LOCUS       NM_199117               3195 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus chromobox 7 (Cbx7), mRNA.
ACCESSION   NM_199117 XM_343292
VERSION     NM_199117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3195)
  AUTHORS   Jiang,W., Yan,Z., Zheng,X., Huang,S., Hu,Y., Xiong,F., He,B.,
            Wu,Y., Fu,Q., Li,Z. and Zhou,B.
  TITLE     Targeting the Ferroptosis and Endoplasmic Reticulum Stress
            Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion
            Injury
  JOURNAL   Cell Biochem Biophys 82 (3), 2171-2181 (2024)
   PUBMED   38809351
  REMARK    GeneRIF: Targeting the Ferroptosis and Endoplasmic Reticulum Stress
            Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion
            Injury.
REFERENCE   2  (bases 1 to 3195)
  AUTHORS   Zhang,F., Lei,F. and Xiao,X.
  TITLE     Knockdown of CBX7 inhibits ferroptosis in rats with cerebral
            ischemia and improves cognitive dysfunction by activating the
            Nrf2/HO-1 pathway
  JOURNAL   J Biosci 47 (2022)
   PUBMED   36222130
  REMARK    GeneRIF: Knockdown of CBX7 inhibits ferroptosis in rats with
            cerebral ischemia and improves cognitive dysfunction by activating
            the Nrf2/HO-1 pathway.
REFERENCE   3  (bases 1 to 3195)
  AUTHORS   Crea,F., Di Paolo,A., Liu,H.H., Polillo,M., Clermont,P.L.,
            Guerrini,F., Ciabatti,E., Ricci,F., Barate,C., Fontanelli,G.,
            Barsotti,S., Morganti,R., Danesi,R., Wang,Y., Petrini,M.,
            Galimberti,S. and Helgason,C.D.
  TITLE     Polycomb genes are associated with response to imatinib in chronic
            myeloid leukemia
  JOURNAL   Epigenomics 7 (5), 757-765 (2015)
   PUBMED   26343356
REFERENCE   4  (bases 1 to 3195)
  AUTHORS   Klauke,K., Broekhuis,M.J.C., Weersing,E., Dethmers-Ausema,A.,
            Ritsema,M., Gonzalez,M.V., Zwart,E., Bystrykh,L.V. and de Haan,G.
  TITLE     Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic
            stem cells by cellular barcoding
  JOURNAL   Stem Cell Reports 4 (1), 74-89 (2015)
   PUBMED   25434821
REFERENCE   5  (bases 1 to 3195)
  AUTHORS   Monaco,M., Chiappetta,G., Aiello,C., Federico,A., Sepe,R.,
            Russo,D., Fusco,A. and Pallante,P.
  TITLE     CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hurthle
            Cell Adenomas and Carcinomas)
  JOURNAL   Eur Thyroid J 3 (4), 211-216 (2014)
   PUBMED   25759796
REFERENCE   6  (bases 1 to 3195)
  AUTHORS   Pallante,P., Federico,A., Berlingieri,M.T., Bianco,M., Ferraro,A.,
            Forzati,F., Iaccarino,A., Russo,M., Pierantoni,G.M., Leone,V.,
            Sacchetti,S., Troncone,G., Santoro,M. and Fusco,A.
  TITLE     Loss of the CBX7 gene expression correlates with a highly malignant
            phenotype in thyroid cancer
  JOURNAL   Cancer Res 68 (16), 6770-6778 (2008)
   PUBMED   18701502
REFERENCE   7  (bases 1 to 3195)
  AUTHORS   Cheng,M.C., Liao,D.L., Hsiung,C.A., Chen,C.Y., Liao,Y.C. and
            Chen,C.H.
  TITLE     Chronic treatment with aripiprazole induces differential gene
            expression in the rat frontal cortex
  JOURNAL   Int J Neuropsychopharmacol 11 (2), 207-216 (2008)
   PUBMED   17868501
REFERENCE   8  (bases 1 to 3195)
  AUTHORS   Scott,C.L., Gil,J., Hernando,E., Teruya-Feldstein,J., Narita,M.,
            Martinez,D., Visakorpi,T., Mu,D., Cordon-Cardo,C., Peters,G.,
            Beach,D. and Lowe,S.W.
