LOCUS       NM_001399563            3886 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Cbl proto-oncogene like 1 (Cbll1), transcript
            variant 1, mRNA.
ACCESSION   NM_001399563 XM_006239986
VERSION     NM_001399563.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3886)
  AUTHORS   Wen,J., Lv,R., Ma,H., Shen,H., He,C., Wang,J., Jiao,F., Liu,H.,
            Yang,P., Tan,L., Lan,F., Shi,Y.G., He,C., Shi,Y. and Diao,J.
  TITLE     Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic
            Stem Cell Self-Renewal
  JOURNAL   Mol Cell 69 (6), 1028-1038 (2018)
   PUBMED   29547716
REFERENCE   2  (bases 1 to 3886)
  AUTHORS   Yue,Y., Liu,J., Cui,X., Cao,J., Luo,G., Zhang,Z., Cheng,T., Gao,M.,
            Shu,X., Ma,H., Wang,F., Wang,X., Shen,B., Wang,Y., Feng,X., He,C.
            and Liu,J.
  TITLE     VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near
            stop codon and associates with alternative polyadenylation
  JOURNAL   Cell Discov 4, 10 (2018)
   PUBMED   29507755
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3886)
  AUTHORS   Mukherjee,M., Chow,S.Y., Yusoff,P., Seetharaman,J., Ng,C.,
            Sinniah,S., Koh,X.W., Asgar,N.F., Li,D., Yim,D., Jackson,R.A.,
            Yew,J., Qian,J., Iyu,A., Lim,Y.P., Zhou,X., Sze,S.K., Guy,G.R. and
            Sivaraman,J.
  TITLE     Structure of a novel phosphotyrosine-binding domain in Hakai that
            targets E-cadherin
  JOURNAL   EMBO J 31 (5), 1308-1319 (2012)
   PUBMED   22252131
REFERENCE   4  (bases 1 to 3886)
  AUTHORS   Fujita,Y., Krause,G., Scheffner,M., Zechner,D., Leddy,H.E.,
            Behrens,J., Sommer,T. and Birchmeier,W.
  TITLE     Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis
            of the E-cadherin complex
  JOURNAL   Nat Cell Biol 4 (3), 222-231 (2002)
   PUBMED   11836526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006239986.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.23539.1,
                                           SRR26643298.35121.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000006.1  53812751-53812785   c
            36-203              JAXUCZ010000006.1  53808299-53808466   c
            204-304             JAXUCZ010000006.1  53805819-53805919   c
            305-388             JAXUCZ010000006.1  53805424-53805507   c
            389-462             JAXUCZ010000006.1  53804545-53804618   c
            463-3886            JAXUCZ010000006.1  53798820-53802243   c
FEATURES             Location/Qualifiers
     source          1..3886
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3886
                     /gene="Cbll1"
                     /note="Cbl proto-oncogene like 1"
                     /db_xref="GeneID:314028"
                     /db_xref="RGD:1310703"
     exon            1..35
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1498
                     /gene="Cbll1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase Hakai; Casitas B-lineage
                     lymphoma-like 1; Cbl proto-oncogene-like 1, E3 ubiquitin
                     protein ligase; Cas-Br-M (murine) ecotropic retroviral
                     transforming sequence-like 1; Cbl proto-oncogene, E3
                     ubiquitin protein ligase-like 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Hakai isoform 1"
                     /protein_id="NP_001386492.1"
                     /db_xref="GeneID:314028"
                     /db_xref="RGD:1310703"
                     /translation="MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKVKPAPRT
                     QRTVSRMPAKAAQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKD
                     DTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTR
                     GSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPD
                     RFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRS
                     VSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHI
                     MPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHII
                     AQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMS
                     PGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ"
     exon            36..203
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..304
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..388
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..462
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..3886
                     /gene="Cbll1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtaccct gcgagccgaa tcatggatca cactgacaat gagttacaag gcactaatag
       61 ttctggatcc ttgggtggtc tcgatgtccg cagaagaatt cctataaaac tcatctccaa
