LOCUS       NM_001013869            3306 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus coiled-coil and C2 domain containing 1A (Cc2d1a),
            mRNA.
ACCESSION   NM_001013869 XM_237884
VERSION     NM_001013869.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Kondaurova,E.M., Ilchibaeva,T.V., Tsybko,A.S., Kozhemyakina,R.V.,
            Popova,N.K. and Naumenko,V.S.
  TITLE     5-HT1A receptor gene silencers Freud-1 and Freud-2 are differently
            expressed in the brain of rats with genetically determined high
            level of fear-induced aggression or its absence
  JOURNAL   Behav Brain Res 310, 20-25 (2016)
   PUBMED   27150226
  REMARK    GeneRIF: Freud-1 and Freud-2 levels were different in rats
            selectively bred for 85 generations for either high level of
            fear-induced aggression or its absence. Freud-1 protein level was
            decreased in the hippocampus, whereas Freud-2 protein level was
            increased in the frontal cortex of highly aggressive rats. There no
            differences in 5-HT1A receptor gene expression were found in the
            brains of highly aggressive and nonaggressive rats.
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Szewczyk,B., Kotarska,K., Daigle,M., Misztak,P., Sowa-Kucma,M.,
            Rafalo,A., Curzytek,K., Kubera,M., Basta-Kaim,A., Nowak,G. and
            Albert,P.R.
  TITLE     Stress-induced alterations in 5-HT1A receptor transcriptional
            modulators NUDR and Freud-1
  JOURNAL   Int J Neuropsychopharmacol 17 (11), 1763-1775 (2014)
   PUBMED   24946016
  REMARK    GeneRIF: In pregnancy stress, prefrontal cortex Cc2d1a levels were
            reduced in rats.
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Shi,Z.Y., Li,Y.J., Zhang,K.J., Gao,X.C., Zheng,Z.J., Han,N. and
            Zhang,F.C.
  TITLE     Positive association of CC2D1A and CC2D2A gene haplotypes with
            mental retardation in a Han Chinese population
  JOURNAL   DNA Cell Biol 31 (1), 80-87 (2012)
   PUBMED   22023432
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Hadjighassem,M.R., Galaraga,K. and Albert,P.R.
  TITLE     Freud-2/CC2D1B mediates dual repression of the serotonin-1A
            receptor gene
  JOURNAL   Eur J Neurosci 33 (2), 214-223 (2011)
   PUBMED   21155902
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Iyo,A.H., Kieran,N., Chandran,A., Albert,P.R., Wicks,I.,
            Bissette,G. and Austin,M.C.
  TITLE     Differential regulation of the serotonin 1 A transcriptional
            modulators five prime repressor element under dual repression-1 and
            nuclear-deformed epidermal autoregulatory factor by chronic stress
  JOURNAL   Neuroscience 163 (4), 1119-1127 (2009)
   PUBMED   19647046
  REMARK    GeneRIF: results point to the importance of understanding the
            mechanism for the differential regulation of 5-HT1AR, Freud-1 and
            NUDR in the prefrontal cortex as a basis for understanding the
            related effects of chronic stress and stress-related disorders
REFERENCE   8  (bases 1 to 3306)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 3306)
  AUTHORS   Ou,X.M., Lemonde,S., Jafar-Nejad,H., Bown,C.D., Goto,A., Rogaeva,A.
            and Albert,P.R.
  TITLE     Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A
            receptor gene
  JOURNAL   J Neurosci 23 (19), 7415-7425 (2003)
   PUBMED   12917378
REFERENCE   10 (bases 1 to 3306)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081948.1.
            
            [WARNING] On Oct 17, 2024 this sequence was replaced by
            NM_001013869.2.
