LOCUS       NM_001012740            2385 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus cerebellin 2 precursor (Cbln2), mRNA.
ACCESSION   NM_001012740 XM_225659
VERSION     NM_001012740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Wang,E.L., Zhang,J.J., Luo,F.M., Fu,M.Y., Li,D., Peng,J. and Liu,B.
  TITLE     Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic
            pulmonary hypertension rats by activating
            NF-kappaB/HIF-1alpha/Twist1 pathway
  JOURNAL   Life Sci 328, 121879 (2023)
   PUBMED   37355224
  REMARK    GeneRIF: Cerebellin-2 promotes endothelial-mesenchymal transition
            in hypoxic pulmonary hypertension rats by activating
            NF-kappaB/HIF-1alpha/Twist1 pathway.
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Seigneur,E., Polepalli,J.S. and Sudhof,T.C.
  TITLE     Cbln2 and Cbln4 are expressed in distinct medial
            habenula-interpeduncular projections and contribute to different
            behavioral outputs
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10235-E10244 (2018)
   PUBMED   30287486
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Tao,W., Diaz-Alonso,J., Sheng,N. and Nicoll,R.A.
  TITLE     Postsynaptic delta1 glutamate receptor assembles and maintains
            hippocampal synapses via Cbln2 and neurexin
  JOURNAL   Proc Natl Acad Sci U S A 115 (23), E5373-E5381 (2018)
   PUBMED   29784783
  REMARK    GeneRIF: Findings demonstrate that hippocampal synapse assembly and
            maintenance require a tripartite molecular complex in which the
            ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and
            postsynaptic GluD1.
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Seigneur,E. and Sudhof,T.C.
  TITLE     Genetic Ablation of All Cerebellins Reveals Synapse Organizer
            Functions in Multiple Regions Throughout the Brain
  JOURNAL   J Neurosci 38 (20), 4774-4790 (2018)
   PUBMED   29691328
  REMARK    Erratum:[J Neurosci. 2024 May 22;44(21):e0793242024. doi:
            10.1523/JNEUROSCI.0793-24.2024.. PMID: 38749705]
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Matsuda,K. and Yuzaki,M.
  TITLE     Cbln family proteins promote synapse formation by regulating
            distinct neurexin signaling pathways in various brain regions
  JOURNAL   Eur J Neurosci 33 (8), 1447-1461 (2011)
   PUBMED   21410790
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Joo,J.Y., Lee,S.J., Uemura,T., Yoshida,T., Yasumura,M., Watanabe,M.
            and Mishina,M.
  TITLE     Differential interactions of cerebellin precursor protein (Cbln)
            subtypes and neurexin variants for synapse formation of cortical
            neurons
  JOURNAL   Biochem Biophys Res Commun 406 (4), 627-632 (2011)
   PUBMED   21356198
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   Iijima,T., Miura,E., Matsuda,K., Kamekawa,Y., Watanabe,M. and
            Yuzaki,M.
  TITLE     Characterization of a transneuronal cytokine family
            Cbln--regulation of secretion by heteromeric assembly
  JOURNAL   Eur J Neurosci 25 (4), 1049-1057 (2007)
   PUBMED   17331201
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Rucinski,M., Albertin,G., Spinazzi,R., Ziolkowska,A.,
            Nussdorfer,G.G. and Malendowicz,L.K.
  TITLE     Cerebellin in the rat adrenal gland: gene expression and effects of
            CER and [des-Ser1]CER on the secretion and growth of cultured
            adrenocortical cells
  JOURNAL   Int J Mol Med 15 (3), 411-415 (2005)
   PUBMED   15702230
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Wada,C. and Ohtani,H.
  TITLE     Molecular cloning of rat cerebellin-like protein cDNA which encodes
            a novel membrane-associated glycoprotein
  JOURNAL   Brain Res Mol Brain Res 9 (1-2), 71-77 (1991)
   PUBMED   1850079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091341.1.
