LOCUS       NP_036654                547 aa            linear   ROD 28-APR-2025
DEFINITION  cystathionine beta-synthase [Rattus norvegicus].
ACCESSION   NP_036654
VERSION     NP_036654.2
DBSOURCE    REFSEQ: accession NM_012522.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 547)
  AUTHORS   Liu,C.Y., Al-Ward,H., Liu,N., Mekontso,F.N., Chen,W., Gao,W.,
            Zhang,C., Murshed,A., Yu,Z.R., Fan,O., Sun,Y.E. and Xu,H.
  TITLE     The Role of Cystathionine-beta-Synthase, H2S, and miRNA-377 in
            Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal
            Studies
  JOURNAL   J Mol Neurosci 73 (11-12), 921-931 (2023)
   PUBMED   37864623
  REMARK    GeneRIF: The Role of Cystathionine-beta-Synthase, H2S, and
            miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human
            and Animal Studies.
REFERENCE   2  (residues 1 to 547)
  AUTHORS   Panagaki,T., Lozano-Montes,L., Janickova,L., Zuhra,K., Szabo,M.P.,
            Majtan,T., Rainer,G., Marechal,D., Herault,Y. and Szabo,C.
  TITLE     Overproduction of hydrogen sulfide, generated by cystathionine
            beta-synthase, disrupts brain wave patterns and contributes to
            neurobehavioral dysfunction in a rat model of down syndrome
  JOURNAL   Redox Biol 51, 102233 (2022)
   PUBMED   35042677
  REMARK    GeneRIF: Overproduction of hydrogen sulfide, generated by
            cystathionine beta-synthase, disrupts brain wave patterns and
            contributes to neurobehavioral dysfunction in a rat model of down
            syndrome.
REFERENCE   3  (residues 1 to 547)
  AUTHORS   Mishra,S., Kumar,G., Chhabra,A., Sethy,N.K., Jain,N., Meena,R.N.,
            Tulsawani,R., Prasad,D.N., Kumar,B. and Sharma,M.
  TITLE     Cysteine becomes conditionally essential during hypobaric hypoxia
            and regulates adaptive neuro-physiological responses through
            CBS/H2S pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (7), 165769 (2020)
   PUBMED   32184133
  REMARK    GeneRIF: Cysteine becomes conditionally essential during hypobaric
            hypoxia and regulates adaptive neuro-physiological responses
            through CBS/H2S pathway.
REFERENCE   4  (residues 1 to 547)
  AUTHORS   Saini,V., Chinta,K.C., Reddy,V.P., Glasgow,J.N., Stein,A.,
            Lamprecht,D.A., Rahman,M.A., Mackenzie,J.S., Truebody,B.E.,
            Adamson,J.H., Kunota,T.T.R., Bailey,S.M., Moellering,D.R.,
            Lancaster,J.R. Jr. and Steyn,A.J.C.
  TITLE     Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration,
            growth and pathogenesis
  JOURNAL   Nat Commun 11 (1), 557 (2020)
   PUBMED   31992699
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 547)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 547)
  AUTHORS   Hu,F.L., Gu,Z., Kozich,V., Kraus,J.P., Ramesh,V. and Shih,V.E.
  TITLE     Molecular basis of cystathionine beta-synthase deficiency in
            pyridoxine responsive and nonresponsive homocystinuria
  JOURNAL   Hum Mol Genet 2 (11), 1857-1860 (1993)
   PUBMED   7506602
REFERENCE   7  (residues 1 to 547)
  AUTHORS   Swaroop,M., Bradley,K., Ohura,T., Tahara,T., Roper,M.D.,
            Rosenberg,L.E. and Kraus,J.P.
  TITLE     Rat cystathionine beta-synthase. Gene organization and alternative
            splicing
  JOURNAL   J Biol Chem 267 (16), 11455-11461 (1992)
   PUBMED   1597473
REFERENCE   8  (residues 1 to 547)
  AUTHORS   Ishihara,S., Morohashi,K., Sadano,H., Kawabata,S., Gotoh,O. and
            Omura,T.
  TITLE     Molecular cloning and sequence analysis of cDNA coding for rat
            liver hemoprotein H-450
  JOURNAL   J Biochem 108 (6), 899-902 (1990)
   PUBMED   2089036
REFERENCE   9  (residues 1 to 547)
  AUTHORS   Doi,T., Kawata,T., Tadano,N., Iijima,T. and Maekawa,A.
  TITLE     Effect of vitamin B12-deficiency on the activity of hepatic
            cystathionine beta-synthase in rats
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 35 (2), 101-110 (1989)
   PUBMED   2732804
REFERENCE   10 (residues 1 to 547)
  AUTHORS   Allsop,J. and Watts,R.W.
  TITLE     Methionine adenosyltransferase, cystathionine beta-synthase and
            cystathionine gamma-lyase activity of rat liver subcellular
            particles, human blood cells and mixed white cells from rat bone
            marrow
  JOURNAL   Clin Sci Mol Med Suppl 48 (6), 509-513 (1975)
   PUBMED   1056281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M88344.1, D01098.1, M88346.1, M88345.1 and AA997754.1.
            
            On Oct 12, 2007 this sequence version replaced NP_036654.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D01098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..547
                     /product="cystathionine beta-synthase"
                     /EC_number="4.2.1.22"
                     /note="beta-thionase; hemoprotein H-450; serine
                     sulfhydrase"
                     /calculated_mol_wt=59973
     Region          73..540
                     /region_name="cysta_beta"
                     /note="cystathionine beta-synthase; TIGR01137"
                     /db_xref="CDD:273464"
     CDS             1..547
                     /gene="Cbs"
                     /coded_by="NM_012522.2:145..1788"
                     /db_xref="GeneID:24250"
                     /db_xref="RGD:2287"
ORIGIN      
        1 mpsgtsqced gsagcpqdle vqpekgqlek gasgdkervw ispdtpsrct wqlgrpmads
       61 phyhtvptks pkilpdilrk igntpmvrin risknaglkc ellakceffn aggsvkdris
      121 lrmiedaera gtlkpgdtii eptsgntgig lalaaavkgy rciivmpekm smekvdvlra
      181 lgaeivrtpt narfdspesh vgvawrlkne ipnshildqy rnasnplahy ddtaeeilqq
      241 cdgkvdmlva sagtggtitg iarklkekcp gckiigvdpe gsilaepeel nqteqtayev
      301 egigydfipt vldravvdrw fksndddsfa farmlisqeg llcggssgsa mavavkaaqe
      361 lkegqrcvvi lpdsvrnyms kflsdkwmlq kgfmkeelsv krpwwwhlrv qelslsaplt
      421 vlptvtceht iailrekgfd qapvvnesga ilgmvtlgnm lssllagkvr psdevckvly
      481 kqfkpihltd tlgmlshile mdhfalvvhe qiqyrnngvs skqlmvfgvv taidllnfva
      541 areqtrk
//