            
            On Apr 20, 2005 this sequence version replaced XM_237884.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132278, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..3306
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /note="coiled-coil and C2 domain containing 1A"
                     /db_xref="GeneID:288908"
                     /db_xref="RGD:1306108"
     exon            1..218
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2849
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /note="freud-1; FRE under dual repression-binding protein
                     1; five repressor element under dual repression-binding
                     protein 1; five prime repressor element under dual
                     repression-binding protein 1"
                     /codon_start=1
                     /product="coiled-coil and C2 domain-containing protein 1A"
                     /protein_id="NP_001013891.1"
                     /db_xref="GeneID:288908"
                     /db_xref="RGD:1306108"
                     /translation="MHKRNGPQAPPGRGAVTARQLGLLVDFSPDGLMIPEDGVNDEEL
                     EAEFLALVGGQPQALEKLKGKGPLPMEAIEKMARLCMRDLDEDEEGTDEDVEADEDLL
                     AELNEVLGEERKAVEPAMPVVQTLENLLVSAKKGNTINEADIPPPVASGKGPAIGHSH
                     THTTSHLAPVSPPAPEPSVTLEAPSTTAQTSAKPQLSPDPCSPLARLQSLQHEYKVAA
                     LRAKHQDDTATAARYLRVSKSFDPVLEALSRGELVDLSRLPPPPDQLSPEPPLPAAQP
                     VTPASTLTRPEVPQPPKNLLEALEQRMERYHVAAAQAKAKGDQRKARMHERIVKQYQD
                     AIRAHKAGRAVDVAELPVPPGFPPIQGLESAEPSQQSLVGVLETAMKLANHEEGSDEE
                     EEETPKKNTPAASTAQPKASPSRAPPSGPAPAGKAASKGTSTRAQQQLAFLEGRKKQL
                     LQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNGLPVDIAKVPPAPVNKDDFVLVQ
                     RPGPGMSQEAVRRYGELTKLLRQQHEMCLNHSTQFTHLGNIAETIKFEKLAEDCKRSM
                     DTLKQAFARSLPTPAARFEQRTFSVIKIFPDLSNNDMLLFIVKGINLPTPPGLSPSDL
                     DAFVRFDFPYPNVEEAQKDKTSVIKSTDSPEFKEQFKLCINRGHRGFRRAIQTKGIKF
                     EVVHKGGLFKTDRVLGTAQLKLDTLETACEVHEILEVLDGRRPTGGRLEVMVRIREPL
                     TAQQLETTTERWLVIDHIPAAVPTVTGPKAKVPLIPASSKEAGNRSSRPLHSLSVLAF
                     DQERLERKILALRQARRPVPPEVAQQYQDVVQRSQWQRAQLEQGGAALRREYASHLER
                     QLHFYTEAARRLGYDGSREAAKEALYRRNLVESELQRLRR"
     exon            219..354
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            355..464
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            465..530
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            531..753
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            754..872
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            873..945
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1017
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1148
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1221
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1355
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1464
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1637
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1760
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1819
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1936
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2010
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2069
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2121
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2221
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2312
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2450
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2512
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2576
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2703
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2780
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2828
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..3230
                     /gene="Cc2d1a"
                     /gene_synonym="RGD1306108"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagctgg gcggccaaaa gtcgagaatc ccaggggccg gtcgcagaga aggaactcgg