      121 acaggccaac aaggttaagc ctgcccctcg gactcaaagg actgttagca ggatgcctgc
      181 aaaggccgca caaggtgatg aagaaggatt tgattataat gaagaacagc ggtatgactg
      241 taaagggggc gaactctttg gaaatcagcg aagatttccg ggacacctgt tttgggattt
      301 taagataaac atcttaggtg aaaaggatga tacaccagtt catttctgtg acaaatgtgg
      361 attgcccatt aaagtctatg gaagaatgat tccatgcaag catgtctttt gctatgactg
      421 tgctatttta catgaaaaaa aaggagataa gatgtgcccg ggatgtagtg atcctgtgca
      481 gcggattgaa cagtgcacac gaggttctct cttcatgtgt agcattgttc aaggttgcaa
      541 gagaacatat ctgtctcaaa gggacttaca agctcacatc aaccatcgcc atatgagagc
      601 tggaaaacct gttacccgtg cttcacttga gaatgttcat cctcctattg cccccccacc
      661 aactgaaatc cctgatcgtt tcataatgcc accagacaag catcatatga gccacattcc
      721 tccaaagcag cacatcatga tgccaccgcc tcctttgcag catgtgccac atgagcacta
      781 taatcagcca cacgaggata tccgtgctcc tccagcagag ttgtccatgg ctccacctcc
      841 acctcgttca gtcagtcagg aaacctttcg tatttcaaca agaaaacaca gcaatttaat
      901 aaccgtccct attcaggatg actcaagttc aggtgctaga gaaccaccac ctcctgcccc
      961 agcacctgct catcaccatc ctgaatatca gggtcaacca gtggtgtctc accctcatca
     1021 catcatgcct ccacagcaac attacgcacc tcccccacct cctccaccac caataagcca
     1081 tccaatgcca catcctcccc aggctgcagg tactcctcac ttggtctata gccaagctcc
     1141 acctccacca atgacctctg ctccaccacc aataacccct ccccctggac atattattgc
     1201 ccaaatgcca ccttatatga atcatcctcc tccaggaccc cctccacctc agcatggtgg
     1261 tccacctgta actgcacccc ctccgcacca ttataatcct aactctttac cccagtttac
     1321 tgaagatcaa ggaactctga gccctccatt tacacaacca ggaggaatga gtcctggtat
     1381 ctggcctgca ccaagagggc caccacctcc tccacgaatg cagggcccac cttctcaaac
     1441 cccactacct ggaccacatc atccagatca aacaagatac agaccgtatt accagtgatc
     1501 atagtgtttt gaactgaaga tataacaagg aaaaaaaatt aaattagtca atcttaattg
     1561 agctttgact gtggaaggaa aacgacctct tgaggtagct gtaaaacaaa gtcttgtctc
     1621 ttaaaatggt tttaatctga ctttaggatt gctttcaagt actattctgt agtgcagata
     1681 aatggcttgg ttgagcacaa ctatatctta acaactgtta cgttgatgtg ataaattttc
     1741 ccaaaagcga ccatttgttt aaaaaaatga aaacaatttc actgttccac tttgagaaat
     1801 actgctttta ttaaacccaa tgtttagttt ccttgtgaca cattttgtta acctgtgtaa
     1861 aagaattaaa tttcaaaatg gttgtaaaaa tgctattttt atgtgaattt aagtgcagcc
     1921 atatcatttt ttaacccata ttttaccact aattttccaa agttaaaata aaatcctaaa
     1981 agtaaaaatg tactaaattg ttactaggca gactgttaaa ttgtagggaa ttatttcacg
     2041 ttttaggcac tgaaatttca aggtgtattg tatagtgcgt ttcacttgga tgccttttca
     2101 tgttgggtaa cctgtgaagc tccaatacac atcagagttt gtgcccttag ttggctgacg
     2161 tgtgtctcag ggtacccgtt gtataatttg gaaggtgacc tgctttacag gctctaaccg
     2221 ccgatgagtg ctgttttcat tgatgctttt cctgagtgct tagtcaccta atttgtcaca
     2281 cttaatccta aattctgtta ctttatagga cttttaaaat ggtgttattt ggatgaaatg
     2341 tgttctctgt tcactctctt aacctacata tttggggctg actaggctct atttaaatct
     2401 gcatttgctc atagtttgat tctgtacttt agtgcatagc gtgttcttat ttatgggatt
     2461 ataaactgca gtttgagtgc agtggaggga tctgactaat gtattagcaa gcggtgttct
     2521 tgtaatcaca agctagcatt tactcaggtt ttgtggctgt ggtgagtttt tcctctaagt
     2581 tgggaatgta aaactattat ttcttctttc ttttcttggt aaaacaatct aaaattggaa
     2641 cattttacaa tggaatcaat agttaaagac acccagataa tttttaattg ggcagaagaa
     2701 aagtaatgat tagattgtga atttcagtgc cgaggaaggt gcctttagag tcagtgtttg
     2761 cattacaggg gcttgttaca gtccactgga gacgaccact cagtttttac tgtttcctat
     2821 gtatacgtca gccttctcag gatgttatta tatatccttc gagttgacta aactcttgtg
     2881 aagcttttct tcccctttaa aatggtgcat aatataaaca tggtgtgtag tgtgcagata
     2941 acatttatta gatagtttgt agtatataaa tttagaacat tggtttttga caaggagtat
     3001 actgattgct aattcaccat tctgtcaggt acaggaaaac attctcatgt tggatgatca
     3061 gatgcaaaaa tcatttctaa actttgagaa gaaataatac aatggccatc catccttggc
     3121 tggccagaga taactaatgc aggtttttct tgagcaagtt ttttttcaca tgtagcattt
     3181 tgagaatctg gtttgctcat gcactatttc tagtgagaaa ttcttgttat tagaagcatg
     3241 aaagtgaaat agtgcgacgt ggtgagtgtt tctatcatta ctgtaggtac ttggactggt
     3301 gcaaacttga ttctttttct tgcccctgtt taggagctat taaaatatta ctgttaaaat
     3361 ccaaataacc ctttgtttca cataattgga aaatagccag tttcatatta gcttcttttt
     3421 agctgtttat gagaagctct tatactgaga ttgactggga ttggctgtgg taagaaacca
     3481 cttcgcctgt ttttggacca aaaaaaaaaa aaaaatcagt atcatgaaaa aaattccaca
     3541 ttatgagaat tcttgtaggc tttaaaaaaa caatttcagt taggttgata cattatgctg
     3601 ggatgcaggt gagatgaatg ttttgtaata gaattttaaa tgttagactc gaatatcagt
     3661 taattgtttg aatgaggggt gggtgggtag acagataaca agattattat taagtgtttc
     3721 tgttcttaag gaaaaagatg tgaatcccag cacctttcag ggaagccttt gaagctgtct
     3781 atgatggaca taagtctaaa tgtatgtatg tttcattaat tgctcttaag actactgagg
     3841 tggcagttta attcttaaaa acaataaaat gaaagcataa atacta
//