  TITLE     Role of the chromobox protein CBX7 in lymphomagenesis
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5389-5394 (2007)
   PUBMED   17374722
REFERENCE   9  (bases 1 to 3195)
  AUTHORS   Bernstein,E., Duncan,E.M., Masui,O., Gil,J., Heard,E. and
            Allis,C.D.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
REFERENCE   10 (bases 1 to 3195)
  AUTHORS   Gil,J., Bernard,D., Martinez,D. and Beach,D.
  TITLE     Polycomb CBX7 has a unifying role in cellular lifespan
  JOURNAL   Nat Cell Biol 6 (1), 67-72 (2004)
   PUBMED   14647293
  REMARK    Erratum:[Nat Cell Biol. 2022 Sep;24(9):1445. doi:
            10.1038/s41556-022-00956-2.. PMID: 35941232]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On May 28, 2010 this sequence version replaced NM_199117.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062392.1, SRR26643291.21266.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN06680416 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000007.1  113358070-113358346 c
            278-321             JAXUCZ010000007.1  113356283-113356326 c
            322-387             JAXUCZ010000007.1  113349232-113349297 c
            388-454             JAXUCZ010000007.1  113346647-113346713 c
            455-527             JAXUCZ010000007.1  113343924-113343996 c
            528-3195            JAXUCZ010000007.1  113341030-113343697 c
FEATURES             Location/Qualifiers
     source          1..3195
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3195
                     /gene="Cbx7"
                     /note="chromobox 7"
                     /db_xref="GeneID:362962"
                     /db_xref="RGD:735027"
     exon            1..277
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..685
                     /gene="Cbx7"
                     /note="chromobox homolog 7"
                     /codon_start=1
                     /product="chromobox protein homolog 7"
                     /protein_id="NP_954548.1"
                     /db_xref="GeneID:362962"
                     /db_xref="RGD:735027"
                     /translation="MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEP
                     EEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLLLQESAAPDVLQATGDWEPVEQP
                     PEEEAEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRSGKL"
     exon            278..321
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            322..387
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            388..454
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            455..527
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            528..3195
                     /gene="Cbx7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctgggga aaacgttgcg caggttcaaa aatggaacgt cggcggcgtg agggagcact
       61 agaaggtgtg cgcgcgtgcg cgtgcgcgcc cggacgagcc tgacggggtc cccgccgtcc
      121 cgagcatcgc gcgcagcagc cgcggccccg cagctccacc cccggcccgg cccggtccgg
      181 tccggggccc actcgcccgc cgccccgcat ggagctgtca gccataggcg agcaggtgtt
      241 tgcggtggag agcatccgga agaagcgcgt gcggaagggc aaagttgaat atctggtgaa
      301 gtggaaagga tggcccccca aatacagcac atgggaacca gaggagcaca ttctggaccc
      361 tcgccttgtc atggcctacg aggagaagga ggagaaagac cgagcatcag ggtataggaa
      421 gagaggtccg aaacccaagc ggcttctgct gcaggaatca gcagcgccag atgtcctgca
      481 ggccactgga gactgggagc ctgtggagca gccccctgaa gaggaggcag aagcagacct
