVPPGFPPIPG
                     LEPRKDTEEDSVTATLAAAQKLASEDTALVDEDEERDTPAQAPLAKKPAQPLVPSSHL
                     LNEPKASSSKESLSPSVREQVTLLEARKLQYQRAALQAKRRQDLEQAKSHLRVAKSLE
                     AQIIQARAGQPIDLSKVPSPLTDEEGDFILIHHEDLRLSQKAEEVYAQLQKILLEQHE
                     KCLLFSKQFMHQGNVAETTRFEKLAEDRKKQLEILQLAQAQGLDPPSHHFELKTLQTV
                     RIFSELNSTEMHLIIVRGMNLPAPPGVTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKN
                     TNSPEFEQVFKLNINRNHRGFRRVIQSKGIKFEIFHKGSFFRSDKLVGTAHLKLERLE
                     KECEIREIMEVLDGRKPTGGKLEVKVRLREPLSSQDVQMVTENWLVLEPRGL"
     exon            217..361
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            362..468
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            469..630
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            631..756
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            757..916
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1089
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1165
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1276
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1407
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1480
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1605
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1723
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1896
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2022
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2081
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2198
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2272
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2331
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2383
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2483
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2574
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2707
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..3353
                     /gene="Cc2d1b"
                     /gene_synonym="RGD1306630"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgccggg cgagagccac cgcctcctgg gcgggtgctt cctgtggctg tctccgccgc
       61 cgcccggggg ccgcgggaag ctaggcggtt ccgggctcga gaaggcccgg ttttggttcg
      121 ggtccgccgc gaggtatcta gcctgccaag atgccagggc caagacctcg gaagggccct
      181 aagaccagtg gccagggtgc cgaaactgcc aagcagctgg ggctttttgt ggagttcaac
      241 cctgaggaca tgctcctggg gatggatgag acagaagatg atggagacct ggaggctgag
      301 ttattggcac tcactgggga aacagggagc acaagcagga agccagcacc caaggggcgg
      361 gccccactgc ccatggccca cattgagaag ttggcagcag actgtatgcg agatgtggag
      421 gaggagggcg aggaagagga agggctggag gacgatgcag accttctgac agagctgcag
      481 gaagtcctgg gtgtggatga agaaactggg ctggtggatg acagtgagga aacaagccca
      541 gacctgtctg aggagaagac aagggacaac actgaacaac ctgtagcacc agcagccttc
      601 cagcaggcct tacctgcagc agtggctcag gctggagggc ctcgggggct gcaggctttg
      661 ctggaggaac ggatccagaa ctaccgggag gctgcggcca gtgccaagga ggctggtgaa
      721 gctgccaaag cccggcgctg tgagcgaggc ctgaagactc tggagtccca gcttgccact
      781 gtgaggaaag gcggcaagat ctgtgaggac gagattccac ctccagtggc cttgggcaaa
      841 aggcccccag cccaccagga aagacccagc aaggactctg agatagactc tgcaggctcc
      901 tgtgccatgg acccaggtga cctttcccaa cctgagtcca gcctccctgc cgttgctgcc
      961 ttgcctgatt cagacccaga cccacaggcc ctgctgttag cccgacaaag agagtacaaa
     1021 gcagctgctc tcagtgccaa gcgggccgga gatctagacc gtgctcggga gctcatgagg
     1081 attgggaaga gatttggtac tgtcctagag gccctggaga aggggcagcc tgtggatctg
     1141 agtggcatgc ccccagcacc tgaggatctg aaggccctcc cccaggcttc tgaggcctct
     1201 gcagcaaccc aagtcctgtc cccagcagtg gagcaaatgc agccagtgat gtcctctgac
     1261 ctcccagcca ccccagcggc ccctgcagag ccaaagacag tgctggatgc tttacaacaa
     1321 aggctgaaca ggtatcgtga ggcaggcatc caggccaggg ccagtgggga tgagcgcaaa
     1381 gccaggatgc atgaccgaat tgccaagcaa tatcaggatg ctattcgagc tcatcaagca
     1441 ggacggaaag ttgactttgc tgagttacct gttcctccag gatttcctcc catccctggc
     1501 ctggagccca gaaaagatac tgaggaggat tcagtgacag caactttggc agctgcccaa
     1561 aaactggcct cagaagatac agccctggta gatgaagatg aggagaggga caccccagca
     1621 caggccccat tggccaagaa gccagcacag cctctggtcc cttcatccca tcttctgaat
     1681 gagcccaagg cctcaagttc taaggagtca ctgagtccat ctgttcggga gcaggtgaca
     1741 ctgctggagg ctcggaaact gcagtaccag cgagcagctc tgcaagccaa gcgcaggcag
     1801 gatctggagc aggccaaatc ccacttacga gtagctaaaa gtcttgaggc tcagatcatc
     1861 caggccagag ctggtcaacc gattgacctc tctaaggtgc cttcaccctt gacagatgaa
     1921 gaaggtgact tcatcctcat tcaccatgag gatcttcgac tctcccagaa ggctgaggag
     1981 gtgtatgccc agctacagaa aatactcctg gagcagcacg agaagtgcct gctgttctcc
     2041 aagcagttca tgcaccaggg taatgtggct gagactacac ggtttgagaa gcttgctgag
     2101 gaccgaaaga aacagcttga gatcctgcag ctggcccaag cccagggcct ggaccctccc
     2161 agtcatcact ttgaattgaa gacattgcag actgtgagga tcttctcaga actcaatagc
     2221 acagaaatgc atctgatcat cgtccgggga atgaacctcc cagccccacc aggagtgact
     2281 ccggatgatt tggatgcttt cgtacggttt gagtttcact accctaactc ggaccaggct
     2341 caaaaaagca aaacagctgt ggtaaaaaat acgaactctc cagaatttga acaagttttc
     2401 aaactaaaca tcaatcgaaa tcaccgaggc tttaggaggg tgatccagag caaaggaatc
     2461 aaatttgaga tcttccacaa aggatccttt tttagaagcg acaagctggt tggcacagca
     2521 cacctgaaac tggaaaggct ggagaaagag tgtgagatca gagagatcat ggaggttctg
     2581 gatggaagaa agcccactgg ggggaagctg gaagttaagg tgaggctgcg ggagcctttg
     2641 agcagccagg acgtgcagat ggtcactgag aactggctgg tcctggagcc taggggcctg
     2701 tgaagaggtg gacatcactg gtacgagctc actgacccgg ctttgctggc tgcaagagcc
     2761 tttgtacatg gagatgctgc tacacaaagc accaaagact gttgaactaa ccgtggctcg
     2821 ggcgctcctc gtgctgcttc tcctgggcct tcgtggaagc tggccacatc ttaggagcgt
     2881 ctcgtagcct cccaccccac tctccagaat gtgggtgaag acaaggatac ccccattgct
     2941 ctgtgccatt gagtcctact gccccgtaac ctctgcatag taattatgta cagcttaacc
     3001 cagcccccca caaccccttg caccatttct ggatgtgcct ttcaaagatg taactgtaag
     3061 ggatgggaga acttgagtgt gatcggaaca tcccctgctt aagggagaga ctggattccg
     3121 tgactccagc tggccagtgg cagactgtcc tgctcagctg tttgcccctc tgcctgtgcc
     3181 tttgttcctg acagctgctg cactagcctt tctgatcccc agaggactcg ggaacaggaa
     3241 agttactttg gtactattgg tggggagtaa ggggaaggtt ctctttggtt tggttcatgt
     3301 acctaagatg aaagactatt aattaaggag aaaaaaaaga aagaaaaact atc
//
