LOCUS       NM_017162               1352 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus cobalamin binding intrinsic factor (Cblif), mRNA.
ACCESSION   NM_017162
VERSION     NM_017162.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Li,K., Gesang,L., Dan,Z., Gusang,L., Dawa,C. and Nie,Y.
  TITLE     Transcriptome Reveals 1400-Fold Upregulation of APOA4-APOC3 and
            1100-Fold Downregulation of GIF in the Patients with
            Polycythemia-Induced Gastric Injury
  JOURNAL   PLoS One 10 (10), e0140534 (2015)
   PUBMED   26485402
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Tanner,S.M., Li,Z., Perko,J.D., Oner,C., Cetin,M., Altay,C.,
            Yurtsever,Z., David,K.L., Faivre,L., Ismail,E.A., Grasbeck,R. and
            de la Chapelle,A.
  TITLE     Hereditary juvenile cobalamin deficiency caused by mutations in the
            intrinsic factor gene
  JOURNAL   Proc Natl Acad Sci U S A 102 (11), 4130-4133 (2005)
   PUBMED   15738392
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Gordon,M.M., Brada,N., Remacha,A., Badell,I., del Rio,E.,
            Baiget,M., Santer,R., Quadros,E.V., Rothenberg,S.P. and Alpers,D.H.
  TITLE     A genetic polymorphism in the coding region of the gastric
            intrinsic factor gene (GIF) is associated with congenital intrinsic
            factor deficiency
  JOURNAL   Hum Mutat 23 (1), 85-91 (2004)
   PUBMED   14695536
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Dugue,B., Ismail,E., Sequeira,F., Thakkar,J. and Grasbeck,R.
  TITLE     Urinary excretion of intrinsic factor and the receptor for its
            cobalamin complex in Grasbeck-Imerslund patients: the disease may
            have subsets
  JOURNAL   J Pediatr Gastroenterol Nutr 29 (2), 227-230 (1999)
   PUBMED   10435666
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Dieckgraefe,B.K., Seetharam,B., Banaszak,L., Leykam,J.F. and
            Alpers,D.H.
  TITLE     Isolation and structural characterization of a cDNA clone encoding
            rat gastric intrinsic factor
  JOURNAL   Proc Natl Acad Sci U S A 85 (1), 46-50 (1988)
   PUBMED   3422425
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1988 May;85(10):3406]
REFERENCE   6  (bases 1 to 1352)
  AUTHORS   Khadapkar,S.V. and Vakil,U.K.
  TITLE     Release of vitamin B-12 in vitro from intrinsic factor-vitamin B-12
            complex. Purification and characterization of a releasing factor
            from rat ileal brush border
  JOURNAL   Biochim Biophys Acta 719 (3), 619-632 (1982)
   PUBMED   7150665
REFERENCE   7  (bases 1 to 1352)
  AUTHORS   Inada,M. and Glass,G.B.
  TITLE     Effect of prolonged administration of homologous and heterologous
            intrinsic factor antibodies on the parietal and peptic cell masses
            and the secretory function of the rat gastric mucosa
  JOURNAL   Gastroenterology 69 (2), 396-408 (1975)
   PUBMED   1097299
REFERENCE   8  (bases 1 to 1352)
  AUTHORS   Zittoun,J., Debril,J., Jarret,J., Sultan,C. and Zittoun,R.
  TITLE     [Search for anti-intrinsic factor antibodies in the diagnosis of
            Biermer's anemia]
  JOURNAL   Sem Hop 51 (4), 229-232 (1975)
   PUBMED   167441
REFERENCE   9  (bases 1 to 1352)
  AUTHORS   James,D., Asherson,G., Chanarin,I., Coghill,N., Hamilton,S.,
            Himsworth,R.L. and Webster,D.
  TITLE     Cell-mediated immunity to intrinsic factor in autoimmune disorders
  JOURNAL   Br Med J 4 (5943), 494-496 (1974)
   PUBMED   4434116
REFERENCE   10 (bases 1 to 1352)
  AUTHORS   BOASS,A. and WILSON,T.H.
  TITLE     CELLULAR LOCALIZATION OF GASTRIC INTRINSIC FACTOR IN THE RAT
  JOURNAL   Am J Physiol 206, 783-786 (1964)
   PUBMED   14166172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03577.1.
