LOCUS       NM_001008313            1745 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus chromobox 3 (Cbx3), mRNA.
ACCESSION   NM_001008313 XM_216146
VERSION     NM_001008313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S,
            Windebank A, Iovanna J, Lomberk G and Urrutia R.
  TITLE     Mechanisms Underlying the Regulation of HP1gamma by the NGF-PKA
            Signaling Pathway
  JOURNAL   Sci Rep 8 (1), 15077 (2018)
   PUBMED   30305677
  REMARK    GeneRIF: these results describe the regulation and participation of
            HP1gamma in a novel membrane-to-nucleus pathway, through NGF-PKA
            signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1745)
  AUTHORS   Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G,
            Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L and
            Washburn MP.
  TITLE     WDR76 Co-Localizes with Heterochromatin Related Proteins and
            Rapidly Responds to DNA Damage
  JOURNAL   PLoS One 11 (6), e0155492 (2016)
   PUBMED   27248496
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1745)
  AUTHORS   Duong HA and Weitz CJ.
  TITLE     Temporal orchestration of repressive chromatin modifiers by
            circadian clock Period complexes
  JOURNAL   Nat Struct Mol Biol 21 (2), 126-132 (2014)
   PUBMED   24413057
REFERENCE   4  (bases 1 to 1745)
  AUTHORS   Rosnoblet C, Vandamme J, Volkel P and Angrand PO.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   5  (bases 1 to 1745)
  AUTHORS   Bose R, Moors M, Tofighi R, Cascante A, Hermanson O and Ceccatelli
            S.
  TITLE     Glucocorticoids induce long-lasting effects in neural stem cells
            resulting in senescence-related alterations
  JOURNAL   Cell Death Dis 1 (11), e92 (2010)
   PUBMED   21368868
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1745)
  AUTHORS   Kourmouli N, Theodoropoulos PA, Dialynas G, Bakou A, Politou AS,
            Cowell IG, Singh PB and Georgatos SD.
  TITLE     Dynamic associations of heterochromatin protein 1 with the nuclear
            envelope
  JOURNAL   EMBO J 19 (23), 6558-6568 (2000)
   PUBMED   11101528
REFERENCE   7  (bases 1 to 1745)
  AUTHORS   Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R,
            Gansmuller A, Chambon P and Losson R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   8  (bases 1 to 1745)
  AUTHORS   Everett RD, Earnshaw WC, Pluta AF, Sternsdorf T, Ainsztein AM,
            Carmena M, Ruchaud S, Hsu WL and Orr A.
  TITLE     A dynamic connection between centromeres and ND10 proteins
  JOURNAL   J Cell Sci 112 (Pt 20), 3443-3454 (1999)
   PUBMED   10504293
REFERENCE   9  (bases 1 to 1745)
  AUTHORS   Lehming N, Le Saux A, Schuller J and Ptashne M.
  TITLE     Chromatin components as part of a putative transcriptional
            repressing complex
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7322-7326 (1998)
   PUBMED   9636147
REFERENCE   10 (bases 1 to 1745)
  AUTHORS   Ye Q and Worman HJ.
  TITLE     Interaction between an integral protein of the nuclear envelope
            inner membrane and human chromodomain proteins homologous to
            Drosophila HP1
  JOURNAL   J Biol Chem 271 (25), 14653-14656 (1996)
   PUBMED   8663349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC086601.1.
            
            On Dec 26, 2004 this sequence version replaced NM_001008313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086601.1, BC127508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1745
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /note="chromobox 3"
                     /db_xref="GeneID:297093"
                     /db_xref="RGD:1549705"
     exon            1..40
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            41..93
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..621
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /note="HP1 gamma; heterochromatin protein 1 gamma;
                     chromobox homolog 3 (HP1 gamma homolog, Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 3"
                     /protein_id="NP_001008314.2"
                     /db_xref="GeneID:297093"
                     /db_xref="RGD:1549705"
                     /translation="MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGK
                     VEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDS
                     KSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKC
                     PQIVIAFYEERLTWHSCPEDEAQ"
     exon            94..236
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            237..399
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            400..494
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            495..1718
                     /gene="Cbx3"
                     /gene_synonym="Hp1-gamma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagactct gcaggatccg cggccctgag catctgagcg ctcttcaagt ctccgattaa
       61 attttaaaaa tggcctccaa taaaactaca ttgcaaaaaa tgggaaagaa acagaatgga
      121 aagagtaaaa aagttgaaga ggcagagcct gaagaatttg tggtagaaaa agtactggac
      181 cgtcgtgtag tgaatgggaa ggtggagtat ttcctgaagt ggaaggggtt cacagatgct
      241 gataatactt gggaaccaga agaaaattta gattgtccag aattaattga agcatttctt
      301 aattctcaaa aagctggtaa agaaaaagat ggtacaaaaa ggaaatcttt atctgacagt
      361 gaatctgatg atagcaaatc gaagaagaag agagatgctg ctgacaagcc caggggcttt
      421 gccaggggcc ttgaccctga gcgaataatc ggtgccacag acagcagtgg agagctaatg
      481 tttctcatga aatggaagga ctcagatgaa gctgacttgg tgctggcaaa ggaggcgaat
      541 atgaagtgtc ctcagattgt catcgccttc tatgaggaga ggctgacttg gcattcttgt
      601 cccgaagatg aagcacaata attgtttgca tttatatata tatatttata tatatatata
      661 tataatctgg atcttgggtt ttgaattact agtgtggaaa aaatagcatt ctaatgaaaa
      721 tcaagtttga tatgctggtt ttgaaagtat tgacagtagt tgggatattt ttggtttttg
      781 ttctgcatca aaaggcactg attcctttga gcaagtgaga gctttctgta gttgcttcct
      841 ttaacagtag aatatttgat accatgttgt atttcctcag ctttgaagaa cagcttttct
      901 taattgctgg ggagatttta cagtcattac tcaagtcaga acttattttt aactgggaca
      961 cagaaggacc attctgggtt tttttgtttg tttgttcgta tgcagtgtat gcataaaaca
     1021 cttacataac ctgtctgttt tatctttttt ttaatactca aaagaactga atgtgaaaac
     1081 gcaagttgat gagattccat caccgtgaat gttctcctga aaccataacc tttcagaata
     1141 agcagagtct gtaatttatt ggatagttta tttacagaat gttgtccata ccaacacccc
     1201 ttcaggaaat ggaattagac aacatagtag tatgatttaa tagcaagact tggccgagta
     1261 tggtggtgtg cacctttaat cccagaactc tggaggcaga tagagctctg atttaagagg
     1321 cccctggtct acagaggcag gtctaggtca gtgggtctgt gtaaaggttc ctctggtgaa
     1381 ccattccttt gtaggacgtt aaaatctgta ctaaaaggtt atgattcatg gaatctgttt
     1441 gatgtggaaa tagaatcatg gttggagctg atgttggcga tttaagacct gctgactaag
     1501 tgagtgaaca aaatttgcta atatcaatta gtgccctgca tgcctttcct ttaccctgac
     1561 tcattcctta cgggtaggat caatcttttc agtatttgca ttctggttca attagccaga
     1621 aaaggaactt tgtagtgtca gaatgtcatc caactgtata tttactttat tgtaaataat
     1681 ggtgaacagt ggtcaataaa tagttttata ttcctttaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaa
//
