LOCUS       NM_145676                465 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chibby 1, beta catenin antagonist (Cby1), mRNA.
ACCESSION   NM_145676
VERSION     NM_145676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Enjolras,C., Thomas,J., Chhin,B., Cortier,E., Duteyrat,J.L.,
            Soulavie,F., Kernan,M.J., Laurencon,A. and Durand,B.
  TITLE     Drosophila chibby is required for basal body formation and
            ciliogenesis but not for Wg signaling
  JOURNAL   J Cell Biol 197 (2), 313-325 (2012)
   PUBMED   22508513
REFERENCE   3  (bases 1 to 465)
  AUTHORS   Steere,N., Chae,V., Burke,M., Li,F.Q., Takemaru,K. and Kuriyama,R.
  TITLE     A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the
            distal end of mother centrioles and functions in primary cilia
            formation
  JOURNAL   PLoS One 7 (7), e41077 (2012)
   PUBMED   22911743
REFERENCE   4  (bases 1 to 465)
  AUTHORS   Mokhtarzada,S., Yu,C., Brickenden,A. and Choy,W.Y.
  TITLE     Structural characterization of partially disordered human Chibby:
            insights into its function in the Wnt-signaling pathway
  JOURNAL   Biochemistry 50 (5), 715-726 (2011)
   PUBMED   21182262
REFERENCE   5  (bases 1 to 465)
  AUTHORS   Voronina,V.A., Takemaru,K., Treuting,P., Love,D., Grubb,B.R.,
            Hajjar,A.M., Adams,A., Li,F.Q. and Moon,R.T.
  TITLE     Inactivation of Chibby affects function of motile airway cilia
  JOURNAL   J Cell Biol 185 (2), 225-233 (2009)
   PUBMED   19364920
REFERENCE   6  (bases 1 to 465)
  AUTHORS   Li,F.Q., Singh,A.M., Mofunanya,A., Love,D., Terada,N., Moon,R.T.
            and Takemaru,K.
  TITLE     Chibby promotes adipocyte differentiation through inhibition of
            beta-catenin signaling
  JOURNAL   Mol Cell Biol 27 (12), 4347-4354 (2007)
   PUBMED   17403895
REFERENCE   7  (bases 1 to 465)
  AUTHORS   Singh,A.M., Li,F.Q., Hamazaki,T., Kasahara,H., Takemaru,K. and
            Terada,N.
  TITLE     Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates
            cardiomyocyte differentiation of murine embryonic stem cells
  JOURNAL   Circulation 115 (5), 617-626 (2007)
   PUBMED   17261658
REFERENCE   8  (bases 1 to 465)
  AUTHORS   Jung,Y., Bang,S., Choi,K., Kim,E., Kim,Y., Kim,J., Park,J., Koo,H.,
            Moon,R.T., Song,K. and Lee,I.
  TITLE     TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving
            antagonistic activity of Chibby
  JOURNAL   Cancer Res 66 (2), 723-728 (2006)
   PUBMED   16424001
REFERENCE   9  (bases 1 to 465)
  AUTHORS   Hidaka,S., Konecke,V., Osten,L. and Witzgall,R.
  TITLE     PIGEA-14, a novel coiled-coil protein affecting the intracellular
            distribution of polycystin-2
  JOURNAL   J Biol Chem 279 (33), 35009-35016 (2004)
   PUBMED   15194699
REFERENCE   10 (bases 1 to 465)
  AUTHORS   Takemaru,K., Yamaguchi,S., Lee,Y.S., Zhang,Y., Carthew,R.W. and
            Moon,R.T.
  TITLE     Chibby, a nuclear beta-catenin-associated antagonist of the
            Wnt/Wingless pathway
  JOURNAL   Nature 422 (6934), 905-909 (2003)
   PUBMED   12712206
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145676.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393211.1, BF547681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                JAXUCZ010000007.1  113097312-113097355
            45-159              JAXUCZ010000007.1  113099385-113099499
            160-265             JAXUCZ010000007.1  113101714-113101819
            266-384             JAXUCZ010000007.1  113101898-113102016
            385-465             JAXUCZ010000007.1  113102979-113103059
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..465
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /note="chibby 1, beta catenin antagonist"
                     /db_xref="GeneID:246768"
                     /db_xref="RGD:708481"
     exon            1..44
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..159
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..465
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /note="PIGEA-14; PKD2 interactor, Golgi and endoplasmic
                     reticulum-associated 1; cytosolic leucine-rich protein;
                     PKD2 interactor, golgi and endoplasmic reticulum
                     associated 1; chibby homolog 1; chibby family member 1,
                     beta catenin antagonist"
                     /codon_start=1
                     /product="protein chibby homolog 1"
                     /protein_id="NP_663709.1"
                     /db_xref="GeneID:246768"
                     /db_xref="RGD:708481"
                     /translation="MPLFGSIFSPKKTPPRKSASLSNLHSLDRSTRELELGLDYGTPT
                     MNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEENNLLRLKVDILLDML
                     SETTAESHLKDKELDELKITNRRRK"
     exon            160..265
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..384
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..465
                     /gene="Cby1"
                     /gene_synonym="Pgea1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaaccct gagggctagc tctggactct ggctttgcac acaggagaaa gaagtgccag
       61 tgtctcctca ttgagtcagg gatgcctctc tttgggagca tattcagccc gaagaagact
      121 cctcctcgga agtcggcctc tctctctaac ctgcactctt tagatcggtc aacgcgagaa
      181 ctggagctgg gtcttgacta tggaactcct accatgaacc tggcggggca aagcctgaag
      241 tttgaaaatg gccagtgggt ggcagactca gtgattagtg ggggtgtgga ccggagggaa
      301 actcagcgcc tgcgcaaacg aaaccagcag ttggaagaag agaacaatct cctgcggctg
      361 aaggtggaca tcctgctgga catgctttca gaaaccactg ctgagtccca cttaaaggac
      421 aaggaactgg atgaactgaa gattaccaac cgcaggagga agtga
//