      541 gaccaatggg ccgcctccct ggacgcccat gctcccctca agtgaagtta ccgtgactga
      601 catcaccgcc aactccgtca cagtcacctt ccgcgaggct caagccgccg agggcttctt
      661 ccgagaccgc agtgggaagc tgtgaacagc ggctttccct cttaaactgt gtttcttggg
      721 gcttgggtga ggaattccag agacaggagg ggctgggagc agggtaaata ttttattttt
      781 ttaaaaaagc agaaacatgg ggaagacccc accaccctgc ccttgcttca tgagggttgt
      841 ttacaaagag gcctctggga aagggtggga aggccagtgc tgtttgggtc tcatctccag
      901 ggcagatggg gacaggctac ccttcccagt attcctctgt cattatcttt cagaggctga
      961 tccttggagt tggaggagcc caggaggtcc agaccttgcc tcaagcagtc accccagctt
     1021 tctggtggtg tccctccctg ttcctttact atgaactttc cactccagct ttgtggtggg
     1081 acatggagat tggccttggc taccaaggac aagatcagga cagtgggccg gaccagggaa
     1141 gaggctgctc accaagcctc tgaatgtgct gtctccccga cattggcctg tgcacaatct
     1201 ctagatggct ggagcacatc cagccgcccc aatgtgcaca cacggcgtgt gtgttcacac
     1261 ctgccctgtg tctatagacc tgtccatgtg gaccttgcac acctttagaa actgaccagg
     1321 tgaacacggc gtcattcaca gcacaaacga acttgccgtg gcacccttgc tccacctcgc
     1381 atgtacgtca catgacagga tcggtctctg ttggtttgca gctgtcagca tgtaatctcc
     1441 gagcctcggt caggaccggg cttggtgtgc aaggtgcaga agcttccaca caggctcaca
     1501 gacacctggc ccaccctgcc tcccacagga gttcacgttc tttctgactc aggtgacttt
     1561 ccagccccac cccttcctct cccctcccct ggtgtgtggg cagtcaggga gggggtgtcc
     1621 caccactttc tcagggcagt ccttatcttc tctgtcaccc ccacccccac ccaacctgaa
     1681 tggcacagct taggacgacc cctcacatct cgtggggatt gagttatatg agtcaggtgt
     1741 gtggtcctgg tggtgggggg cggtttgcta gtttgcacag gtgccctata ggctgacacc
     1801 ttcctgccag gggaagggcc cctcccttgt tgagggcaca ctgctctctc agccctgcta
     1861 ccataggaac ctatgtggtg gggtcatagc agctaccagt tctgctgtgt ctttagggcg
     1921 ccagcagggt ctgtatgagc aagggtagga tgacttactt ttagacactc ccgttcccaa
     1981 accaaagatc ctgtaccctg tgtctgtctg ggattctgtc ctctaccttc tctagtccct
     2041 ggtctccctc tccttaattc tcagttgtcc agggctatct cagtgcttcc attgagggca
     2101 gtcttctgtg ggtgacctga atctggaggg tttctgggtg ggcctgggac aggaggagcc
     2161 ttagtcagtg gcctccagga gcctgggagt ggggagaagc tgggtgttct tgagctcctg
     2221 gagagaaggt gagggtgggt ggctgaagct tttctttgct gttggatttg atggcccaca
     2281 atactggggg acagcatcct gttgatgtca tgctccccat ccctaggggc atgagactaa
     2341 atacctgtac agttccatcc tgaggctcca ggaggctttc caggcagctg tcttctgtct
     2401 ttagcagtag gcagtgtcct tttctctcac ggggcccttt gtgcaaccca ccagttcctg
     2461 gagagtatgg cctaagctgg gtatccctca gggtggccat gtcactctgg actgctggaa
     2521 actggccacc tagggagaat ggctgaaggc ttcgagtggc tacacaggct tctcccagcc
     2581 caaagctacc caagtggaca gtgacctcct ccacccacat acactaaccc cttacagggc
     2641 cagtacagag caatgagtgg tggccaccag cctgtgtttt ccctggctcc actcatctga
     2701 atgtagagat tgggttgttc tccctcactg ggttggggtg aagacacgcc tcagcctctg
     2761 gtgtggactc ttgcagtgcc acagttgagc ccatccaggc catgtggttc tcgtctgtta
     2821 agacggtgat cttattgcca agctcctctc gcctcctgcc cactgaggga ggagctcagt
     2881 gtcggtgagg tggggtcgac tttgctttat aaacggcggg cccgacctgg ccaccaggtc
     2941 tcagcacaag accgcttcct ttgcacagaa tgagctacga gctttgttca gactacctga
     3001 atgtattggg aggaatcggg cataggcctt cccctggggg gtatgtgctg ggaagggtca
     3061 gcaagtgtag accgcagttt tatttttgta ctgatattgg tgagagacta tatcatctat
     3121 ttatttaggt gatttatctg gtaggtgagg caaaaaatta tcaaaaaaat acattaaaat
     3181 gactttagaa actta
//