            
            On Apr 17, 2014 this sequence version replaced NM_017162.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03577.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1352              J03577.1           2-1353
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1352
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /note="cobalamin binding intrinsic factor"
                     /db_xref="GeneID:29319"
                     /db_xref="RGD:62084"
     exon            1..102
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1277
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /note="IF; INF; intrinsic factor; gastric intrinsic
                     factor"
                     /codon_start=1
                     /product="cobalamin binding intrinsic factor precursor"
                     /protein_id="NP_058858.1"
                     /db_xref="GeneID:29319"
                     /db_xref="RGD:62084"
                     /translation="MWKGMAWLSFYLLNVLWAVAGTSTRAQRSCSVPPDQQPWVNGLQ
                     LLMENSVTESDLPNPSILIAMNLASTYNLEAQKLLTYQLMASDSADLTNGQLALTIMA
                     LTSSCRDPGSKVSILQKNMESWTPSNLGAESSSFYGPALAILALCQKNSEATLPIAVR
                     FAKTLMMESSPFSVDTGAVATLALTCMYNRIPVGSQENYRDLFGQALKVIVDNISLRI
                     KADGIIGDIYSTGLAMQALSVTPEQPTKEWDCEKTMYTILKEIKQGKFQNPMSIAQIL
                     PSLKGKTYLDVPQVTCGPDHEVPPTLTDYPTPVPTSISNITVIYTINNQLRGVDLLFN
                     VTIEVSVKSGSVLLAVLEEAQRRNHMFKFETTMTSWGLIVSSINNIAENVKHKTYWEF
                     LSGKTPLGEGVAYYIPFNYEHITANFTQY"
     exon            103..279
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            280..393
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            394..534
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            535..716
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            717..894
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1096
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1215
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1352
                     /gene="Cblif"
                     /gene_synonym="Gif"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaaaggga gatgtggaaa ggcatggcct ggctttcctt ctacctccta aatgttctct
       61 gggctgtggc aggaaccagt accagagccc agcgctcttg ctctgtcccc ccagatcagc
      121 agccctgggt caatggccta caattgctca tggaaaactc agtaactgag tcagacctcc
      181 caaaccccag catcctgatt gccatgaacc tggccagcac ctacaacctg gaggcccaga
      241 agctcctgac ttaccagctc atggccagtg acagtgcaga cctgacaaat gggcagctcg
      301 ccctcaccat tatggctctc acctcctcct gccgagaccc tggaagtaaa gtgtccattc
      361 tacaaaagaa tatggagagc tggacacctt caaacctggg tgctgaatcc tcatccttct
      421 atgggcctgc tctggcgatc cttgcactgt gccagaagaa ctcagaggca accttaccca
      481 tcgcggtgcg cttcgctaag accctcatga tggaatcctc tcccttcagt gtggacacag
      541 gagcagtggc aaccttggcc ctgacatgca tgtacaacag gattcctgtg ggttctcagg
      601 aaaactacag agacctgttt ggtcaggcac tgaaggttat tgtggataat atcagcttga
      661 ggatcaaagc tgatggtatt attggagaca tctacagcac tggccttgcc atgcaggctc
      721 tctctgtgac acctgagcaa cctaccaaag agtgggactg tgagaagact atgtatacga
      781 tactcaagga gattaagcag gggaaattcc agaaccccat gtccattgcc cagattctcc
      841 cttccttgaa aggcaagact tacctagatg tgccccaagt aacgtgtggc cctgatcatg
      901 aagtgccacc aactttaact gactatccta ccccggtccc cacttcaata tctaatatca
      961 cagtcatata caccataaac aaccagctga ggggggttga tctgcttttc aatgtgacca
     1021 tcgaggttag tgtgaaaagt ggatctgtgc tccttgctgt cctggaagaa gcgcagcgca
     1081 gaaaccacat gttcaaattt gaaaccacaa tgacatcctg gggccttatt gtctcttcta
     1141 tcaacaatat cgctgagaat gttaagcaca agacctattg ggagttcctt agtggcaaaa
     1201 cgcctttggg tgaaggggtt gcatactata ttcccttcaa ctacgagcac atcacagcca
     1261 acttcaccca atactgagaa ggagtatctt ctgttgtatg tgaccaaagg atggtttggt
     1321 ttcttttcat atcgtttcaa atctgtacca ag
//