       61 ggctcaggca cagcgcgagc tctgagacgc gacttcggtg aagaggcaag gcaaggcaaa
      121 ggtgcagggg ctggtagtcc gggcttcgag cctggaagat gcacaagagg aatggacccc
      181 aggcaccccc gggccgaggt gctgtcaccg cccgccagct tggtctgctg gttgacttct
      241 ccccagatgg cctgatgatc cctgaggatg gggtaaatga tgaagaattg gaggctgaat
      301 tcctggcttt ggtggggggt cagccccagg ccctagagaa actgaaaggc aaaggtcccc
      361 tgccaatgga agccattgag aaaatggccc ggctctgcat gagagacctg gatgaggatg
      421 aggaggggac agatgaggat gtggaggctg acgaggacct gctggcagag ctaaatgagg
      481 tccttggaga agaaaggaag gctgtggagc ccgcgatgcc tgtggtccag acgctggaaa
      541 acctgctggt ctctgcaaag aagggcaaca ccatcaatga agccgatatt ccaccacctg
      601 tagcctcggg gaaggggcca gcaattgggc acagccacac ccacactact tcccacctgg
      661 ctcctgtaag cccgccagcc ccagagccca gcgtcacctt ggaggcccca tctaccactg
      721 cacaaacctc tgctaagccc cagctatccc cagatccctg cagccccctt gcccggttgc
      781 agagcctcca gcatgagtac aaagtggctg ctctcagagc caagcatcag gatgacactg
      841 ctacagccgc cagatacttg agagtctcga agagctttga ccctgtcttg gaggccctga
      901 gccgagggga actggtagac ctgtcccgcc tgccccctcc acctgaccag ctgtccccag
      961 agcccccctt gccagcagcc caacctgtga ctcctgcctc aacactcacc aggccagagg
     1021 ttccccagcc cccgaagaac ctcctggagg cgctggagca gcgaatggag cggtaccacg
     1081 tggctgcagc ccaggccaag gccaagggtg accagaggaa ggcacgcatg cacgaacgaa
     1141 ttgtcaagca ataccaagat gctattcgag cccacaaggc aggccgagct gtggatgtgg
     1201 ctgagctccc agtgccccca ggcttccccc caattcaggg cttggagtct gcggagcctt
     1261 ctcagcagag cctggtggga gtcctagaaa ccgccatgaa gcttgccaac cacgaagaag
     1321 gctcagatga ggaagaggaa gagactccaa agaagaacac ccctgctgcc tccacagccc
     1381 agccgaaggc ctcgccctcc agggcacctc catcaggacc agccccagca ggcaaagctg
     1441 cttccaaggg cacctccacc agggcccagc agcagctggc cttcctggag ggccgtaaga
     1501 agcagctcct tcaggctgcg ctgcgcgcca agcaaaagaa cgacgtagag ggcgccaaga
     1561 tgcatctgcg ccaggccaaa gggctggagc ccatgctaga ggcctcccgc aatggactgc
     1621 ctgtggatat tgccaaggtg ccacctgctc ctgtcaacaa ggatgatttt gtgctggtcc
     1681 agcggcctgg cccaggcatg tctcaggagg ccgtgcgtcg ctatggggag cttaccaagc
     1741 tcctgagaca gcaacatgaa atgtgtctaa accactccac acagttcacc cacctgggca
     1801 acattgctga aaccattaag ttcgagaagc tggcagaaga ctgtaagcgg agcatggaca
     1861 ccttaaaaca agccttcgcc cgcagtctgc ccacacctgc agcccgcttt gagcaaagga
     1921 ccttcagtgt catcaagatc tttccggact tgagcaacaa cgacatgctc ctgtttattg
     1981 tgaagggcat caacttgccc acacccccag gactgtcccc cagtgacctg gatgcctttg
     2041 tccgcttcga cttcccttat cccaatgtgg aggaagctca gaaagataag accagcgtga
     2101 tcaaaagcac agactcccct gaattcaagg agcagttcaa actctgcatc aaccgtggcc
     2161 accgtggctt ccgaagggcc atccaaacca agggcatcaa gttcgaagtg gtccacaagg
     2221 ggggattatt taagactgac agggtgctgg ggacagccca gctgaagctg gatacattgg
     2281 aaacagcttg tgaggtccac gagatcctgg aggttttgga tggccgccgg cccacagggg
     2341 gtcgccttga ggtgatggtc cgcatccggg agccactgac agcccagcag ttggagacta
     2401 caactgagag gtggctggtc attgatcaca tcccagcagc tgtgcccact gtcactgggc
     2461 ccaaagcaaa ggttcctctc atacctgcgt cttcaaagga agcaggcaac agatcatcac
     2521 ggcccctgca tagccttagt gtgctggcct ttgaccaaga gcggctagaa aggaagatcc
     2581 tggccctgag gcaggcacgc cggcctgtac ctccagaagt ggcccagcag taccaggacg
     2641 tagtacagcg tagccagtgg cagagggcac agctggagca gggaggtgct gccctccgca
     2701 gggagtatgc aagccatctg gagcgccagc tgcacttcta tacagaggct gcccggcgcc
     2761 tgggctatga cggaagcagg gaggccgcga aggaggcatt gtaccggcgg aacctggtgg
     2821 agagtgagct gcagcgactc cgcaggtgag gcccatcctg gaccacagcc tgatgccagg
     2881 cagagctcca gggccaccga agagacaagc agacaatcag tggacaatca gtggttctgg
     2941 gctccccctg tccgggcccc cggccctagg ggcatcagga cagcacctca ccccagcctg
     3001 gctggtcggg ccttggagag tcctgtttgc acatccagga gcgtctggag caaggagagt
     3061 agctaggaca cgagcccaga gggccctgca agcactttac ttcctgccct tcccatcgtt
     3121 gaccccaaag atacctctga ggctgtcaag ctcagctgac tctctaagga ctgtgctgac
     3181 cccgctgccc ctcaccccca gggccaacac agaatgaaca gccaaggcca aaaaaaaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaaaaa
//
