LOCUS       NM_182672               1187 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus carbonyl reductase 4 (Cbr4), mRNA.
ACCESSION   NM_182672 XM_579723
VERSION     NM_182672.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1187)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1187)
  AUTHORS   Venkatesan,R., Sah-Teli,S.K., Awoniyi,L.O., Jiang,G., Prus,P.,
            Kastaniotis,A.J., Hiltunen,J.K., Wierenga,R.K. and Chen,Z.
  TITLE     Insights into mitochondrial fatty acid synthesis from the structure
            of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA
            dehydrogenase
  JOURNAL   Nat Commun 5, 4805 (2014)
   PUBMED   25203508
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1187)
  AUTHORS   Bains,O.S., Grigliatti,T.A., Reid,R.E. and Riggs,K.W.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   4  (bases 1 to 1187)
  AUTHORS   Endo,S., Matsunaga,T., Kitade,Y., Ohno,S., Tajima,K., El-Kabbani,O.
            and Hara,A.
  TITLE     Human carbonyl reductase 4 is a mitochondrial NADPH-dependent
            quinone reductase
  JOURNAL   Biochem Biophys Res Commun 377 (4), 1326-1330 (2008)
   PUBMED   19000905
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY305858.1.
            
            On Aug 31, 2012 this sequence version replaced NM_182672.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY305858.1, BC086378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1187              AY305858.1         2-1188
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     gene            1..1187
                     /gene="Cbr4"
                     /note="carbonyl reductase 4"
                     /db_xref="GeneID:359725"
                     /db_xref="RGD:727826"
     exon            1..246
                     /gene="Cbr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..815
                     /gene="Cbr4"
                     /EC_number="1.1.1.100"
                     /EC_number="1.6.5.10"
                     /note="carbonyl reductase family member 4; quinone
                     reductase CBR4; carbonic reductase 4; KAR beta subunit;
                     3-ketoacyl-[acyl-carrier-protein] reductase beta subunit"
                     /codon_start=1
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="NP_872613.1"
                     /db_xref="GeneID:359725"
                     /db_xref="RGD:727826"
                     /translation="MDKVCAVFGGSRGIGKAVAQLMAQKGYRLAIVARNLEVAKATAS
                     ELGGIHLAFRCNIAKEGDVHSTFEEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDMLS
                     QLHTNLLGTMLTCRAAMRTMIQQGGSIVNVGSIIGLKGNVGQAAYSATKGGLIGFSRS
                     LAKEVARKKIRVNVVAPGFIHTDMTKHLKEEHFKKNIPLGRFGEALEVAHAVVFLLES
                     PYITGHVLIVDGGLQLTA"
     exon            247..367
                     /gene="Cbr4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..501
                     /gene="Cbr4"
                     /inference="alignment:Splign:2.1.0"
     exon            502..636
                     /gene="Cbr4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1170
                     /gene="Cbr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtcggtt gttcaaagag cttgttgaat tgtttttcca gttgttgtgc ctttattata
       61 agttctgtgt cttagggatc catcttgccg gtccgaggtc caagatggac aaagtctgtg
      121 cggtttttgg aggctcccgg ggcatcggca aggctgtagc ccagctaatg gcccagaagg
      181 gttaccgcct ggcgatcgtc gccagaaact tggaagtggc caaagccact gcgagcgagc
      241 tcggcggaat ccacttggca tttaggtgca acattgccaa agaaggagat gttcacagta
      301 catttgaaga gatggagaaa catttaggtc cagtaaattt cttggtaaat gcagctggta
      361 ttaacagaga cagtctttta gtaagaacaa aaactgaaga tatgctgtct cagcttcata
      421 ccaacctctt gggcaccatg ctgacctgca gagccgctat gaggacaatg attcagcagg
      481 gcgggtctat tgttaatgtc gggagtatta ttggtttaaa aggcaatgtg ggccaggccg
      541 catatagtgc caccaaagga gggcttatcg ggttttcacg ctcgcttgct aaagaggttg
      601 cccggaagaa aatcagagtg aatgtggttg caccaggatt tattcacacg gatatgacaa
      661 aacacttgaa agaagaacat ttcaagaaaa acatccctct tgggaggttt ggagaagctc
      721 ttgaggtggc acatgccgtt gtgtttcttt tagagtcacc atacatcaca ggacatgttc
      781 ttatcgtgga tggaggatta cagctcactg cctaattaga gatgatatta ctgtaatggt
      841 gatctggatc aagcacacat tttcctatta attagacaat catatctata tgggtgacat
      901 ttgctaatgg aaacaaatta gctaatggat actacaaatg attccttcca tctttgtatg
      961 aacatgtctc aaaacaaagt gtgactagtt gtaatctaaa aggtgtgaag tctctgtctt
     1021 tacaggcagc agcagtttta gtgcatggac attctgtaag ggctacacat cagtattaat
     1081 ttctacattt ttgccttgga agtagaaaat tctgttgtct aattgtgata tacctgtatc
     1141 aagccggatg ttaaagactt cagccttcta aaaaaaaaaa aaaaaaa
//
