LOCUS       NM_001107071            3751 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus chromobox 2 (Cbx2), mRNA.
ACCESSION   NM_001107071 XM_001081755 XM_221185
VERSION     NM_001107071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Wang T, Dai L, Shen S, Yang Y, Yang M, Yang X, Qiu Y and Wang W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Gil J and O'Loghlen A.
  TITLE     PRC1 complex diversity: where is it taking us?
  JOURNAL   Trends Cell Biol 24 (11), 632-641 (2014)
   PUBMED   25065329
  REMARK    Review article
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Parris TZ, Aziz L, Kovacs A, Hajizadeh S, Nemes S, Semaan M, Chen
            CY, Karlsson P and Helou K.
  TITLE     Clinical relevance of breast cancer-related genes as potential
            biomarkers for oral squamous cell carcinoma
  JOURNAL   BMC Cancer 14, 324 (2014)
   PUBMED   24885002
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Simon JA and Kingston RE.
  TITLE     Occupying chromatin: Polycomb mechanisms for getting to genomic
            targets, stopping transcriptional traffic, and staying put
  JOURNAL   Mol Cell 49 (5), 808-824 (2013)
   PUBMED   23473600
  REMARK    Review article
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Norling A, Hirschberg AL, Iwarsson E, Wedell A and Barbaro M.
  TITLE     CBX2 gene analysis in patients with 46,XY and 46,XX gonadal
            disorders of sex development
  JOURNAL   Fertil Steril 99 (3), 819-826 (2013)
   PUBMED   23219007
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Bernstein E, Duncan EM, Masui O, Gil J, Heard E and Allis CD.
  TITLE     Mouse polycomb proteins bind differentially to methylated histone
            H3 and RNA and are enriched in facultative heterochromatin
  JOURNAL   Mol Cell Biol 26 (7), 2560-2569 (2006)
   PUBMED   16537902
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P and
            Kingston RE.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Katoh-Fukui Y, Tsuchiya R, Shiroishi T, Nakahara Y, Hashimoto N,
            Noguchi K and Higashinakagawa T.
  TITLE     Male-to-female sex reversal in M33 mutant mice
  JOURNAL   Nature 393 (6686), 688-692 (1998)
   PUBMED   9641679
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Alkema MJ, Jacobs J, Voncken JW, Jenkins NA, Copeland NG, Satijn
            DP, Otte AP, Berns A and van Lohuizen M.
  TITLE     MPc2, a new murine homolog of the Drosophila polycomb protein is a
            member of the mouse polycomb transcriptional repressor complex
  JOURNAL   J Mol Biol 273 (5), 993-1003 (1997)
   PUBMED   9367786
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Schoorlemmer J, Marcos-Gutierrez C, Were F, Martinez R, Garcia E,
            Satijn DP, Otte AP and Vidal M.
  TITLE     Ring1A is a transcriptional repressor that interacts with the
            Polycomb-M33 protein and is expressed at rhombomere boundaries in
            the mouse hindbrain
  JOURNAL   EMBO J 16 (19), 5930-5942 (1997)
   PUBMED   9312051
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001107071.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001107071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.68315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JACYVU010000220.1  61103404-61103527
            125-168             JACYVU010000220.1  61103605-61103648
