LOCUS       NM_001109127            2444 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus cerebellin 1 precursor (Cbln1), mRNA.
ACCESSION   NM_001109127 XM_001067551 XM_574210
VERSION     NM_001109127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Rong,Y., Bansal,P.K., Wei,P., Guo,H., Correia,K., Parris,J. and
            Morgan,J.I.
  TITLE     Glycosylation of Cblns attenuates their receptor binding
  JOURNAL   Brain Res 1694, 129-139 (2018)
   PUBMED   29782851
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Seigneur,E. and Sudhof,T.C.
  TITLE     Genetic Ablation of All Cerebellins Reveals Synapse Organizer
            Functions in Multiple Regions Throughout the Brain
  JOURNAL   J Neurosci 38 (20), 4774-4790 (2018)
   PUBMED   29691328
  REMARK    Erratum:[J Neurosci. 2024 May 22;44(21):e0793242024. doi:
            10.1523/JNEUROSCI.0793-24.2024.. PMID: 38749705]
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Cheng,S., Seven,A.B., Wang,J., Skiniotis,G. and Ozkan,E.
  TITLE     Conformational Plasticity in the Transsynaptic
            Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex
  JOURNAL   Structure 24 (12), 2163-2173 (2016)
   PUBMED   27926833
  REMARK    GeneRIF: Results determined the crystal structures of the trimeric
            C1q-like domain of cerebellin-1, and the first complete ectodomain
            of GluD2. Cerebellin binds to the LNS6 domain of alpha- and
            beta-neurexin-1 through a high-affinity interaction that involves
            its highly flexible N-terminal domain.
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Wang,Y., Dong,J., Wang,Y., Wei,W., Song,B., Shan,Z., Teng,W. and
            Chen,J.
  TITLE     Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel
            Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of
            Neurexin1/Cbln1/GluD2 Tripartite Complex
  JOURNAL   Biol Trace Elem Res 173 (2), 465-474 (2016)
   PUBMED   27033232
  REMARK    GeneRIF: study supports the hypothesis that developmental
            hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which
            may be attributed to the downregulation of Neurexin1/Cbln1/GluD2
            tripartite complex.
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Elegheert,J., Kakegawa,W., Clay,J.E., Shanks,N.F., Behiels,E.,
            Matsuda,K., Kohda,K., Miura,E., Rossmann,M., Mitakidis,N.,
            Motohashi,J., Chang,V.T., Siebold,C., Greger,I.H., Nakagawa,T.,
            Yuzaki,M. and Aricescu,A.R.
  TITLE     Structural basis for integration of GluD receptors within synaptic
            organizer complexes
  JOURNAL   Science 353 (6296), 295-299 (2016)
   PUBMED   27418511
REFERENCE   6  (bases 1 to 2444)
  AUTHORS   Rucinski,M., Albertin,G., Spinazzi,R., Ziolkowska,A.,
            Nussdorfer,G.G. and Malendowicz,L.K.
  TITLE     Cerebellin in the rat adrenal gland: gene expression and effects of
            CER and [des-Ser1]CER on the secretion and growth of cultured
            adrenocortical cells
  JOURNAL   Int J Mol Med 15 (3), 411-415 (2005)
   PUBMED   15702230
REFERENCE   7  (bases 1 to 2444)
  AUTHORS   Pang,Z., Zuo,J. and Morgan,J.I.
  TITLE     Cbln3, a novel member of the precerebellin family that binds
            specifically to Cbln1
  JOURNAL   J Neurosci 20 (17), 6333-6339 (2000)
   PUBMED   10964938
REFERENCE   8  (bases 1 to 2444)
  AUTHORS   Albertin,G., Malendowicz,L.K., Macchi,C., Markowska,A. and
            Nussdorfer,G.G.
  TITLE     Cerebellin stimulates the secretory activity of the rat adrenal
            gland: in vitro and in vivo studies
  JOURNAL   Neuropeptides 34 (1), 7-11 (2000)
   PUBMED   10688962
REFERENCE   9  (bases 1 to 2444)
  AUTHORS   Burnet,P.W., Bretherton-Watt,D., Ghatei,M.A. and Bloom,S.R.
  TITLE     Cerebellin-like peptide: tissue distribution in rat and guinea-pig
            and its release from rat cerebellum, hypothalamus and cerebellar
            synaptosomes in vitro
  JOURNAL   Neuroscience 25 (2), 605-612 (1988)
   PUBMED   3399060
REFERENCE   10 (bases 1 to 2444)
  AUTHORS   Morgan,J.I., Slemmon,J.R., Danho,W., Hempstead,J., Berrebi,A.S. and
            Mugnaini,E.