            
            On Apr 20, 2005 this sequence version replaced XM_225659.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091341.1, CO393408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q13"
     gene            1..2385
                     /gene="Cbln2"
                     /note="cerebellin 2 precursor"
                     /db_xref="GeneID:291388"
                     /db_xref="RGD:1309715"
     exon            1..11
                     /gene="Cbln2"
                     /inference="alignment:Splign:2.1.0"
     exon            12..536
                     /gene="Cbln2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..854
                     /gene="Cbln2"
                     /note="cerebellin-2; cerebellin-like protein; cerebellin 2
                     precursor protein"
                     /codon_start=1
                     /product="cerebellin-2 precursor"
                     /protein_id="NP_001012758.1"
                     /db_xref="GeneID:291388"
                     /db_xref="RGD:1309715"
                     /translation="MPAPGRGPRGPLLSMPGRRGALREPADFGSSLGAALALLLLLLP
                     ACCPVKAQNDTEPIVLEGKCLVVCDSSPSGDGAVTSSLGISVRSGSAKVAFSATRSTN
                     HEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQV
                     SLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSG
                     FLVFPL"
     exon            537..656
                     /gene="Cbln2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2356
                     /gene="Cbln2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacgttcca ggtctgcagg tgccttcctt ctgagaatca tttggccttg accatctaag
       61 gcgaggacct accccagaga aagctactac tctagccctg cgtattcctg tgcgcaccca
      121 gccagccagc cctccggctt ctgcaggcct tgacctatac agggcgcccc ccagcccaga
      181 tgcccgctcc tggccggggc cccagagggc cgctgctgag catgcccggg cgccgggggg
      241 cgctgcgtga gccggccgac tttggctcca gcctgggggc ggcgctggcc ctgctgttgc
      301 tgctgctgcc cgcctgctgc ccggtaaagg ctcagaacga cacggagccc atcgtgctag
      361 agggcaagtg cctggtagtg tgcgattcca gtccatcggg ggatggcgct gtcacttctt
      421 ccctgggcat atctgtgcgc tcaggcagtg ccaaggtggc cttctccgct actcggagca
      481 ccaaccacga gccttcagag atgagcaacc gtaccatgac catctacttc gaccaggttt
      541 tagtaaacat tggcaaccac tttgaccttg cctcgagtat atttgtagca ccaaggaaag
      601 gaatttatag cttcagcttc cacgtggtca aagtgtacaa cagacaaact atccaggtca
      661 gtttaatgca gaacggctac ccggtgatct ctgcctttgc tggagaccag gatgttacca
      721 gggaagcagc cagcaatggt gttctgcttc tcatggaaag agaagacaaa gttcatctca
      781 aactggagag aggcaacctc atgggaggct ggaaatactc cacattctcg ggcttcttgg
      841 tttttcctct atagacacag agccaccagg atggtgggaa ggttttgatc aggacccagg
      901 gatctgcccc tgtaacacct tgaacttgtc tgactaggat ggcttgggcc gacttccatc
      961 agattattgc cgtagaagaa tgactttctt ctaaagctcc agtattttct ttgactattg
     1021 acaattcctc gggaacctgg ccgctaatta gttttagacg acaaggtctt aaggagaaat
     1081 gaaattattg atttgagcaa tttgtacctg tgattgtaaa gtcaatatcg gattttattg
     1141 ttgtaaccat tgacttaact tctcttgttt gtacattgta tcttgtcctg atgacataga
     1201 tgctgctgac cctcagatgg attgcacgct tcagtcaggg cttcaagagc ccagcaaaga
     1261 accacctacc agacagtctt tgacctgtgt tctgtgtgtg tgtagcctta agaaaaagaa
     1321 tggcttcatt ttcattctgt agctttcccc tagggttttg gggatattgg gagggagctg
     1381 ggcattggga acttgtcgaa aagtgcttta tcccgagaag caaaatttgc acgattggac
     1441 tgcagttttt gttttgtacc gtccgtgatt ttcttttttt cctctggaag ctttccttcc
     1501 cttcctcagg tttcactcct caaacctact tagttttcat gctggggtct cagagagggg
     1561 aaaaaaagaa caacaataac aacaaacaaa acagaacaaa acttaagttc agtccttgta
     1621 tgagatcaga ggaaacagaa caaaatctgc acactttgtt ttggataaag gaaaccgaga
     1681 atggaaaaag tctttatttc aaagtaagga cagcaaatag accattctgc atattcttcc
     1741 ctggagtctt tctcaatgca tcttcaaaat tgcaatgtgg attttatttt atttttttta
     1801 gattatactc tgggatccct tagtaacctg gcattgctct ttgctcatga atcccttaac
     1861 aatggcggag ctgacgtggc ctaatcccct ttgcttttcc tctggatatg tctcagtagt
     1921 gagttagagc tgcctccgag tggccacaca gttacaaggg atgcttcaaa gaaacaggac
     1981 cagtgtctct tcctggagat cttcctttga tctgtcaagg agagggttgt gttgactgac
     2041 tgatgctctg tggatgaaca tctggccaga agccacctgg actggaaatc tcagcagtta
     2101 aaggtactgg ctgctgtacc ccaagggtgg ctttccaaac cctgcttctt ttggcatctt
     2161 gtgctacaac actattaagt tgcaactgtg agagacctgg tgcggtattt gtgtgccaag
     2221 gaaatgtcac taatcccaaa gcaatcaaag atgtgacctc aaactggatg ttaatttgtc
     2281 ctttgtgtaa caatgtaacc aaaatattga tgataaaact cataatttaa gattcagaat
     2341 aaatggattt gacgtcaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