            169-234             JACYVU010000220.1  61104516-61104581
            235-340             JACYVU010000220.1  61107278-61107383
            341-3751            JACYVU010000220.1  61108825-61112235
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..3751
                     /gene="Cbx2"
                     /note="chromobox 2"
                     /db_xref="GeneID:303730"
                     /db_xref="RGD:1588561"
     exon            1..124
                     /gene="Cbx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1624
                     /gene="Cbx2"
                     /note="chromobox homolog 2 (Pc class homolog, Drosophila)"
                     /codon_start=1
                     /product="chromobox protein homolog 2"
                     /protein_id="NP_001100541.1"
                     /db_xref="GeneID:303730"
                     /db_xref="RGD:1588561"
                     /translation="MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWE
                     PEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKHTVMSSCSRRSKLKEPDAPS
                     KSKSSSSSSSSTSSSSSSDEEEEDDDDSDLDSKRGSRGRETHPVPQKKAQILVAKPEL
                     KDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLVTSAPKLPPPLSAPVAGLAAL
                     KAHTKEACGGPSTMATPENLASLMKGMAGSPSRGGISWQSSIVHYMNRMSQSQAQAAS
                     RLALKAQAANKCSLGPDLKVRTQKGELGVNPAGSKVPKAPGSVAAEQQRGNNSGSPGS
                     QLPPTQELSLQVLDLQSVKNGVPGVGLPARHATATKAIPATNTATGKGPGSGPTGVNV
                     TNAPTDTSKGEKLTCKTAALPAPSVKRDAAKSIAASGGQEGHTVPGEGQKPPALCELS
                     TGEENSSSDSDPDSSSLPSAGQNLSVAVQTSQDWKPTRSLIEHVFVTDVTANLITVTV
                     KESPTSVGFFNLKHY"
     exon            125..168
                     /gene="Cbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..234
                     /gene="Cbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..340
                     /gene="Cbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..3751
                     /gene="Cbx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgcagcag taagccgggg tctgcggggc gcgggccgcg gcgggcggcg gcatggagga
       61 gctgagcagc gtgggcgagc aggtcttcgc cgccgagtgc atcctgagca agaggctccg
      121 caagggcaag ctggagtacc tggtcaagtg gcgcggctgg tcctccaaac acaacagctg
      181 ggagcccgaa gagaacatct tggacccgag gctgctcctg gccttccaga agaaggaaca
      241 tgagaaggag gtgcagaacc ggaaaagagg caagaggccc aggggcaggc caaggaagca
      301 cacagtcatg tcctcctgca gccggcgctc caagctcaag gaaccagatg caccgtccaa
      361 gtccaaatcc agcagttcat cctcttcctc cacatcttcc tcctcttcct cagatgaaga
      421 agaagaagac gacgacgaca gtgacctgga ctccaagagg ggatcccggg gccgtgaaac
      481 ccacccggtc cctcagaaaa aagcccagat cctggtagcc aagccagagc tgaaggatcc
      541 catccgaaag aagcgcggac gcaagcctct acccccggaa cagaaggcag ctcggagacc
      601 ggtaagcctg gccaaggtgc taaagaccac caggaaggac ctggtgacct cagcccccaa
      661 gctgccccct ccactcagtg ctcctgtggc aggcctggct gccttgaaag cccacaccaa
      721 agaggcctgt ggcggcccca gcactatggc aaccccagag aacctggcca gtctgatgaa
      781 aggcatggcc gggagcccca gccgaggcgg catcagctgg cagagttcta tcgtacacta
      841 catgaaccgc atgagccaga gtcaggctca ggccgccagc cggctggcgc tcaaggccca
      901 ggctgccaac aagtgcagcc tcgggccgga cctgaaagtg cggacgcaga aaggggagct
      961 aggggtgaac cccgcaggaa gcaaggttcc caaggcccct ggcagtgttg ctgcagagca
     1021 gcagagaggg aataattcgg ggagtccagg ttcccagctg ccacccactc aggagttgag
