LOCUS       NM_001401046            5439 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chromobox 6 (Cbx6), transcript variant 1, mRNA.
ACCESSION   NM_001401046 XM_006241994
VERSION     NM_001401046.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5439)
  AUTHORS   Gil,J. and O'Loghlen,A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   2  (bases 1 to 5439)
  AUTHORS   Li,G., Warden,C., Zou,Z., Neman,J., Krueger,J.S., Jain,A.,
            Jandial,R. and Chen,M.
  TITLE     Altered expression of polycomb group genes in glioblastoma
            multiforme
  JOURNAL   PLoS One 8 (11), e80970 (2013)
   PUBMED   24260522
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5439)
  AUTHORS   Simon,J.A. and Kingston,R.E.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   4  (bases 1 to 5439)
  AUTHORS   Vandamme,J., Volkel,P., Rosnoblet,C., Le Faou,P. and Angrand,P.O.
  TITLE     Interaction proteomics analysis of polycomb proteins defines
            distinct PRC1 complexes in mammalian cells
  JOURNAL   Mol Cell Proteomics 10 (4), M110.002642 (2011)
   PUBMED   21282530
REFERENCE   5  (bases 1 to 5439)
  AUTHORS   Bernstein,E., Duncan,E.M., Masui,O., Gil,J., Heard,E. and
            Allis,C.D.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006241994.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.40969.1,
                                           SRR26643293.42100.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000007.1  113263319-113263413 c
            96-139              JAXUCZ010000007.1  113263093-113263136 c
            140-205             JAXUCZ010000007.1  113262887-113262952 c
            206-272             JAXUCZ010000007.1  113262697-113262763 c
            273-5439            JAXUCZ010000007.1  113253364-113258530 c
FEATURES             Location/Qualifiers
     source          1..5439
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5439
                     /gene="Cbx6"
                     /note="chromobox 6"
                     /db_xref="GeneID:315136"
                     /db_xref="RGD:1307314"
     exon            1..95
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1271
                     /gene="Cbx6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chromobox protein homolog 6; chromobox homolog 6"
                     /codon_start=1
                     /product="chromobox protein homolog 6 isoform 1"
                     /protein_id="NP_001387975.1"
                     /db_xref="GeneID:315136"
                     /db_xref="RGD:1307314"
                     /translation="MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEP
                     EENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPS
                     ASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGNPGLRPPISPFSETVRII
                     NRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSES
                     MLRTQIRHMKFGTFALYKPPPAPLVPSTAGKADVASSGPGLLLATPAAAPFDAHSSSS
                     SGCPSPTLQSSDPDDAPPKLLPETISRSASNWRESEVLDLSIPPEAAATGQRVPPDVT
                     AAAGQALHTVLEATGTGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPED
                     FEKVAAGVAGATGGGGGTGPSK"
     exon            96..139
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            140..205
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            206..272
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
     exon            273..5439