  TITLE     Cerebellin and related postsynaptic peptides in the brain of normal
            and neurodevelopmentally mutant vertebrates
  JOURNAL   Synapse 2 (2), 117-124 (1988)
   PUBMED   3420533
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474037.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067551.1, XM_574210.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO405063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2444
                     /gene="Cbln1"
                     /note="cerebellin 1 precursor"
                     /db_xref="GeneID:498922"
                     /db_xref="RGD:1562813"
     CDS             1..582
                     /gene="Cbln1"
                     /note="cerebellin-1; precerebellin; cerebellin 1 precursor
                     protein"
                     /codon_start=1
                     /product="cerebellin-1 precursor"
                     /protein_id="NP_001102597.1"
                     /db_xref="GeneID:498922"
                     /db_xref="RGD:1562813"
                     /translation="MLGVVELLLLGAAWLAGPARGQNETEPIVLEGKCLVVCDSNPTS
                     DPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERS
                     TFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQ
                     MEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL"
     exon            1..264
                     /gene="Cbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..384
                     /gene="Cbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..2444
                     /gene="Cbln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgggcg tcgtggagct gctgttgttg ggggctgcgt ggctggcagg cccagcccgc
       61 gggcagaatg agacagaacc catcgtcctg gagggcaagt gcctggtggt gtgtgactcc
      121 aaccccacgt ccgaccctac gggcactgct ctgggcatct ctgtgcgctc gggcagcgcc
      181 aaggtggctt tctctgccat caggagcacc aaccatgagc cgtccgagat gagtaatcgc
      241 accatgatca tctacttcga ccaggtacta gtgaacatcg ggaacaactt tgactcagaa
      301 cgcagcactt tcatcgcccc gcgcaaaggc atctacagtt ttaacttcca cgtggtgaaa
      361 gtctacaaca gacagaccat ccaggtgagc ctcatgttga acggttggcc ggtgatttca
      421 gccttcgccg gcgaccaaga cgtgacacgc gaggctgcca gcaacggcgt cctcatccag
      481 atggagaaag gcgaccgagc atacctcaag ctggagcggg ggaacttgat ggggggctgg
      541 aagtactcaa ccttctctgg attcctcgtg tttcccctct gactggctcg tatcgggaat
      601 ggaggcagga gagaggcagg aggggagtga gaaagaggcc gaaaattacc agggcgagga
      661 agcggcgaca ccggaaactt cctacgtgtt cctagctaca ctgggtacca aggtgcgcgc
      721 cgcccgcggt ccaacttcgt ccgctccctt actaagagaa gtaaatttcg cttagctctg
      781 cacactcccg tttccaaaat tagtctcgcc tcccccaagc cagttgcagt aatcgaggaa
      841 gagactttgc cttgtcatta tggttcctta cccacgtcca tgtccctaac aattaacgaa
      901 gtaatgtgaa atgtttctcc cgacccgatc cccctctgaa ccctgccact tactgaaact
      961 tagtatgccc ccctgcccca gttcgaagag ggggtcagtt tggtttctgt ttgtttttga
     1021 atggggcagg tagttttaat aaacagattt tgctcttcaa acaccgcgcc agttaagctg
     1081 gagagaattc atcccccgct tattagcgga cgaaagactc accttcgtgg tgactggttt
     1141 aactatacat aaatacgtat catttgtaca cgaagagctc ttccaggtgg acgctggctg
     1201 tattccgtat ttctgtcctg ttcggagtga tcgtgaaatc taaggctgct tggtgtttgt
     1261 tctctgatgc ttgtcaatgc cccgtgttct gtggctccac caaacgccaa ggaggttctt
     1321 cgggactctt cttcctctgt aacatacgtg tgaatagcca aattttaatt ttgctttaat
     1381 ccaataaagt caaagtggga cttttatttt tctgaaacag ctttctgaac ttcgcctttt
     1441 ccgggttgcg aggttgaggt gggcggaaaa acaagatact tggaagctgc gaggagaggc
     1501 cagggcacaa ggccttcttc acaaagccat ttctgcgctg tctcccgcag caggctcgct
     1561 ttgccttccc tgtgtcccct gctttggtgc aatgtgagat atatgaccca aatcctacta
     1621 gccgtgactg agagcctgga agcaatctgt tgccctccct caattccaaa tgcatcagga
     1681 attattccca attctagtac tcgaacccgc ctgccccgcg tgacagtgtc ttcacgccta
     1741 ctttccttgg atgtctccag ctctctccgc tccgcggctc ccgaagcacc ttacactttg
     1801 taccagcgcc tctgaacctg aggtccaccc gccaaacaac ctcggcggcg gccagacttg
     1861 cgattgcgct cattcgtagg attttaaagg ggttcgtcca gaagttttga ttgtaccgaa
     1921 acataatgtg caaagcaaaa ttgaaataaa cgacttcgtt ttaagtctgg aaagctgacc
     1981 ctgtgttgaa cgcgggtgat gcaacgccag aagcgggcgg aagccaaggg tccaggactg
     2041 agatccgcga cccggtgggt tcctgtggta ctgggccctc ctccagggtt tttttgggtt
     2101 gagattcagt tttgagtttc agtggttctt gagtgagggg tggggaaagc aggggttaac
     2161 accaccgcag gcaaaatttc tggcatttct gtctcctgcc cccaacccca tccccagcgc
     2221 ttcacaagca cagcagtcct gggaacccag ctcctctttg tcgaccgcac agcttaaagt
     2281 gcttctggca gcagcgccct tcacagggct agggaccgag ggggccgtag gtgacaaaag
     2341 ggggttccga gggaatgtag tggaaccgcc ggtctcttcc attctcacag ttctggtgag
     2401 aggggcctta gggaattaaa tttttaaaaa ggtgaatttt tttt
//
