LOCUS       NM_001107110            1175 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carbonyl reductase 3 (Cbr3), mRNA.
ACCESSION   NM_001107110 XM_001055098 XM_221641
VERSION     NM_001107110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Karanges,E.A., Kashem,M.A., Sarker,R., Ahmed,E.U., Ahmed,S., Van
            Nieuwenhuijzen,P.S., Kemp,A.H. and McGregor,I.S.
  TITLE     Hippocampal protein expression is differentially affected by
            chronic paroxetine treatment in adolescent and adult rats: a
            possible mechanism of 'paradoxical' antidepressant responses in
            young persons
  JOURNAL   Front Pharmacol 4, 86 (2013)
   PUBMED   23847536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Swaminathan,S., Huentelman,M.J., Corneveaux,J.J., Myers,A.J.,
            Faber,K.M., Foroud,T., Mayeux,R., Shen,L., Kim,S., Turk,M.,
            Hardy,J., Reiman,E.M. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative  and  NIA-LOAD/NCRAD
            Family Study Group
  TITLE     Analysis of copy number variation in Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   PLoS One 7 (12), e50640 (2012)
   PUBMED   23227193
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Thorn,C.F., Oshiro,C., Marsh,S., Hernandez-Boussard,T., McLeod,H.,
            Klein,T.E. and Altman,R.B.
  TITLE     Doxorubicin pathways: pharmacodynamics and adverse effects
  JOURNAL   Pharmacogenet Genomics 21 (7), 440-446 (2011)
   PUBMED   21048526
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Miura,T., Itoh,Y., Takada,M., Tsutsui,H., Yukimura,T., Nishinaka,T.
            and Terada,T.
  TITLE     Investigation of the role of the amino acid residue at position 230
            for catalysis in monomeric carbonyl reductase 3
  JOURNAL   Chem Biol Interact 178 (1-3), 211-214 (2009)
   PUBMED   18983987
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Mordente,A., Meucci,E., Silvestrini,A., Martorana,G.E. and
            Giardina,B.
  TITLE     New developments in anthracycline-induced cardiotoxicity
  JOURNAL   Curr Med Chem 16 (13), 1656-1672 (2009)
   PUBMED   19442138
  REMARK    Review article
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Miura,T., Nishinaka,T. and Terada,T.
  TITLE     Different functions between human monomeric carbonyl reductase 3
            and carbonyl reductase 1
  JOURNAL   Mol Cell Biochem 315 (1-2), 113-121 (2008)
   PUBMED   18493841
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Ohkura-Hada,S., Kondoh,N., Hada,A., Arai,M., Yamazaki,Y.,
            Shindoh,M., Kitagawa,Y., Takahashi,M., Ando,T., Sato,Y. and
            Yamamoto,M.
  TITLE     Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced
            Cytostatis and is a Potential Prognostic Marker for Oral Malignancy
  JOURNAL   Open Dent J 2, 78-88 (2008)
   PUBMED   19088887
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474083.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055098.1, XM_221641.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234106.1, BC166553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1175
                     /gene="Cbr3"
                     /note="carbonyl reductase 3"
                     /db_xref="GeneID:304078"
                     /db_xref="RGD:1309728"
     exon            1..400
                     /gene="Cbr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..945
                     /gene="Cbr3"
                     /EC_number="1.1.1.184"
                     /EC_number="1.6.5.10"
                     /note="quinone reductase CBR3; monomeric carbonyl
                     reductase 3"
                     /codon_start=1
                     /product="carbonyl reductase [NADPH] 3"
                     /protein_id="NP_001100580.1"
                     /db_xref="GeneID:304078"
                     /db_xref="RGD:1309728"
                     /translation="MSSCSRVALVTGANKGIGFAITRDLCRKFSGDVVLTARDEARGR
                     AAVKQLQAEGLSPRFHQLDIDNPQSIRALRDFLRKEYGGLNVLVNNAGIAFRMDDPTP
                     FDVQAEVTLKTNFFATRNVCTELLPIMKPHGRVVNVSSLQGLKALENCSEDLQERFRC
                     DTLTEGDLVDLMKKFVEDTKNEVHEREGWPDSAYGVSKLGVTVLTRILARQLDEKRKA
                     DRILLNACCPGWVKTDMARDQGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQT
                     W"
     exon            401..508
                     /gene="Cbr3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..1175
                     /gene="Cbr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagtcgca gcgcccagtt ccagaatcaa gtcctacgcc agggttctga ccacggcgtg
       61 acccgctgcc cagccggtct gacagtccgg tggtccgtgt gtccctctga catgtcgtcc
      121 tgcagccgcg tggccctggt gactggggct aacaaaggca tcggcttcgc gatcacgcgt
      181 gacctgtgtc ggaaattctc gggggacgtg gtgctcacgg cgcgggacga ggcgcggggc
      241 cgcgcagcgg tgaagcagct gcaggcggag ggcctgagcc cacgcttcca ccagctggac
      301 atcgacaacc cgcagagcat ccgcgcgctg cgcgactttc tgcgcaagga gtacggagga
      361 cttaacgtgc tggtcaacaa tgcgggcatc gcctttagaa tggatgatcc aacgcccttc
      421 gacgttcaag ctgaggtgac actgaagacg aacttctttg ccactagaaa tgtctgcacc
      481 gagctgctgc ccataatgaa accacatggt agagtggtga atgtcagcag tctgcagggg
      541 ttaaaagccc ttgaaaactg cagcgaagat cttcaggaaa ggttccgatg tgacacactt
      601 accgaggggg atctggtcga cctcatgaaa aagtttgtgg aggacacaaa aaatgaagtc
      661 cacgagagag aaggttggcc agactcagct tacggggtgt ccaagctggg cgtgacagtc
      721 cttacgagaa tcctggcccg gcagctggac gagaagagga aagcggacag gattttgctg
      781 aatgcctgct gcccgggatg ggtgaagacc gacatggcga gggaccaggg ctccaggacc
      841 gtggaagagg gggcagaaac ccccgtttac ttggccctcc tgcctccaga tgccactgag
      901 cctcatggcc agctcgtccg tgacaaagtt gtgcaaacgt ggtgaacgtc tgctctgggg
      961 cttaacagtt tgataaacgt tagcgtgaga gatgaatgca ggctggtgcg gtttggtttt
     1021 tttccccacg aggaggagga aggtccgttt ctctctgtgg ctctacaagc tcaatctgaa
     1081 caatttgctt tgtccaaact ctcttagctc gcggtgtttt catccagtta atgtgcctgc
     1141 tttgtttttc aaattaaaaa gatttatttg tttta
//