                     /gene="Cbx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggctgtg ggtgccgctg agcaagatgg agctgtctgc agtaggcgag cgggtcttcg
       61 cggccgaatc catcatcaaa cgccggatcc gaaagggacg catcgagtac ctggtgaaat
      121 ggaaagggtg ggcgatcaag tacagcactt gggagccaga ggagaacatt ctggattcga
      181 ggctcatcgc agccttcgag cagaaggaaa gggaacgtga gctgtatggg cccaagaaga
      241 ggggacctaa acccaaaact ttcctcctaa aggcccgggc ccaggcggag gccctccgca
      301 tcagtgatgt gcatttctct gtcaagccaa gcgccagcgc ctcctcgccc aagctgcact
      361 ccagcgctgc ggtgcaccgg ctcaagaaag acatccgccg ctgccaccgt atgtcccgcc
      421 gccccctgcc acgaccagac ccacaagggg gtaaccctgg cctgcgccca cccatctcgc
      481 ccttttctga gaccgtgcgc atcatcaacc gcaaggtgaa gccccgggaa cccaagcgga
      541 accgcatcat cctgaacctg aaggtgattg acaagggccc gggaggtggc agcactgccc
      601 agggcaccgg ggcactggcc cgcccgaaag tcccctcgcg gaaccgggtc attgggaaga
      661 gcaagaagtt cagcgagagc atgctccgca cccagatccg ccacatgaag tttggcacct
      721 ttgcactcta caagccccct cccgcccctc tggtgccctc tactgcgggc aaagctgacg
      781 tggcctcctc ggggcctggg ctgctcctgg ccaccccagc tgctgccccc tttgacgcac
      841 acagctctag ctcttccggc tgcccctcac ccacactgca gtcctctgac ccagatgatg
      901 caccacccaa gctcctcccc gagaccataa gccgatctgc gtccaactgg cgagagtcag
      961 aggtgctcga tctgtccatc cctcctgagg cagctgccac cggccagcgg gtgcctcctg
     1021 atgtcactgc tgctgcgggc caggcgctac acacagttct ggaggccaca ggtaccggct
     1081 cctccgagcc tgaggctggg gactggcgcc ccgagatgtc gccatgctcc aatgtagtcg
     1141 tcacagatgt caccagcaac ctcctgaccg tgaccatcaa ggaattctgc agccctgagg
     1201 atttcgagaa ggtggctgct ggggtggcag gtgctacagg gggtgggggt ggcactgggc
     1261 caagtaagtg aggagcttcc tcaaggaggg aggctttggg gggcctcctt ccaggagttg
     1321 tacttgtgct cccaccctat ccctgccctc agacccgtat gcctgtgctt tgcttgcctc
     1381 gaacggctca gtgttgaccc agggatggtg ctggcagtcc tggacttggt cggggccctg
     1441 gtagggcaca ggaaggaagc tctgctccct ggtgtccctg ccactgtccc tgattgtgca
     1501 ggtggggccc actaggtggt ttctggggaa tccccagaac ttggggttca cctatcctat
     1561 ccacacccca ccctgcctct cctagcttgc ttcttgctct gtgtgcagtg tctggtctcg
     1621 gtgctatctt ggtatctgca gggcccctag gagatcccac ctagggcggg cacagtctct
     1681 tagtaccacc tggcactgag tgaaggatga ggccaaaatg ggtccctccc tcgacaccat
     1741 tgagggtggt ggcagctggg ccagaggtcc cctctcctgc ttgcctacat gtggaccagg
     1801 cccgtgcaga tctcctgccc cacacactgt ctctatccaa accccccttt gaaggtggag
     1861 gggctggcag acatggcacc gagccacagc ctctgggcat ctgaaaaccc cttccgtctt
     1921 ctaccaaagg tgctgcaagg acctgctgta gaggcttctg gccgtgcatg tgtttgcccc
     1981 tggcccattc ttgtgtagat ccatgtgtgt gttgggtgca gggccttagc tctccctgca
     2041 acacccttta cggttctcct cagaacaggg tcgctaaagg cgtggcctcc gttgccttaa
     2101 ccaggcctgg cacagtccag tctgtggttt gtcgtggaag ccacaggcct ctccaatccc
     2161 aggttgctgg gggatgtgga gccctcagtc ccttctcggg atggtcctct tgaaggtcag
     2221 accttcactg cagacatggc gcagtaggga ctgtggcaga ggaggagccc agctgcagcc
     2281 tcttgttgca gatgtttgtg gaggaaagag gaggcccaga gacctcccag gggtcttcag
     2341 tttcccccac tcctcccgtt tgcttttaac tgctgaggct tcctaacagt ctggcctgtt
     2401 ggaagacttc gggtgccttg ggcagcttct acctgccctc tgctgctagg gaaccgaggc
     2461 atccatgcca atggcaggca gagaccaaag ccccagattt aggcagagag gggagagagg
     2521 gtagaagtgt ctgtgttcaa aagagaggga ggtgcccatc cccaggcagc actgggagtc
     2581 cattggccta cccttggcca ctgcctggga gtcacctggg tgttgaatgg catgttcctg
     2641 tgtgtagtct gagctggctt ctggtgttca cagcctttgg taccttgctc agaagcatgg
