LOCUS       NM_001034920            1712 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Cbl proto-oncogene C (Cblc), mRNA.
ACCESSION   NM_001034920 XM_214861
VERSION     NM_001034920.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1712)
  AUTHORS   Kim,M., Tezuka,T., Tanaka,K. and Yamamoto,T.
  TITLE     Cbl-c suppresses v-Src-induced transformation through
            ubiquitin-dependent protein degradation
  JOURNAL   Oncogene 23 (9), 1645-1655 (2004)
   PUBMED   14661060
  REMARK    Erratum:[Oncogene. 2004 Oct 14;23(47):7903-4]
REFERENCE   2  (bases 1 to 1712)
  AUTHORS   Keane,M.M., Ettenberg,S.A., Nau,M.M., Banerjee,P., Cuello,M.,
            Penninger,J. and Lipkowitz,S.
  TITLE     cbl-3: a new mammalian cbl family protein
  JOURNAL   Oncogene 18 (22), 3365-3375 (1999)
   PUBMED   10362357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN934498.1 and BC105776.1.
            
            On Jun 19, 2009 this sequence version replaced NM_001034920.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DN934498.1         29-43
            16-1712             BC105776.1         1-1697
FEATURES             Location/Qualifiers
     source          1..1712
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1712
                     /gene="Cblc"
                     /note="Cbl proto-oncogene C"
                     /db_xref="GeneID:292699"
                     /db_xref="RGD:1307651"
     exon            1..375
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1516
                     /gene="Cblc"
                     /EC_number="2.3.2.27"
                     /note="Casitas B-lineage lymphoma c; Cas-Br-M (murine)
                     ecotropic retroviral transforming sequence c; Cbl
                     proto-oncogene, E3 ubiquitin protein ligase C; Cbl
                     proto-oncogene C, E3 ubiquitin protein ligase; RING-type
                     E3 ubiquitin transferase CBL-C"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CBL-C"
                     /protein_id="NP_001030092.1"
                     /db_xref="GeneID:292699"
                     /db_xref="RGD:1307651"
                     /translation="MAAATAPQGWQWGEPRALGRAVKLLQRLEEQCRDLRLFVGPPSL
                     RDLLPRTAQLLREVAKARSDKTRGDPEGPGGAGDFLVIYLTNLEAKGRQVAELLPHRG
                     KKDANQDVFPEGSRFRRQLAKLALIFSHMHAELSALFPEGKYCGHLYQITKGSANTFW
                     RENCGVRCVLPWAEFQSLLCSCHPVEPGPIMQALRSTLDLTCSGHVSVFEFDIFTRLF
                     QPWPTLLKNWQLLAVNHPGYMAFLTYDEVQTRLQAYRDKPGSYIFRPSCTRLGQWAIG
                     YVSSNGSILQTIPLNKPLLQVLLKGQKDGIFLYPDGKNHNPDLTELCRAELNQCIQVS
                     QEQLQLYQAMNSTFELCKICTERDKDVRIEPCGHLLCSCCLAAWQHSDSQTCPFCRCE
                     IKGREAVSICQAQERSMEVRTTAGDSGDNCHQEAAEWKLESVTPSAPPLPPEVPCPQR
                     PQDKGWLTLAPFTLPRLRPPLPLPKMASVLWEVTSRPQVREGATESS"
     exon            376..522
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            523..679
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            680..801
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            802..939
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1027
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1159
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1321
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1399
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1506
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1581
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1659
                     /gene="Cblc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccaggcca cccgagcgac ccatggctgc ggctacagcc ccgcaagggt ggcagtgggg
       61 agagccacgc gcgcttggcc gggcggtaaa gttgctccag cgcctggaag agcaatgcag
      121 ggatctcagg ctgttcgtgg ggcccccgtc gctacgggac ctgctacccc gcaccgcaca
      181 gctacttcga gaggtggcaa aagcccggag cgataagacc aggggagacc ccgagggtcc
      241 cggaggcgcc ggtgattttc tggttatcta cctgaccaac ctggaggcca aaggcaggca
      301 ggtggctgag ctcctgccac accgcggcaa aaaggacgcg aaccaggatg ttttcccgga
      361 gggctccaga ttcaggcgac aactggccaa gctggctctc atcttcagtc acatgcatgc
      421 ggagttgagc gcactcttcc ctgagggcaa gtactgtggg cacctgtacc agatcaccaa
      481 gggctctgcc aacaccttct ggagggagaa ttgtggagtt cggtgcgtcc ttccctgggc
      541 tgagttccag tccctcctgt gctcctgcca ccctgtggaa ccaggcccca tcatgcaggc
      601 cttgcggtcc accttggacc tcacctgtag cggccacgtg tctgtctttg agttcgacat
      661 cttcaccagg ctcttccagc cgtggcccac tttactgaag aattggcaac tcctggctgt
      721 caaccatcct ggctacatgg ccttcctcac ctacgatgag gtccaaacac gtctgcaggc
      781 ctacagggac aaaccgggca gctatatctt ccggcccagc tgtacccgcc tagggcagtg
      841 ggccattggg tacgtgagct ccaatggaag catcctacag accattcctc tcaacaagcc
      901 tctgctccag gtgctcctga aaggacaaaa ggacggcatc ttcctctacc ctgatggaaa
      961 gaaccacaac ccagacttga ctgagctctg ccgtgcagaa ctgaaccagt gcatccaagt
     1021 gtcacaggaa caactgcagc tctaccaagc catgaactcc acctttgagc tgtgcaagat
     1081 ctgcacagag agggacaagg acgtgagaat tgagccctgt gggcatcttc tctgcagctg
     1141 ctgcctggct gcctggcagc actcagacag ccagacctgt cccttctgcc gctgtgagat
     1201 caaaggccga gaggctgtga gtatctgtca ggcacaggag aggtcaatgg aggtcaggac
     1261 tactgcaggt gactcaggag acaactgtca ccaggaggct gccgaatgga aactggaatc
     1321 ggtgactcct tctgctcccc cactgccccc tgaagttcca tgccctcaga gaccccaaga
     1381 caaaggctgg ctgacactgg caccgttcac cctgcccaga ctccgacctc cacttcctct
     1441 ccccaaaatg gcatcagttc tgtgggaagt cacctccagg ccccaggtca gggagggggc
     1501 cacagaaagc tcctgaaaag ggaaagcacc ctccaggtgg ccctgcgaga ccctcggttc
     1561 tgcccaaaac ccagaggcca gggcacctgg actggaggaa gggagccttg gagctggaag
     1621 gggtgacaaa gccgaaataa attaatcctg atctttcaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
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