     1081 ccttcaggtc cttgacttac agagcgtcaa gaacggtgtg cccggtgtgg gcctgcctgc
     1141 tcgccatgcc acagccacca aggctattcc tgccaccaac acagccacgg ggaaaggtcc
     1201 tgggagcggc cccacaggag taaacgtgac caacgctccc acagacacca gcaaagggga
     1261 aaaactgact tgcaagacag cggctctgcc tgccccttct gtcaagaggg acgccgctaa
     1321 aagcattgct gcctctggtg ggcaggaggg ccacacagtc cccggagaag gtcagaagcc
     1381 acctgcactg tgtgaactga gcacaggaga ggagaacagc agttctgact cagaccccga
     1441 ctcatcctcg ctgcctagtg ctgggcagaa cctgtcggta gctgtccaga ccagccagga
     1501 ctggaaacct acccgaagtc tcatcgagca cgtcttcgtc acggatgtca cagccaacct
     1561 catcactgtc accgtgaagg agtcccccac cagtgtgggc ttcttcaact tgaagcatta
     1621 ttgagcccat tgcccaagtc agacctgcct tccagtctct ggttttgctt tgatgcttga
     1681 ccgggggggg gggggggggc agctctgcct tgtcctgaga ctctgggctg ggaaatggct
     1741 tcctgctgat tctacctctc tgggcctcca cttcagtctg tcctgtcacc tcaggaaagc
     1801 cgggtggcca ctgacttgaa agcaggctgc ttggaaaagg catttttttc tagagtccct
     1861 ccctgaccta gtgagaccct ccccatcgct gcccaactac caggaggtgg gtaaggggag
     1921 gggctgctga tagagctccc tccccaggcc agcgaggaga cgggtggggc tggcaggacc
     1981 ttctctcaag tccacccatg gcagagcctt tctggtgagg gagaggcact ctgtgctttg
     2041 caagtaaggc tatattgctt catttcttaa aaggataact agttgtgaag ttgggctcag
     2101 ggaccccgca gaactcttga gtctctctat ccctggtttg gcgtcctctc tagctgtgac
     2161 tgtagtccca gagcccagcc agggtttgga gttccagcac gaagatgtac ctgggtgtta
     2221 ctggacttgg gaacagaggg aatcgtgttg ttaccacctc cttcctgcag gcaggcctga
     2281 gcttcagtga gaagtgaccc tgttcccagg cccctgcttt ggcccactaa gttgtaccct
     2341 agttctgagg tctgacactc ctgggcttgg gggaggagtg gggctagaaa cccagagcag
     2401 gctaaagtag aagccaggag tcctgggtga gcaattttcc ccacagagtt tttttttttt
     2461 tttacaaggg tcccctaagt cgccacggta gctccagtgt gggaataaag gtgtttcatg
     2521 ggggcctgtc tagactggac atctctagac tgctgcgtaa gcatttcctg tagtcaatcc
     2581 tggtgcagag atccctacct ggtgagtgag ccactcttgg gtcccgtttt ccctgacaat
     2641 cctctcccgc gtttgggagc ttgtgtttcc ttcctccctg agaagcaata tccctatgcc
     2701 ttttgtgtgg tggggtagtt gggagcctac ctggcagagg gccctaattc cttccctctc
     2761 tttaggagac gagctagttc tgagctcctt accagatgcc ttctcccctg tcccccatcc
     2821 caggtagccg tcatgaaact accttgtcat attgctggcc gatgtcagga ttgtctgtcc
     2881 tggaatatcg ctgtgggcca tgacaatccg gtcagtgagt ctgtaatgcc aaaaagtggg
     2941 ggtggtgtga aacccttgtt tctacttctg ccattgactg atcagccagc gggtatgggc
     3001 tctcactcca gtggccttga agggaagtct ttccccttct aaaaccagcc agacaggggg
     3061 ctgaggtgtc cgggacctgc cgtgctttca gagtgcatcc cacccctgcc cccagtagct
     3121 cactctgcac accaaataag acagacggtc tttgtgtaac caaaccaacc tcagcactgt
     3181 gccttttggg gacagaccca catccatggc tcctgagagg tgcctgtgat gtgccagggg
     3241 gccatgtcac tggcagctgg agctaccggt gggaattcag gaccaagaag tgggtagcaa
     3301 ggagcaaaga gttacctact gggccatcgg cttccttccc tgcccccagc cagggtcctt
     3361 tgctgcctta cccaaggtct gcagcttctg tgtcagacac tgccttacag gcacctccat
     3421 gtcttttggg ggtcccatga gctattggag aagtgatggt gtttggggat ctgggttgac
     3481 tggcctttgt cccctgctgc cagtctccaa aaaccctgat ttggtgcctt tttaatttta
     3541 ctggttatgt aagtcccaaa gttgaaatct acaaatcctt tcctctcagc cactttgcct
     3601 tctcgtgttt ttctttcctg gtgctgtgac ctcagcggtc tgttacaaag catacgtgtg
     3661 tagtgtgccg gcgtgagagc cccactggag cggcaccata cgctccgagt caagttctcg
     3721 tgtttaccaa taaataaagt agttggtttt t
//