     2701 gaagaggcag gaccacgtga tctaaggaca agtattctgg tctttgggga agctacttct
     2761 ccttaccatt cccctgccag ggtctgcagc acagccccag cccccttgcc ccagggtata
     2821 aaacaggggc tctcacaggg tttgagaggg atacagtccg gtcccaccct gtcctgtgtt
     2881 agctcccata ccgtccaagt gccaattggc ttttccccca aataagggct ggtatttcgc
     2941 ctctgtcccc aggggcgatt tccccctccc ccttccccag gtgagccacc acctgggtgc
     3001 cagttacagg tgtttgcaga gaccatagaa atgtgttttc ctgagagtct gtgtcatttg
     3061 tgaccttttt ttgtaaagaa gttgtgtttg cagaggcgat tttatgacag gaaagtgaaa
     3121 gagttagttt tgcagaaaaa aaagaaaaaa aaagaaaaaa attttaaaaa gtaaaaaaaa
     3181 aagaaagaaa agagaaaaat attaaaaaaa aaaccatcat aggactccta agagtgcgag
     3241 gctgggggga gaaagctatt taagaagaac gtatcaacgc agcgattgca caggtgaggt
     3301 ggcaatgttg gggtggggtg gaggcctgcg ctagccggtg ggctccctgg gatagaaggc
     3361 acacagaggt ggtcactgtc ctccttcctt gacagcaggc aggatgagtc tgttgtgact
     3421 taggagcatg cttccacttg cttggaagga tggcaccagt cctaaggtaa cttgcaggaa
     3481 gctcggggga caggcaggtg gcggtagtgg gcctcggagg gaccgactca ctgttggtgc
     3541 ctttccgccg aaaggcttcc cctccgtgag cttttgtcag ctctctgggt cacgtggttc
     3601 ccagcagctc caccgacact ctaacgaccc aggcgccttt gagcatccct ggttaggagg
     3661 agggatgcag gcttcagaaa gtggctgacg gagtaatctc ctcgctcatg cacaaggcct
     3721 caaggtgcac ggacccaggg aagatgtggg cccgccagcg agcagacccc tttcctctcc
     3781 tgaatggtca ggagcaggag gcccagaggc tgcacagact cctacacagc cctgcaccat
     3841 cagcctactg caggcccctc ccccacccct gctgcttttc atttgcctac ttaccaagca
     3901 gaagttgcag tccctgtttg ctttattttt gtatgtgaaa tgaccccctc ccccctacag
     3961 gtcatgcctt gtaagcgcat ccttcccacc cacttgtcag gaaacaggag tgggtgagtt
     4021 ctgcgtcttg ggttttgaga cggagggttg ggacccatcc ctcttgtgga tcttgctctg
     4081 atctcagtca gtccctctgt gaaagggctg gacaaggcag tgaggcctca gcacgaagca
     4141 ctctggggct tccagctgcc cagcctgagc gaaccgaatg tgcctccctc cctggcttca
     4201 gtgggagctg atgggatgga gggcgttgtc tcatttcaaa ggaggctgaa ctacttcacg
     4261 ggagtctggc tggcaacttc agagccctgg ctgtcctggc ttttaaaggg aaaggtggga
     4321 ctctggggct ggtgtaggct ggagggttgt ccctagcaga cactaggtca gtcaaggatg
     4381 ggctggcctg gtctctgggg acctgagagg gcaaactcac cccttcttac tttaatggtt
     4441 tgttgggttt ttcttggttt ttatgtttct tgtttctctt tttcttcctt tgttttgttt
     4501 tttgcacttc atgaatggtg gagcccagcc tggtcagctc tacccttggg ttccagtgca
     4561 ctagaccaag gtagcctctc tggggcttct atggttcaag gactcacttt tttaaaagat
     4621 aagagaaaat ttaagggttt tagttttgtt ctgtctgctt ctcttcttgg ttcagaaagc
     4681 ctagagagtg tggttacccc cttctgacag acatttgaga aacaaaaaca ggtacctggt
     4741 caggtggggg ctcgggaccc cacttcccag cctacagttc cctccgtcct taaaggagtc
     4801 agggttccac tccagctgat gcagagcacc agtcatgtga tggaaccaga gggtatgaag
     4861 gggccaagtg gtgggggtca gacgctgggc acccctgggc tgaggggagg aagcaggcat
     4921 ctttttgttg cttttaactt aaagacacaa aggcctaaag aaatatgtat cttataattt
     4981 ttttaatttt taagaagctc atttgatgaa ctgcacgaat ggattctata tatatatata
     5041 tataatatac gtacatagct ctatatttgg ggacgggcac tgtctctttt ctctcgcatt
     5101 ttaaagatga agtgtctttg cctttgtctg tggttcaacc atccagctcc cagctggcta
     5161 aactttgcct ccagtggtta acggcaggaa cgtactaaag ctggccaacg gaggaagggg
     5221 cggggcctca gtctgccctg ccccctgggg aggagctcca gtggggaaga tagcttattt
     5281 tggatgtggg ttcggtagat ctgggccagg ggagggcggg ctcgtgctga tcactctgtc
     5341 ttgtacgttt tgttctgctg ctcttcaata ttgtatcgat gccaggaaag ggggtgaaac
     5401 ctccttcacc cccaaataaa ttgtcacatt ccgaagcta
//
